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Super-Resolution Fluorescence Microscopy for Cilia Investigation and Ciliopathy Diagnosis（特邀）

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激光与光电子学进展 2024年第6期 270-281页

作者： Liu Zhen wu yang Division of Life Science The Hong Kong University of Science and Technology

The last two decades have witnessed the invention and development of super-resolution microscopy(SRM) that breaks the diffraction limit of light and pushes the fluorescence microscopy resolution to several nanometers. While SRM is widely used in biological studies, such as resolving subdiffraction structures, molecular mapping, tracking single molecules, probing protein-protein interactions, and observing organelle dynamics, its direct application in translational medicine, such as disease diagnosis, is still preliminary. Despite their small size, cilia play a crucial role as organelles in cell signaling and motility, with defects in cilia leading to ciliopathy. Similar to other miniature organelles and macromolecular complexes, cilia are ideal for super-resolution imaging. In this review, we will 1) introduce cilia and ciliopathy, 2) show how SRM extends our knowledge of cilia, and 3) focus on how SRM improves the diagnosis of motile ciliopathies.

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Activity Pattern and Habitat Use of Shorebirds in an Artificial Wetland Complex:A Case Study of Breeding Pied Avocet in the Yellow River Delta,China

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Chinese Geographical Science 2024年第4期34卷 618-630页

作者： LI Dong LI Bin XU He FAN Chao wu yang ZHANG Yuxin HOU Xiyong Yantai Institute of Coastal Zone Research Chinese Academy of SciencesYantai 264003China Beijing VMinFull Limited Beijing 100086China CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation Yantai Institute of Coastal Zone ResearchChinese Academy of SciencesYantai 264003China University of Chinese Academy of Sciences Beijing 100049China School of Information Engineering Zhejiang Ocean UniversityZhoushan 316022China Key Laboratory for Biodiversity Science and Ecological Engineering College of Life SciencesBeijing Normal UniversityBeijing 100875China

With the loss of substantial natural wetlands in coastal zones,artificial wetlands provide alternative habitats for many shorebirds.Scientific management of artificial wetlands used by shorebirds plays an important role in maintaining the stability of shorebird population.Satellite tracking technique can obtain high-precision location information of individuals day and night,providing a good technical support for the study of quantitative relationship between waterfowls and their habitats.In this study,satellite tracking method,Remote Sensing(RS)and Geographic Information System(GIS)technology were used to analyze the activity pattern and habitat utilization characteristics of Pied Avocet during breeding period in an artificial wetland complex in the Yellow River Delta(YRD),China.The results showed that the breeding Pied Avocets had a small range of activity,with a total core and main home range of 33.10 km^(2) and 216.30 km^(2),respectively.This species tended to forage in the pond and salt pan during the day and night,respectively,with an unfixed staying time in the breeding ground.The distance between breeding ground and feeding ground was less than 6 km.It is emphasized that in addition to improving the conditions of the remaining natural habitats,effective managing artificial habitats is a priority for shorebird conservation.This research could provide reference for the management of artificial wetlands in coastal zones and supply technique support for the protection of shorebirds and their habitats,and alleviate human-bird conflicts and sustainable development of coastal zones.

关键词： satellite tracking home range habitat use artificial wetland coastal zone Pied Avocet Yellow River Delta China

Cobalt doping amount determines dominant reactive species in peroxymonosulfate activation via porous carbon catalysts co-doped by cobalt and nitrogen

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Journal of Environmental Sciences 2024年第4期138卷 212-226页

作者： Xiang Li Limeng wu Aiqin Zhang Shaohua wu Yan Lin Chunping yang Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle Nanchang Hangkong UniversityNanchang 330063China Academy of Environmental and Resource Sciences School of Environmental Science and EngineeringGuangdong University of Petrochemical TechnologyMaoming 525000China College of Environmental Science and Engineering Hunan University and Key Laboratory of Environmental Biology and Pollution Control(Hunan University)Ministry of EducationChangsha 410082China

Switching the reaction routes in peroxymonosulfate(PMS)-based advanced oxidation processes have attracted much attention but remain challenging.Herein,a series of Co-N/C catalysts with different compositions and structures were prepared by using bimetallic zeolitic imidazolate frameworks based on ZIF-8 and ZIF-67(x Zn/Co-ZIFs).Results show that Co doping amount could mediate the transformation of the activation pathway of PMS over CoN/C.When Co doping amount was less than 10%,the constructed x Co-N/C/PMS system(x≤10%)was singlet oxygen-dominated reaction;however further increasing Co doping amount would lead to the generation and coexistence of sulfate radicals and high-valent cobalt,besides singlet oxygen.Furthermore,the nitrogen-coordinated Co(Co-NX)sites could serve as main catalytically active sites to generate singlet oxygen.While excess Co doping amount caused the formation of Co nanoparticles from which leached Co ions were responsible for the generation of sulfate radicals and high-valent cobalt.Compared to undoped N/C,Co doping could significantly enhance the catalytic performance.The 0.5%Co-N/C could achieve the optimum degradation(0.488 min^(-1))and mineralization abilities(78.4%)of sulfamethoxazole among the investigated Co-N/C catalysts,which was superior to most of previously reported catalysts.In addition,the application prospects of the two systems in different environmental scenarios(pH,inorganic anions and natural organic matter)were assessed and showed different degradation behaviors.This study provides a strategy to regulate the reactive species in PMS-based advanced oxidation process.

关键词： Peroxymonosulfate Sulfate radical Singlet oxygen Cobalt Zeolitic imidazolate framework Advanced oxidation process

Resource allocation for D2D-assisted haptic communications

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Digital Communications and Networks 2024年第1期10卷 63-74页

作者： Yan wu Chao Yue yang yang Liang Ao College of Telecommunication Engineering Army Engineering University of PLANanjing210000China

Haptic communications is recognized as a promising enabler of extensive services by enabling real-time haptic control and feedback in remote environments,e.g.,teleoperation and autonomous driving.Considering the strict transmission requirements on reliability and latency,Device-to-Device(D2D)communications is introduced to assist haptic communications.In particular,the teleoperators with poor channel quality are assisted by auxiliaries,and each auxiliary and its corresponding teleoperator constitute a D2D pair.However,the haptic interaction and the scarcity of radio resources pose severe challenges to the resource allocation,especially facing the sporadic packet arrivals.First,the contentionbased access scheme is applied to achieve low-latency transmission,where the resource scheduling latency is omitted and users can directly access available resources.In this context,we derive the reliability index of D2D pairs under the contention-based access scheme,i.e.,closed-loop packet error probability.Then,the reliability performance is guaranteed by bidirectional power control,which aims to minimize the sum packet error probability of all D2D pairs.Potential game theory is introduced to solve the problem with low complexity.Accordingly,a distributed power control algorithm based on synchronous log-linear learning is proposed to converge to the optimal Nash Equilibrium.Experimental results demonstrate the superiority of the proposed learning algorithm.

关键词： Haptic communications D2D Power control Contention-based access Potential game

Intelligent feedforward gust alleviation based on neural network

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Chinese Journal of Aeronautics 2024年第3期37卷 116-132页

作者： Yitao ZHOU Zhigang wu Chao yang School of Aeronautic Science and Engineering Beihang UniversityBeijing 100191China

This paper proposes a neural network-based intelligent feedforward gust alleviation framework,which includes a neural network identification model and a neural network controller.A neural network training dataset is formed by collecting flight data and the gust data encountered during the aircraft flight.A neural network identification model is first trained to accurately predict the aircraft’s output.Then,based on the output of the identification model and the collected flight data,the parameters of the time-delay neural network controller are obtained through a learning process.The simulation results show that the designed intelligent controller has good gust alleviation effects for both continuous turbulence excitation and discrete gust excitation.For example,when the aircraft is 40000 kg and the flight speed is 0.81Ma,the controller achieves a 67.82%reduction in wingtip acceleration and a 35.90%reduction in center of mass acceleration under continuous turbulence excitation.When considering the measurement uncertainties,such as noise existing in the collected data,the trained controller can still achieve an acceptable gust alleviation effect.Finally,considering a flight in which the aircraft mass is constantly changing,the intelligent controller,which continuously learns from new flight data,maintains a good gust alleviation effect throughout the flight.

关键词： Gust alleviation Intelligent control Feedforward control Neural networks Time-varying aircraft

Active flutter suppression of nonlinear fin-actuator system via inverse system and immersion and invariance method

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Chinese Journal of Aeronautics 2024年第4期37卷 343-362页

作者： Jin LU Zhigang wu Chao yang Chinese Aeronautical Establishment Beijing 100029China School of Aeronautic Science and Engineering Beihang UniversityBeijing 100191China

Structural nonlinearities such as freeplay will affect the stability and even flight safety of the fin-actuator system.There is a lack of a practical method for designing Active Flutter Suppression (AFS) control laws for nonlinear fin-actuator systems.A design method for the AFS controller of the nonlinear all-movable fin-electromechanical actuator system is established by combining the inverse system and the Immersion and Invariance (I&I) theory.First,the composite control law combining the inverse system principle and internal model control is used to offset the nonlinearity and dynamics of the actuator,so that its driving torque can follow the ideal signal.Then,the ideal torque of the actuator is designed employing the I&I theory.The unfavorable oscillation of the fin is suppressed by making the output torque of the actuator track the ideal signal.The simulation results reveal that the proposed AFS method can increase the flutter speed of the nonlinear finactuator system with freeplay,and a set of controller parameters is also applicable for wider freeplay within a certain range.The power required for the actuator does not exceed the power that can be provided by the commonly used aviation actuator.This method can also resist a certain level of noise and external disturbance.

关键词： Aeroelasticity Active flutter suppression Fin-actuator system Freeplay Inverse system Immersion and invariance

Exosomal let-7a-5p derived from human umbilical cord mesenchymal stem cells alleviates coxsackievirus B3-induced cardiomyocyte ferroptosis via the SMAD2/ZFP36 signal axis

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第5期25卷 422-437页

作者： Xin LI Yanan HU Yueting wu Zuocheng yang yang LIU Hanmin LIU Department of Pediatric Pulmonology and Immunology West China Second University HospitalSichuan UniversityChengdu 610041China Key Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University) Ministry of EducationChengdu 610041China NHC Key Laboratory of Chronobiology(Sichuan University) Chengdu 610041China The Joint Laboratory for Lung Development and Related Diseases of West China Second University Hospital Sichuan University and School of Life Sciences of Fudan UniversityWest China Institute of Women and Children's HealthWest China Second University HospitalSichuan UniversityChengdu 610041China Sichuan Birth Defects Clinical Research Center West China Second University HospitalSichuan UniversityChengdu 610041China Department of Pediatrics the Third Xiangya HospitalCentral South UniversityChangsha 410013China

Viral myocarditis(VMC)is one of the most common acquired heart diseases in children and teenagers.However,its pathogenesis is still unclear,and effective treatments are lacking.This study aimed to investigate the regulatory pathway by which exosomes alleviate ferroptosis in cardiomyocytes(CMCs)induced by coxsackievirus B3(CVB3).CVB3 was utilized for inducing the VMC mouse model and cellular model.Cardiac echocardiography,left ventricular ejection fraction(LVEF),and left ventricular fractional shortening(LVFS)were implemented to assess the cardiac function.In CVB3-induced VMC mice,cardiac insufficiency was observed,as well as the altered levels of ferroptosis-related indicators(glutathione) peroxidase 4(GPX4),glutathione(GSH),and malondialdehyde(MDA).However,exosomes derived from human umbilical cord mesenchymal stem cells(hucMSCs-exo)could restore the changes caused by CVB3 stimulation.Let-7a-5p was enriched in hucMSCs-exo,and the inhibitory ffect of hucMSCs-exoa-ie-pmimo on CVB3-induced ferroptosis was higher than that of hucMSCs-exommie N(NC:negative control).Mothers against decapentaplegic homolog 2(SMAD2)increased in the VMC group,while the expression of zinc-finger protein 36(ZFP36)decreased.Let-7a-5p was confirmed to interact with SMAD2 messenger RNA(mRNA),and the SMAD2 protein interacted directly with the ZFP36 protein.Silencing SMAD2 and overexpressing ZFP36 inhibited the expression of ferroptosis-related indicators.Meanwhile,the levels of GPX4,solute carrier family 7,member 11(SLC7A11),and GSH were lower in the SMAD2 overexpression plasmid(oe-SMAD2)+let-7a-5p mimic group than in the oe-NC+let-7a-5p mimic group,while those of MDA,reactive oxygen species(ROS),and Fe^(2+)increased.In conclusion,these data showed that ferroptosis could be regulated by mediating SMAD2 expression.Exo-let-7a-5p derived from hucMSCs could mediate SMAD2 to promote the expression of ZFP36,which further inhibited the ferroptosis of CMCs to alleviate CVB3-induced VMC.

关键词： Exosome Let-7a-5p Mothers against decapentaplegic homolog 2(SMAD2) Coxsackievirus B3(CVB3) Ferroptosis

Natural marmatite photocatalyst for treatment of mineral processing wastewater to help zero wastewater discharge

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Journal of Environmental Sciences 2024年第8期142卷 83-91页

作者： Meirong wu Wei Sun Xiangsong Meng Jianhua Kang Yue yang School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083China Key Laboratory of Hunan Province for Clean and Efficient Utilization of Strategic Calcium-containing Mineral Resources Central South UniversityChangsha 410083China

Mineral processing wastewater(MPW)with large discharge and high toxicity affects environmental safety,and the realizing zero discharge of MPW is of great significance for reducing environmental pollution,saving water resources,and promoting the sustainable development of the mining industry.In this study,we reported natural marmatite(NM)as a low-cost and efficient photocatalyst for the treatment of MPW to help zero wastewater discharge.The photocatalytic activity of NM was evaluated by the removal of total organic carbon(TOC)from MPW under visible-light illumination,and the optimal degradation conditions were discussed.Results showed that superoxide free radicals(^(·)O_(2)^(-))were the dominant active species responsible for organic pollutants degradation,and 74.25%TOC removal was obtained after 120 min reaction under the optimum treatment conditions.Meanwhile,the wastewater treated by NM photocatalysis can be reused in the flotation system without adverse impact on the product index.Based on these findings,a model of zero wastewater discharge for flotation with the help of photocatalytic treatment was established,it indicated that the water of the whole system can be balanced without affecting the ore dressing index,which showed that visible light-driven photocatalyst has a promising application prospect in the treatment and recycling of industrial wastewater.

关键词： Natural mineral Photocatalysis Industrial wastewater Wastewater recycling Water balance

Modeling wave propagation across rock masses using an enriched 3D numerical manifold method

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Science China(Technological Sciences) 2024年第3期67卷 835-852页

作者： yang YongTao LI JunFeng wu WenAn State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan 430071China Key Laboratory of Urban Security and Disaster Engineering Ministry of EducationBeijing University of TechnologyBeijing 100124China University of Chinese Academy of Sciences Beijing 100049China

The three-dimensional numerical manifold method(3DNMM) method is further enriched to simulate wave propagation across homogeneous/jointed rock masses. For the purpose of minimizing negative effects from artificial boundaries, a viscous nonreflecting boundary, which can effectively absorb the energy of a wave, is firstly adopted to enrich 3DNMM. Then, to simulate the elastic recovery property of an infinite problem domain, a viscoelastic boundary, which is developed from the viscous nonreflecting boundary, is further adopted to enrich 3DNMM. Finally, to eliminate the noise caused by scattered waves, a force input method which can input the incident wave correctly is incorporated into 3DNMM. Five typical numerical tests on P/S-wave propagation across jointed/homogeneous rock masses are conducted to validate the enriched 3DNMM. Numerical results indicate that wave propagation problems within homogeneous and jointed rock masses can be correctly and reliably modeled with the enriched 3DNMM.

关键词： 3D numerical manifold method viscous nonreflecting boundary rock masses force input method wave propagation