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Constructing hierarchical ZSM-5 coated with small ZSM-5 crystals via oriented-attachment and in situ assembly for methanol-to-aromatics reaction

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Frontiers of Chemical Science and Engineering 2024年第7期18卷 41-53页

作者： Ning Yang Tingjun Fu Chuntao Cao xueqing wu Huiling Zheng Zhong Li State Key Laboratory of Clean and Efficient Coal Utilization College of Chemical Engineering and TechnologyTaiyuan University of TechnologyTaiyuan 030024China

Developing hierarchical and nanoscale ZSM-5 catalysts for diffusion-limited reactions has received ever-increasing attention. Here, ZSM-5 architecture integrated with hierarchical pores and nanoscale crystals was successfully prepared via in situ self-assembly of nanoparticles-coated silicalite-1. First, the oriented attachment of amorphous nanoparticles on external surface of silicalite-1 was achieved by controlling the alkalinity of Si-Al coating solution. The partial exposure of the external surface of silicalite-1 ensured the uniform removal of silicon in the bulk phase for the creation of hierarchical pores during the subsequent desilication-recrystallization. The uniform removal of silicon species in the bulk phase was mainly due to the synergistic effect of surface protection and alkaline etching, which could be balanced by regulating the relative amount of tetrapropylammonium cation and OH– in desilication-recrystallization solution. Importantly, the removed silicon from silicalite-1 recrystallized and in situ assembled into final ZSM-5 nanocrystals induced by surface Si-Al nanoparticles. The hierarchical pores and nanoscale crystals on this integrated architecture not only promoted the removal of coke precursors from micropores but also provided large external specific surface (91 m^(2)·g^(-1)) for coke deposition. Consequently, a much longer catalytic lifetime was achieved for methanol-to-aromatics reaction compared to conventional hollow structure ZSM-5 (84 h vs 46 h), with relatively high stability.

关键词： hierarchical ZSM-5 nanocrystal integrated architecture diffusion coke

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Hierarchical Voronoi Structure Inspired by Cat Paw Pads Substantially Enhances Landing Impact Energy Dissipation

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Journal of Bionic Engineering 2024年第4期21卷 1847-1861页

作者： Da Lu Baoqing Pei Yangyang Xu Mengyuan Hu Shijia Zhang Le Zhang Xin Huang Yangwei Wang xueqing wu Beijing Key Laboratory for Design and Evaluation Technology of Advanced Implantable&Interventional Medical Devices Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang University100083BeijingChina National Key Laboratory of Science and Technology on Materials under Shock and Impact Beijing Institute of Technology100081BeijingChina Shenzhen Institute of Beihang University 518000ShenzhenChina

When a human lands from a high drop,there is a high risk of serious injury to the lower *** the other hand,cats can withstand jumps and falls from heights without being fatally wounded,largely due to their impact-resistant paw *** aim of the present study was to investigate the biomechanism of impact resistance in cat paw pads,propose an optimal hierarchical Voronoi structure inspired by the paw pads,and apply the structure to bionic cushioning shoes to reduce the impact force of landing for *** microstructure of cat paw pads was observed via tissue section staining,and a simulation model was reconstructed based on CT to verify and optimize the structural cushioning *** distribution pattern,wall thickness of compartments,thickness ratio of epidermis and dermis,and number of compartments in the model were changed and simulated to achieve an optimal composed structure.A bionic sole was 3D-printed,and its performance was evaluated via compression test and a jumping-landing *** results show that cat paw pads are a spherical cap structure,divided from the outside to the inside into the epidermis,dermis,and compartments,each with different cushioning capacities.A finite element simulation of different cushioning structures was conducted in a cylinder with a diameter of 20 mm and a height of 10 mm,featuring a three-layer *** optimal configuration of the three layers should have a uniform distribution with 0.3–0.5 mm wall thickness,a 1:1–2 thickness ratio of epidermis and dermis,and 100–150 compartments.A bionic sole with an optimized structure can reduce the peak impact force and delay the peak arrival *** energy absorption rate is about 4 times that of standard *** jumping 80,100,and 120 cm,the normalized ground reaction force is also reduced by 8.7%,12.6%and 15.1%compared with standard *** study provides theoretical and technical support for effective protection against human lower limb landing injuries.

关键词： Cat paw pads Hierarchical Voronoi structure Landing impact Energy dissipation Bionic sole

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Correction of a CADASIL point mutation using adenine base editors in hiPsCsandbloodvessel organoids

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Journal of Genetics and Genomics 2024年第2期51卷 197-207页

作者： Jingwen Wang Lei Zhang Guanglan wu Jinni wu Xinyao Zhou Xiaolin Chen Yongxia Niu Yiren Jiao Qianyi Liu Puping Liang Guang Shi xueqing wu Junjiu Huang MOE Key Laboratory of Gene Function and Regulation State Key Laboratory of BiocontrolSchool of Life SciencesSun Yat-sen UniversityGuangzhouGuangdong 510275China Key Laboratory of Reproductive Medicine of Guangdong Province The First Affiliated Hospital and School of Life SciencesSun Yat-sen UniversityGuangzhouGuangdong 510275China Center of Reproductive Medicine Children's Hospital of Shanxi and Women Health Center of ShanxiTaiyuanShanxi 030013China

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a monogenic small vessel disease caused by mutations in the NOTCH3 gene. However, the pathogenesis of CADASIL remains unclear, and patients have limited treatment options. Here, we use human induced pluripotent stem cells (hiPSCs) generated from the peripheral blood mononuclear cells of a patient with CADASIL carrying a heterozygous NOTCH3 mutation (c.1261C>T, p.R421C) to develop a disease model. The correction efficiency of different adenine base editors (ABEs) is tested using the HEK293T-NOTCH3 reporter cell line. ABEmax is selected based on its higher efficiency and minimization of predicted off-target effects. Vascular smooth muscle cells (VSMCs) differentiated from CADASIL hiPSCs show NOTCH3 deposition and abnormal actin cytoskeleton structure, and the abnormalities are recovered in corrected hiPSC-derived VSMCs. Furthermore, CADASIL blood vessel organoids generated for in vivo modeling show altered expression of genes related to disease phenotypes, including the downregulation of cell adhesion, extracellular matrix organization, and vessel development. The dual adeno-associated virus (AAV) split-ABEmax system is applied to the genome editing of vascular organoids with an average editing efficiency of 8.82%. Collectively, we present potential genetic therapeutic strategies for patients with CADASIL using blood vessel organoids and the dual AAV split-ABEmax system.

关键词： CADASIL Induced pluripotent stem cells Adenine base editors AAV Blood vessel Organoid

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生物育种研发支出的会计选择:资本化与费用化

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分子植物育种 2024年第2期22卷 459-464页

作者：王彩吴雪青绍兴职业技术学院绍兴312000

本研究深入探讨了生物育种研发支出的会计选择,具体研究了资本化和费用化这两种不同的会计方法。本研究详细分析了这两种方法的优势和劣势,以及它们对公司、投资者和决策者的潜在影响。资本化有助于提高资产负债表的质量,但可能带来更... 详细信息

本研究深入探讨了生物育种研发支出的会计选择,具体研究了资本化和费用化这两种不同的会计方法。本研究详细分析了这两种方法的优势和劣势,以及它们对公司、投资者和决策者的潜在影响。资本化有助于提高资产负债表的质量,但可能带来更多复杂性和税务问题。而费用化有助于提升短期盈利和现金流,但可能导致长期创新潜力被忽视。本研究还考察了公司规模和类型、法规和行业标准,以及研发项目性质和可量化性等多个因素对会计选择的影响。本研究突出了监管机构的角色,提出政策建议和未来研究方向,以协助公司更明智地应对这一关键的会计决策。

关键词：生物育种会计选择研发支出资本化费用化

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基于多尺度分段的长时间序列预测方法

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深圳大学学报（理工版） 2024年第2期41卷 232-240页

作者：何胜林龙琛郑静王爽文振焜吴惠思倪东何小荣吴雪清深圳大学计算机与软件学院广东深圳518060 深圳市卫生健康发展研究和数据管理中心广东深圳518028 深圳市荔康科技有限公司广东深圳518052 深圳大学总医院妇产科广东深圳518071

针对目前长时间序列预测(long sequence time-series forecasting,LSTF)存在历史数据量大、计算复杂度高、预测精度要求高等问题,提出一种基于多尺度分段的Transformer模型.该模型基于Transformer架构进行改进和优化,使用多尺度分段将... 详细信息

针对目前长时间序列预测(long sequence time-series forecasting,LSTF)存在历史数据量大、计算复杂度高、预测精度要求高等问题,提出一种基于多尺度分段的Transformer模型.该模型基于Transformer架构进行改进和优化,使用多尺度分段将时间序列切片成多个时间段进行训练和预测,降低了长时间序列的复杂性,并实现了更高精度的预测.在电力变压器油温(electricity transformer temperature,ETT)数据集、用电负荷(electricity consumption load,ECL)数据集和天气(Weather)数据集中,分别采用传统Transfomer、Informer、门控循环单元(gated recurrent unit,GRU)、时序卷积网络(temporal convolutional network,TCN)和长短期记忆(long short-term memory,LSTM)5种基准模型与本研究提出的多尺度分段的Transformer模型,对长时间序列进行预测.结果表明,采用基于多尺度分段的Transformer模型在Weather数据集上对预测长度为192的时间序列预测的均方误差和平均绝对误差分别为0.367和0.407,均优于其他模型.基于多尺度分段的Transformer模型可以综合Transformer模型的优点,且计算速度更快,预测性能更高.

关键词：计算机神经网络时间序列预测 Transformer模型多尺度分段深度学习电力预测

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普雷沃氏菌在细菌性阴道病和人乳头瘤病毒持续感染中的研究进展

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温州医科大学学报 2024年第3期54卷 244-248,254页

作者：张琦李修身吴雪清深圳大学医学部广东深圳518000 深圳大学总医院妇产科广东深圳518000

细菌性阴道病中相关微生物可能导致人乳头瘤病毒(HPV)感染甚至持续感染,同时HPV感染能促进细菌性阴道病的发生。最近研究发现细菌性阴道病相关微生物普雷沃氏菌(普氏菌)与HPV持续感染密切相关。普氏菌是阴道常见的共生菌,它是一种专性... 详细信息

细菌性阴道病中相关微生物可能导致人乳头瘤病毒(HPV)感染甚至持续感染,同时HPV感染能促进细菌性阴道病的发生。最近研究发现细菌性阴道病相关微生物普雷沃氏菌(普氏菌)与HPV持续感染密切相关。普氏菌是阴道常见的共生菌,它是一种专性厌氧菌,培养困难,也很少受到关注,随着基因测序工程技术越来越成熟,普氏菌在妇科疾病中的重要性也越来越突出。已有研究表明普氏菌可能是生殖道炎症发生时的早期定植菌群,为其他细菌、病毒入侵生殖道奠定基础。笔者总结了近年来普氏菌在细菌性阴道病和HPV持续感染中的研究进展,增强对普氏菌的了解,为HPV感染和相关疾病的预防和治疗提供参考。

关键词：细菌性阴道病普雷沃氏菌阴道微生态失调人类乳头瘤病毒

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How do Cats Resist Landing Injury:Insights into the Multi-level Buffering Mechanism

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Journal of Bionic Engineering 2020年第3期17卷 600-610页

作者： xueqing wu Baoqing Pei Yuyang Pei Wei Wang Yan Hao Kaiyuan Zhou School of Biological Science and Medical Engineering Beihang UniversityBeijing 100083China Beijing Advanced Innovation Centre for Biomedical Engineering Beihang UniversityBeijing 100083China School of Public Health Nanjing Medical UniversityNanjing 211166China

When humans jump down from a high position,there is a risk of serious injury to the lower ***,cats can jump down from the same heights without any injury because of their excellent ability to attenuate impact *** present study aims to investigate the macro/micro biomechanical features of paw pads and limb bones of cats,and the coordination control of joints during landing,providing insights into how cats protect themselves from landing ***,histological analysis,radiological analysis,finite element method,and mechanical testing were performed to investigate the mechanical properties,microstructure,and biomechanical response of the pads and limb *** addition,using a motion capture system,the kinematic/kinetic data during landing were analysed based on inverse *** results show that the pads and limb bones are major contributors to non-impact-injuries,and cats actively couple their joints to adjust the parameters of movement to dissipate the higher ***,the paw pads,limb bones,and coordinated joints complement each other and constitute a multi-level buffering mechanism,providing the cat with the sophisticated shock absorption *** biomechanical analysis can accordingly provide biological inspiration for new approaches to prevent human lower limb injuries.

关键词： cat multi-level buffering paw pads limb bones coordinated joints

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医学研究生心理健康教育及支持研究

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全科医学临床与教育 2024年第1期22卷 65-67页

作者：伍雪晴蒋琰俞云松浙江大学医学院附属邵逸夫医院感染科浙江杭州310016

目的研究医学研究生的心理健康状况及对心理健康教育和支持的偏好,有效促进医学院校医学研究生心理健康教育发展。方法在2023年5月对90名浙江省医学院校医学专业研究生进行问卷调查,调查问卷内容包括:心理状态及其影响评估、心理咨询... 详细信息

目的研究医学研究生的心理健康状况及对心理健康教育和支持的偏好,有效促进医学院校医学研究生心理健康教育发展。方法在2023年5月对90名浙江省医学院校医学专业研究生进行问卷调查,调查问卷内容包括:心理状态及其影响评估、心理咨询经历和意愿、心理健康教育和支持。结果有效调查问卷有83份,调查结果显示,心理状态很差的医学研究生有17名(20.48%),且仅有23名(27.71%)医学研究生认为自己的心理状态受到学校重视。调查还发现,43名(51.80%)医学研究生更愿意接受面对面的直接交流,65名(78.13%)学生愿意选择校内心理咨询。34名(40.96%)医学研究生愿意积极参加学校提供的心理健康方面的培训或工作坊,并且有42名(50.60%)医学研究生认为可以考虑参加。最受欢迎的心理支持服务类型是学校提供专业的心理咨询专员(53名,63.86%),其次是提供在线资源或健康自助手册(41名,49.40%),以及建立心理健康支持机构(35名,42.17%),开设心理健康课程位列第四(33名,39.76%)。结论医学研究生心理状态受学校重视程度不足,并且存在很大的心理健康支持和教育缺口,提供校内培训课程和心理支持专员可有效促进医学研究生心理健康状况。

关键词：医学研究生心理健康心理健康支持心理健康培训课程

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Mechanisms of Physiological Regulation for Improving Dryland Crop Water Use

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Agricultural Sciences in China 2003年第9期2卷 957-963页

作者： SHANGGUANZhou-pingI xueqing-wu NationalLaboratoryofSoilErosionandDrylandAgricultureontheLoessPlateau InstituteofSoilandWaterConservationChineseAcademyofSciencesYangling712100P.R.China NorthwesternAgriculturalResearchCenter MontanaStateUniversity4570Montana35KalispellMT59901USA

This paper briefly reviews the physiological mechanisms for improving crop water use and water use efficiency in dryland farming regions of Loess Plateau on the basis of its environmental conditions and progress in crop water relations and the biological basis of water saving agriculture, especially in non uniform stomatal closure, ABA effects, communication between root and shoot, and water use efficiency. Root chemical signals about water shortage are feedforward effect which contributes to balanced water relations within the plant compartment of the soil plant atmosphere continuum. ABA production is increased in tissues during these stresses, and this causes a variety of physiological effects, including stomata closure in leaves. It is concluded that the root chemical signal ABA is very important to improve the crop water use efficiency in semi arid area of Loess Plateau.

关键词： Water use efficiency Non uniform stomatal closure Root chemical signal Semi arid area

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基于DEM的电铲装卸载过程中铲斗内物料分布研究

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机械管理开发 2024年第5期39卷 1-3,8页

作者：田筱剑王勇澎吴雪晴智能采矿装备技术全国重点实验室山西太原030032 山西太重智能采矿装备技术有限公司山西太原030032 大连理工大学工程力学系辽宁大连116024 工业装备结构分析优化与CAE软件全国重点实验室辽宁大连116024

电铲是大型露天矿开采的核心和源头装备,承担着物料的装载和卸载两大主要功能。铲斗内颗粒物料在铲载和卸载过程中的运动规律是分析铲斗内衬板磨损、提高装卸载作业效率的重要基础。基于此,以太原重工股份有限公司生产的某型电铲为研究... 详细信息

电铲是大型露天矿开采的核心和源头装备,承担着物料的装载和卸载两大主要功能。铲斗内颗粒物料在铲载和卸载过程中的运动规律是分析铲斗内衬板磨损、提高装卸载作业效率的重要基础。基于此,以太原重工股份有限公司生产的某型电铲为研究对象,基于离散元法(DEM)对铲装和卸载过程中铲斗内颗粒的分布规律进行分析。结果表明,装载过程中铲斗内的颗粒分布和卸载过程中颗粒流出铲斗的顺序与颗粒在堆积状态时距离斗齿运动轨迹的偏移距离有关,为后续制定电铲装卸载控制策略提供依据。

关键词：电铲离散元法(DEM) 铲斗装卸载物料分布

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