检索结果-南通市图书馆

Effects of Inoculation with Phosphate Solubilizing Bacteria on the Physiology,Biochemistry,and Expression of Genes Related to the Protective Enzyme System of Fritillaria taipaiensis P.Y.Li

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Phyton-International Journal of Experimental Botany 2024年第2期93卷 247-260页

作者： Zhifen Shi Fumei Pan xiaotian Kong Jiaqi Lang Mingyan Ye Qian wu Guangzhi Wang Liang Han Nong Zhou College of Pharmacy Chengdu University of Traditional Chinese MedicineChengdu611130China College of Pharmacy Dali UniversityDali671000China College of Food and Biological Engineering Chongqing Three Gorges UniversityChongqing404120China Diqing Tibetan Autonomous Prefecture Institute of Plateau Biology Diqing674400China Chongqing Institute of Medicinal Plant Cultivation Chongqing408435China

Fritillaria taipaiensis P.Y.Li is a widely used medicinal herb in treating pulmonary diseases.In recent years,its wild resources have become scarce,and the demand for efficient artificial cultivation has significantly increased.This article is the first to apply phosphate solubilizing bacteria isolated from the rhizosphere soil of F.taipaiensis P.Y.Li to the cultivation process of F.taipaiensis P.Y.Li.The aim is to identify suitable reference strains for the artificial cultivation and industrial development of F.taipaiensis P.Y.Li by examining the effects of various phosphate solubilizing bacteria and their combinations on photosynthesis,physiological and biochemical properties,and gene expression related to the protective enzyme system in F.taipaiensis P.Y.Li.The experiment,conducted in pots at room temperature,included a control group(CK)and groups inoculated with inorganic phosphorussolubilizing bacteria:W1(Bacillus cereus),W2(Serratia plymuthica),W12(Bacillus cereus and Serratia plymuthica),and groups inoculated with organophosphorus-solubilizing bacteria:Y1(Bacillus cereus),Y2(Bacillus cereus),Y12(Bacillus cereus and Bacillus cereus),totaling seven groups.Compared to CK,most growth indices in the bacterial addition groups showed significant differences,with W12 achieving the highest values in all indices except the leaf area index.The content of photosynthetic pigments,photosynthetic parameters,and osmoregulatory substances increased variably in each bacterial treatment group.W12 exhibited the highest content of chlorophyll a and soluble protein,while W1 had the highest free proline content.The activities of peroxidase(POD),superoxide dismutase(SOD),and catalase(CAT)in all inoculated groups were higher than in CK,with significant changes in SOD and CAT activities.The malondialdehyde(MDA)content in all inoculated groups was lower than in CK,with Y12 being the lowest,at approximately 30%of CK.Gene expression corresponding to these three enzymes also increased variably,with POD expression in Y2 being the highes

关键词： Fritillaria taipaiensis P.Y.Li phosphate solubiliozing bacteria photosynthesis physiology and biochemistry protective enzymes

Qianjin Wenwu decoction suppresses renal interstitial fibrosis by enhancing the degradation of extracellular matrix in mice with unilateral ureteral obstruction

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2023年第4期21卷 253-262页

作者： JIN Chengshan wu xiaotian YOU Yue WANG Yuing wu Jing ZUO Along ZHENG Yan GUO Jianpeng Key Laboratory of Natural Medicines of the Changbai Mountain Ministry of EducationCollege of PharmacyYanbian UniversityYanji 133002China Yanbian University Hospital Yanji 133002China Yanbian Medical and Health Industry Pilot Base College of PharmacyYanbian UniversityYanji 133002China Yanbian Chaoyao Biotechnology Co. Ltd.Yanji 133002China

Diabetic kidney disease(DKD)is the most common complication of diabetes mellitus(DM).Qianjin Wenwu decoction(QWD),a well-known traditional Korean medicine,has been used for the treatment of DKD,with satisfactory therapeutic effects.This study was designed to investigate the active components and mechanisms of action of QWD in the treatment of DKD.The results demonstrated that a total of 13 active components in five types were found in QwD,including flavonoids,flavonoid glycosides,phenylpropionic acids,saponins,coumarins,and lignins.Two key proteins,TGF-β1 and TIMP-1,were identified as the target proteins through molecular docking.Furthermore,QWD significantly suppressed Scr and BUN levels which increased after unilateral ureteral obstruction(UUO).Hematoxylin&eosin(H&E)and Masson staining results demonstrated that QWD significantly alleviated renal interstitial fibrosis in UUO mice.We also found that QWD promoted ECM degradation by regulating MMP-9/TIMP-1 homeostasis to improve renal tubulointerstitial fibrosis and interfere with the expression and activity of TGF-βl in DKD treatment.These findings explain the underlying mechanism of QWD for the treatment of DKD,and also provide methodological reference for investigating the mechanism of traditional medicine in the treatment of DKD.

关键词： QianJin Wenwu Decoction(QWD) Diabetic kidney disease(DKD) Pharmacodyamic material basis Molecular docking TGF-β1 Extracellular matrix(ECM)

乙醇耦合其他预处理提高扇贝柱热泵干燥速率及品质

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

农业工程学报 2024年第2期40卷 72-81页

作者：赵亚吴小恬石启龙山东理工大学农业工程与食品科学学院淄博255000

干燥后期速率低、能耗高是限制热泵干燥(heat pump drying,HPD)在水产品干燥中应用的瓶颈。非热力预处理技术在易腐食品干燥中具有提高干燥速率和改善干制品品质的巨大潜力。基于此,该研究以乙醇(E)单独和联合真空(VC+E)、超声波(US+E)... 详细信息

干燥后期速率低、能耗高是限制热泵干燥(heat pump drying,HPD)在水产品干燥中应用的瓶颈。非热力预处理技术在易腐食品干燥中具有提高干燥速率和改善干制品品质的巨大潜力。基于此,该研究以乙醇(E)单独和联合真空(VC+E)、超声波(US+E)、超声波辅助真空(USVC+E)预处理作为处理组,以未经预处理的扇贝柱为对照(CK),探究其对扇贝柱干燥动力学及干制品品质特性的影响。利用低场核磁共振(low-field nuclear magnetic resonance,LF-NMR)技术,对扇贝柱热泵干燥过程中水分状态及分布进行了研究。结果表明:扇贝柱热泵干燥处于降速干燥阶段,干燥过程受水分内部扩散的控制。Weibull模型能较好地描述扇贝柱热泵干燥过程。与CK相比,乙醇单独处理和US和/或真空联合预处理都能提高水分有效扩散系数(Deff),进而提高干燥速率。LF-NMR结果表明,扇贝柱中主要水分为不易流动水;随着干燥进行,各组分的横向弛豫时间向左偏移;不易流动水所占比例降低,而紧密结合水、疏松结合水和自由水所占比例增加。与CK相比,预处理有利于扇贝柱不易流动水向自由水转化,进而提高干燥速率。与CK相比,乙醇单独处理和US和/或真空联合预处理可降低扇贝柱黄度、总色差、收缩率、硬度、弹性和咀嚼性,但是增加了扇贝柱的亮度、红度和复水比。预处理组中,US+E和USVC+E色泽参数(总色差:US+E,(7.40±0.22);USVC+E,(6.99±0.16))最佳,收缩率(US+E,35.97%±1.29%;USVC+E,34.43%±1.24%)和硬度(US+E,(25.20±1.08)N;USVC+E,(26.68±0.61)N)最低;而US+E弹性(0.55±0.01)和咀嚼性(7.27±0.30)N最低,但复水比(1.753±0.022)最高。相比于CK,US+E可显著降低(P<0.05)总色差58.24%,收缩率32.75%、硬度23.17%、弹性15.38%、咀嚼性38.91%,但是复水180 min后,能显著提高(P<0.05)复水比9.975%。综合考虑,US+E作为一种非热力、绿色预处理技术,可用于强化扇贝柱热泵干燥效率,改善干制品品质。

关键词：热泵干燥乙醇超声波扇贝柱干燥动力学品质特性

在线全文

学校读者我要写书评

暂无评论

煤层顶板间接压裂裂缝扩展机制及影响因素

煤炭科学技术 2024年第2期52卷 171-182页

作者：李勇陈涛马啸天吴翔中国矿业大学(北京)地球科学与测绘工程学院北京100083 中联煤层气有限责任公司北京100016

碎软低渗煤层在我国普遍发育,制约煤层气单井产气量提高和产业发展。间接压裂是通过在邻近层产生垂直裂缝沟通煤层进而实现煤层有效改造的一种压裂方式,可以有效应对钻井塌陷、煤粉产出、压裂液滤失和煤层厚度薄等不利因素。通过间接压... 详细信息

碎软低渗煤层在我国普遍发育,制约煤层气单井产气量提高和产业发展。间接压裂是通过在邻近层产生垂直裂缝沟通煤层进而实现煤层有效改造的一种压裂方式,可以有效应对钻井塌陷、煤粉产出、压裂液滤失和煤层厚度薄等不利因素。通过间接压裂物理模拟试验和扩展有限元数值模拟分析,揭示煤层顶板间接压裂裂缝扩展影响因素,明确裂缝扩展机制,以期为间接压裂技术提供指导。通过直接压裂煤层和不同起裂位置、垂向应力和施工排量影响下间接压裂试验表明,起裂压力高,更易产生长裂缝,且受原生裂缝影响程度减小;但起裂点距离煤层越远,起裂所需能量越大,高破裂压力会对煤层造成粉碎性破坏;大施工排量下,起裂压力对应升高,起裂时间变短,原生裂缝影响程度变小。考虑地应力、起裂位置、岩石力学和施工排量等参数的数值模拟结果显示,在模型参数设置条件下,最大水平主应力和垂向应力差在3 MPa、弹性模量差<15 GPa的地层和岩性组合适合间接压裂,起裂位置距离煤层最优距离为<6 m,施工排量需要根据力学性质、断裂能密度等参数确定最优范围。

关键词：碎软低渗煤层间接压裂储层改造裂缝扩展数值模拟压裂模拟地应力

在线全文

学校读者我要写书评

暂无评论

转发式干扰条件下LFM雷达的检测概率估计

系统工程与电子技术 2024年第2期46卷 497-504页

作者：田元荣王俊迪吴笑天国防科技大学电子对抗学院安徽合肥230037 空军工程大学航空工程学院陕西西安710038

对多雷达干扰效果评估的难点在于分析干扰机对非目标雷达的影响。针对干扰机转发一部线性调频(linear frequency modulation,LFM)雷达的信号无意干扰另一部LFM雷达时的检测概率估计问题,首先计算了被干扰雷达对干扰信号在空域、频域和... 详细信息

对多雷达干扰效果评估的难点在于分析干扰机对非目标雷达的影响。针对干扰机转发一部线性调频(linear frequency modulation,LFM)雷达的信号无意干扰另一部LFM雷达时的检测概率估计问题,首先计算了被干扰雷达对干扰信号在空域、频域和时域上的接收增益;其次将干扰信号在判决单元中的统计特性建模为非中心卡方分布,并给出了检测概率和虚警概率的计算方法。仿真结果表明,在一部干扰机的无意干扰下,估计的检测概率可作为被干扰雷达检测概率的上限;为达到同样的干扰效果,转发非目标雷达的信号实施干扰,比转发目标雷达的信号进行干扰所需的干扰功率更少。

关键词：线性调频雷达转发干扰无意干扰雷达检测概率非相参积累

Double-blinded,randomized clinical trial of Gegen Qinlian decoction pinpoints Faecalibacterium as key gut bacteria in alleviating hyperglycemia

在线全文

学校读者我要写书评

暂无评论

Precision Clinical Medicine 2024年第1期7卷 21-33页

作者： Zezheng Gao Wenhui Zhang Lisha He Han Wang Yufei Li xiaotian Jiang Sha DI Xinmiao Wang Xuan Zhang Lin Han Yanwen Liu Chengjuan Gu Mengyi wu Xinhui He Lei Cheng Jun Wang Xiaolin Tong Linhua Zhao Institute of Metabolic Diseases Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China Department of Endocrinology Guang anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Chengdu University of Traditional Chinese Medicine Chengdu 611137China School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 100029China Centre for Evidence-Based Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China Department of Endocrinology Affiliated Hospital of Changchun University of Chinese MedicineChangchun 13000oChina Biologicals Science and Technology Institute Baotou Teacher's CollegeBaotou 014030China Department of Endocrinology Zhengzhou T.C.M.HospitalZhengzhou 450007China Shenzhen Hospital Guangzhou University of Chinese Medicine(Futian)Shenzhen 518000China Department of Cardiology Guangdong Provincial Hospital of Chinese MedicineGuangzhou 510120China Department of Cardiology Yunnan Provincial Hospital of Traditional Chinese MedicineKunming 650000China Key Laboratory of Development and Application of Rural Renewable Energy Biogas Institute of Ministry of Agriculture and Rural AffairsChengdu 610041China

Background:Accumulating evidence suggests that metabolic disorders,including type 2 diabetes mellitus(T2DM),can be treated with traditional Chinese medicine formulas,such as the Gegen Qinlian decoction(GQD).This study elucidates the mechanisms by which gut microbes mediate the anti-diabetic effects of GQD.Methods:We conducted a double-blind randomized clinical trial involving 120 untreated participants with T2DM.During the 12-week intervention,anthropometric measurements and diabetic traits were recorded every 4 weeks.Fecal microbiota and serum metabolites were measured before and after the intervention using 16S rDNA sequencing,liquid chromatography-mass spectrometry,and Bio-Plex panels.Results:Anti-diabetic effects were observed in the GQD group in the human trial.Specifically,glycated hemoglobin,fasting plasma glucose,and two-hour postprandial blood glucose levels were significantly lower in the GQD group than in the placebo group.Additionally,Faecalibacterium was significantly enriched in the GQD group,and the short-chain fatty acid levels were higher and the serum inflammation-associated marker levels were lower in the GQD group compared to the placebo group.Moreover,Faecalibacterium abundance negatively correlated with the levels of serum hemoglobin,fasting plasma glucose,and pro-inflammatory cytokines.Finally,the diabetes-alleviating effect of Faecalibacterium was confirmed by oral administration of Faecalibacterium prausnitzi(DSMZ 17677)in T2DMmousemodel.Conclusions:GQD improved type 2 diabetes primarily by modulating the abundance of Faecalibacterium in the gut microbiota,alleviating metabolic disorders and the inflammatory state.

关键词： double-blinded randomized controlled trial type 2 diabetes mellitus Gegen Qinlian decoction Faecalibacterium metabolic disorders inflammation

人类对人工智能信任的接受度及脑认知机制研究:实证研究与神经科学实验的元分析

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

管理工程学报 2024年第1期38卷 60-73页

作者：吴俊张迪刘涛刘潇天赵士南江苏科技大学经济管理学院江苏镇江212100 浙江大学管理学院浙江杭州310058 昆士兰大学商学院澳大利亚布里斯班4072

人工智能技术广泛渗透到工作与生活的各方面,在带来巨大变革的同时,其自身固有的不确定性、脆弱性和恐怖谷效应,使得用户对其采纳抱有怀疑与犹豫的态度。人类对人工智能的信任问题由此产生。基于此,本文将信任纳入传统的技术接受模型之... 详细信息

人工智能技术广泛渗透到工作与生活的各方面,在带来巨大变革的同时,其自身固有的不确定性、脆弱性和恐怖谷效应,使得用户对其采纳抱有怀疑与犹豫的态度。人类对人工智能的信任问题由此产生。基于此,本文将信任纳入传统的技术接受模型之中,探讨在人工智能的使用环境下,信任与感知易用性、感知有用性和系统采纳意愿之间的关系。同时,将信任分为认知信任和情绪信任两个维度,研究了这两个维度的前因:透明度和拟人化。通过实证研究文献的元分析,验证了包含信任元素的人工智能接受模型的有效性。进一步,通过脑成像元分析方法,研究了信任概念在人类大脑中的发生位置和运行机理。研究结果表明:(1)信任对于技术接受模型中的感知有用性、感知易用性和采纳意愿均有显著的正向影响,证明信任是驱动模型中上述结构的重要因素。(2)信任区分为认知信任和情绪信任,透明度和拟人化分别是认知信任和情绪信任的重要前因。(3)信任的心理理念主要发生在大脑的壳核和颞上回,壳核的激活表征对奖励的预期,颞上回的激活表征同理心的激发,这些证据揭示了人机协作过程中“信任”的神经生理机制。本研究以信任为核心,拓展了人工智能使用环境下的技术接受模型,同时揭示了人类对人工智能信任的脑认知机制。这些理论成果为采纳人工智能技术的企业正确实施该项技术,提升用户的可信度提供了管理启示。

关键词：人工智能信任脑认知元分析

2022年中国12~30岁人群轻断食行为及影响因素

在线全文

学校读者我要写书评

暂无评论

中国公共卫生 2024年第4期40卷 461-465页

作者：文啸天武璐丽牛丕业首都医科大学基础医学院北京100069 首都医科大学公共卫生学院北京100069

目的了解中国12~30岁人群轻断食行为发生情况及其影响因素。方法本研究数据来自“2022中国居民心理与行为调查研究”。于2022年6—8月采用多阶段抽样对23个省、5个自治区、4个直辖市的居民进行问卷调查,选取其中12~30岁8858人作为研究对... 详细信息

目的了解中国12~30岁人群轻断食行为发生情况及其影响因素。方法本研究数据来自“2022中国居民心理与行为调查研究”。于2022年6—8月采用多阶段抽样对23个省、5个自治区、4个直辖市的居民进行问卷调查,选取其中12~30岁8858人作为研究对象,采用广泛性焦虑障碍量表(GAD-7)、孤独量表(T-ILS)、轻断食行为自编量表进行问卷调查,采用单因素分析和多因素logistic回归分析发生轻断食行为的影响因素。结果最终纳入分析的8858名研究对象中有1036人近1年内有轻断食行为,发生率为11.70%;有轻断食行为的人群平均年龄为(20.83±4.56)岁,无轻断食人群平均年龄为(20.67±4.80)岁,2组人群年龄差异无统计学意义。多因素非条件logistic回归分析结果显示,女性(OR=1.991,95%CI=1.718~2.309)、居住地为城镇(OR=1.262,95%CI=1.082~1.472)、吸烟(OR=1.411,95%CI=1.123~1.774)、饮酒(OR=1.432,95%CI=1.216~1.687)、体质指数高(OR_(肥胖)=2.153,95%CI=1.528~3.032)、焦虑(OR_(重度焦虑)=4.157,95%CI=3.164~5.463)和孤独(OR=1.258,95%CI=1.070~1.479)是发生轻断食行为的危险因素(P<0.05)。结论12~30岁人群中轻断食行为的发生受自身因素与心理因素多重影响,需从生理和心理双层面考虑轻断食行为。

关键词：轻断食间歇性禁食青少年青年焦虑

在线全文

学校读者我要写书评

暂无评论

一则居家安宁疗护个案的多声部叙事

中国医学科学院学报 2024年第1期46卷 68-71页

作者：张晓天王梓丹王明辉吴玲玲岳鹏首都医科大学护理学院北京100069 蒲黄榆社区卫生服务中心北京100075

临终患者在居家照顾时面临多方面的困难,而居家安宁疗护秉承全人、全家、全队、全程的照顾理念,能够满足居家临终患者和家属的全方位需求。本文报道1例乳腺恶性肿瘤终末期患者的照顾历程和居家安宁疗护过程,并总结居家安宁疗护工作经验... 详细信息

临终患者在居家照顾时面临多方面的困难,而居家安宁疗护秉承全人、全家、全队、全程的照顾理念,能够满足居家临终患者和家属的全方位需求。本文报道1例乳腺恶性肿瘤终末期患者的照顾历程和居家安宁疗护过程,并总结居家安宁疗护工作经验,以期为今后的居家安宁疗护工作提供参考。

关键词：安宁疗护个案管理临终照顾多声部叙事