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Effect of BaO and MgO on structure and properties of aluminate slag with various CaO/Al_(2)0_(3)ratios

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Journal of Iron and Steel Research(International) 2024年第1期31卷 204-214页

作者： Yu-qi Kong Ting wu Wen-zhi xia Wen Yang Hai-chuan Wang School of Metallurgical Engineering Anhui University of TechnologyMa’anshan243032AnhuiChina Key Laboratory of Metallurgical Emission Reduction and Resource Recycling(Ministry of Education) Anhui University of TechnologyMa’anshan243002AnhuiChina

To provide theoretical guidance for performance stability control of low-reactive mold fluxes,the effects of BaO and MgO on the structure and properties of aluminate slag with various CaO/Al_(2)0_(3)(C/A)ratios were investigated using the Fourier transform infrared spectrometer,Raman spectroscope,hemispherical melting point instrument,rotational viscometer and X-ray *** results indicated that with BaO and MgO addition,the structure polymerization was first weakened and then enhanced at C/A of 1.1,and the transition contents corresponded to 8 wt.%BaO and 2 wt.%MgO,respectively,while the structure polymerization decreased continuously at C/A of *** the viscosity change was well consistent with the structure evolution,the polymerization degree played a more prominent role in the slag viscosity than superheat degree when the melting temperature difference was within 40℃.The break temperature decreased initially and then increased with augment of BaO and MgO at C/A of 1.1,while it manifested a decrease trend with BaO addition,and it decreased obviously but then turned to increase with MgO increment at C/A of *** crystallization phase and crystallization ratio kept stable with BaO increment,while the crystallization ratio rose greatly with MgO promoting LiAlO_(2)precipitation at C/A of *** crystal types of all experimental slags were mainly Ca_(12)Al_(14)O_(33)and CaF_(2)at C/A of 1.3,and the precipitation of crystalline phase BaAl2O4 demonstrated a rising trend,while that of Ca_(12)Al_(14)O_(33)gradually declined with BaO augment.

关键词： Aluminate slag Structure MgO BaO Viscosity Property

Oleuropein alleviates sepsis-induced acute lung injury via the AMPK/Nrf-2/HO-1 signaling

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Asian Pacific Journal of Tropical Biomedicine 2024年第5期14卷 187-198页

作者： Shan-Hu Wang Yang-Yang wu xiao-Jiao xia Department of Pediatrics The Second Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang 325027China

Objective:To explore the effect of oleuropein on sepsis-induced acute lung injury(ALI)in vitro and in vivo and investigate the underlying ***:In an lipopolysaccharide(LPS)-mediated cell model of sepsis-induced ALI and a cecal ligation and puncture-induced mouse model of septic ALI,CCK-8 assay and flow cytometry analysis were used to detect cell activity and *** and relevant assay kits were used to measure the levels of inflammatory cytokines and oxidative stress,*** blot was applied to determine the expression of apoptosis-and AMP-activated protein kinase(AMPK)/nuclear factor erythroid 2-related factor-2(Nrf-2)/heme oxygenase-1(HO-1)signaling-associated ***-1 staining,adenosine triphosphate(ATP)assay kit,and MitoSOX Red assays were performed to detect mitochondrial membrane potential,ATP content,and mitochondrial ROS formation,***,lung injury was evaluated by measuring lung morphological alternations,lung wet-to-dry ratio,myeloperoxidase content,and total protein ***:Oleuropein reduced inflammatory reaction,oxidative damage,and apoptosis,and ameliorated mitochondrial dysfunction in LPS-exposed BEAS-2B cells and mice with septic ***,oleuropein activated the AMPK/Nrf-2/HO-1 signaling ***,these effects of oleuropein were abrogated by an AMPK inhibitor compound ***:Oleuropein can protect against sepsis-induced ALI in vitro and in vivo by activating the AMPK/Nrf-2/HO-1 signaling,which might be a potential therapeutic agent for the treatment of sepsis-induced ALI.

关键词： AMPK/Nrf-2/HO-1 signaling Inflammatory response Lung damage Mitochondrial dysfunction Oleuropein Oxidative stress Sepsis

不同喀斯特土壤类型下常见蕨类植物氮磷养分策略差异及其与土壤养分供给关系

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广西科学院学报 2024年第2期40卷 162-171页

作者：庞丽邹琼丽吴霞李家鑫张明豪张红霞安顺学院农学院贵州安顺561000 安顺学院化学化工学院贵州安顺561000

蕨类植物是喀斯特生态系统的先锋植物,研究其对瘠薄的喀斯特地区土壤的适应策略,对退化生态系统的恢复与重建具有重要意义。本研究以贵州省植物园内地带性黄壤、非地带性石灰土上均有分布的常见蕨类植物毛蕨[Cyclosorus interruptus(Wil... 详细信息

蕨类植物是喀斯特生态系统的先锋植物,研究其对瘠薄的喀斯特地区土壤的适应策略,对退化生态系统的恢复与重建具有重要意义。本研究以贵州省植物园内地带性黄壤、非地带性石灰土上均有分布的常见蕨类植物毛蕨[Cyclosorus interruptus(Willd.)***]、剑叶凤尾蕨(Pteris ensiformis Burm.)和金粉蕨[Onychium siliculosum(Desv.)***.]为试验材料,研究2种喀斯特土壤类型下3种常见蕨类植物氮磷养分策略的差异,及其与土壤氮磷养分供给的关系。结果表明:①石灰土上蕨类植物根系分泌的有机酸主要为酒石酸、草酸和苹果酸,黄壤上为酒石酸、苹果酸和柠檬酸,且石灰土上根系分泌的有机酸总量远高于黄壤;②与黄壤上生长的蕨类植物相比,石灰土上蕨类植物干物质积累量、氮素与磷素吸收量均较高,分别高出2.7倍、30.8%和43.8%;③2种土壤条件下蕨类植物地上部分的氮(N)、磷(P)平均含量均较地下部分高;石灰土上蕨类植物地上部分N/P为13.17,黄壤上为11.35;④2种土壤条件下蕨类植物的氮素吸收量均与土壤有效磷含量呈显著正相关,说明蕨类植物对土壤氮素的吸收利用受土壤有效磷含量的限制。综上可知,蕨类植物在2种土壤类型上的氮磷养分利用与分配策略存在显著差异,其在石灰土上生长时对土壤养分循环的影响较黄壤上大。

关键词：喀斯特地区不同土壤类型蕨类植物氮磷养分特征养分适应策略

伪狂犬病病毒在小鼠原代神经细胞中潜伏感染模型的建立

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中国预防兽医学报 2024年第1期46卷 1-6,15页

作者：向广韬吴红霞王异民周末王亚林王翌尹航仇华吉孙元中国农业科学院哈尔滨兽医研究所动物疫病防控全国重点实验室黑龙江哈尔滨150069

缺少PRV良好的潜伏感染模型已成为研究其潜伏感染机制的障碍。为建立PRV潜伏感染的体外细胞模型,本研究通过分离新生鼠背根神经节(DRG)获取神经细胞,并利用间接免疫荧光试验(IFA)对其进行鉴定,获得了DRG中的神经细胞。采用重组报告病毒r... 详细信息

缺少PRV良好的潜伏感染模型已成为研究其潜伏感染机制的障碍。为建立PRV潜伏感染的体外细胞模型,本研究通过分离新生鼠背根神经节(DRG)获取神经细胞,并利用间接免疫荧光试验(IFA)对其进行鉴定,获得了DRG中的神经细胞。采用重组报告病毒r PRV-EGFP感染神经细胞,同时添加阿昔洛韦(ACV)抑制病毒复制以建立潜伏感染,并采用棋盘法对病毒感染剂量和ACV浓度进行优化,结果显示,感染复数(MOI)为0.001,ACV浓度为0.5 mmol/L,病毒能够在神经细胞中稳定建立潜伏感染。采用荧光定量RT-PCR、病毒滴度测定、药物刺激再激活的方法对潜伏感染模型鉴定,结果显示,潜伏感染时病毒不能复制,且不产生感染性病毒粒子;而经LY294002(PI3K抑制剂)诱导病毒再激活后,病毒大量复制并产生感染性病毒粒子。本研究首次利用小鼠原代神经细胞建立了PRV的潜伏感染模型,该模型的建立为PRV潜伏感染机制的研究奠定了基础。

关键词：伪狂犬病毒小鼠背根神经节潜伏感染再激活模型

基于无人机航拍图像的水稻叶片SPAD值反演

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杂交水稻 2024年第2期39卷 14-22页

作者：陈兆中段少坤岳云开李焕群吴霞陈建福王小卉李绪孟湖南农业大学农学院湖南长沙410128

为利用无人机航拍图像实现水稻叶绿素含量的高通量检测,以籼型三系杂交水稻品种兆优5431为材料,设置3个密度水平和5个施氮量水平,共15个处理,在水稻不同生育期通过大疆精灵4RTK无人机获取航拍图像和人工测定水稻叶片SPAD值,并选取7种与... 详细信息

为利用无人机航拍图像实现水稻叶绿素含量的高通量检测,以籼型三系杂交水稻品种兆优5431为材料,设置3个密度水平和5个施氮量水平,共15个处理,在水稻不同生育期通过大疆精灵4RTK无人机获取航拍图像和人工测定水稻叶片SPAD值,并选取7种与水稻叶片SPAD值显著相关的可见光植被指数,采用线性回归和机器学习方法构建了水稻叶片SPAD值反演模型,通过精度验证确定水稻叶片SPAD值最优预测模型。结果表明,机器学习模型中,随机森林模型精度均高于其他回归模型,该算法构建的模型具有较高的预测精度,其模型各项指标分别是建模集R^(2)为0.85、RMSE为2.73,验证集R^(2)为0.76、RMSE为3.64。因此,机器学习模型能为水稻叶片SPAD值进行无损、快速监测提供参考。

关键词：水稻叶绿素含量 SPAD值无人机航拍图机器学习随机森林算法

Urinary metabolic profiles during Helicobacter pylori eradication in chronic gastritis

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World Journal of Clinical Cases 2024年第5期12卷 951-965页

作者： Wen-Ting An Yu-xia Hao Hong-xia Li Xing-Kang wu Department of Pharmacy Shanxi Provincial People’s HospitalTaiyuan 030012Shanxi ProvinceChina Department of Gastroenterology Shanxi Provincial People's HospitalTaiyuan 030012Shanxi ProvinceChina Department of Oncology Shanxi Provincial People’s HospitalTaiyuan 030012Shanxi ProvinceChina Modern Research Center for Traditional Chinese Medicine Shanxi UniversityTaiyuan 030006Shanxi ProvinceChina

BACKGROUND Helicobacter pylori(***)infection is a major risk factor for chronic gastritis,affecting approximately half of the global *** eradication is a popular treatment method for ***-positive chronic gastritis,but its mecha-nism remains *** metabolomics has been used to elucidate the mechanisms of gastric disease ***,no clinical study has been conducted on urinary metabolomics of chronic *** To elucidate the urinary metabolic profiles during *** eradication in patients with chronic *** We applied LC–MS-based metabolomics and network pharmacology to in-vestigate the relationships between urinary metabolites and ***-positive chronic gastritis via a clinical follow-up *** Our study revealed the different urinary metabolic profiles of ***-positive chronic gastritis before and after *** *** metabolites regulated by *** eradication therapy include cis-aconitic acid,isocitric acid,citric acid,L-tyrosine,L-phenylalanine,L-tryptophan,and hippuric acid,which were involved in four metabolic pathways:(1)Phenylalanine metabolism;(2)phenylalanine,tyrosine,and tryptophan biosynthesis;(3)citrate cycle;and(4)glyoxylate and dicarboxylate *** metabolomics and network pharmacology revealed that MPO,COMT,TPO,TH,EPX,CMA1,DDC,TPH1,and LPO were the key proteins involved in the biological progress of *** eradication in chronic *** Our research provides a new perspective for exploring the significance of urinary metabolites in evaluating the treatment and prognosis of ***-positive chronic gastritis patients.

关键词： LC-MS metabolomics chronic gastritis Helicobacter pylori urinary metabolites

Evaluation of the binding affinity and antioxidant activity of phlorizin to pepsin and trypsin

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Food Science and Human Wellness 2024年第1期13卷 392-400页

作者： Jing Zhang Lan Tang xia Hu Zhen Zeng Wen wu Fang Geng Hui Li Di wu Meat Processing Key Laboratory of Sichuan Province School of Food and Biological EngineeringChengdu UniversityChengdu 610106China School of Chemical Engineering Sichuan UniversityChengdu 610065China

Phlorizin(PHL)is a natural compound with strong antioxidant properties mainly found in *** this paper,the interaction mechanism of PHL with pepsin and trypsin was comparatively evaluated by computer simulation,fluorescence spectra,circular dichroism(CD),and Fourier transform infrared(FT-IR)spectra at a molecular *** spectra showed that PHL quenches the pepsin/trypsin by static *** parameters indicated that PHL binds to pepsin mainly through hydrogen bonds and van der Waals forces,and that of trypsin was electrostatic *** ground state complexes PHL and protease have a moderate affinity of 105 L/mol PHL binds more strongly to trypsin than to *** and FT-IR spectra results showed that pepsin/trypsin decreased theβ-sheet content and slightly changed its secondary structure upon *** experimental results are mutually verified with the predicted computer-aid simulation *** PHL and trypsin binding,the antioxidant capacity of PHL was ***,the antioxidant capacity of PHL was decreased after binding to *** work elucidates the binding of PHL binding mechanisms to pepsin/trypsin and provides useful information for the digestion of PHL to improve the application of PHL in food processing.

关键词： Interaction Phlorizin Pepsin Trypsin Antioxidation

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抗肿瘤药审方规则的设置优化及实施效果评价

海峡药学 2024年第6期36卷 107-110页

作者：冯晓杰吴春霞张师刘岩贾佳侯娟河北医科大学第四医院药学部河北石家庄050011

目的探讨抗肿瘤药审方规则设置及优化流程,提高处方合理率,降低不合理处方退费率。方法统计抗肿瘤药规则设置优化前(2021年12月~2022年3月)规则维护后(2022年4月~2022年7月)的门诊处方。比较规则设置优化前后处方合理率及退费率评价实... 详细信息

目的探讨抗肿瘤药审方规则设置及优化流程,提高处方合理率,降低不合理处方退费率。方法统计抗肿瘤药规则设置优化前(2021年12月~2022年3月)规则维护后(2022年4月~2022年7月)的门诊处方。比较规则设置优化前后处方合理率及退费率评价实施效果。结果设置了抗肿瘤药规则,建立了规则优化模式,形成了超说明书用药规则库。门诊处方合理率由96.53%提高到99.19%(P<0.001),处方退费率由1.11%降至0.23%(P<0.001),差异有统计学意义。结论我院维护的抗肿瘤药审方规则库提高了处方合理率,保障临床用药的同时提高了患者用药安全性及合理性。

关键词：抗肿瘤药规则设置规则优化处方合理率

2022—2023年安徽口岸出境劳务人员慢性非传染性疾病监测情况分析

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中国口岸科学技术 2024年第3期6卷 31-35页

作者：何翠王赛寒黄慧陈源吴瑕沈苗苗石泉安徽国际旅行卫生保健中心(合肥海关口岸门诊部) 合肥230061

本研究以2022—2023年在安徽口岸进行法定体检的出境劳务人员为研究对象,分析出境劳务人员慢性非传染性疾病的患病情况,采用描述性流行病学方法对监测结果进行分类统计,为口岸慢性非传染性疾病的防控工作提供科学依据。研究结果显示,在6... 详细信息

本研究以2022—2023年在安徽口岸进行法定体检的出境劳务人员为研究对象,分析出境劳务人员慢性非传染性疾病的患病情况,采用描述性流行病学方法对监测结果进行分类统计,为口岸慢性非传染性疾病的防控工作提供科学依据。研究结果显示,在6602名出境劳务人员中共检出慢性非传染性疾病5122例,患病率为77.58%。其中,患病率较高的前4种疾病分别为脂肪肝、高血压、尿常规异常、心电图异常,男性>女性,年龄以51~60岁为主。连续两年脂肪肝患病率最高,不同年份、性别、年龄组间比较,差异均有统计学意义(P<0.05);不同年龄组间比较差异性显著(P<0.001)。研究结果提示,迫切需要加强对出境劳务人员慢性非传染性疾病的防控力度,针对疾病高发人群进行健康管理宣教,密切随访,保障出境劳务人员的身体健康。

关键词：慢性非传染性疾病出境劳务人员疾病监测