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The Zuo Jin Wan Formula increases chemosensitivity of human primary gastric cancer cells by AKT mediated mitochondrial translocation of cofilin-1

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Chinese Journal of Natural Medicines 2019年第3期17卷 198-208页

作者： SUN Meng-Yao WANG Dan-Dan SUN Jian ZHAO Xiao-Hua CAI Si wu qiu-xue JIE Tao NI Zhen-Hua SUN Jian-Yue TANG Qing-Feng Department of Clinical Laboratory and Central Laboratory Putuo Hospital Shanghai University of Traditional Chinese Medicine Institute of Interdisciplinary Medical Sciences Shanghai University of Traditional Chinese Medicine Department of Clinical Laboratory Shuguang Hospital Shanghai University of Traditional Chinese Medicine Department of Pediatrics Putuo Hospital Shanghai University of Traditional Chinese Medicine

Resistance to cisplatin(DDP)-based chemotherapy is a major cause of treatment failure in human gastric cancer(GC). It is necessary to identify the drugs to re-sensitize GC cells to DDP. In our previous research, Zuo Jin Wan Formula(ZJW) has been proved could increase the mitochondrial apoptosis via cofilin-1 in a immortalized cell line, SGC-7901/DDP. Due to the immortalized cells may still difficult highly recapitulate the important molecular events in vivo, primary GC cells model derived from clinical patient was constructed in the present study to further evaluate the effect of ZJW and the underlying molecular mechanism. Immunofluorescent staining was used to indentify primary cultured human GC cells. Western blotting was carried out to detect the protein expression. Cell Counting Kit-8(CCK-8) was used to evaluate cell proliferation. Flow cytometry analysis was performed to assess cell apoptosis. ZJW inhibited proliferation and induced apoptosis in primary DDP-resistant GC cells. Notably, the apoptosis in GC cells was mediated by inducing cofilin-1 mitochondrial translocation, down-regulating Bcl-2 and up-regulating Bax expression. Surprisingly, the level of p-AKT protein was higher in DDP-resistant GC cells than that of the DDP-sensitive GC cells, and the activation of AKT could attenuate ZJW-induced sensitivity to DDP. These data revealed that ZJW can increase the chemosensitivity in DDP-resistant primary GC cells by inducing mitochondrial apoptosis and AKT inactivation. The combining chemotherapy with ZJW may be an effective therapeutic strategy for GC chemoresistance patients.

关键词： Primary GC cells ZJW AKT Chemoresistance

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Observation of acoustic hybrid topological phases induced by the p-d orbital interactions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 132-139页

作者： Xiao Xiang Feng Gao Yu-Gui Peng Peng wu Zong-Lin Li xue-Feng Zhu School of Physics and Innovation Institute Huazhong University of Science and Technology

In spinless systems,growing attention has recently been attracted to synthetic gauge fields,which redefine the fundamental crystal symmetries by utilizing the projective algebraic ***,synthetic gauge fields have been commonly investigated in single orbital systems,and explorations on hybrid orbitals remain elusive in ***,we report the experimental observation of hybrid topological phases induced by hybrid synthetic gauge flux,which is formed by the interaction between p and d orbitals embedded in acoustic *** breaking the translation symmetries of Lxand/or Ly,we unambiguously demonstrate the first-order M?bius edge states and higher-order corner *** work establishes a platform for seeking exotic topological phases induced by hybrid-orbitals interactions and initializing the framework of hybrid-orbitalsrelated topological *** applications can be anticipated in scenarios such as high-quality sensing and robust wave trapping due to the stepwise energy distribution of the hybrid topological phase.

关键词： topological insulator synthetic gauge field projective symmetry corner states

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Grounded-source short offset transient electromagnetic method:Theory and applications in deep mineral exploration

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Science China Earth Sciences 2025年

作者： Guoqiang xue Xin wu Weiying CHEN Nannan ZHOU Key Laboratory of Mineral Resources Institute of Geology and Geophysics Chinese Academy of Sciences College of Earth and Planetary Sciences University of Chinese Academy of Sciences

Abstract The Transient Electromagnetic (TEM) method is a critical geophysical technique for subsurface exploration of metal ore bodies, primarily utilizing either loop or grounded transmitters. The Long Offset Transient Electromagnetic(LOTEM) method employs a grounded-source transmitter, relying on a far-source observation mode and plane wave approximation for detection. However, LOTEM’s far-source configuration weakens signal strength, and the plane wave approximation reduces precision, limiting effective detection depth to approximately 1000 m with a comprehensive error of about 15%. Recently, we have developed the grounded-source Short Offset Transient Electromagnetic (SOTEM) method,achieving greater detection depth and accuracy within the 500–2000 m depth range, a crucial interval for mineral resource exploration. This study explores the theoretical framework, instrumentation, data processing, and field applications of SOTEM. Based on a point charge element model, SOTEM accurately computes surface wave effects in EM field calculations,optimized for near-source observation. High-power, high-resolution, wide-bandwidth exploration equipment and an advanced three-dimensional hybrid inversion technique were also developed to enhance the method’s effectiveness. Application of SOTEM to the deep exploration of the Zhou’an Ni-Cu-PGE deposit in Henan Province yielded high-resolution imaging of conductivity structures to about 2.5 km depth. These results, consistent with existing drill data, delineated mineralized ore bodies from surrounding formations, identified zones of mineralization potential, and suggested extensive resource prospects in the region.

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“One stone, two birds”: Salt template enabling porosity engineering and single metal atom coordinating toward high-performance zinc-ion capacitors

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Journal of Energy Chemistry 2025年第1期100卷 637-645页

作者： Chunliu Zhu Huanyu Liang Ping Li Chenglong qiu Jingyi wu Jingwei Chen Weiqian Tian Yue Zhu Zhi Li Huanlei Wang School of Materials Science and Engineering Ocean University of China Department of Chemical and Materials Engineering University of Alberta

Zinc-ion hybrid capacitors （ZIHCs） have received increasing attention as energy storage devices owing to their low cost,high safety,and environmental ***,their progress has been hampered by low energy and power density,as well as unsatisfactory long-cycle stability,mainly due to the lack of suitable electrode *** this context,we have developed manganese single atoms implanted in nitrogen-doped porous carbon nanosheets （MnSAs/NCNs） using a metal salt template method as cathodes for *** metal salt serves a dual purpose in the synthesis process:It facilitates the uniform dispersion of Mn atoms within the carbon matrix and acts as an activating agent to create the porous *** applied in ZIHCs,the MnSAs/NCNs electrode demonstrates exceptional performance,including a high capacity of 203 m Ah g-1,an energy density of 138 Wh kg-1at 68 W kg-1,and excellent cycle stability with 91%retention over 10,000 *** calculations indicate that the introduced Mn atoms modulate the local charge distribution of carbon materials,thereby improving the electrochemical *** work demonstrates the significant potential of carbon materials with metal atoms in zinc-ion hybrid capacitors,not only in enhancing electrochemical performance but also in providing new insights and methods for developing high-performance energy storage devices.

关键词： Zinc ion hybrid capacitors Cathodes Carbon materials Heteroatoms Single atoms

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Preparation of Co/S co-doped carbon catalysts for excellent methylene blue degradation

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 169-181页

作者： Haixu Li Haobo He Tiannan Jiang Yunfei Du Zhichen wu Liang Xu Xinjie Wang Xiaoguang Liu Wanhua Yu Wendong xue School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China Beijing Jinyu Tongda Refractory Technologies Co. Ltd.Beijing 100085China

S and Co co-doped carbon catalysts were prepared via pyrolysis of MOF-71 and thiourea mixtures at 800℃at a mass ratio of MOF-71 to thiourea of 1:0.1 to effectively activate peroxymonosulfate(PMS)for methylene blue(MB)*** effects of two different mixing routes were identified on the MB degradation ***,the catalyst obtained by the alcohol solvent evaporation(MOF-AEP)mixing route could degrade 95.60%MB(50 mg/L)within 4 min(degradation rate:K=0.78 min^(-1)),which was faster than that derived from the direct grinding method(MOF-DGP,80.97%,K=0.39 min^(-1)).X-ray photoelectron spectroscopy revealed that the Co-S content of MOF-AEP(43.39at%)was less than that of MOF-DGP(54.73at%),and the proportion of C-S-C in MOF-AEP(13.56at%)was higher than that of MOF-DGP(10.67at%).Density functional theory calculations revealed that the adsorption energy of Co for PMS was -2.94 eV when sulfur was doped as C-S-C on the carbon skeleton,which was higher than that when sulfur was doped next to cobalt in the form of Co-S bond(-2.86 eV).Thus,the C-S-C sites might provide more contributions to activate PMS compared with ***,the degradation parameters,including pH and MOF-AEP dosage,were ***,radical quenching experiments and electron paramagnetic resonance(EPR)measurements revealed that ^(1)O_(2)might be the primary catalytic species,whereas·O~(2-)might be the secondary one in degrading MB.

关键词： advanced oxidation process alcohol solvent evaporation hydrogen bond S and Co co-doped carbon catalysts wastewater remediation

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Resting-state brain network remodeling after different nerve reconstruction surgeries:a functional magnetic resonance imaging study in brachial plexus injury rats

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Neural Regeneration Research 2025年第5期20卷 1495-1504页

作者： Yunting Xiang Xiangxin Xing Xuyun Hua Yuwen Zhang Xin xue Jiajia wu Mouxiong Zheng He Wang Jianguang Xu School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghaiChina Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation Ministry of EducationShanghaiChina Department of Rehabilitation Medicine Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Department of Traumatology and Orthopedics Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Institute of Science and Technology for Brain-Inspired Intelligence Fudan UniversityShanghaiChina Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence(Fudan University) Ministry of EducationShanghaiChina Human Phenome Institute Fudan UniversityShanghaiChina

Distinct brain remodeling has been found after different nerve reconstruction strategies,including motor representation of the affected ***,differences among reconstruction strategies at the brain network level have not been *** study aimed to explore intranetwork changes related to altered peripheral neural pathways after different nerve reconstruction surgeries,including nerve repair,endto-end nerve transfer,and end-to-side nerve ***–Dawley rats underwent complete left brachial plexus transection and were divided into four equal groups of eight:no nerve repair,grafted nerve repair,phrenic nerve end-to-end transfer,and end-to-side transfer with a graft sutured to the anterior upper ***-state brain functional magnetic resonance imaging was obtained 7 months after *** independent component analysis algorithm was utilized to identify group-level network components of interest and extract resting-state functional connectivity values of each voxel within the *** in intra-network resting-state functional connectivity were compared among the *** muscle reinnervation was assessed by behavioral observation(elbow flexion)and *** results showed that alterations in the sensorimotor and interoception networks were mostly related to changes in the peripheral neural *** repair was related to enhanced connectivity within the sensorimotor network,while end-to-side nerve transfer might be more beneficial for restoring control over the affected limb by the original motor *** thalamic-cortical pathway was enhanced within the interoception network after nerve repair and end-to-end nerve *** areas related to cognition and emotion were enhanced after end-to-side nerve *** study revealed important brain networks related to different nerve *** networks may be potential targets for enhancing motor recovery.

关键词： brain functional networks end-to-end nerve transfer end-to-side nerve transfer independent component analysis nerve repair peripheral plexus injury resting-state functional connectivity

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左金丸醇提物抑制人胃癌SGC-7901细胞糖酵解的作用机制

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中草药 2021年第1期52卷 145-151页

作者：吴秋雪孙梦瑶许博张辉汤庆丰上海中医药大学附属普陀医院上海200062 上海中医药大学上海200135

目的研究左金丸醇提物对人胃癌细胞SGC-7901增殖和糖酵解的作用及机制。方法采用CCK-8法检测左金丸醇提物(5、10、25、50、100、200μg/mL)对SGC-7901细胞增殖的影响;检测左金丸醇提物对SGC-7901细胞葡萄糖摄取量、乳酸和三磷酸腺苷(ade... 详细信息

目的研究左金丸醇提物对人胃癌细胞SGC-7901增殖和糖酵解的作用及机制。方法采用CCK-8法检测左金丸醇提物(5、10、25、50、100、200μg/mL)对SGC-7901细胞增殖的影响;检测左金丸醇提物对SGC-7901细胞葡萄糖摄取量、乳酸和三磷酸腺苷(adenosine triphosphate,ATP)含量的影响,评价左金丸醇提物对SGC-7901细胞糖酵解的作用;采用qRT-PCR和Western blotting法检测左金丸醇提物对细胞糖酵解途径相关蛋白Rhotekin(RTKN)表达的影响;采用RTKN shRNA干扰慢病毒感染SGC-7901细胞,检测左金丸醇提物对SGC-7901细胞葡萄糖摄取、乳酸和ATP含量的影响。结果左金丸醇提物对SGC-7901细胞增殖具有显著抑制作用(P<0.001),呈剂量、时间相关性;左金丸醇提物显著降低SGC-7901细胞葡萄糖摄取、乳酸和ATP含量(P<0.01、0.001);左金丸醇提物显著降低SGC-7901细胞中RTKN mRNA和RTKN蛋白表达(P<0.001);干扰RTKN抵消了左金丸醇提物对SGC-7901细胞葡萄糖摄取、乳酸和ATP含量的抑制作用(P<0.001)。结论左金丸醇提物可显著抑制SGC-7901细胞增殖、降低细胞糖酵解水平,其机制与下调RTKN表达相关。

关键词：左金丸胃癌细胞增殖糖酵解 Rhotekin

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