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High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury

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Neural Regeneration Research 2025年第9期20卷 2611-2623页

作者： Mengshi Yang Miao Bai Yuan Zhuang Shenghua Lu Qianqian Ge Hao Li Yu Deng hongbin wu Xiaojian Xu Fei Niu Xinlong Dong Bin Zhang Baiyun Liu Beijing Tiantan Hospital Capital Medical UniversityBeijingChina Department of Neurology The First Hospital of Tsinghua UniversityBeijingChina Department of Neurotrauma and Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Critical Care Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Center for Nerve Injury and Repair Beijing Institute of Brain DisordersChina National Clinical Research Center for Neurological DiseasesBeijingChina

Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently *** potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet *** the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of *** vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial ***,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were ***-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of *** Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our ***-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain *** dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in *** receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain ***,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is th

关键词： apoptosis BV2 microglia dexamethasone glucocorticoid receptor glucocorticoids innate immune system microglial polarization neuroinflammation primary microglia traumatic brain injury

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Frequency Analyses for Mechanism Research of Unsteady Flow Inside Three Dimensional Compressor Cascade

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Journal of Thermal Science 2004年第3期13卷 207-212页

作者： Sheng Zhou hongbin wu Xinqian Zheng Beijing Univ Aeronaut & Astronaut Natl Key Lab Aircraft Engine Beijing 100083 Peoples R China

Numerical simulations are carried out for unsteady flow field of certain kind of 3D compressor cascade. Emphasis is laid on vortex shedding and frequency analysis in a compressor cascade. Numerical simulations using unsteady Reynolds-averaged viscous turbulent equations are carried out. The results show that the flows in separated areas and wake areas are characterized as periodic or quasi-periodic vortex shedding and the frequencies of vortex shedding vary with incidences and Mach number. At the same Mach number, the frequency of vortex shedding will decrease as the incidence increases. Yet, the frequency will increase as the Mach number increases at the same incidence. In the same computation case, the frequency of vortex shedding will vary along the span of blade. The frequency is smaller at the middle of the span than that at the hub.

关键词： axial flow compressor cascade unsteady flow separated flow frequency of vortex shedding.

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Influence of Surface Nano-structured Treatment on Pack Boriding of H13 Steel

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Journal of Materials Science & Technology 2007年第4期23卷 525-528页

作者： Lingyun XU Xiaochun wu hongbin WANG School of Materials Science and Engineering Shanghai University Shanghai 200072 China

In order to lower the boriding temperature of hot work steel H13, method of surface mechanical attrition treatment （SMAT）, which can make the grain size of the surface reach nano-scale, was used before pack boriding. The growth of the boride layer was studied in a function of boriding temperature and time. By TEM （transmission electron microscopy）, SEM （scanning electron microscopy）, XRD （x-ray diffraction） and microhardness tests, the grain size, thermal stability of the nano-structured （NS） surface and the thickness,appearance, phases of the surface boride layer were studied. Kinetic of boriding was compared between untreated samples and treated samples. Results showed that after SMAT, the boride layer was thicker and the hardness gradient was smoother. Furthermore, after boriding at a low temperature of 700℃ for 8 h, a boride layer of about 5 μm formed on the NS surface. This layer was toothlike and wedged into the substrate, which made the surface layer combine well with the substrate. The phase of the boride layer was Fe2B. Research on boriding kinetics indicated that the activation energy was decreased for the treated samples.

关键词： Boriding Surface mechanical attrition treatment (SMAT) H13 steel Boriding kinetic

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Hybrid Network Model Based on Data Enhancement for Short-term Power Prediction of New PV Plants

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Journal of Modern Power Systems and Clean Energy 2024年第1期12卷 77-88页

作者： Shangpeng Zhong Xiaoming Wang Bin Xu hongbin wu Ming Ding the Anhui Province Key Laboratory of Renewable Energy Utilization and Energy Saving Hefei University of TechnologyHefei 230009China the State Grid Anhui Electric Power Research Institute Hefei 230061China

This study proposes a hybrid network model based on data enhancement to address the problem of low accuracy in photovoltaic(PV)power prediction that arises due to insuffi cient data samples for new PV ***,a time-series gener ative adversarial network(TimeGAN)is used to learn the distri bution law of the original PV data samples and the temporal correlations between their features,and these are then used to generate new samples to enhance the training ***,a hybrid network model that fuses bi-directional long-short term memory(BiLSTM)network with attention mechanism(AM)in the framework of deep&cross network(DCN)is con structed to effectively extract deep information from the origi nal features while enhancing the impact of important informa tion on the prediction ***,the hyperparameters in the hybrid network model are optimized using the whale optimi zation algorithm(WOA),which prevents the network model from falling into a local optimum and gives the best prediction *** simulation results show that after data enhance ment by TimeGAN,the hybrid prediction model proposed in this paper can effectively improve the accuracy of short-term PV power prediction and has wide applicability.

关键词： New photovoltaic(PV)plant short-term predic tion time-series generative adversarial network(TimeGAN) hy brid network hyperparameter

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Efficient Polymer Solar Cells Based on Solution-processed Vanadium Oxide as Hole-extracting Layer

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Chinese Journal of Chemistry 2013年第11期31卷 1423-1427页

作者： Biao Xiao Xiaoping Cheng Baofeng Zhao hongbin wu Institute of Polymer Optoelectronic Materials and Devices State Key Laboratory of Luminescent Materials and Devices South China University of Technology Guangzhou Guangdong 510640 China

Here we reported the fabrication of efficient polymer solar cells from regioregular poly（3-hexylthiophene）（P3HT）：fullerene derivative [6,6]-phenyl-C61 butyric acid methyl ester （PC6jBM） mixtures, in which solution- processed vanadium oxide （VOx） was used as a hole-extracting layer （HEL）. The obtained devices exhibited a high power conversion efficiency of 3.96%, and can be enhanced to 4.06% and 4.16%, respectively, when two types of PEDOT：PSS with different conductivities were used in conjunction with the VOx layer. All the VOx-based devices showed a high fill factor （FF） over 70%, which was ascribed to efficient hole extracting efficiency associated with the solution-processed VOx hole-extracting layer. The origins of the improvement were also studied by transmission spectra, atomic force microscope （AFM）, and capacitance-voltage characteristics.

关键词： polymer solar cells vanadium oxide hole-extracting layer solution-processed

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Distributed cooperative voltage control based on curve-fitting in active distribution networks

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Journal of Modern Power Systems and Clean Energy 2017年第5期5卷 777-786页

作者： hongbin wu Chenyang HUANG Ming DING Bo ZHAO Peng LI School of Electrical Engineering and Automation Hefei University of TechnologyHefei 230009China Zhejiang Electric Power Corporation Research Institute Hangzhou 310014China

This study investigates a hybrid hierarchical multi-agent system for distributed cooperative voltage control in active distribution networks. The hybrid hierarchical multi-agent system adopts on-load tap-changing(OLTC) agents for the distribution transformers and feeder control section(FCS) agents for the distributed generators(DGs). The objective is to minimize the voltage deviations over the network. The FCS agents also have the objective of minimizing reductions in DG power output. A least squares method is used for curve fitting to achieve the two objectives. The OLTC agent receives voltage information from the FCS agents to evaluate the state of the voltage in each feeder and the distribution network and cooperates with the FCS agents to control the voltage of the *** FCS agents exchange the fitted curve parameters and basic information on the DGs with other agents to achieve the objectives. The effectiveness of the proposed distributed cooperative voltage control scheme is verified through simulations. Depending on the network voltages obtained by the OLTC agent, different operations are executed to prevent voltage limit violations and to minimize the voltage deviations and reductions in the DG power outputs.

关键词： Active distribution network Distribution cooperative control Voltage control Multi-agent system

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Petroleum pitch derived hard carbon via NaCl-template as anode materials with high rate performance for sodium ion battery

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Frontiers of Chemical Science and Engineering 2024年第7期18卷 1-10页

作者： Baoyu wu Hao Sun Xiaoxue Li Yinyi Gao Tianzeng Bao hongbin wu Kai Zhu Dianxue Cao Key Laboratory of Superlight Materials and Surface Technology of Ministry of Education College of Materials Science and Chemical EngineeringHarbin Engineering UniversityHarbin 150001China Hunan Hongshan New Energy Technology Co. LtdYiyang 413000China

Sodium-ion batteries(SIBs)have garnered significant interest in energy storage due to their similar working mechanism to lithium ion batteries and abundant reserves of sodium *** facile synthesis of a carbon-based anode materials with capable electrochemical performance is key to promoting the practical application of *** this work,a combination of petroleum pitch and recyclable sodium chloride is selected as the carbon source and template to obtain hard carbon(HC)anode for *** times and temperatures are optimized by assessing the sodium ion storage behavior of different HC *** optimized HC exhibits a remarkable capacity of over 430 mAh·g^(-1) after undergoing full activation through 500 cycles at a density of current of 0.1 A·g^(-1).Furthermore,it demonstrates an initial discharge capacity of 276 mAh·g^(-1) at a density of current of 0.5 A·g^(-1).Meanwhile,the optimized HC shows a good capacity retention(170 mAh·g^(-1) after 750 cycles)and a remarkable rate ability(166 mAh·g^(-1) at 2 A·g^(-1)).The enhanced capacity is attributed to the suitable degree of graphitization and surface area,which improve the sodium ion transport and storage.

关键词： petroleum pitch hard carbon sodium-ion batteries high rate recyclable template

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Improving photovoltaic parameters of all-polymer solar cells through integrating two polymeric donors

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Science China Chemistry 2021年第11期64卷 2010-2016页

作者： Kang An Feng Peng Wenkai Zhong Wanyuan Deng Difei Zhang Lei Ying hongbin wu Fei Huang Yong Cao Institute of Polymer Optoelectronic Materials and Devices State Key Laboratory of Luminescent Materials and DevicesSouth China University of TechnologyGuangzhou510640China

The incorporation of an additional component into the bulk-heterojunction light-harvesting layer of polymer solar cells has been considered as an effective strategy to enhance photovoltaic *** we demonstrated that the photovoltaic parameters of all-polymer solar cells could be enhanced upon replacing a certain ratio of electron-donating polymer PTz BI-o F with a widely used wide-bandgap polymer donor *** photoluminescent characterizations confirmed the F?rster resonance energy transfer from incorporated PM6 to PTz BI-o ***,the combination of Fourier-transform photocurrent spectroscopy and electroluminescence external quantum efficiencies measurements demonstrated reduced non-radiative recombination energy loss upon the incorporation of PM6,resulting in a slightly enhanced open-circuit voltage of 0.88 V of the ternary cell regarding the binary PTz BI-o F:PFA1 *** optimized ternary blend devices comprising of PTz BI-o F:PM6:PFA1 presented an impressively high power conversion efficiency of 16.3%,and the efficiency remains 15%on a device with an enlarged effective area of 1 cm^(2),demonstrating the great potential of these all-PSCs for potential applications.

关键词： all-polymer solar cells ternary blend high performance large area device

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APPROXIMATED-ASYMPTOTIC SOLUTION OF THE COMPLEX VARIABLE EQUATION OF TOROIDAL SHELLS UNDER AXIAL SYMMETRIC LOADS

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Acta Mechanica Sinica 1986年第1期2卷 58-65页

作者： wu Zhenhui Zhao hongbin Shen Zhupei (Tsinghua University) 1. Tsinghua University Beijing China

The series-approach and the asymptotic-approach are usually used to solve thecomplex variable equation of the toroidal shells under axial symmetric *** is known,theconvergence of the series-solution is good only for small values of μ=(12(1-v2)1/2a2/(r0h).Onthe other hand,the convergence of the asymptotic solution is good only for large values of μ.Inthis paper,based on an earlier work,a new approach which may be called the approximated-asymptotic solution has been developed and it is valid for both small and large values of μ.It isshown that the results of the approximated-asymptotic solution for toroidal shell with μ=0.5coincide very well with those of the series-solution,while the results of the asymptotic solutionfor this value of μ are not as good,and the results of the approximated-asymptotic solution for μ=15 agree with those of the asymptotic solution.

关键词： approximated-asymptotic solution complex variable equation axial symmetric load

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Recent advance in polymer solar cells: enhancing power conversion efficiency over 10% with deterministic aperiodic nanostructures

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Science China Chemistry 2015年第2期58卷 189-189页

作者： hongbin wu Institute of Polymer Optoelectronic Materials and Devices State Key Laboratory of Luminescent Materials and DevicesSouth China University of Technology

Polymer solar cell （PSC） is a promising photovoltaic technology for clean and renewable energy sources owing to its mechanical flexibility and large-area, low-cost manufacturing compatibility. Significant progress in device per- formance has been made in the recent years through the development of new materials, morphology control in photo-active layer, interface engineering in multi-layer device, and device fabrication processes. However, further improvement in efficiency exceeding 10% in single-junction PSCs remains a daunting challenge for commercial applications owing to the compromise between optical absorption and charge transport in the active layer.

关键词：太阳能电池电源转换效率聚合物纳米结构非周期性设备接口制造工艺 PSCs

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