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International Journal of Ophthalmology(English edition) 2022年第3期15卷 413-419页

作者： Bo Yu Yun-Hai Tu Guang-Ming Zhou Jie-Liang Shi En-de wu Wen-Can wu department of Orbital and Oculoplastic Surgery Eye Hospital of Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina

AIM: To demonstrate the outcomes of endoscopic endonasal dacryocystorhinostomy(En-DCR) with an novel lacrimal ostium stent(LOS) which was performed in patients with recurrent epiphora after failed external dacryocystorhinostomy(Ex-DCR) and analyze the causes of failed ***: From September 2015 and december 2017, the clinic data of 29 cases suffered from recurrent epiphora after failed Ex-DCR was *** LOS were implanted into the ostium at the end of the revisional *** causes of failed Ex-DCR were analyzed before revisional *** of revisional surgeries with the new device were evaluated as ***: The major causes of failure of the external approach were synechiae formation in the nasal ostium(29/29), followed by inadequate removal of the bony wall(21/29), nasal synechiae formation between lateral wall of nose and middle turbinate(11/29), and the bone opening was not in good location(7/29).The rate of success after revisional surgery was 82.76%.Re-obstruction of the ostiums were found in 5 failed ***: Endoscopic approach with a novel LOS may be an effective procedure to manage recurrent epiphora after previous failed Ex-DCR *** formation in the nasal ostium and inadequate removal of the bony wall were the major causes of failure of Ex-DCR.

关键词： external dacryocystorhinostomy failed endoscopic technique lacrimal ostium stent

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异型单元式拼装人行天桥雨棚施工技术应用

广州建筑 2024年第4期52卷 53-57页

作者：陈德武胡健健赵运郭伟河广州市盾建建设有限公司广州511400 中建四局土木工程有限公司深圳518000

为解决异型拼装式人行天桥雨棚安装精度及安装效率等问题,通过采用BIM+Midas Gen有限元分析软件进行几何建模和网格划分,建立胎架和吊装构件模型,合理地划分雨棚网格,将其分成弧度较小的单元后进行单独吊装及空中原位安装,合理布置吊点... 详细信息

为解决异型拼装式人行天桥雨棚安装精度及安装效率等问题,通过采用BIM+Midas Gen有限元分析软件进行几何建模和网格划分,建立胎架和吊装构件模型,合理地划分雨棚网格,将其分成弧度较小的单元后进行单独吊装及空中原位安装,合理布置吊点和精密测控。结果表明:采用BIM+有限元软件分析、分段分节优化、安装方法优化、支撑胎架布置等一系列措施,得出施工过程中拱桁架最大竖向位移为39.68 mm,最大压应力为92.30 N/mm^(2),最大拉应力为104.30 N/mm^(2)。结构容许变形值、最大压应力和拉应力均满足规范要求;可以精确实现大跨度人行天桥钢结构的安装作业,且可以显著提高安装效率。研究成果也可为结构造型复杂、悬挑长度长、跨度大、且在空间呈现异形弯扭造型的人行天桥雨棚施工提供新思路。

关键词：钢结构雨棚异型双曲面单元式拼装有限元分析

Comparative effects of enzymatic soybean,fish meal and milk powder in diets on growth performance,immunological parameters,SCFAs production and gut microbiome of weaned piglets

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Journal of Animal Science and Biotechnology 2022年第2期13卷 567-577页

作者： Yingjie Li Yang Liu Jiangnan wu Qiuhong Chen Qiang Zhou Fali wu Ruinan Zhang Zhengfeng Fang Yan Lin Shengyu Xu Bin Feng Yong Zhuo de wu Lianqiang Che Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education Institute of Animal NutritionSichuan Agricultural UniversityNo.211Huimin RoadWenjiang DistrictChengdu 611130SichuanPeople’s Republic of China

Background:The objective of this study was to evaluate the replacement effects of milk powder(MK)and fish meal(FM)by enzymatic soybean(ESB)in diets on growth performance,immunological parameters,SCFAs production and gut microbiome of weaned ***:A total of 128 piglets with initial body weight at 6.95±0.46 kg,were randomly assigned into 4 dietary treatments with 8 replicates per treatment and 4 piglets per replicate for a period of 14 *** were offered isonitrogenous and iso-energetic diets as follows:CON diet with MK and FM as high quality protein sources,ESB plus FM diet with ESB replacing MK,ESB plus MK diet with ESB replacing FM,and ESB diet with ESB replacing both MK and ***:No significant differences were observed in growth performance among all treatments(P>0.05).However,piglets fed ESB plus FM or ESB diet had increased diarrhea index(Pde protein(CP),relative to piglets fed CON diet(Pdecreased the plasma concentration of HPT and fecal concentration of butyric acid(BA)(Pdex,which could be associated with lower nutrients digestibility and more gut pathogenic ***,piglets fed diet using ESB to replace FM did not markedly affect gut health-related parameters,indicating the potential for replacing FM with ESB in weaning diet.

关键词： Enzymatic soybean Growth performance Gut microbiome Immunology SCFAs Weaned piglets

Multi-endpoint assays reveal more severe toxicity induced by chloraminated effluent organic matter than chloraminated natural organic matter

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Journal of Environmental Sciences 2024年第1期135卷 310-317页

作者： Hai-Yan Wang de-Xiu wu Ye Du Xiao-Tong Lv Qian-Yuan wu State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing 100012China Environmental Protection Key Laboratory of Microorganism Application and Risk Control Guangdong Provincial Engineering Research Center for Urban Water Recycling and Environmental SafetyTsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055China College of Architecture and Environment Sichuan UniversityChengdu 610000China

Disinfection by chloramination produces toxic byproducts and the difference in toxicity of reclaimed and drinking water treated by chloramination remains *** study investigated cytotoxic effects at the same concentrations of dissolved organic matter and showed that chloraminated effluent organic matter(EfOM)induced 1.7 times higher cytotoxicity than chloraminated natural organic matter(NOM)applied to simulate drinking *** EfOM induced more reactive nitrogen species than chloraminated NOM,and chloraminated EfOM and NOM induced similar and higher levels of reactive oxygen species than the negative control,***,intracellular macromolecule damage indicated by DNA/RNA damage marker 8–hydroxy-(deoxy)guanosine and the intracellular protein carbonyl concentration induced by chloraminated EfOM was higher and slightly more than that induced by chloraminated NOM,*** data were consistent with the effects on cell physiological *** cycle arrest mainly occurred in G2 phase by chloraminated EfOM and *** apoptotic cells,which could return to normal,increased upon exposure to high concentrations of chloraminated EfOM and ***,necrotic cells were significantly increased from 0.5%to 2.5%when the concentration increased from 20-to 60-fold chloraminated EfOM,but were not obviously changed by chloraminated *** results indicated that the comprehensive intracellular changes induced by toxic substances in chloraminated EfOM were more irreversible and induced more cell death than chloraminated NOM.

关键词： Cytotoxicity Intracellular active nitrogen/oxygen Intracellular oxidative damage Cell necrosis Reclaimed water

松果菊苷下调Skp2的表达抑制胶质母细胞瘤上皮间质转化及胶质瘤干细胞干性

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中南药学 2024年第3期22卷 626-632页

作者：吴振德王兆涛鞠其超张波厦门长庚医院神经外科福建厦门361028 广州医科大学附属第二医院神经外科广州560210

目的研究松果菊苷(ECH)对胶质母细胞瘤(GBM)的上皮间质转化(EMT)及其对GBM干细胞的影响,并探讨其分子机制。方法①体外实验:将GBM U87和U251细胞以0、5、10和20μmol·L^(-1) ECH浓度处理24 h。采用CCK-8法评估细胞活性;进行克隆形成实... 详细信息

目的研究松果菊苷(ECH)对胶质母细胞瘤(GBM)的上皮间质转化(EMT)及其对GBM干细胞的影响,并探讨其分子机制。方法①体外实验:将GBM U87和U251细胞以0、5、10和20μmol·L^(-1) ECH浓度处理24 h。采用CCK-8法评估细胞活性;进行克隆形成实验以测定克隆能力;通过Transwell实验评估迁移和侵袭能力;利用球形成实验评价GBM干细胞的成球能力;通过细胞免疫荧光检测干细胞标志物;使用Western blot分析EMT和干细胞相关蛋白表达。②体内实验:在裸鼠皮下注射U87细胞,每组5只。实验组腹腔注射ECH,对照组注射等体积溶剂。最后测定肿瘤体积、重量和体重,并用Western blot分析肿瘤中的Skp2、EMT和干细胞相关蛋白表达。结果①体外实验显示,相较于0μmol·L^(-1) ECH组,10、20μmol·L^(-1) ECH处理显著降低了细胞活性(P0.05)。结论ECH通过降低Skp2表达抑制GBM的EMT和干细胞特性。

关键词：胶质母细胞瘤松果菊苷上皮间质转化干细胞干性 Skp2

外源硅和钙添加对盐胁迫下小麦幼苗叶绿素含量的影响研究

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菏泽学院学报 2024年第2期46卷 90-94页

作者：伍丙德周炫齐彭潇张帮磊昭通学院化学化工学院云南昭通657000

以小麦种子为试验处理受试材料,采用水培法研究了盐胁迫下不同浓度外源硅和钙添加对小麦幼苗叶绿素含量和叶绿素比(a∶b)的影响.结果表明,低浓度硅、低浓度钙和高浓度钙添加均降低了盐胁迫下小麦幼苗的叶绿素a含量、叶绿素b含量和总叶... 详细信息

以小麦种子为试验处理受试材料,采用水培法研究了盐胁迫下不同浓度外源硅和钙添加对小麦幼苗叶绿素含量和叶绿素比(a∶b)的影响.结果表明,低浓度硅、低浓度钙和高浓度钙添加均降低了盐胁迫下小麦幼苗的叶绿素a含量、叶绿素b含量和总叶绿素含量,然而,低浓度硅和低浓度钙协同(1∶5)、高浓度硅和高浓度钙协同(2∶10)处理均增加了小麦幼苗叶绿素a含量、叶绿素b含量和总叶绿素含量,其他混合处理的影响规律不一致.因此,一定浓度的硅和钙协同处理可对一定盐害程度下的小麦幼苗光合效应起到缓解作用.

关键词：硅和钙盐胁迫小麦幼苗叶绿素含量

基于ESP32与Phyphox的磁感应强度定量分析实验装置

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物理教学探讨 2024年第6期42卷 62-65页

作者：王秋毕皓天付庭松蔡武德云南师范大学物理与电子信息学院昆明650500 云南师范大学附属世纪金源学校昆明650214

物理概念教学是发展学生物理观念的重要环节,定量物理概念的建构离不开定量探究实验。以ESP32芯片、Phyphox软件为载体,设计制作了高精度磁感应强度定量分析实验装置,以期将信息技术融入物理概念教学,使磁感应强度概念的建构过程由定性... 详细信息

物理概念教学是发展学生物理观念的重要环节,定量物理概念的建构离不开定量探究实验。以ESP32芯片、Phyphox软件为载体,设计制作了高精度磁感应强度定量分析实验装置,以期将信息技术融入物理概念教学,使磁感应强度概念的建构过程由定性向定量转变。

关键词：自制教具磁感应强度定量实验

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WPT系统线圈移动的零相角频率跟踪研究

电力电子技术 2024年第2期58卷 47-50页

作者：赵钦涛武晋德韩晓霞金卓航太原理工大学电气与动力工程学院山西太原030024

在家用电器自主充电的无线电能传输(WPT)系统中,由于其难以每次移动到相同的位置,因此在初次级磁芯的相互影响下,线圈的自感会随着其相对位置的改变而发生变化,进而使得系统失谐、零相角(ZPA)频率漂移,最终影响系统的平稳运行。这里基... 详细信息

在家用电器自主充电的无线电能传输(WPT)系统中,由于其难以每次移动到相同的位置,因此在初次级磁芯的相互影响下,线圈的自感会随着其相对位置的改变而发生变化,进而使得系统失谐、零相角(ZPA)频率漂移,最终影响系统的平稳运行。这里基于串联-串联(SS)型拓扑结构,提出了线圈移动条件下追踪ZPA频率的方法,通过对SS型拓扑结构的电路进行建模,推导了出现频率分裂现象(FSP)时系统ZPA对应的角频率,在Matlab仿真中建立电流相角和初级电流幅值的关系,并采用梯度下降(GD)算法分别在频率分裂是否发生两种情况下,对电流幅值的谷值和峰值进行追踪。实验结果表明:无论系统是否出现频率分裂,都可以实现ZPA频率的追踪。

关键词：无线电能传输线圈移动零相角频率梯度下降

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某分离螺母壳体裂纹产生原因分析及结构改进

火工品 2024年第1期 33-37页

作者：雷山玉金吴瑞德郭晓荣陈文龙孙洁李清旭陕西应用物理化学研究所陕西西安710061

针对某分离螺母发火后壳体上端面产生裂纹的问题,对分离螺母的作用过程进行了仿真,分析了裂纹产生原因,提出了改进措施,并对其有效性进行了验证。结果表明:由于解锁过程中,分瓣螺母轴线与产品轴线的相对位置发生偏移,并且内筒活塞也发... 详细信息

针对某分离螺母发火后壳体上端面产生裂纹的问题,对分离螺母的作用过程进行了仿真,分析了裂纹产生原因,提出了改进措施,并对其有效性进行了验证。结果表明:由于解锁过程中,分瓣螺母轴线与产品轴线的相对位置发生偏移,并且内筒活塞也发生偏转,造成结构间冲击载荷传递不均匀,从而导致壳体上端面锥台根部局部位置受冲击过大而出现裂纹。通过增大内筒活塞对分瓣螺母的接触长度和径向约束,能够改善壳体上端面锥台根部受力不均的问题,从而减少裂纹产生。

关键词：分离螺母壳体裂纹仿真分析受力不均结构改进

Diagnosis,treatment,outcome,and reasons for delayed treatment of cryptorchidism with torsion in children:a 16-year retrospective study in a large pediatric medical center

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Asian Journal of Andrology 2022年第4期24卷 386-389页

作者： Meng Yang Sheng Wen Tao Lin Xing Liu de-Ying Zhang Feng Liu Sheng-de wu Guang-Hui Wei Pei-Ru He Yi Hua department of Urology Children's Hospital of Chongqing Medical UniversityChongqing 400000China Pediatrics Research Institute Children's Hospital of Chongqing Medical UniversityMinistry of Education Key Laboratory of Child Development and DisordersNational Clinical Research Center for Child Health and DisordersChina International Science and Technology Cooperation Base of Child Development and Critical DisordersChildren's Hospital of Chongqing Medical UniversityChongqing 400000China Chongqing Key Laboratory of Pediatrics Chongqing Key Laboratory of Children Urogenital Development and Tissue EngineeringChongqing 400000China.

We describe and summarize the diagnosis,treatment,and reasons for delayed treatment of children with cryptorchidism torsion in Children's Hospital of Chongqing Medical *** study included 19 cases of cryptorchidism *** age of the children ranged from 16 days to 12 years(median:6 years).The interval from diagnosis to surgery varied from 4 h to 16 days(median:3 days).Ultrasound was performed in all *** cases had cryptorchidism torsion,2 cases had a soft tissue mass in the inguinal region,and 2 cases had an inguinal/abdominal *** cases were treated with an orchidopexy,12 cases were treated with orchiectomy,and 2 cases received resection of a testicular *** 5 children with an orchidopexy were followed up from 1 month to 7 years(median:3 years),with 1 child having a testis retraction and no blood *** the 12 children who had an orchiectomy,three had delayed diagnosis due to family unawareness of the condition,while other delays were due to delayed referral from primary care *** relative rarity and insufficient awareness of cryptorchidism torsion resulted in a low rate of testicular ***,hospitals of all levels should be fully aware of cryptorchidism with torsion and ensure a male child's genital system and inguinal region are examined to improve the success rate of testicular salvage.

关键词： children cryptorchidism testicular torsion