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Journal of Ocean University of China 2024年第1期23卷 23-32页

作者： wu de’an LI Xin WANG Yigang College of Harbor Coastal and Offshore EngineeringHohai UniversityNanjing 210098China Tianjin Research Institute For Water Transport Engineering Tianjin 300456China

To study the stratified stability of a water column in the North Passage of the Yangtze River Estuary,a numerical model of the hydrodynamics of this estuary is established using the EFDC *** the basis of EFDC results,this paper derives and pro-vides the discriminative index of water body stability caused by salinity and analyzes the along-range variation in water body strati-fication stability in the North Passage of the Yangtze River Estuary and the periodic variation at a key location(bend area)based on the simulation results of the numerical *** work shows that the water body in the bend area varies between mixed and strati-fied types,and the vertical average flow velocity has a good negative correlation with the differential velocity between the surface and bottom layers of the water *** model simulation results validate the formulae for the stratified stability discriminant during spring tides.

关键词： Yangtze Estuary North Passage EFDC model stratification stability salinity distribution

A computational model to identify fertility-related proteins using sequence information

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Frontiers of Computer Science 2024年第1期18卷 229-237页

作者： Yan LIN Jiashu WANG Xiaowei LIU Xueqin XIE de wu Junjie ZHANG Hui DING Key Laboratory for Animal Disease-Resistance Nutrition of the Ministry of Agriculture Animal Nutrition InstituteSichuan Agricultural UniversityChengdu 611130China School of Life Science and Technology and Center for Informational Biology University of Electronic Science and Technology of ChinaChengdu 610054China

Fertility is the most crucial step in the development process,which is controlled by many fertility-related proteins,including spermatogenesis-,oogenesis-and embryogenesis-related *** identification of fertility-related proteins can provide important clues for studying the role of these proteins in ***,in this study,we constructed a two-layer classifier to identify fertility-related *** this classifier,we first used the composition of amino acids(AA)and their physical and chemical properties to code these three fertility-related ***,the feature set is optimized by analysis of variance(ANOVA)and incremental feature selection(IFS)to obtain the optimal feature *** five-fold cross-validation(CV)and independent data tests,the performance of models constructed by different machine learning(ML)methods is evaluated and ***,based on support vector machine(SVM),we obtained a two-layer model to classify three fertility-related *** the independent test data set,the accuracy(ACC)and the area under the receiver operating characteristic curve(AUC)of the first layer classifier are 81.95%and 0.89,respectively,and them of the second layer classifier are 84.74%and 0.90,*** results show that the proposed model has stable performance and satisfactory prediction accuracy,and can become a powerful model to identify more fertility related proteins.

关键词： sfertility-related proteins machine1 learning sequence information feature selection

Effects of maternal methyl donor intake during pregnancy on ileum methylation and function in an intrauterine growth restriction pig model

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Journal of Animal Science and Biotechnology 2024年第3期15卷 1173-1189页

作者： Yan Lin Jiangnan wu Yong Zhuo Bin Feng Zhengfeng Fang Shengyu Xu Jian Li Hua Zhao de wu Lun Hua Lianqiang Che Key Laboratory of Animal Disease‑Resistance Nutrition Animal Nutrition InstituteSichuan Agricultural UniversityChengdu 611130SichuanChina

Background Intrauterine growth retardation(IUGR)affects intestinal growth,morphology,and function,which leads to poor growth performance and high *** present study explored whether maternal dietary methyl donor(MET)supplementation alleviates IUGR and enhances offspring’s growth performance by improving intestinal growth,function,and DNA methylation of the ileum in a porcine IUGR *** Forty multiparous sows were allocated to the control or MET diet groups from mating until *** farrowing,8 pairs of IUGR and normal birth weight piglets from 8 litters were selected for sampling before suckling *** The results showed that maternal MET supplementation tended to decrease the IUGR incidence and increased the average weaning weight of ***,maternal MET supplementation significantly reduced the plasma concentrations of isoleucine,cysteine,urea,and total amino acids in sows and newborn *** also increased lactase and sucrase activity in the jejunum of newborn *** addition resulted in lower ileal methionine synthase activity and increased betaine homocysteine S-methyltransferase activity in the ileum of newborn *** methylation analysis of the ileum showed that MET supplementation increased the methyla-tion level of DNA CpG sites in the ileum of newborn ***-regulated differentially methylated genes were enriched in folic acid binding,insulin receptor signaling pathway,and endothelial cell *** contrast,up-regulated methylated genes were enriched in growth hormone receptor signaling pathway and nitric oxide biosyn-thetic *** Maternal MET supplementation can reduce the incidence of IUGR and increase the weaning litter weight of piglets,which may be associated with better intestinal function and methylation status.

关键词： Ileum Intrauterine growth restriction Methyl donor Methylation Sows

Standardized ileal digestibility of amino acids in soybean meal fed to non-pregnant and pregnant sows

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Journal of Animal Science and Biotechnology 2024年第1期15卷 362-373页

作者： Ke Wang Ya Wang Lei Guo Yong Zhuo Lun Hua Lianqiang Che Shengyu Xu Ruinan Zhang Jian Li Bin Feng Zhengfeng Fang Xuemei Jiang Yan Lin de wu Institute of Animal Nutrition Key Laboratory for Animal Disease‑Resistance Nutrition of ChinaMinistry of EducationSichuan Agricultural University211 Huimin RoadWenjiang DistrictChengdu 611130SichuanChina

Background Two studies were designed to determine standard ileal crude protein(CP)and amino acid(AA)digestibility of soybean meal(SBM)from different origins fed to non-pregnant and pregnant *** solvent-extracted SBMs from soybeans produced in the USA,Brazil,and China were *** Exp.1,eight different diets were created:a nitrogen(N)-free diet and 7 experimental diets containing SBM from different origins as the only N *** non-pregnant,multiparous sows were arranged in an 8×8 Latin square design(8 periods and 8 diets).In Exp.2,the diet formula was the same as in *** gestating sows(parity 3)were assigned to 4 different diets in a replicated 4×3 Youden square design(three periods and four diets)in mid-gestation and again in late-gestation *** When fed to non-pregnant and late-gestating sows,the standardized ileal digestibility(SID)of CP and most AAs from different SBM were not significantly different(P>0.05).When fed to mid-gestating sows,the SID values for Arg,His,Lys,Phe,Cys,Gly,Ser,and Tyr in SBM 1 were lower than in SBM 4 and 5(Pde a cornerstone for accurate SBM use in sow diets.

关键词： Amino acids Sows Soybean meal Standardized ileal digestibility

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算子方程耦合解的存在性

数学的实践与认识 2024年第2期54卷 175-181页

作者：吴德宇郑州科技学院基础部河南有郑州450064

研究抽象的算子方程组的耦合解的存在性.主要是运用算子单调迭代方法,得到所需要的良序集,即文中的良序链,然后得到抽象算子方程组的耦合解和极大极小耦合解的存在性定理.

关键词：耦合不动点极大极小耦合不动点耦合解极大极小耦合解

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Preoperative serum cortisone levels are associated with cognition in preschool‑aged children with tetralogy of Fallot after corrective surgery:new evidence from human populations and mice

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World Journal of Pediatrics 2024年第2期20卷 173-184页

作者： Si-Yu Ma Yu-Ting Liu Yue-Shuang Cun Qiang Wang Ming-Cui Fu Ke-de wu Xin-Yu Cai Shu-Ting Cheng Nishant Patel Min Da Liang Hu Zhuoga deqin Xue-Jun Kang Ming Yang Xu-Ming Mo department of Cardiothoracic Surgery Children’s Hospital of Nanjing Medical University72 Guangzhou RoadNanjing 210008China department of Radiology Children’s Hospital of Nanjing Medical University72 Guangzhou RoadNanjing 210008China Key Laboratory of Child development and Learning Science Research Center For Learning ScienceSchool of Biological Sciences&Medical EngineeringMinistry of EducationSoutheast UniversityNanjing 210096China Medical School of Nanjing University Nanjing 210093China

Background Tetralogy of Fallot(TOF)is the most common cyanotic congenital heart *** with TOF would be confronted with neurological impairment across their *** study aimed to identify the risk factors for cerebral morphology changes and cognition in postoperative preschool-aged children with *** We used mass spectrometry(MS)technology to assess the levels of serum metabolites,Wechsler preschool and primary scale of intelligence-Fourth edition(WPPSI-Ⅳ)index scores to evaluate neurodevelopmental levels and multimodal magnetic resonance imaging(MRI)to detect cortical morphological *** Multiple linear regression showed that preoperative levels of serum cortisone were positively correlated with the gyrification index of the left inferior parietal gyrus in children with TOF and negatively related to their lower visual spaces index and nonverbal ***,preoperative SpO_(2) was negatively correlated with levels of serum cortisone after adjusting for all ***,after intervening levels of cortisone in chronic hypoxic model mice,total brain volumes were reduced at both postnatal(P)11.5 and P30 *** Our results suggest that preoperative serum cortisone levels could be used as a biomarker of neurodevelopmental impairment in children with *** study findings emphasized that preoperative levels of cortisone could influence cerebral development and cognition abilities in children with TOF.

关键词： Cognition Cortisone MRI Neurodevelopment Tetralogy of Fallot

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突变体p53的翻译后修饰与“功能获得”

中国生物化学与分子生物学报 2024年第08期40卷 1043-1056页

作者：吴德轩吴臻王冬来中国医学科学院基础医学研究所北京协和医学院基础学院医学遗传学系

p53是细胞内最重要的抑癌基因之一，超过50%的人类肿瘤存在以错义突变为主的p53基因变异，导致肿瘤细胞中突变体p53蛋白的产生和积累。除了丧失正常的生物学功能、并通过显性负效应抑制野生型p53的转录活性和肿瘤抑制能力，越来越多的... 详细信息

p53是细胞内最重要的抑癌基因之一，超过50%的人类肿瘤存在以错义突变为主的p53基因变异，导致肿瘤细胞中突变体p53蛋白的产生和积累。除了丧失正常的生物学功能、并通过显性负效应抑制野生型p53的转录活性和肿瘤抑制能力，越来越多的研究表明，突变体p53的“功能获得(gain-of-function)”是其促进肿瘤进展和转移的重要途径。翻译后修饰是调节p53分子功能的关键方式，对野生型p53及不同类型突变体p53的调控表现出普遍性和特异性的双重特征，是靶向突变体p53进而逆转肿瘤的新兴潜在靶点。本文以突变体p53的翻译后修饰为切入点，对突变体p53通过“功能获得”参与肿瘤发生发展的过程、翻译后修饰对突变体p53的调控机制，以及靶向突变体p53及其翻译后修饰在肿瘤治疗中的应用做一综述。此外，我们还讨论了突变体p53在肿瘤生物学研究中尚未解决的问题，并对未来的研究方向进行了展望。本综述旨在系统概括翻译后修饰对突变体p53“功能获得”的调控和在肿瘤发生发展中的意义，为开发基于靶向突变体p53翻译后修饰的肿瘤干预策略提供依据。

关键词： p53 突变功能获得翻译后修饰肿瘤

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市政道路不良路基填料改良施工控制技术研究

建筑与装饰 2024年第7期 102-104页

作者：吴德胜肥东县住房和城乡建设局安徽肥东 231600

路基填料是市政道路施工中最为主要的内容,必须得到重视,一旦出现了不良路基,可以通过填料改良的方式进行处理解决.基于此,本文结合具体的施工项目,在深入分析这一施工项目不良路基现状的基础上,深入研究分析路基填料改良施工流程,明确... 详细信息

路基填料是市政道路施工中最为主要的内容,必须得到重视,一旦出现了不良路基,可以通过填料改良的方式进行处理解决.基于此,本文结合具体的施工项目,在深入分析这一施工项目不良路基现状的基础上,深入研究分析路基填料改良施工流程,明确其中的施工参数和施工标准,落实具体可行的控制技术,以求切实提高市政道路的建设质量和建设效率.

关键词：市政道路不良路基填料改良施工控制

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目标检测算法在滑坡识别中的应用

兰州大学学报（自然科学版） 2024年第2期60卷 229-234页

作者：唐烽顺郝利娜宋雨洋武德宏成都理工大学地球科学学院成都610059

基于目视解译的滑坡数据集选取两大类(6个)目标检测算法构建滑坡自动识别模型,以四川省阿坝州作为研究区进行滑坡自动识别.基于高分辨率卫星影像构建包含3 120个样本的滑坡样本数据集;选取4种一阶段检测算法YOLOv5(s、 m、 l、 x)与两... 详细信息

基于目视解译的滑坡数据集选取两大类(6个)目标检测算法构建滑坡自动识别模型,以四川省阿坝州作为研究区进行滑坡自动识别.基于高分辨率卫星影像构建包含3 120个样本的滑坡样本数据集;选取4种一阶段检测算法YOLOv5(s、 m、 l、 x)与两种二阶段检测算法Faster R-CNN(VGG16和ResNet-50)分别构建滑坡自动识别模型;为探究样本数量对模型识别精度的影响,将样本数据集总数分为1 000、 2 000和3 000,通过滑坡测试样本对识别结果进行评价.结果表明,基于目标检测的两类滑坡识别模型中,一阶段YOLOv5模型比二阶段Faster R-CNN模型更适用于滑坡识别;样本数对滑坡识别模型的性能具有一定影响.在较少样本的情况下,选择YOLOv5s模型能够获得较高的识别精度,随着样本数的增加,使用YOLOv5m模型可以获得更好的滑坡识别效果.

关键词：滑坡深度学习 YOLOv5 Faster R-CNN

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乳酸菌生物膜的形成、特性及应用研究

中国调味品 2024年第4期49卷 212-220页

作者：姚尚杰金垚黄钧周荣清吴重德四川大学轻工科学与工程学院成都610065 贵州习酒股份有限公司贵州遵义636600

大多数乳酸菌作为益生菌被人们熟知并广泛应用于食品领域。生物膜是细菌应对不利环境的自然生长状态。而近些年的相关研究揭示了乳酸菌生物膜的成膜规律和优良特性,也初步探究了乳酸菌生物膜在生产中的应用。为进一步调控和利用乳酸菌... 详细信息

大多数乳酸菌作为益生菌被人们熟知并广泛应用于食品领域。生物膜是细菌应对不利环境的自然生长状态。而近些年的相关研究揭示了乳酸菌生物膜的成膜规律和优良特性,也初步探究了乳酸菌生物膜在生产中的应用。为进一步调控和利用乳酸菌生物膜,对乳酸菌生物膜的深入研究和理解十分必要。文章综述了乳酸菌生物膜的形成、细胞黏附胞外聚合物在生物膜形成中的作用,以及乳酸菌与酵母菌的混菌生物膜形成和酵母-乳酸菌相互作用,介绍了乳酸菌生物膜在抗逆、抑菌、食品生产、人体健康等方面的应用,以期为人们了解乳酸菌生物膜和对其进行更深入的研究和应用提供帮助。

关键词：乳酸菌生物膜混菌生物膜抗逆抗菌应用