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Z世代消费特征下国产户外服装品牌研究

西部皮革 2024年第3期46卷 32-34页

作者：吴唱雨天津工业大学艺术学院

文章通过总结Z世代的消费习惯，分析时下户外生活潮，并搜集相关行业报告，探索国产户外服装的发展路径。通过纵向整理国内户外服装品牌的行业困境,得出符合Z世代消费诉求的国产户外服装品牌设计方案。研究试图为相关产业提供品牌营销... 详细信息

文章通过总结Z世代的消费习惯，分析时下户外生活潮，并搜集相关行业报告，探索国产户外服装的发展路径。通过纵向整理国内户外服装品牌的行业困境,得出符合Z世代消费诉求的国产户外服装品牌设计方案。研究试图为相关产业提供品牌营销行之有效的建议，为国产户外服装品牌与消费者之间构建桥梁，为服装企业提供设计思路与未来发展方向。

关键词： Z世代户外服装国潮消费心理

电子技术类课程实验教学改革探索——以徐州医科大学为例

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医学教育管理 2024年第4期10卷 417-422页

作者：张静刘志成吴长宇徐州医科大学医学影像学院徐州221004 首都医科大学生物医学工程学院北京100069

电子技术是基于电子学的原理,运用电子元器件设计和制造具有某种特定功能的电路,从而达到解决实际问题的目的。电子技术课程主要特点包括知识点较多、概念抽象、逻辑性和实践性较强,学习电子技术讲求理论与实践的结合,想要锻炼学生对理... 详细信息

电子技术是基于电子学的原理,运用电子元器件设计和制造具有某种特定功能的电路,从而达到解决实际问题的目的。电子技术课程主要特点包括知识点较多、概念抽象、逻辑性和实践性较强,学习电子技术讲求理论与实践的结合,想要锻炼学生对理论知识的应用,最直观且最重要的途径就是实践教学。本文基于对以往实验教学的思考,根据医学影像技术专业培养目标,对电子技术实验课内容进行相应调整,同时对教学方法和考核方式进行改善。实验教学改革实施后,学生的操作分析能力、理论知识的掌握程度、实验素养、专业认同度等都得到了一定程度的提高,实验教学效果得到了积极的反响。

关键词：电子技术教学改革实验教学

Spectroscopic and electrochemical studies on molecular recognition of tetrathiafulvalene derivative with P-glycoprotein and drug-resistant leukemia cells

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Science China Chemistry 2015年第7期58卷 1193-1199页

作者： Yuanyuan Zhang changyu wu Hui Jiang Jinglin Zuo Xuemei Wang State Key Laboratory of Bioelectronics (Chien-Shiung wu Laboratory) Southeast University State Key Laboratory of Coordination Chemistry School of Chemistry and Chemical Engineering Nanjing University

Cancer is still one of the important diseases that threatens the health of people. Multidrug resistance(MDR) is the main factor that leads to the failure of cancer chemotherapy. Thus, MDR diagnosis could facilitate the monitoring of the therapy process and realization of efficient treatment of tumors. In this study, we have tried to use a new tetrathiafulvalene(TTF) derivative(TTF-(COONBu4)2) to sensitively recognize the MDR through the multi-signal responsive strategy. The relevant electrochemical and spectroscopic studies demonstrate the specific binding behavior of TTF-(COONBu4)2 with P-glycoprotein(P-gp) as well as drug-resistant leukemia cells. Especially due to the over-expression of specific components of P-gp on the plasma membranes of drug resistant cells, the electrochemical and hydrophilic/hydrophobic features of drug resistant-leukemia cells are apparently different from those of other kinds of leukemia cells. Meanwhile, Fourier transform infrared spectroscopic study illustrates that the most intense vibration band of TTF moieties in the 1400–1600 cm-1 range is almost smeared out upon binding to P-gp, and the binding of TTF-(COONBu4)2 to P-gp may also lead to changes in protein secondary structure and backbone. This observation may advance the development of the new TTF agent for the promising clinical diagnosis and monitoring of MDR of tumors with the aim of successful chemotherapy for human cancer.

关键词： tetrathiafulvalene derivative leukemia cell P-glycoprotein electrochemical detection Fourier transform infraredspectroscopy

Real-time detection of the interaction between anticancer drug daunorubicin and cancer cells by Au-MCNT nanocomposites modified electrodes

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Science China Chemistry 2011年第5期54卷 812-815页

作者： LI QingNing wu XiaoJing ZHAO Juan wu changyu WANG XueMei State Key Laboratory of Bioelectronics Southeast University Nanjing 210096China Medical School Ningbo UniversityNingbo 315211China

In this study,we have prepared the blending of gold nanoparticles-multiwalled nanotubes (Au-MCNTs) and then applied the new nanocomposites to modify the glassy carbon electrode (GCE) for highly sensitive detection of the interaction between anticancer drug daunorubicin (DNR) and cancer cells. Electrochemical analysis indicates that the Au-MCNT modified GCE shows high sensitivity and could track the real time response of cancer cells under DNR treatments. Therefore,this new nano-interface and Au-MCNT modified electrode could be explored as a rapid,highly sensitive,and convenient real-time detection strategy in cancer related research and would have prospect in other biomedical applications.

关键词： pharmaceutical analysis electrochemical detection anticancer drugs gold nanoparticles multi-walled carbon nanotubes

Enhanced in vitro anticancer activity of quercetin mediated by functionalized CdTe QDs

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Science China Chemistry 2014年第11期57卷 1579-1588页

作者： wu ChunHui SHI LiXin wu changyu GUO DaDong SELKE Matthias WANG XueMei School of Life Science and Technology University of Electronic Science and Technology of China State Key Laboratory of Bioelectronics (Chien-Shiung wu Laboratory) Southeast University Department of Chemistry and Biochemistry California State University

We report in this study the effects of red-emitting CdTe QDs capped with cysteamine(Cys-CdTe) on the in vitro anticancer activity of the well-known flavenoid quercetin(Qu). Various techniques, including the methylthiazolyldiphenyl-tetrazolium bromide assay, the real-time cell electronic sensing system, the optical and fluorescence imaging, and electrochemical methods have been utilized to study the potential interactions of Cys-CdTe QDs with Qu. The observations demonstrate that the safe-dosage Cys-CdTe QDs can greatly improve the drug uptake and enhance the inhibition efficiency of Qu towards the proliferation of cancer cells such as HepG2 cells. This study implies that Cys-CdTe QDs may be used for cancer therapy and that they exert a synergic anticancer effect when bound to drug molecules.

关键词： quantum dots quercetin nanocomposites cancer cell inhibition

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漏磁检测在管道损伤探测中的应用

无损检测 2024年第3期46卷 56-63页

作者：左万君戴西斌吴昌玉江西省检验检测认证总院特种设备检验检测研究院南昌330000

漏磁检测技术是油气管道损伤检测中最常用的方法之一。其是一种利用磁敏传感器检测漏磁信号进而探测管道缺陷的无损检测技术。首先介绍了漏磁检测的原理和操作流程,而后综述了近年来漏磁检测技术在信号预处理、异常识别以及缺陷量化3方... 详细信息

漏磁检测技术是油气管道损伤检测中最常用的方法之一。其是一种利用磁敏传感器检测漏磁信号进而探测管道缺陷的无损检测技术。首先介绍了漏磁检测的原理和操作流程,而后综述了近年来漏磁检测技术在信号预处理、异常识别以及缺陷量化3方面取得的重要成果。其中,重点介绍了基于深度学习的异常识别和缺陷量化方法,并分析了这些方法存在的不足。最后,对管道漏磁检测的未来发展进行了展望。

关键词：无损检测漏磁检测神经网络异常识别缺陷量化

Synergy and translation of allogenic bone marrow stem cells after photodynamic treatment of rheumatoid arthritis with tetra sulfonatophenyl porphyrin and TiO2 nanowhiskers

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Nano Research 2016年第11期9卷 3305-3321页

作者： Fawad U. Rehman Chunqiu Zhao changyu wu Xiaoqi Li Hui Jiang Matthias Selke Xuemei Wang State Key Laboratory of Bioelectronics School of Biological Science and Medical Engineering Southeast University Nanjing 210096 China Department of Chemistry and Biochemistry California State University Los Angeles CA 90032 USA Nanjing Foreign Language School Nanjing 210096 China

Rheumatoid arthritis （RA） etiology and amelioration remains a challenge in modern therapeutics. Herein, we explored the synergistic effect of allogenic bone marrow stem cell （BMSC） translation and photodynamic treatment of RA with tetra sulfonatophenyl porphyrin （TSPP） and TiO2 nanocomposites as a new strategy for RA theranostics. The translation of BMSCs with miRNAs into infected joints in long bones post-photodynamic therapy is helpful for treating and understanding RA pathophysiology. We observed that allogenic BMSC translation combined with TSPP-TiO2 nanocomposites can significantly （p 〈 0.01） lower the concentrations of serum biomarkers （tumor necrosis factor-α and interleukin-17） in a collagen induced arthritis （CIA） murine model, both in vitro and in vivo, as well as improve other parameters such as arthritis score, BMSC count, complete blood count, and numbers of platelets, red blood cells, and white blood cells. Moreover, a fluorescent TSPP in the feet or long bones and X-ray bioimaging of RA joints revealed the clinical efficacy of BMSCs combined with TSPP-TiO2 nanocomposites. Microarray data analysis illustrated that rnomir-375-3p and rno-mir-196b-3p were up-regulated by approximately 100-fold in the BMSCs of ameliorated RA post-photodynamic therapy with TSPP-TiO2 nanocomposites. Our study not only suggests a new approach for RA theranostics, but also helps in understanding RA pathophysiology.

关键词： rheumatoid arthritis allogenic bone marrowstem cells (BMSCs) tetra sulfonatophenyl porphyrin (TSPP)-TiO2nanocomposites photodynamic treatment miRNAs

New strategy for reversing biofilm-associated antibiotic resistance through ferrocene-substituted carborane ruthenium(Ⅱ)-arene complex

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Science China Chemistry 2013年第5期56卷 595-603页

作者： LI ShuiHong wu changyu TANG Xiao GAO ShengPing ZHAO XinQing YAN Hong WANG XueMei State Key Laboratory of Bioelectronics (Chien-Shiung wu Laboratory) Southeast University School of Chemistry and Chemical Engineering Nanjing University School of Life Science and Biotechnology Dalian University of Technology

Bacterial biofilms are inherently resistant to antimicrobial agents and are difficult to eradicate with conventional antimicrobial agents, resulting in many persistent and chronic bacterial infections. In this contribution, a new strategy for reversing the biofilm-associated antibiotic resistance has been explored by induction of a carborane ruthenium(II)-arene complex (FcRuSB). Our results demonstrate that the FcRuSB could be utilized as an inducer to efficiently reverse the biofilm-associated antibiotic resistance of multidrug-resistant (MDR) clinical isolates of Staphylococcus aureus and Pseudomonas aeruginosa. The induced effect of FcRuSB is correlated with a considerable decrease in the expression of extracellular matrix proteins (EMP) of the two strains. The considerable decrease of the EMP of induced cells, resulting in the reduction of adherence and biofilm formation ability of the two types of MDR pathogens, and then can cause significantly enhanced sensitivity of them to antibiotics.

关键词： bacterial biofilms carborane ruthenium(Ⅱ)-arene complex antibiotic resistance

Discovery of ferrocene-carborane derivatives as novel chemical antimicrobial agents against multidrug-resistant bacteria

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Science China Chemistry 2012年第11期55卷 2388-2395页

作者： LI ShuiHong wu changyu LV XiaYi TANG Xiao ZHAO XinQing YAN Hong JIANG Hui WANG XueMei State Key Laboratory of Bioelectronics(Chien-Shiung wu Laboratory) Southeast University Nanjing 211189China Sehool of Chemistry and Chemical Engineering Nanjing UniversityNanjing 210093China School of Life Science and Biotechnology Dalian University of TechnologyDalian 116024China

Antimicrobial resistance has now become a very serious global public health problem. New drug discovery and development are urgently needed to combat the growing threat of multidrug-resistant (MDR) bacteria. The aim of this study was to explore the potential application of three ferrocene-carborane derivatives as new promising agents to confront the problem of increasing antibiotic resistance. The results of agar diffusion bioassay, minimal inhibitory concentrations (MIC) testing and time-kill assay illustrate their broad-spectrum antimicrobial activities to both American Type Culture Collection (ATCC) control strains and MDR clinical isolates. It is evident that the relevant antimicrobial properties are all in a dose-dependent manner and gradually transform into a bactericidal effect from a bacteriostatic effect with the increasing of the drug concentration. Furthermore, these ferrocene-carborane derivatives have no/little toxic effect on normal cells like HELF cells and lead to little hemolysis at their MICs. This raises the possibility to develop novel antimicrobial drugs using these new ferrocene carborane derivants.

关键词： multidrug-resistant bacteria ferrocene-carborane derivatives bactericidal effect biocompatibility minimal inhibitoryconcentration