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Mitochondria-targeted nanoparticles overcome chemoresistance via downregulating BACH1/CD47 axis in ovarian carcinoma

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chinese Chemical Letters 2024年第5期35卷 344-350页

作者： Ke gong Jinghan Liao Jiangtao Lin Quan Wang Zhihua wu Liting Wang Jiali Zhang Yi Dong Yourong Duan Jianhua Chen State Key Laboratory of Systems Medicine for Cancer Shanghai Cancer InstituteRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200032China Department of Ultrasound Xinhua HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200092China Department of Oncology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China

The platinum-based chemotherapy is a routine strategy for the treatment of ovarian cancer,while it is prone to chemoresistance in clinical,which hinders the ***,it is urgently needed to elucidate the underlying mechanism of drug resistance and form the appropriate *** sequencing results showed that cisplatin(DDP)resistant ovarian cancer overexpressed BTB and CNC homology 1(BACH1),and up-regulated the“don’t eat me”signal *** identified that hemin,a BACH1 inhibitor,could effectively down-regulate BACH1 and simultaneously inhibit ***,hemin has a synergistic effect with *** designed a pH-responsive nanoparticle(H/D@FA-CaP-NPs)in which folic acid(FA)ensured targeting of ovarian cancer cells,while hemin inhibited BACH1 as well as down-regulated CD47,achieving the promotion of apoptosis of tumor cells and inducing phagocytosis of tumors by ***,hemin has a synergistic effect with DDP to promote apoptosis of tumor ***,hemin and DDP was encapsulated within hydrophobic 1,2-distearoyl-sn-glycero-3-phosphoethanolamine(DSPE)to form a tight core,and hydrophilic polyethylene glycol 2000(PEG2000)and calcium phosphate(CaP)formed the outside shell,and FA was modified on the surface of *** terms of function,(a)FA enhanced the active targeting of nanoparticles to tumors;(b)NPs targeted mitochondria to induce reactive oxygen species(ROS)production;(c)hemin encapsulated in nanoparticles could specifically target BACH1,thereby down regulating CD47;(d)hemin had a synergistic effect with DDP,thus augmenting the ***,mitochondria-targeted nanoparticles H/D@FA-CaP-NPs promoted tumor apoptosis and mobilized phagocytosis to treat tumor,providing a novel scheme for clinical treatment of cisplatin-resistant ovarian carcinoma.

关键词： Cisplatin-resistant Hemin BACH1 CD47 Phagocytosis ROS Synergistic effect

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Secure Tracking Control via Fixed-Time Convergent Reinforcement Learning for a UAV CPS

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IEEE/CAA Journal of Automatica Sinica 2024年第7期11卷 1699-1701页

作者： Zhenyu gong Feisheng Yang the School of Automation Northwestern Polytechnical UniversityXi’an 710129 the Research&Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518063China

Dear Editor,This letter is concerned with the secure tracking control problem in the unmanned aerial vehicle(UAV) system by fixed-time convergent reinforcement learning(RL). By virtue of the zero-sum game,the false da... 详细信息

关键词： Secure Fixed false

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Unique anti-angiogenic effects,pharmacological targets and therapeutic mechanisms of chinese herbal medicines for endometriosis

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Genes & Diseases 2024年第5期11卷 63-65页

作者： Bo Liang Rui Dong Sze Wan Hung Yiran Li Yuezhen Lin Ling wu Tao Zhang Gene chi Wai Man Hui Xu Jacqueline Pui Wah Chung chi chiu Wang Guangdong Provincial Key Laboratory of Marine Biotechnology Institute of Marine SciencesShantou UniversityShantouGuangdong 515063China Department of Obstetrics and Gynaecology The Chinese University of Hong KongHong Kong SARChina Reproduction and Development Laboratory Li Ka Shing Institute of Health SciencesThe Chinese University of Hong KongHong Kong SARChina School of Biomedical Sciences The Chinese University of Hong KongHong Kong SARChina chinese University of Hong Kong-Sichuan University Joint Laboratory in Reproductive Medicine The Chinese University of Hong KongHong Kong SARChina

Endometriosis is a common and benign angiogenesisdependent gynecological disorder,which refers to the proliferation and growth of endometrium-like tissues with neovasculature formation outside of the uterus.1 Available medical treatments for endometriosis containing hormonal and non-hormonal treatments had been limited for longterm usage by their side effects.2 Ideal medical treatment for endometriosis with efficacy to relieve symptoms and suppress endometriotic lesion growth and minimal side effects has been longing for decades.3 Angiogenesis is a promising therapeutic target for endometriosis.

关键词： therapeutic endometriosis herbal

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Analysis of the joint detection capability of the SMILE satellite and EISCAT-3D radar

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Earth and Planetary Physics 2024年第1期8卷 299-306页

作者： JiaoJiao Zhang TianRan Sun XiZheng Yu DaLin Li Hang Li JiaQi Guo ZongHua Ding Tao Chen Jian wu chi Wang State Key Laboratory of Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190China Key Laboratory of Solar Activity and Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190China University of chinese Academy of Sciences Beijing 101408China Key Laboratory of Electronics and Information Technology for Space Systems Chinese Academy of SciencesBeijing 100190China china Research Institute of Radio-wave Propagation Qingdao 266075China

The Solar wind Magnetosphere Ionosphere Link Explorer(SMILE)satellite is a small magnetosphere–ionosphere link explorer developed cooperatively between china and *** pioneers the use of X-ray imaging technology to perform large-scale imaging of the Earth’s magnetosheath and polar cusp *** uses a high-precision ultraviolet imager to image the overall configuration of the aurora and monitor changes in the source of solar wind in real time,using in situ detection instruments to improve human understanding of the relationship between solar activity and changes in the Earth’s magnetic *** SMILE satellite is scheduled to launch in *** European Incoherent Scatter Sciences Association(EISCAT)-3D radar is a new generation of European incoherent scatter radar constructed by EISCAT and is the most advanced ground-based ionospheric experimental device in the high-latitude polar *** has multibeam and multidirectional quasi-real-time three-dimensional(3D)imaging capabilities,continuous monitoring and operation capabilities,and multiple-baseline interferometry *** detection by the SMILE satellite and the EISCAT-3D radar is of great significance for revealing the coupling process of the solar wind–magnetosphere–***,we performed an analysis of the joint detection capability of the SMILE satellite and EISCAT-3D,analyzed the period during which the two can perform joint detection,and defined the key scientific problems that can be solved by joint *** addition,we developed Web-based software to search for and visualize the joint detection period of the SMILE satellite and EISCAT-3D radar,which lays the foundation for subsequent joint detection experiments and scientific research.

关键词： Solar wind Magnetosphere Ionosphere Link Explorer(SMILE)satellite European Incoherent Scatter Sciences Association(EISCAT)-3D radar joint detection

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Hierarchically Structured Nb_(2)O_5 Microflowers with Enhanced Capacity and Fast-Charging Capability for Flexible Planar Sodium Ion Micro-Supercapacitors

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Nano-Micro Letters 2024年第4期16卷 97-109页

作者： Jiaxin Ma Jieqiong Qin Shuanghao Zheng Yinghua Fu Liping chi Yaguang Li Cong Dong Bin Li Feifei Xing Haodong Shi Zhong‑Shuai wu State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of Sciences457 Zhongshan RoadDalian 116023People’s Republic of China School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001People’s Republic of China College of Science Henan Agricultural UniversityNo.63 Agricultural RoadZhengzhou 450002People’s Republic of China Dalian National Laboratory for Clean Energy Chinese Academy of Sciences457 Zhongshan RoadDalian 116023People’s Republic of China University of chinese Academy of Sciences 19A Yuquan RoadShijingshan DistrictBeijing 100049People’s Republic of China Hebei Key Lab of Optic‑Electronic Information and Materials The College of Physics Science and TechnologyInstitute of Life Science and Green DevelopmentHebei UniversityBaoding 071002People’s Republic of China

Planar Na ion micro-supercapacitors(NIMSCs) that offer both high energy density and power density are deemed to a promising class of miniaturized power sources for wearable and portable microelectron-ics. Nevertheless, the development of NIMSCs are hugely impeded by the low capacity and sluggish Na ion kinetics in the negative ***, we demonstrate a novel carbon-coated Nb_(2)O_5 microflower with a hierarchical structure composed of vertically intercrossed and porous nanosheets, boosting Na ion storage performance. The unique structural merits, including uniform carbon coating, ultrathin nanosheets and abun-dant pores, endow the Nb_(2)O_5 microflower with highly reversible Na ion storage capacity of 245 mAh g^(-1) at 0.25 C and excellent rate *** from high capacity and fast charging of Nb_(2)O_5 microflower, the planar NIMSCs consisted of Nb_(2)O_5 negative electrode and activated car-bon positive electrode deliver high areal energy density of 60.7 μWh cm^(-2),considerable voltage window of 3.5 V and extraordinary cyclability. Therefore, this work exploits a structural design strategy towards electrode materials for application in NIMSCs, holding great promise for flexible microelectronics.

关键词： Nb_(2)O_5 nanosheets Microflowers Sodium ion micro-supercapacitors Flexibility Energy storage

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Some Rotundities of Orlicz–Lorentz Spaces

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Acta Mathematica Sinica,English Series 2024年第8期40卷 1893-1919页

作者： Wan Zhong gong Peng WANG Department of Mathematics Anhui Normal UniversityWuhu 241000P.R.China

K-UR,K-LUR and K-R are the generalizations of UR,LUR and R respectively,which are of great significance in Banach space *** in Orlicz–Lorentz function spaceΛ_(ϕ,ω)^(◦)[0,γ)equipped with the Orlicz norm,the research methods of K-UR,K-LUR and K-R are much more complicated than those of UR,LUR and *** this paper we obtain some criteria of K-UR,K-LUR and K-R ofΛ_(ϕ,ω)^(◦)[0,γ)by means of the norm of dual space and H_(μ)property ofΛ_(ϕ,ω)^(◦)[0,γ).

关键词： Orlicz-Lorentz space Orlicz norm k-uniform rotundity locally k-uniform rotundity krotundity

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Plasma-assisted ammonia synthesis under mild conditions for hydrogen and electricity storage:Mechanisms,pathways,and application prospects

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Frontiers in Energy 2024年第4期18卷 418-435页

作者： Feng gong Yuhang JING Rui XIAO Key Laboratory of Energy Thermal Conversion and Process Measurement and Control of the Ministry of Education School of Energy and EnvironmentSoutheast UniversityNanjing 210096China

Ammonia,with its high hydrogen storage density of 17.7 wt.%(mass fraction),cleanliness,efficiency,and renewability,presents itself as a promising zero-carbon ***,the traditional Haber−Bosch(H−B)process for ammonia synthesis necessitates high temperature and pressure,resulting in over 420 million tons of carbon dioxide emissions annually,and relies on fossil fuel *** contrast,dielectric barrier discharge(DBD)plasma-assisted ammonia synthesis operates at low temperatures and atmospheric pressures,utilizing nitrogen and hydrogen radicals excited by energetic electrons,offering a potential alternative to the H−B *** method can be effectively coupled with renewable energy sources(such as solar and wind)for environmentally friendly,distributed,and efficient ammonia *** review delves into a comprehensive analysis of the low-temperature DBD plasma-assisted ammonia synthesis technology at atmospheric pressure,covering the reaction pathway,mechanism,and catalyst system involved in plasma nitrogen *** from current research,it evaluates the economic feasibility of the DBD plasmaassisted ammonia synthesis technology,analyzes existing dilemmas and challenges,and provides insights and recommendations for the future of nonthermal plasma ammonia processes.

关键词： plasma catalysis nitrogen fixation ammonia synthesis hydrogen storage catalyst carbon neutralization

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Prognostic value of circulating tumor cells combined with neutrophil-lymphocyte ratio in patients with hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 372-385页

作者： Jia-Li Chen Lu Guo Zhen-Ying wu Kun He Han Li chi Yang Yun-Wei Han Department of Oncology The Affiliated Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Ophthalmology The Affiliated Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Clinical Research Institute The Affiliated Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Plastic Surgery Meguiar's Medical Beauty HospitalChengdu 610000Sichuan ProvinceChina

BACKGROUND Circulating tumor cell(CTC)count and neutrophil-to-lymphocyte ratio(NLR)are both closely associated with the prognosis of hepatocellular carcinoma(HCC).AIM To investigate the prognostic value of combining these two indicators in *** Clinical data were collected from patients with advanced HCC who received im-mune therapy combined with targeted therapy at the Department of Oncology,the Affiliated Hospital of Southwest Medical University,Sichuan,china,from 2021 to *** optimal cutoff values for CTC programmed death-ligand 1(PD-L1)(+)>1 or CTC PD-L1(+)≤1 and NLR>3.89 or NLR≤3.89 were evaluated using X-Tile *** were categorized into three groups based on CTC PD-L1(+)counts and NLR:CTC-NLR(0),CTC-NLR(1),and CTC-NLR(2).The relationship between CTC-NLR and clinical variables as well as survival rates was *** Patients with high CTC PD-L1(+)expression or NLR at baseline had shorter median progression-free survival(m-PFS)and median overall survival(mOS)than those with low levels of CTC PD-L1(+)or NLR(P<0.001).Mean-while,patients in the CTC-NLR(2)group showed a significant decrease in mPFS and *** regression analysis revealed that alpha-fetoprotein(AFP),CTC PD-L1(+),and CTC-NLR were independent predictors of *** time-dependent receiver operating characteristic curve showed that the area under the curve of CTC-NLR at 12 months(0.821)and 18 months(0.821)was superior to that of AFP and CTC PD-L1(+).CONCLUSION HCC patients with high CTC PD-L1(+)or NLR expression tend to exhibit poor prognosis,and a high baseline CTC-NLR score may indicate low ***-NLR may serve as an effective prognostic indicator for patients with advanced HCC receiving immunotherapy combined with targeted therapy.

关键词： Circulating tumor cells Neutrophil–lymphocyte ratio Hepatocellular carcinoma Prognosis Survival Marker

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Projections of summer light rain frequency in typical terrain over eastern china under wind speed constraint

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Science china Earth Sciences 2024年第6期67卷 1885-1894页

作者： Xuechen DONG Daoyi gong Cuicui SHI Institute of Disaster Risk Science Faculty of Geographical ScienceBeijing Normal UniversityBeijing 100875China Key Laboratory of Environmental Change and Natural Disaster MOEFaculty of Geographical ScienceBeijing Normal UniversityBeijing 100875China School of National Safety and Emergency Management Beijing Normal UniversityBeijing 100875China School of Systems Science Beijing Normal UniversityBeijing 100875China

The variation in near-surface wind speed is a key dynamic parameter in the orographic effect of precipitation over eastern *** this study,we used the latest high-resolution outputs from six GCMs in CMIP6-HighResMIP to evaluate the performance of high-resolution models in simulating the orographic precipitation characteristics of typical mountainous areas in summer over eastern *** orographic precipitation under warming scenarios was projected and constrained according to observational *** results indicated that during the contemporary climate reference period(1979-2009),although the relationship between model-simulated near-surface wind speed and orographic light rain frequency was consistently stable,the sensitivity of the orographic light rain frequency to surface wind variability was generally underestimated,with a deviation approximately 24.1% lower than the observational *** estimated orographic light rain frequency corrected based on the observed near-surface wind speed under a 1.5℃ warming scenario,was 36.1% lower than that of the contemporary period;this reduction was 8.6 times that without the wind speed constraint(4.2%).The MRI-AGCM3-2-S model,with a longer dataset,demonstrated relatively stable reductions in orographic light rain frequency under different warming scenarios(1.5℃,2℃,3℃,and 4℃)after the application of wind speed *** all cases,the reductions exceeded those for the predictions made without the wind speed constraint.

关键词： Frequency of orographic light rain HighResMIP High-resolution projection Observational constraint Eastern china

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Predicting the strut forces of the steel supporting structure of deep excavation considering various factors by machine learning methods

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Underground Space 2024年第5期18卷 114-129页

作者： Haibo Hu Xunjian Hu Xiaonan gong Research Center of Coastal and Urban Geotechnical Engineering Zhejiang UniversityHangzhou 310058China

The application of steel strut force servo systems in deep excavation engineering is not widespread,and there is a notable scarcity of in-situ measured *** presents a significant research gap in the *** this,our study introduces a valuable dataset and application scenarios,serving as a reference point for future *** main objective of this study is to use machine learning(ML)methods for accurately predicting strut forces in steel supporting structures,a crucial aspect for the safety and stability of deep excavation *** employed five different ML methods:radial basis function neural network(RBFNN),back propagation neural network(BPNN),K-Nearest Neighbor(KNN),support vector machine(SVM),and random forest(RF),utilizing a dataset of 2208 measured *** points included one output parameter(strut forces)and seven input parameters(vertical position of strut,plane position of strut,time,temperature,unit weight,cohesion,and internal frictional angle).The effectiveness of these methods was assessed using root mean square error(RMSE),correlation coefficient(R),and mean absolute error(MAE).Our findings indicate that the BPNN method outperforms others,with RMSE,R,and MAE values of 72.1 kN,0.9931,and 57.4 kN,respectively,on the testing *** study underscores the potential of ML methods in precisely predicting strut forces in deep excavation engineering,contributing to enhanced safety measures and project planning.

关键词： Deep excavation Steel supporting structure Strut forces Machine learning Time Temperature

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