检索结果-南通市图书馆

Communications in Theoretical Physics 2024年第3期76卷 113-119页

作者： Dan Zhu Khai-Ming wong Guo-Quan wong School of Physics Universiti Sains Malaysia11800 USMPenangMalaysia

We present the first numerical solution that corresponds to a pair of Cho–Maison monopoles and antimonopoles(MAPs) in the SU(2) × U(1) Weinberg–Salam(ws) *** monopoles are finitely separated,while each pole carries a magnetic charge ±4π/*** positive pole is situated in the upper hemisphere,whereas the negative pole is in the lower *** Cho–Maison MAP is investigated for a range of Weinberg angles,0.4675≤ tan θ_(W)≤10,and Higgs self-coupling,0 ≤ β ≤ *** magnetic dipole moment(μm) and pole separation(d_(z)) of the numerical solutions are calculated and *** total energy of the system,however,is infinite due to point singularities at the locations of monopoles.

关键词： magnetic monopole Cho-Maison monopole Weinberg-Salam model

维普期刊数据库

β_2-adrenoceptor in obstructive airway diseases:Agonism, antagonism or both?

在线全文

学校读者我要写书评

暂无评论

World Journal of Respirology 2015年第3期5卷 199-206页

作者： Daniel ws Tan Jyi Lin wong Siew Teck Tie John A Abisheganaden Albert YH Lim ws fred wong Department of Pharmacology Yong Loo Lin School of MedicineNational University Health System Respiratory Unit Department of MedicineSarawak General Hospital Department of Respiratory and Critical Care Medicine Tan Tock Seng Hospital Immunology Program Life Science InstituteNational University of Singapore

Obstructive airway disease is a complex disease entity including several maladies characterized by bronchoconstriction and abnormal airway inflammation. Reversing bronchoconstriction leads to symptomatic relief and improvement in quality of life, both in reversible(bronchial asthma) and partially reversible(chronic obstructive airway disease) obstructive airway diseases. β2-adrenoceptor expressed in human airway is the main β-receptor subtype, and its activation in airway smooth muscle cells leads to bronchodilatation. Drugs targeting β-adrenoceptors have been around for many years, for which agonists of the receptors are used in bronchodilation while antagonists are used in cardiovascular diseases. This review article summarizes the effect and usage of β2-agonist in obstructive airway disease, addressing the benefits and potential risks of β2-agonist. The article also looks at the safety of β-blocker usage for cardiovascular disease in patients with obstructive airway disease. There is also emerging evidence that non-selective β-blockers with inverse agonism ironically can have longterm beneficial effects in obstructive airway disease that is beyond cardiovascular protection. Further trials are urgently needed in this area as it might lead to a dramatic turnaround in clinical practice for obstructive airway diseases as has already been seen in the usage of β-blockers for heart failure.

关键词： β-adrenoceptors β2-agonist β-blocker Inverse agonist Heart failure β-arrestin

Virtual colonoscopy-induced perforation in a patient with Crohn's disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2007年第6期13卷 978-979页

作者： Sunny H wong Vincent ws wong Joseph JY Sung Institute of Digestive Disease and Department of Medicine and Therapeutics The Chinese University of Hong Kong Hong Kong China

We report a case of sigmoid colon perforation in a patient with Crohn's disease undergoing computed-tomographic (CT) colonography. A 70-year-old patient with Crohn's disease with terminal ileitis and sigmoid stricture underwent CT colonography after incomplete conventional colonoscopy. During the procedure, the colon was inflated by air insufflation and the patient developed abdominal pain with radiological evidence of retroperitoneal and intraperitoneal free gas. Hartmann's operation was performed. This case highlights that CT colonography is not risk-free. The risk of perforation may be higher in patients with inflammatory bowel disease.

关键词： Perforation Colonography Crohn's disease Stricture Hartmann's Inflammatory bowel disease

Effect of music on procedure time and sedation during colonoscopy:A meta-analysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2008年第34期14卷 5336-5343页

作者： Wilson ws Tam Eliza LY wong Sheila F Twinn Nethersole School ofNursing 8/F Esther Lee BuildingThe Chinese University of Hong Kong School of Public Health 4/F PostgraduateEducation CentrePrince of Wales Hospital

AIM:To integrate results from different studies in examining the effectiveness of music in reducing the procedure time and the amount of sedation used during colonoscopic procedure. METHODS: An electronic search in various databases was performed to identify related articles. Study quality was evaluated by the Jadad’s scale. The random effect model was used to pool the effect from individual trials and the Cohen Q-statistic was used to determine heterogeneity. Egger’s regression was used to detect publication bias. RESULTS: Eight studies with 722 subjects were included in this meta-analysis. The combined mean difference for the time taken for the colonoscopy procedure between the music and control groups was -2.84 with 95% CI (-5.61 to -0.08), implying a short time for the music group. The combined mean difference for the use of sedation was -0.46 with 95%CI (-0.91 to -0.01), showing a significant reduction in the use of sedation in the music group. Heterogeneity was observed in both analyses but no publication bias was detected. CONCLUSION: Listening to music is effective in reducing procedure time and amount of sedation during colonoscopy and should be promoted.

关键词： Colonoscopy Colon cancer Meta-analysis Music therapy Screening

Pharmacological approach to restoring steroid sensitivity in respiratory diseases

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国药理学与毒理学杂志 2018年第4期32卷 242-243页

作者： W.S. fred wong Department of Pharmacology Yong Loo Lin School of Medicine National University Health System 117600 Singapore Immunology Program Life Science Institute National University of Singapore 117456 Singapore Singapore-HUJ Alliance for Research a

Inhaled corticosteroid is the first-line controller for asthma and ***,about 10% of the asthmatics(severe/refractory asthma) and most of the COPD patients are resistant to the beneficial effects of *** is a pressing unmet medical need to develop novel therapeutic agents to restore corticosteroid efficacy in affected *** have been reports showing the promise of theophylline and rapamycin in reversing steroid resistance in *** laboratory has demonstrated that andrographolide,a bioactive diterpenoid lactone isolated from the plant Andrographis paniculata,is an effective anti-inflammatory and anti-oxidative compound in both asthma and COPD experimental *** a severe asthma mouse model using combined IFN-γ/LPS exposure,production of IL-27 and methacholine-induced airway hyperresponsiveness(AHR) were found to be *** was found to restore the anti-inflammatory effect of dexamethasone in LPS/IFN-γ-induced IL-27 levels in bronchoalveolar lavage(BAL) fluid and AHR in ***/IFN-γ markedly reduced the nuclear level of histone deacetylase-2(HDAC2),an essential epigenetic enzyme that mediates corticosteroid anti-inflammatory *** significantly restored nuclear HDAC2 levels and diminished total HAT/HDAC activity ratio in mouse lungs exposed to LPS/IFN-γ,probably via suppression of PI3K/Akt/HDAC2 phosphorylation and up-regulation of the antioxidant transcription factor Nrf2 *** a cigarette smoke(CS)-induced COPD model,andrographolide markedly restored dexamethasone actions in inhibiting CS-induced lung *** addition,andrographolide facilitated dexamethasone actions to suppress BAL fluid IL-6,IL-1b,KC and IL-17 *** lung lysates,andrographolide markedly restored total nuclear HDAC *** complete steroid re-sensitization mechanism of andrographolide remains to be ***,our existing data strongly implicate a potentially novel steroid re

关键词：皮质类固醇治疗方法药物治疗哮喘

维普期刊数据库

Nitric oxide removal by wastewater bacteria in a biotrickling filter

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2014年第3期26卷 555-565页

作者： Hejingying Niu Dennis Y C Leung Chifat wong Tong Zhang Mayngor Chan fred C C Leung Department of Mechanical Engineering The University of Hong Kong School of Biological Sciences The University of Hong Kong Department of Civil Engineering The University of Hong Kong

Nitric oxide （NO） is one of the most important air pollutants in atmosphere mainly emitted from combustion source. A biotriclding filter was designed and operated to remove NO from an air stream using bacteria extracted from the sewage sludge of a municipal sewage treatment plant. To obtain the best operation conditions for the biotrickling filter, orthogonal experiments （L9（34）） were designed. Inlet oxygen concentration was found to be the most significant factor of the biotrickling filter and has a significant negative effect on the system. The optimal conditions of the biotrickling filter occurred at a temperature of 40℃, a pH of 8.0 and a chemical oxygen demand of 165 mg/L in the recycled water with no oxygen in the system. The bacteria sample was detected by DNA sequencing technology and showed 93%-98% similarity to Pseudomonas mendocina. Moreover, a full gene sequencing results indicated the bacterium was a brand new strain and named as P. mendocina DLHK. This strain can transfer nitrate to organic nitrogen. The result suggested the assimilation nitrogen process in this system. Through the isotope experimental analysis, two intermediate products （^15NO and ^15N2O） were found. The results indicated the denitrification function and capability of the biotrickling filter in removing NO.

关键词： NO reduction biotrickling filter orthogonal experiment Pseudomonas mendocina isotope labeling

维普期刊数据库

Icteric flare of chronic hepatitis B in a 95-year old patient

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2003年第12期9卷 2876-2877页

作者： ws wong Wai Keung Leung Henry L Y Chan Department of Medicine and Therapeutics the Prince of Wales HospitalHong Kong SARThe Chinese University of Hong Kong

A 95-year old gentleman developed fatal icteric flare of chronic hepatitis B despite lamivudine treatment. This article highlights the atypical presentations of chronic hepatitis B in elderly patient and the need to c... 详细信息

关键词：慢性乙型肝炎高龄患者黄疸拉米夫定急性暴发性肝炎

Gene Silencing of Receptor-Interacting Protein 2 （RIP2） Attenuates Allergic Airway

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国药理通讯 2013年第3期30卷 7-8页

作者： W. S. fred wong Department of Pharmacology Yong Loo Lin School of Medicine National University Health System Singapore Immunology Program Life Science Institute National University of Singapore Singapore

Persistent activation of nuclear factor-κB (NF-κB) is associated with the development of allergic asthma. Receptor Interacting Protein 2 (RIP2) is an adaptor protein encoded with serine/threonine kinase activity, and its protein-protein interaction function plays a critical role in mediating T-cell receptor engagement-induced NF-κB activation. A genetic analysis study has associated RIP2 gene with asthma severity. We hypothesized that silencing of RIP2 gene may attenuate allergic airway inflammation.

关键词：论文摘要药理学 OVA TSLP

DOUBLE VALVE DENVER PERITONEAL VENOUS SHUNT USED IN OVARIAN MALIGNANT ASCITES: A CASE REPORT

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中华医学杂志(英文版) 1989年第4期102卷 302-302页

作者： KW Michael Li ws Felix wong Department of Surgery and Department of Obstetrics and Gynecology Prince of Wales Hospital Chinese University of Hong Kong Shatin Hong Kong

Malignant ascites in patients with advanced or recurrent ovarian cancer poses a common problem to gynecologic oncologists. The traditional treatment with diuretics, salt, and fluid restriction is rarely effective. The patients usually undergo repeated paracentesis, resulting in the imbalance of protein and electrolytes. We treated a patient with ovarian malignant ascites by using a double valve Denver peritoneal venous shunt with satisfactory results.

关键词：