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Ruling Proteins with Protons:Proof of Principle Study on Proton transfer Mechanism

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Ruling Proteins with Protons:Proof of Principle Study on Pro...

The Need of Industry to Go FAIR

第一届全国生物物理化学会议暨生物物理化学发展战略研讨会

作者： Edward Manda wouter D.Hoff Richard Martin Ben McMahon Department of Physics Oklahoma State University Los Alamos National Lab Los Alamos

＜正＞Proteins are able to perform an enormous variety of functions,while using only a limited number of underlying *** of these is proton *** physical mechanism underlying proton transfer in proteins has been extensively studied,however remains elusive. New ideas and methods are therefore much needed in order to achieve a breakthrough over

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Data Intelligence 2020年第1期2卷 276-284,320,321,322页

作者： Herman van Vlijmen Albert Mons Arne Waalkens wouter Franke Arie Baak Gerbrand Ruiter Christine Kirkpatrick Luiz Olavo Bonino da Silva Santos Bert Meerman Renger Jellema Derk Arts Martijn Kersloot Sebastiaan Knijnenburg Scott Lusher Rudi Verbeeck Jean-Marc Neefs Janssen Pharmaceuticals Antwerpseweg 152340 BeerseBelgium Phortos Consultants The Netherlands Accenture Gustav Mahlerplein 901082 MA AmsterdamThe Netherlands Zorg Instituut Nederland Willem Dudokhof 11112 ZA DiemenThe Netherlands Euretos Yalelaan 13584 CL UtrechtThe Netherlands Mobiquity Tommaso Albinonistraat 91083 HM AmsterdamThe Netherlands UCSD and National Data Service 10100 Hopkins DrLa JollaCA 92093USA GO FAIR International Support&Coordination Office(GFISCO) LeidenThe Netherlands GO FAIR Foundation Rijnsburgerweg 102333 AA LeidenThe Netherlands DSM Biotechnology Center Alexander Fleminglaan 12613 AX DelftThe Netherlands Castor Paasheuvelweg 25Vleugel 5D1105 BP AmsterdamThe Netherlands

The industry sector is a very large producer and consumer of data,and many companies traditionally focused on production or manufacturing are now relying on the analysis of large amounts of data to develop new products and *** many of the data sources needed are distributed and outside the company,FAIR data will have a major impact,both by reducing the existing internal data silos and by enabling the efficient integration with external(public and commercial)*** companies are still in the early phases of internal data”FAIRification”,providing opportunities for SMEs and academics to apply and develop their expertise on FAIR data in collaborations and public-private *** a global Internet of FAIR Data&Services to thrive,also involving industry,professional tools and services are *** metrics and certifications on individuals,data,organizations,and software,must ensure that data producers and consumers have independent quality metrics on their *** this opinion article we reflect on some industry specific challenges of FAIR implementation to be dealt with when choices are made regarding”Industry GOing FAIR”.

关键词： FAIR application

U-Pb baddeleyite ages,distribution and geochemistry of 925 Ma mafic dykes and 900 Ma sills in the North China craton:Evidence for a Ne0Droterozoic mantle plume

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U-Pb baddeleyite ages,distribution and geochemistry of 925 M...

2060年中国实现碳中和所面临的挑战:现状与展望

中国科学院地质与地球物理研究所第11届（2011年度）学术年会

作者： wouter Bleeker Richard E.Ernst Ulf Sderlund Vicki McNicoll Geological Survey of Canada OttawaCanada K1A 0E9 Department of Earth Sciences Carleton Universityand Ernst Geosc iences43 Margrave AvenueOttawaOntarioCanada KIT 3Y2 Department of Earth and Ecosystem Sciences Lund UniversitySlvegatan 12SE-223 62 LundSweden

Numerous Neoproterozoic mafic dykes,referred to as the Dashigou swarm,are identified in the central and southeastern parts of the North China craton(NCC).They are 305-010°trending dykes,with widths of～10- 100 m and exposed lengths of several to >10 *** U-Pb isotope dilution thermal ionization mass spectrometry (ID-TIMS) measurements on baddeleyite grains separated from three dykes yield Pb/Pb average ages of 924.0±3.7 Ma(Dashigou dyke),921.8±2.6 Ma(Yangjiaogou dyke) and 925.8±1.7 Ma(Taohuagou dyke).Baddeleyite grains from a late-stage pegmatite vein in the Dashigou dyke were analyzed by secondary ion mass spectrometry(SIMS) *** yield a Pb/Pb average age of 920.4±5.7 *** Dashigou dyke swarm exhibits an overall radiating geometry(the overall fan angle is about 60°),with a focal point located along the southern margin of the eastern NCC,where a large ca.900 Ma sill swarm was previously recognized. The rift system hosting these slightly younger sills,named the Xu-Huai Rift System,could represent two breakup-parallel arms of a rift-rift-rift triple junction related to the initiation of the magma center that produced the Dashigou *** sills have similar characteristics and could be cogenetic with the Dashigou dykes. The Dashigou dykes are coarse-grained,composed mainly of clinopyroxene and plagioclase feldspar,with or without *** of the most primitive dykes has 47.79 wt.%SiO,6.41 wt.%MgO,1.38 wt.%TiO,17.77 wt.%A1O, 10.47 wt.%CaO and 0.62 wt.%*** shows slight enrichment in light rare earth elements and a slightly positive Eu/Eu anomaly(1.1),and is slightly depleted in high field-strength elements compared to neighboring elements on a primitive mantle-normalized *** Dashigou dykes show some similarities with enriched-mid ocean ridge basalts(E-MORB) or ocean island basalts(OIB) and haveεNd values of +1.8 to + 3.1 and Sr/Sr values of 0.7019-0.7047(t = 920 Ma).All these characteristics indicate that they are not likely derived from

关键词： Baddeleyite U-Pb age North China craton Mafic dyke swarm Subcontinental litliospheric mantle Neoproterozoic Mantle plume

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Science Bulletin 2022年第20期67卷 2030-2035,M0003页

作者： Baozhang Chen Fahu Chen Philippe Ciais Huifang Zhang Honggang Lü Tao Wang Frédéric Chevallier Zhu Liu Wenping Yuan wouter Peters School of Remote Sensing and Geomatics Engineering Nanjing University of Information Science and TechnologyNanjing 210044China State Key Laboratory of Resource and Environmental Information System Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100190China Alpine Paleoecology and Human Adaption Group State Key Laboratory of Tibetan Plateau Earth System ScienceInstitute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101Chin Laboratoire des Sciences du Climat et de l’Environnement CEA-CNRS-UVSQUniversitéParis-SaclayGif-sur-Yvette 91191France Key Laboratory of Marine Hazards Forecasting National Marine Environmental Forecasting CenterMinistry of Natural Resources of ChinaBeijing 100081China Key Laboratory of Alpine Ecology Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100085China Center for Excellence in Tibetan Earth Science Chinese Academy of SciencesBeijing 100085China Department of Earth System Science Tsinghua UniversityBeijing 100084China School of Atmospheric Sciences Guangdong Province Key Laboratory for Climate Change and Natural Disaster StudiesZhuhai Key Laboratory of Dynamics Urban Climate and EcologySun Yat-sen UniversityZhuhai510245China Department of Meteorology and Air Quality Environmental Sciences GroupWageningen UniversityWageningen 6708 PBthe Netherlands Centre for Isotope Research Energy and Sustainability Research Institute GroningenGroningen UniversityGroningen 729700 ABthe Netherlands

China’s high ambitions to reach peak CO_(2) emissions by 2030 and carbon neutrality by 2060 make carbon mitigation an urgent issue with widespread societal *** develop an achievable roadmap and an effective portfolio of climate policies,it is essential that a clear picture of the magnitude and uncertainty of China’s current carbon balance is available,at both national and regional levels.

关键词：碳中和 consequences neutral

Multilayer CVD graphene electrodes using a transfer-free process for the next generation of optically transparent and MRI-compatible neural interfaces

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Microsystems & Nanoengineering 2022年第5期8卷 183-196页

作者： Nasim Bakhshaee Babaroud Merlin Palmar Andrada Iulia Velea Chiara Coletti Sebastian Weingärtner Frans Vos wouter A.Serdijn Sten Vollebregt Vasiliki Giagka Department of Microelectronics Faculty of Electrical EngineeringMathematics and Computer ScienceDelft University of TechnologyMekelweg 4Delft 2628 CDThe Netherlands Technologies for Bioelectronics Group Department of System Integration and Interconnection TechnologiesFraunhofer Institute for Reliability and Micro-integration IZMGustav-Meyer-Allee 25Berlin 13355Germany Department of Imaging Physics Faculty of Applied ScienceDelft University of TechnologyLorentzweg 1Delft 2628 CJThe Netherlands Erasmus University Medical Center(Erasmus MC) dr.Molewaterplein 40Rotterdam 3015 GDThe Netherlands

Multimodal platforms combining electrical neural recording and stimulation,optogenetics,optical imaging,and magnetic resonance(MRI)imaging are emerging as a promising platform to enhance the depth of characterization in neuroscientific *** conductive,optically transparent,and MRI-compatible electrodes can optimally combine all *** as a suitable electrode candidate material can be grown via chemical vapor deposition(CVD)processes and sandwiched between transparent biocompatible ***,due to the high graphene growth temperature(≥900℃)and the presence of polymers,fabrication is commonly based on a manual transfer process of pre-grown graphene sheets,which causes reliability *** this paper,we present CVD-based multilayer graphene electrodes fabricated using a wafer-scale transfer-free process for use in optically transparent and MRI-compatible neural *** fabricated electrodes feature very low impedances which are comparable to those of noble metal electrodes of the same size and *** also exhibit the highest charge storage capacity(CSC)reported to date among all previously fabricated CVD graphene *** graphene electrodes did not reveal any photo-induced artifact during 10-Hz light pulse ***,we show here,for the first time,that CVD graphene electrodes do not cause any image artifact in a 3T MRI *** results demonstrate that multilayer graphene electrodes are excellent candidates for the next generation of neural interfaces and can substitute the standard conventional metal *** fabricated graphene electrodes enable multimodal neural recording,electrical and optogenetic stimulation,while allowing for optical imaging,as well as,artifact-free MRI studies.

关键词： transparent transfer process

In vitro 3D phenotypic drug screen identifies celastrol as an effective in vivo inhibitor of polycystic kidney disease

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Journal of Molecular Cell Biology 2020年第8期12卷 644-653页

作者： Tijmen H.Booij wouter N.Leonhard Hester Bange Kuan Yan Michiel Fokkelman Anna J.Plugge Kimberley A.M.Veraar Johannes G.Dauwerse Gerard J.P.van Westen Bob van de Water Leo S.Price Dorien j.M.Peters Division of Toxicology Leiden Academic Centre for Drug Research(LACDR)Leiden UniversityLeidenThe Netherlands Present address:NEXUS Personalized Health Technologies ETH ZurichSwitzerland Department of Human Genetics Leiden University Medical Center(LUMC)LeidenThe Netherlands OcellO B.V. LeidenThe Netherlands Division of Medicinal Chemistry Leiden Academic Centre for Drug Research(LACDR)LeidenThe Netherlands

Polycystic kidney disease(PKD)is a prevalent genetic disorder,characterized by the formation of kidney cysts that progressively lead to kidney *** currently available drug tolvaptan is not well tolerated by all patients and there remains a strong need for alternative *** signalling rewiring in PKD that drives cyst formation is highly complex and not fully *** a consequence,the effects of drugs are sometimes difficult to *** previously established a high-throughput microscopy phenotypic screening method for quantitative assessment of renal cyst ***,we applied this 3D cyst growth phenotypic assay and screened 2320 small drug-like molecules,including approved *** identified 81 active molecules that inhibit cyst ***-parametric phenotypic profiling of the effects on 3D cultured cysts discriminated molecules that showed preferred pharmacological effects above genuine toxicological ***,a triterpenoid from Tripterygium wilfordii,was identified as a potent inhibitor of cyst growth in *** an in vivo iKspCre-Pkd1^lox,lox mouse model for PKD,celastrol inhibited the growth of renal cysts and maintained kidney function.

关键词： PKD celastrol pyrvinium pamoate high-content screening 3D

Correction to:Efficient DNA-assisted synthesis of trans-membrane gold nanowires

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Microsystems & Nanoengineering 2018年第1期4卷 298-299页

作者： Maoxiang Guo Iván Hernández-Neuta Narayanan Madaboosi Mats Nilsson wouter van der Wijngaart Department of Micro and Nanosystems KTH Royal Institute of TechnologyOsquldas väg 10Stockholm 10044Sweden Science for Life Laboratory Department of Biochemistry and BiophysicsStockholm UniversityTomtebodavägen 23 ASolna SE-17165Sweden

Figure 2 and the descriptive text in the Section“SEM characterization of synthesized nanowires”of the previously published version of this Article were *** authors would like to replace Fig.2 and section“SEM charac... 详细信息

关键词： nanowires Figure replace

Bacterial inclusion bodies function as vehicles for dendritic cell-mediated T cell responses

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Cellular & Molecular Immunology 2020年第4期17卷 415-417页

作者： Sjoerd T.T.Schetters wouter S.P.Jong Laura J.W.Kruijssen H.B.van den Berg van Saparoea Steef Engels Wendy W.J.Unger Diane Houben Joke M.M.den Haan Joen Luirink Yvette van Kooyk Department of Molecular Cell Biology and Immunology Amsterdam UMCLocation VUmcAmsterdamThe Netherlands Abera Bioscience AB SolnaSweden Laboratory of Pediatrics Division of Pediatric Infectious Diseases and ImmunologyErasmus MC-Sophia Children’s HospitalRotterdamThe Netherlands Department of Molecular Cell Biology Section Molecular MicrobiologyFaculty of ScienceVU UniversityAmsterdamThe Netherlands

Immunogenic antigens for vaccination are often created through the production of recombinant proteins using Escherichia coli.1 As a side product,aggregates called inclusion bodies(IBs)are formed,containing largely misfolded forms of the overexpressed recombinant protein.2 The effect of IBs on the immune system and whether they can be used as effective vaccine products remain *** non-native conformation of proteins upon accumulation in IBs abrogates their use as vaccines aimed at generating high-affinity antibodies.3 However,IBs exhibit unique properties,including mechanical and thermal stability due to their intrinsic particulate nature,biocompatibility,high antigenic content,low toxicity and relative resistance to *** characteristics make IBs attractive as an antigenic vaccine formulation for T cell responses to linear *** IBs can trigger adaptive cellular responses initiated via uptake by dendritic cells for presentation to T cells is unknown.

关键词： vaccine attractive initiated

弄潮新消费:与新一代中国汽车买家面对面——2017中国汽车消费者调查报告

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科技中国 2017年第12期 67-72页

作者： wouter Baan 高旭王平 Daniel Zipser 麦肯锡公司

自2011年增长触底以来,中国汽车市场在2016年实现了强势反弹（见图1）.销量增长20%,增幅是2015年的两倍,这主要是市场对小排量汽车购置税减半的积极反应.到2017年,增长再次波动.

关键词：中国汽车市场汽车消费者调查报告小排量汽车触底