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Towards high-performance and robust anion exchange membranes(AEMs)for water electrolysis:Super-acid-catalyzed synthesis of AEMs

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Journal of Energy Chemistry 2024年第6期93卷 478-510,I0012页

作者： Geun woong Ryoo sun Hwa Park Ki Chang Kwon Jong Hun Kang Ho Won Jang Min Sang Kwon Department of Materials Science and Engineering Research Institute of Advanced Materials(RIAM)Seoul National UniversitySeoul 08826Republic of Korea Interdisciplinary Materials Measurement Institute Korea Research Institute of Standards and Science(KRISS)Daejeon 34113Republic of Korea Department of Chemical and Biological Engineering and Institute of Chemical ProcessSeoul National UniversitySeoul 08826Republic of Korea Department of Applied Measurement Science University of Science and TechnologyDaejeon 34113Republic of Korea

The increasing demand for hydrogen energy to address environmental issues and achieve carbon neutrality has elevated interest in green hydrogen production,which does not rely on fossil *** various hydrogen production technologies,anion exchange membrane water electrolyzer(AEMWE)has emerged as a next-generation technology known for its high hydrogen production efficiency and its ability to use non-metal ***,this technology faces significant challenges,particularly in terms of the membrane durability and low ionic *** address these challenges,research efforts have focused on developing membranes with a new backbone structure and anion exchange groups to enhance durability and ionic ***,the super-acid-catalyzed condensation(SACC)synthesis method stands out due to its user convenience,the ability to create high molecular weight(MW)polymers,and the use of oxygen-tolerant organic *** the synthesis of anion exchange membranes(AEMs)using the SACC method began in 2015,and despite growing interest in this synthesis approach,there remains a scarcity of review papers focusing on AEMs synthesized using the SACC *** review covers the basics of SACC synthesis,presents various polymers synthesized using this method,and summarizes the development of these polymers,particularly their building blocks including aryl,ketone,and anion exchange *** systematically describe the effects of changes in the molecular structure of each polymer component,conducted by various research groups,on the mechanical properties,conductivity,and operational stability of the *** review will provide insights into the development of AEMs with superior performance and operational stability suitable for water electrolysis applications.

关键词： Green hydrogen production Water electrolysis Anion exchange membrane water electrolyzer(AEMWE) Anion exchange membranes(AEMs) Super-acid-catalyzed condensation(SACC)

Neural Wiskott-Aldrich syndrome protein(N-WASP)promotes distant metastasis in pancreatic ductal adenocarcinoma via activation of LOXL2

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Oncology Research 2024年第4期32卷 615-624页

作者： HYUNG sun KIM YUN sun LEE SEUNG MYUNG DONG HYO JUNG KIM DA EUN LEE HYEON woong KANG MYEONG JIN KIM JOON SEONG PARK Department of Surgery Gangnam Severance HospitalYonsei University College of MedicineSeoulKorea Department of Surgery Graduate School of Medical ScienceBrain Korea 21 ProjectYonsei University College of MedicineSeoulKorea Gibiome Co. Ltd.Gyeonggi-doKorea

Pancreatic ductal adenocarcinoma(PDAC)is one of the most aggressive solid malignancies.A specific mechanism of its metastasis has not been *** this study,we investigated whether Neural Wiskott-Aldrich syndrome protein(N-WASP)plays a role in distant metastasis of *** found that N-WASP is markedly expressed in clinical patients with *** analysis showed a notably more distant metastatic pattern in the N-WASP-high group compared to the N-WASP-low group.N-WASP was noted to be a novel mediator of epithelialmesenchymal transition(EMT)via gene expression profile *** of N-WASP in pancreatic cancer cells significantly inhibited cell invasion,migration,and *** also observed positive association of lysyl oxidase-like 2(LOXL2)and focal adhesion kinase(FAK)with the N-WASP-mediated response,wherein EMT and invadopodia function were *** N-WASP and LOXL2 depletion significantly reduced the incidence of liver and lung metastatic lesions in orthotopic mouse models of pancreatic *** results elucidate a novel role for N-WASP signaling associated with LOXL2 in EMT and invadopodia function,with respect to regulation of intercellular communication in tumor cells for promoting pancreatic cancer *** findings may aid in the development of therapeutic strategies against pancreatic cancer.

关键词： Pancreatic cancer Neural Wiskott-Aldrich syndrome protein(N-WASP)signaling Metastasis Epithelial-mesenchymal transition(EMT) Lysyl oxidase-like 2(LOXL2)

Enhancement of porcine in vitro embryonic development through luteolin‑mediated activation of the Nrf2/Keap1 signaling pathway

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Journal of Animal Science and Biotechnology 2024年第2期15卷 600-613页

作者： Se-Been Jeon Pil-Soo Jeong Min Ju Kim Hyo-Gu Kang Bong-Seok Song sun-Uk Kim Seong-Keun Cho Bo-woong Sim Futuristic Animal Resource&Research Center(FARRC) Korea Research Institute of Bioscience and Biotechnology(KRIBB)Cheongju 28116Republic of Korea Department of Animal Science College of Natural Resources&Life SciencePusan National UniversityMiryang 50463Republic of Korea Department of Animal Science and Biotechnology College of Agriculture and Life ScienceChungnam National UniversityDaejeon 34134Republic of Korea Department of Functional Genomics University of Science and TechnologyDaejeon 34113Republic of Korea Department of Animal Science Life and Industry Convergence Research Institute(RICRI)College of Natural Resources&Life SciencePusan National UniversityMiryang 50463Republic of Korea

Background Oxidative stress,caused by an imbalance in the production and elimination of intracellular reactive oxygen species(ROS),has been recognized for its detrimental effects on mammalian embryonic ***(Lut)has been documented for its protective effects against oxidative stress in various ***,its specific role in embryonic development remains *** study aims to investigate the influence of Lut on porcine embryonic development and to elucidate the underlying *** After undergoing parthenogenetic activation(PA)or in vitro fertilization,embryos supplemented with 0.5μmol/L Lut displayed a significant enhancement in cleavage and blastocyst formation rates,with an increase in total cell numbers and a decrease in the apoptosis rate compared to the *** on D2 and D6 revealed that embryos with Lut supplementation had lower ROS levels and higher glutathione levels compared to the ***,Lut supplementation significantly augmented mitochondrial content and membrane ***,activation of the Nrf2/Keap1 signaling pathway was observed in embryos supplemented with Lut,leading to the upregulation of antioxidant-related gene transcription *** further validate the relationship between the Nrf2/Keap1 signaling pathway and effects of Lut in porcine embryonic development,we cultured PA embryos in a medium supplemented with brusatol,with or without the inclusion of *** positive effects of Lut on developmental competence were negated by brusatol *** Our findings indicate that Lut-mediated activation of the Nrf2/Keap1 signaling pathway contributes to the enhanced production of porcine embryos with high developmental competence,and offers insight into the mechanisms regulating early embryonic development.

关键词： Luteolin Mitochondrial function Nrf2/Keap1 signaling pathway Oxidative stress Porcine embryo development

Defect-rich spinel ferrites with improved charge collection properties for efficient solar water splitting

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Journal of Advanced Ceramics 2023年第3期12卷 612-624页

作者： Runfa Tan yoo Jae Jeong Qu Li Minje Kang In sun Cho Department of Materials Science&Engineering Ajou UniversitySuwon 16499Republic of Korea Department of Energy Systems Research Ajou UniversitySuwon 16499Republic of Korea

Spinel zinc ferrite(ZnFe_(2)O_(4),ZFO)is a potential photoanode material for photoelectrochemical(PEC)water splitting because of its ideal bandgap(1.9–2.1 eV)and superior chemical stability in aqueous ***,the low charge collection efficiency significantly hinders the improvement in PEC ***,we report an ultrafast and effective flame activation route to enhance the charge collection properties of ***,high-temperature flame(>1300℃)facilitated surface and grain boundary diffusions,increasing the grain size and connectivity of the ZFO ***,the reducing atmosphere of the flame enabled the formation of surface defects(oxygen vacancy and Fe^(2+)),thereby increasing the charge carrier density and surface adsorption ***,these two factors promoted charge transport and transfer kinetics,resulting in a 10-fold increase in the photocurrent density over the unactivated ***,we deposited a thin Al_(2)O_(3)overlayer to passivate the ZFO surface and then the NiFeOx oxygen evolution catalyst(OEC)to expedite hole injection into the *** surface passivation and OEC deposition led to a remarkable photocurrent density of~1 mA/cm^(2)at 1.23 V versus the reversible hydrogen electrode,which is the highest value among all reported ZFO ***,the NiFeOx/Al_(2)O_(3)/F-ZFO photoanode achieved excellent photocurrent stability over 55 h(96%retention)and superior faradaic efficiency(FE>94%).Our flame activation method is also effective in improving the photocurrent densities of other spinel ferrites:CuFe_(2)O_(4)(93 times),MgFe_(2)O_(4)(16 times),and NiFe_(2)O_(4)(12 times).

关键词： spinel ferrites flame activation defect-rich surface charge collection photoelectrochemical(PEC) water splitting

Extracorporeal membrane oxygenation for lung cancer-related life-threatening hypoxia:A case report

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World Journal of Clinical Cases 2022年第25期10卷 8974-8979页

作者： Seung Soo yoo Shin Yup Lee sun Ha Choi Department of Internal Medicine Kyungpook National UniversityDaegu 41404South Korea Lung Cancer Center Kyungpook National University Chilgok HospitalDaegu 41404South Korea

BACKGROUND Life-threatening hypoxia can occur in patients with lung cancer due to bronchial *** membrane oxygenation(ECMO)can be used as a bridge therapy for patients with severe hypoxia not relieved by conventional mechanical ***,the usefulness of chemotherapy in patients with lung cancer receiving ECMO therapy is not well *** SUMMARY A 53-year-old man visited the emergency room with worsening dyspnea for 1 mo.A series of imaging and diagnostic tests were performed,and stageⅢB(cT4N2M0)lung cancer was eventually *** hospital day 3,he experienced dyspnea and hypoxia that was not relieved with oxygen support via a high-flow nasal *** was initiated because his respiratory condition did not improve even with mechanical *** patient then underwent gemcitabine/cisplatin chemotherapy without dose reduction while on *** two cycles of chemotherapy,there was a decrease in the size of the primary tumor in the right main *** the completion of concurrent chemoradiotherapy,a computed tomography scan revealed further improvement in the right main bronchus *** months after a lung cancer diagnosis,the patient did well without any *** ECMO is a potential bridge therapy for respiratory failure in patients with central airway obstruction secondary to lung cancer.

关键词： Extracorporeal membrane oxygen Lung cancer Hypoxia Respiratory failure Chemoradiotherapy Case report

Point-defect engineering of nanoporous CuBi_(2)O_(4) photocathode via rapid thermal processing for enhanced photoelectrochemical activity

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Journal of Energy Chemistry 2022年第8期31卷 201-209,I0007页

作者： Li Qu Runfa Tan Arumugam Sivanantham Min Je Kang yoo Jae Jeong Dong Hyun Seo sungkyu Kim In sun Cho Department of Materials Science&Engineering Ajou UniversitySuwon 16499South Korea Department of Energy Systems Research Ajou UniversitySuwon 16499South Korea Department of Nanotechnology and Advanced Materials Engineering Sejong UniversitySeoul 05006South Korea

Engineering point defects such as metal and oxygen vacancies play a crucial role in manipulating the electrical,optical,and catalytic properties of oxide semiconductors for solar water ***,we synthesized nanoporous CuBi_(2)O_(4)(np-CBO)photocathodes and engineered their surface point defects via rapid thermal processing(RTP)in controlled atmospheres(O_(2),N_(2),and vacuum).We found that the O_(2)-RTP treatment of np-CBO increased the charge carrier density effectively without hampering the nanoporous morphology,which was attributed to the formation of copper vacancies(VCu).Further analyses revealed that the amounts of oxygen vacancies(Vo)and Cu^(1+)were reduced simultaneously,and the relative electrochemical active surface area increased after the O_(2)-RTP ***,the point defects(VC_(u),Cu^(1+),and Vo)regulated np-CBO achieved a superb water-splitting photocurrent density of-1.81 m A cm^(-2) under simulated sunlight illumination,which is attributed to the enhanced charge transport and transfer properties resulting from the regulated surface point ***,the reversibility of the formation of the point defects was checked by sequential RTP treatments(O_(2)-N_(2)-O_(2)-N_(2)),demonstrating the strong dependence of photocurrent response on the RTP ***,the surface point defect engineering via RTP treatment in a controlled atmosphere is a rapid and facile strategy to promote charge transport and transfer properties of photoelectrodes for efficient solar water-splitting.

关键词： Nanoporous Copper bismuth oxide Rapid thermal processing Copper vacancy Charge transport

Adult-onset hypophosphatemic osteomalacia as a cause of widespread musculoskeletal pain:A retrospective case series of single center experience

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World Journal of Clinical Cases 2023年第32期11卷 7785-7794页

作者： sungwon Kim sun woong Kim Byung Chan Lee Du Hwan Kim Duk Hyun sung Department of Physical and Rehabilitation Medicine Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351South Korea Department of Physical and Rehabilitation Medicine Jungdap HospitalSuwon 16480South Korea Physical Medicine and Rehabilitation Chung-Ang University HospitalSeoul 06973South Korea Physical Medicine and Rehabilitation Chung-Ang UniversitySeoul 06973South Korea Department of Physical and Rehabilitation Medicine Samsung Medical CenterSeoul 06351South Korea

BACKGROUND Osteomalacia(OM)is frequently confused with various musculoskeletal or other rheumatic diseases,especially in patients with adult-onset widespread musculoskeletal pain because of its low prevalence and non-specific *** To facilitate the early diagnosis and etiology-specific treatment of adult-onset hypophosphatemic *** A retrospective review of medical records was performed to screen adult patients who visited a physiatry locomotive medicine clinic(spine and musculoskeletal pain clinic)primarily presenting with widespread musculoskeletal pain at a single tertiary hospital between January 2011 and December *** enrolled patients with hypophosphatemia,high serum bone-specific alkaline phosphatase levels,and at least one imaging finding suggestive of *** Eight patients with adult-onset hypophosphatemic OM were *** back was the most common site of *** dominant symmetric muscle weakness was observed in more than half of the *** scintigraphy was the most useful imaging modality for diagnosing OM because radiotracer uptake in OM showed characteristic *** patients were diagnosed with adefovir(ADV)-induced Fanconi syndrome,and the other two patients were diagnosed with tumor-induced OM and light-chain nephropathy,*** phosphorus and vitamin D supplementation and treatment for the underlying etiologies,improvements in pain,muscle strength,and gait were observed in all *** Mechanical pain characteristics,hypophosphatemia,and distinctive bone scintigraphy patterns are the initial diagnostic indicators of adult-onset hypophosphatemic ***-induced Fanconi syndrome is the most common etiology of hypophosphatemic OM in hepatitis B virus-endemic countries.

关键词： Hypophosphatemia Osteomalacia Widespread musculoskeletal pain Bone scintigraphy Hepatitis B virus Phosphaturic mesenchymal tumor

Geometric-phase intraocular lenses with multifocality

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Light(Science & Applications) 2022年第11期11卷 2805-2816页

作者： Seungmin Lee Gayeon Park Senho Kim Yeonghwa Ryu Jae woong yoon Ho Sk Hwang In Seok Song Chang sun Lee Seok Ho Song Department of Physics Hanyang UniversitySeoul 04763Republic of Korea Department of Ophthalmology Catholic University of KoreaSeoul 07345Republic of Korea Seoul Ophthalmic Clinic Goyang 10463Republic of Korea Koryoeyetech In.Seoul 06093Republic of Korea Tigernics IncSeoul 04763Republic of Korea

We demonstrate a new type of multifocal and extended depth of focus(EDOF)intraocular lenses(IOLs)embeddingμm-thin geometric phase(GP)lens *** an emerging approach for lens phase design,the GP modulated IOLs outperform conventional diffractive IOLs in multifocality while completely avoiding the clinically undesirable demand for additional surface patterns to standard monofocal IOL *** number of foci and light splitting ratio of the GP IOLs are adjusted by changing the number of stacked GP layers and the thickness of each *** and trifocal GP IOLs are fabricated by radial alignment of anisotropic orientation in UV-curable liquid crystal *** characterizing the defocus image and modulation transfer function of the GP IOLs,it is expected that GP IOLs will alleviate the most common problems associated with multifocal and EDOF IOLs,blurred vision and photic phenomena caused by light scattering and posterior capsule opacification.

关键词： layer phase alignment

Migration routes and differences in migration strategies of Whooper Swans between spring and autumn

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Avian Research 2023年第3期14卷 345-353页

作者： Ji-Yeon Lee Hyung-Kyu Nam Jin-Young Park Seung-Gu Kang Nyambayar Batbayar Dong-Won Kim Jae-woong Hwang Otgonbayar Tsend Tseveenmyadag Natsagdorj Jugdernamjil Nergui Tuvshintugs Sukhbaatar Wee-Haeng Hur Jeong-Chil yoo The Korea Institute of Ornithology and Department of Biology Graduate SchoolKyung Hee University26 Kyungheedae-roDongdaemun-guSeoul02447Republic of Korea National Institute of Biological Resources 42 Hwangyeong-roSeo-guIncheon22689Republic of Korea Endangered Species Research Center National Institute of EcologyYeongyang36351Republic of Korea Wildlife Sciences and Conservation Center of Mongolia Union BuildingB-701UNESCO str.Ulaanbaatar14210Mongolia

Long-distance migratory birds travel more rapidly in spring than in autumn,as they face temporal breeding ***,several species travel slower in spring owing to environmental influences,such as food availability and wind *** trackers were attached to 17 Whooper Swans(Cygnus cygnus) inhabiting northeastern Mongolia,to determine their migration routes and stopover sites in spring and *** between spring and autumn migrations,migration-influencing parameters,and the effect of spring stopover site temperatures were *** swans completed perfect tours between their wintering and breeding sites,and these data were used for *** migration lasted 57 days,with 49.2 days spent at 3.7 stopover *** migration lasted 21.5 days,with 17.5 days spent at 1.0 stopover ***,the swans traveled more rapidly in autumn than in *** distance,number of stopovers,migration speed,and straightness were important migration determinants in both spring and *** distance,stopover duration,number of stopovers,daily travel speed,travel duration,and migration speed differed significantly between spring and *** spring migration,the temperature at the current stopover sites and that at the future stopover sites displayed significant variations(t=1585.8,df=631.6,p <0.001).These findings are critical for the conservation and management of Whooper Swans and their key habitats in East Asian regions,and the data are anticipated to make a particularly significant contribution toward developing detailed management plans for the conservation of their key habitats.

关键词： Key stopover sites Migration characteristics Migration route Migration strategy Tracking Whooper Swan