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Risk prediction platform for pancreatic fistula after pancreatoduodenectomy using artificial intelligence

World Journal of Gastroenterology 2020年第30期26卷 4453-4464页

作者： In Woong Han Kyeongwon Cho Youngju Ryu Sang hyun Shin Jin Seok Heo Dong wook Choi Myung Jin Chung Oh Chul Kwon Baek Hwan Cho Department of Surgery Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351South Korea Medical Artificial Intelligence Research Center Department of Medical Device Management and ResearchSAIHSTSamsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351South Korea Department of Radiology Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351South Korea Artificial Intelligence Research Center Medical DataBase IncorporatedSeoul 06048South Korea

BACKGROUND Despite advancements in operative technique and improvements in postoperative managements,postoperative pancreatic fistula(POPF)is a life-threatening complication following pancreatoduodenectomy(PD).There are some reports to predict POPF preoperatively or intraoperatively,but the accuracy of those is *** intelligence(AI)technology is being actively used in the medical field,but few studies have reported applying it to outcomes after *** To develop a risk prediction platform for POPF using an AI *** Medical records were reviewed from 1769 patients at Samsung Medical Center who underwent PD from 2007 to 2016.A total of 38 variables were inserted into AI-driven *** algorithms tested to make the risk prediction platform were random forest(RF)and a neural network(NN)with or without recursive feature elimination(RFE).The median imputation method was used for missing *** area under the curve(AUC)was calculated to examine the discriminative power of algorithm for POPF *** The number of POPFs was 221(12.5%)according to the International Study Group of Pancreatic Fistula definition *** median imputation,AUCs using 38 variables were 0.68±0.02 with RF and 0.71±0.02 with *** maximal AUC using NN with RFE was *** risk factors for POPF were identified by AI algorithm:Pancreatic duct diameter,body mass index,preoperative serum albumin,lipase level,amount of intraoperative fluid infusion,age,platelet count,extrapancreatic location of tumor,combined venous resection,co-existing pancreatitis,neoadjuvant radiotherapy,American Society of Anesthesiologists’score,sex,soft texture of the pancreas,underlying heart disease,and preoperative endoscopic biliary *** developed a web-based POPF prediction platform,and this application is freely available at http://*** This study is the first to predict POPF with multiple risk factors using *** platform is reli

关键词： Postoperative pancreatic fistula Pancreatoduodenectomy Neural networks Recursive feature elimination

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Ethanol extracts of Hizikia fusiforme induce apoptosis in human prostate cancer PC3 cells via modulating a ROS-dependent pathway

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Asian Pacific Journal of Tropical Biomedicine 2020年第2期10卷 78-86页

作者： Eun Ok Choi Hyesook Lee Cheol Park Gi-Young Kim Hee-Jae cha Suhkmann Kim Heui-Soo Kim You-Jin Jeon Hye Jin Hwang Yung hyun Choi Anti-Aging Research Center Dong-eui UniversityBusan 47340Republic of Korea Department of Biochemistry College of Korean MedicineDong-eui UniversityBusan 47227Republic of Korea Department of Molecular Biology College of Natural SciencesDong-eui UniversityBusan 47340Republic of Korea Laboratory of Immunobiology Department of Marine Life SciencesJeju National UniversityJeju 63243Republic of Korea Department of Parasitology and Genetics Kosin University College of MedicineBusan 49267Republic of Korea Department of Chemistry College of Natural SciencesCenter for Proteome Biophysics and Chemistry Institute for Functional MaterialsPusan National UniversityBusan 46241Republic of Korea Department of Biological Sciences College of Natural SciencesPusan National UniversityBusan 46241Republic of Korea Department of Food and Nutrition College of NursingHealthcare Sciences&Human EcologyDong-eui UniversityBusan 47340Republic of Korea

Objective:To investigate whether ethanol extracts of Hizikia fusiforme could induce apoptosis in human prostate cancer PC3 ***:Cell viability was evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium *** and mitochondrial membrane potential(MMP)were measured using flow cytometry in PC3 *** damage was assessed by nuclear staining and DNA fragmentation *** of apoptosis-associated proteins were determined by Western blotting *** of caspase-3,-8,and-9 were determined by colorimetric ***,intracellular reactive oxygen species(ROS)generation was detected using a flow cytometer and fluorescence ***:Treatment of PC3 cells with ethanol extracts of Hizikia fusiforme inhibited proliferation,which was associated with induction of apoptosis,and accompanied by increased expression of Fas,Fas-ligand(Fas L),Bax and t Bid,and decreased expression of *** addition,ethanol extracts of Hizikia fusiforme reduced c-Flip expression and activated caspase-8,-9 and-3,resulting in an increase in poly(ADP-ribose)polymerase(PARP)***,in the presence of a pan-caspase inhibitor,ethanol extracts of Hizikia fusiforme-mediated growth inhibition and apoptosis were significantly *** extracts of Hizikia fusiforme also destroyed the integrity of mitochondria due to the loss of MMP,leading to cytosolic release of cytochrome ***,the levels of ROS were markedly increased by treatment with ethanol extracts of Hizikia fusiforme,which was significantly suppressed by the ROS scavenger *** investigation of whether ethanol extracts of Hizikia fusiforme-induced apoptosis was related to the generation of ROS was conducted and the results showed that N-acetyl-L-cysteine fully blocked ethanol extracts of Hizikia fusiforme-induced apoptotic events including loss of MMP,activation of caspase-3,the cytosolic release of cytochrome c and ***:E

关键词： Hizikia fusiforme Apoptosis Prostate cancer cells Caspase Reactive oxygen species

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Younger patients have poorer biochemical outcome after radical prostatectomy in high-risk prostate cancer

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Asian Journal of Andrology 2011年第5期13卷 719-723页

作者： Sung Kyu Hong Jung Soo Nam Woong Na Jong Jin Oh Cheol Yong Yoon chang wook Jeong hyun June Kim Seok-Soo Byun Sang Eun Lee Department of Urology Seoul National University Bundang Hospital Seongnam Kyunggi-do 463-707 Korea

The aim of this study was to investigate the prognostic significance of patient age with respect to tumour aggressiveness in men who underwent radical prostatectomy （RP） for prostate cancer. In this study, we reviewed the records of 743 patients who received RP without neoadjuvant or adjuvant therapy at our institution and were followed up for 〉2 years postoperatively. For our analyses, the patients were divided into two groups according to age： younger （〈60 years） and older （≥ 60 years）. Through uni- and multivariate analyses, associations of various clinicopathological parameters, including biochemical recurrence-free survival, with patient age, were evaluated among all patients, and the patients were stratified according to their D＇Amico risk classification. Among all subjects, younger （n= 126） and older （n=617） patients showed no significant differences regarding pathological parameters and biochemical recurrence-free survival （P=0.288）. For the high-risk group （n= 206）, younger patients had a lower rate of biochemical recurrence-free survival following surgery than older patients （P=0.017）, despite the fact that no significant differences were observed regarding various known prognostic parameters between the two age groups. In addition, multivariate analysis revealed that age was an independent predictor of biochemical recurrence-free survival among the high-risk group （P=O.O03）. Our results showed that relatively younger patients have a comparable biochemical outcome compared with their older counterparts following RP performed for prostate cancer. However, among patients with high-risk disease, younger patients have a worse biochemical outcome following RP compared with older patients.

关键词： age factors biochemical outcome prostate prostatic neoplasms prostatectomy

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Robust FIR Filters for Linear Continuous-time State Space Models with Uncertainties

Robust FIR Filters for Linear Continuous-time State Space Mo...

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第二十六届中国控制会议

作者： Han Soohee Kwon wook hyun BK21 School for Creative Engineering Design of Next Generation Mechanical and Aerospace Systems Seoul Nat'l Univ.Seoul151-742Korea School of Electrical Engr.& Computer Science Seoul Nat'l Univ.Seoul151-742Korea

This paper proposes robust finite impulse response（FIR）filters for linear continuous-time state space models with bounded uncertainties.A set of all reachable current states under bounded uncertainties is determined from inputs and outputs on a recent finite time *** some condition is met,this set is shown to be represented in an ellipsoidal *** derivation procedure is much simplified by utilizing the result on the optimal tracking control with an indefinite cost *** order to minimize the maximum estimation error due to uncertainties,the center of the reachable ellipsoidal set is chosen as an estimated *** is shown through simulation that the proposed robust FIR filter achieves a more robust performance than existing robust infinite impulse response（IIR）filters.

关键词： Robust filter FIR filter Uncertain systems Reachable set Robust observability

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Metastasis of hepatocellular carcinoma to the small bowel manifested by intussusception

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World Journal of Gastroenterology 2006年第12期12卷 1969-1971页

作者： hyun Soo Kim Jung WooShin In Du Jeong Sung-Jo Bang Do Ha Kim Neung Hwa Park Gyu Yeol Kim Young Min Kim Hee Jeong cha Yoong Ki Jeong Division of Gastroenterology Department of Internal MedicineUniversity of Ulsan College of MedicineUlsan University HospitalUlsanKorea Department of Surgery University of Ulsan College of MedicineUlsan University HospitalUlsanKorea Department of Pathology University of Ulsan College of MedicineUlsan University HospitalUlsanKorea Department of Radiology University of Ulsan College of MedicineUlsan University HospitalUlsanKorea

Hepatocellular carcinoma （HCC） is a so highly invasive tumor that metastasizes hematogenously and lymphogenously to distant site. Frequent sites are lung, regional lymph node, bone, and adrenal gland. But metastasis to the gastrointestinal （GI） tract is rare, and most common site is stomach. Metastasis to the small intestine is extremely rare. Moreover, metastatic HCC of the small bowel causing intussusception has not been reported until now. Here, we report a case of metastasis of HCC to the small bowel manifested by intussusception.

关键词： Hepatocelluar carcinoma Small bowel metastasis Intussusception

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Effect of various red phosphorescent dopants in single emissive white phosphorescent organic light-emitting devices

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Chinese Optics Letters 2017年第5期15卷 53-57页

作者： Jong hyun Lim Jin wook Kim Geum Jae Yoon Ayse Turak Woo Young Kim Department of Green Energy & Semiconductor Engineering Hoseo University Asan 31499 Korea R&D Center A-PRO Co. Ltd. Gunpo 15830 Korea Department of Electrical and Electronic Engineering The University of Hong Kong Hong Kong 070 China Department of Engineering Physcis McMaster University Hamilton Ontario L8S 4L7 Canada

In order to realize single emissive white phosphorescent organic light-emitting devices （PHOLEDs） with three color phosphorescent dopants （red, green, and blue）, the energy transfer between the host material and the three dopants, as well as the among the three dopants themselves, should be considered and optimized. To explore the effect of red phosphorescent dopant on the color rendering index （CRI）, the authors investigate the wavelength position of the maximum emission peak from three phosphorescent dopants. The CRI and luminous efficiency of white PHOLED in which Ir（pq）2（acac） acts as the red phosphorescent dopant are found to be greater than those of devices prepared using Ir（piq）3 and Ir（btp）2（acac） as the emission spectrum has a relatively high intensity near the human perception of blue, red, and green wavelengths. Furthermore, we demonstrate that the performance of the three dopants is related to the absorption characteristics of the red phosphorescent dopant. With a maximum emission peak at 600 nm, Ir（pq）2（acac） has a higher intensity in the concave section between 550 and 600 nm seen for red and blue dopants. In addition, the long metal-to-ligand charge transfer （MLCT） absorption tail of Ir（pq）2（acac） overlaps with the emission spectra of the green dopant, enhancing emission. Such energy transfer mechanisms are confirmed to optimize white emission in the single emissive white PHOLEDs.

关键词： charge transfer Current density Doping (additives) Emission spectroscopy Energy transfer Light emission

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Phase-controlled synthesis of thermally stable nitrogen-doped carbon supported iron catalysts for highly efficient Fischer-Tropsch synthesis

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Nano Research 2019年第10期12卷 2568-2575页

作者： Jin Hee Lee Hack-Keun Lee Dong hyun Chun hyunkyung Choi Geun Bae Rhim Min Hye Youn Heondo Jeong Shin wook Kang Jung-ll Yang Heon Jung Chui Sung Kim Ji chan Park Clean Fuel Laboratory Korea Institute of Energy ResearchDaejeon 34129Republic of Korea Department of Chemical Engineering University of SeoulSeoul 02504Republic of Korea Advanced Energy and System Technology University of Science and TechnologyDaejeon 34113Republic of Korea Department of Physics Kookmin UniversitySeoul 02707Republic of Korea

Iron-based nan oparticles with un iform and high particle dispersi on,which are supported on carb on structures,have been used for various ***,their preparation still suffers from complicated synthesis involving multiple steps and from the high price of precursors and solve *** the prese nt work,a new carbon en capsulated iron-carbide nano particle supported on n itroge rvdoped porous carbon(Fe5C2@C/NPC)structure was *** was made using a simple solid-state reaction with sequential thermal ***5C2@C/NPC is a highly active and stable catalyst for the high-temperature Fischer-Tropsch synthesis *** showed very high hydrocarbon productivity(4.71 gHc gcat^-1·h^-1)with high CO conversions(up to 96%).

关键词： iron-carbide one-pot synthesis nitrogen-doped graphene Fischer-Tropsch synthesis Mdssbauer spectroscopy

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Organic photodiode with dual functions of indoor photovoltaic and high-speed photodetector

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Frontiers of Optoelectronics 2022年第2期15卷 45-51页

作者： Tae wook Kim Sung hyun Kim Jae Won Shim Do Kyung Hwang Center of Opto-Electronic Materials and Devices Post-Silicon Semiconductor InstituteKorea Institute of Science and Technology(KIST)Seoul02792Republic of Korea School of Electrical Engineering Korea UniversitySeoul02841Republic of Korea Division of Nano&Information Technology KIST SchoolUniversity of Science and Technology(UST)Seoul02792Republic of Korea

Energy harvesting and light detection are key technologies in various emerging optoelectronic *** high absorption capability and bandgap tunability of organic semiconductors make them promising candidates for such ***,a poly(3-hexylthiophene-2,5-diyl)(P3HT):indene-C60 bisadduct(ICBA)bulk heterojunction-based organic photodiode(OPD)was reported,demonstrating dual functionality as an indoor photovoltaic(PV)and as a high-speed *** OPD demonstrated decent indoor PV performance with a power conversion efficiency(PCE)of(11.6±0.5)%under a light emitting diode(LED)lamp with a luminance of 1000 *** a photodetector,this device exhibited a decent photoresponsivity of 0.15 A/W(green light)with an excellent linear dynamic range(LDR)of over 127 dB within the optical power range of 3.74×10^(−7) to 9.6×10^(−2) W/cm^(2).Furthermore,fast photoswitching behaviors could be observed with the rising/falling times of 14.5/10.4μs and a cutoff(3 dB)frequency of 37 *** results might pave the way for further development of organic optoelectronic applications.

关键词： Organic semiconductor Photodiode Indoor photovoltaics Photodetector

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Trends and risk factors of elderly-onset Crohn’s disease: A nationwide cohort study

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World Journal of Gastroenterology 2020年第4期26卷 404-415页

作者： Jung Min Moon Eun Ae Kang Kyungdo Han Seung wook Hong Hosim Soh Seona Park Jooyoung Lee hyun Jung Lee Jong Pil Im Joo Sung Kim Department of Internal Medicine Liver Research InstituteSeoul National University College of MedicineSeoul 03080South Korea Department of Biostatistics College of MedicineThe Catholic University of KoreaSeoul 06591South Korea

BACKGROUND The incidence of inflammatory bowel disease(IBD)is increasing in *** risk factors associated with IBD development have been *** To investigate trends and environmental risk factors of Crohn’s disease(CD)diagnosed in persons aged≥40 years in South *** Using the National Health Insurance Service database,a total of 14060821 persons aged>40 years who underwent national health screening in 2009 were followed up until December *** with newly diagnosed CD were enrolled and compared with non-CD *** was identified according to the International Classification of Diseases 10th revision and the rare/intractable disease registration program codes from the National Health Insurance Service *** mean follow-up periods was 7.39 ***,sex,diabetes,hypertension,smoking,alcohol consumption,regular exercise,body mass index,anemia,chronic kidney disease(CKD)and dyslipidemia were adjusted for in the multivariate analysis *** During the follow-up,1337(1.33/100000)patients developed *** in the middle-aged group(40-64 years)had a higher risk than women[adjusted hazard ratio(aHR)1.46,95%confidence interval(CI):1.29-1.66];however,this difference tended to disappear as the age of onset *** the middle-aged group,patients with a history of smoking[(aHR 1.46,95%CI:1.19-1.79)and anemia(aHR 1.85,95%CI:1.55-2.20)]had a significantly higher CD *** the elderly group(age,≥65 years),ex-smoking and anemia also increased the CD risk(aHR 1.68,95%CI:1.22-2.30)and 1.84(95%CI:1.47-2.30,respectively).Especially in the middle-aged group,those with CKD had a statistically elevated CD risk(aHR 1.37,95%CI:1.05-1.79).Alcohol consumption and higher body mass index showed negative association trend with CD incidence in both of the age groups.[Middle-aged:aHR 0.77(95%CI:0.66-0.89)and aHR 0.73(95% CI:0.63-0.84),respectively][Elderly-group:aHR 0.57(95% CI:0.42-0.78)and aHR 0.84(95%CI 0.67-1.04),respectively].For regular p

关键词： Crohn’s disease Aged Environmental Risk factors Epidemiology Nationwide cohort

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Incremental age-related one-year MACCE after acute myocardial infarction in the drug-eluting stent era （from KAMIR-NIH registry）

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Journal of Geriatric Cardiology 2018年第9期15卷 574-584页

作者： Dae-Won Kim Sung-Ho Her Ha wook Park Kiyuk chang wook Sung Chung Ki Bae Seung Myung Ho Jeong Hyo-Soo Kim Hyeon Cheoi Gwon In Whan Seong Kyung Kuk Hwang Shung Chull chae Kwon-Bae Kim Young Jo Kim Kwang Soo cha Seok Kyu Oh Jei Keon chae Ji-Hoon Jung Division of Cardiology Daejeon St. Mary's Hospital College of Medicine the Catholic University of Korea Seoul South Korea Division of Cardiology Seoul St. Mary's Hospital College of Medicine the Catholic University of Korea Seoul South Korea Chonnam National University Hospital Gwangju South Korea Seoul National University Hospital Seoul South Korea Sungkyunkwan Universtiy Samsung Medical Center Seoul South Korea Chungnam National University Hospital Daejeon South Korea Chungbuk National University Hospital Cheongju South Korea Kyungpook National University Hospital Daegu South Korea Keimyung University Dongsan Medical Center Daegu South Korea Yeungnam University Hospital Daegu South Korea Pusan National University Hospital Busan South Korea Wonkwang University Hospital Iksan South Korea Chonbuk National University Hospital Jeonju South Korea Statistical Manager Institute of Toxicology Daejeon South Korea

Objectives To evaluate the age-related one-year major adverse cardiocerebrovascular events （MACCE） after percutaneous coronary intervention （PCI） in acute myocardial infarction （AMI）. We analyzed the association between age and one-year MACCE after AMI. Methods A total of 13,104 AMI patients from Korea Acute Myocardial Infarction Registry-National Institue of Health （KAMIR-NIH） between November 2011 and December 2015 were classified into four groups according to age （Group I, 〈 60 years, n = 4199; Group II, 60-70 years, n = 2577; Group III; 70-80 years, n = 2774; Group IV, ≥ 80 years, n = 1018）. Patients were analyzed for one-year composite of MACCE （cardiac death, myocardial infarction, target vessel revascularization, cerebrovascular events） after AMI. Results The one-year MACCE in AMI were 3.5% （Group I）, 6.3% （Group II）, 9.6% （Group III） and 17.6% （Group IV）. After adjustment for confounding para- meters, the analysis results showed that patients with AMI had incremental risk of one-year MACCE [Group II, adjusted hazard ratios （aHR） = 1.224, 95% CI： 0.965-1.525, P = 0.096; Group III, aHR = 1.316, 95% CI： 1.037-1.671, P= 0.024; Group IV, aHR = 1.975, 95% CI： 1.500-62.601, P〈 0.001） compared to Group I. Especially, cardiac death in the composite of primary end point played a major role in this effect （Group II, aHR = 1.335, 95% CI： 0.941-1.895, P= 0.106; Group III, aHR = 1.575, 95% CI： 1.122-2.210, P= 0.009; Group IV, aHR = 2.803, 95% CI： 1.937-4.054, P 〈 0.001）. Conclusions Despite advanced techniques and medications for PCI in AMI, age still exerts a powerful influence in clinical outcomes. Careful approaches, even in the modem era of developed cardiology are needed for aged-population in AMI intervention.

关键词： Acute myocardial infarction Aged-population Major adverse cardiocerebrovascular events

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