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Catalpa bignonioides extract improves exercise performance through regulation of growth and metabolism in skeletal muscles

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Asian Pacific Journal of Tropical Biomedicine 2024年第2期14卷 47-54页

作者： Hoibin Jeong Dong-joo lee Sung-Pil Kwon SeonJu Park Song-Rae Kim Seung Hyun Kim Jae-Il Park deug-chan lee Kyung-Min Choi Wonwoo lee Ji-Won Park Bohyun Yun Su-Hyeon Cho Kil-Nam Kim Seoul Center Korea Basic Science InstituteSeoul 02841Republic of Korea Chuncheon Center Korea Basic Science InstituteChuncheon 24341Republic of Korea Research&Development Center Chungdam CDC JNPharm LLC.Chuncheon 24341Republic of Korea Department of Biomedical Technology Kangwon National UniversityChuncheon 24341Republic of Korea Yonsei Institute of Pharmaceutical Sciences College of PharmacyYonsei UniversityIncheon 21983Republic of Korea Gwangju Center Korea Basic Science InstituteGwangju 61751Republic of Korea Honam National Institute of Biological Resources 99Gohadoan-gilMokpo-siJeollanam-do58762Republic of Korea Department of Bio-analysis Science University of Science&TechnologyDaejeon34113Republic of Korea

Objective:To evaluate the effects of Catalpa bignonioides fruit extract on the promotion of muscle growth and muscular capacity in vitro and in ***:Cell viability was measured using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide *** proliferation was assessed using a 5-bromo-2’-deoxyuridine(BrdU)assay *** blot analysis was performed to determine the protein expressions of related *** effects of Catalpa bignonioides extract were investigated in mice using the treadmill exhaustion test and whole-limb grip strength *** composition analysis was performed using high-performance liquid chromatography(HPLC).Results:Catalpa bignonioides extract increased the proliferation of C2C12 mouse myoblasts by activating the Akt/mTOR signaling *** also induced metabolic changes,increasing the number of mitochondria and glucose metabolism by phosphorylating adenosine monophosphate-activated protein *** an in vivo study,the extract-treated mice showed improved motor abilities,such as muscular endurance and grip ***,HPLC analysis showed that vanillic acid may be the main component of the Catalpa bignonioides extract that enhanced muscle ***:Catalpa bignonioides improves exercise performance through regulation of growth and metabolism in skeletal muscles,suggesting its potential as an effective natural agent for improving muscular strength.

关键词： Catalpa bignonioides Skeletal muscle Cell proliferation Mitochondria Energy metabolism C2C12

Characteristics of machined surface controlled by cutting tools and conditions in machining of brittle material

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中国有色金属学会会刊：英文版 2009年第B09期19卷 194-201页

作者： Yong-woo KIM Soo-Chang CHOI Jeung-woo PARK deug-woo lee Department of Nano Fusion Technology Pusan National University Department of Mechanical Design Engineering Chosun University Department of Nanosystem and Nanoprocess Engineering Pusan National University

One of the ultra-precision machining methods was adapted for brittle material as well as soft material by using multi-arrayed diamond tips and high speed spindle. Conventional machining method is too hard to control surface roughness and surface texture against brittle material because the particles of grinding tools are irregular size and material can be fragile. Therefore, we were able to design tool paths and machine controlled pattern on surface by multi-arrayed diamond tips with uniform size made in MEMS fabrication and high speed spindle, and the maximum speed was about 3×105 r/min. We defined several parameters that can affect the machining surface. Those were multi-array of diamond tips (n×n), speed of air spindle and feeding rate. The surface roughness and surface texture can be controlled by those parameters for micro machining.

关键词：加工表面脆性材料条件控制刀具路径表面粗糙度特征高速主轴加工方法

Attaching single carbon nanotube on tip's apex using dielectrophoresis of DC-pulse voltage

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中国有色金属学会会刊：英文版 2009年第B09期19卷 280-283页

作者： Hee-Jin JEONG Yoong-Ho JUNG deug-woo lee Gyeongbuk Hybrid Technology Institute School of Mechanical Engineering Pusan National University Department of Nanosystem and Nanoprocess Engineering Pusan National University

Single carbon nanotubes (CNTs) are candidates for a number of electronics and sensing applications, provided that single CNTs can be separated from a bundle of CNTs in suspension. Dielectrophoresis has recently been demonstrated as one route for the extraction of desired CNTs. However, previous methods using dielectrophoresis have found it difficult to extract single nanotubes from bundles of CNTs in solution. Here, we show that this restriction can be overcome by using pulsed DC voltage of an electric field, instead of regular AC and DC voltages.

关键词：碳纳米管直流脉冲脉冲电压介电顶点消息电子号码 CNTs

Microstructure of fast tool servo machining on copper alloy

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中国有色金属学会会刊：英文版 2012年第S3期22卷 820-824页

作者： Hong LU Soo-chang CHOI Sang-min lee deug-woo lee Department of Nano Fusion Technology Pusan National University Korea Institute of Machinery & Materials Department of Nano Mechatronics Engineering Pusan National University

The development of the fast tool servo (FTS) for precision machining was *** micron machining performance of a piezoelectric-assisted FTS on copper alloy was *** results indicate that the quality of the microstructure depends mainly on two important factors:the cutting speed (or spindle speed) and the driving frequency of the *** excessive driving frequency increases the formation of *** effect of the clearance angle of the diamond tool on the microstructure machining precision was also investigated.

关键词： fast tool servo microstructure piezoelectric diamond machining copper alloy

Cavity noise sensitivity analysis of tire contour design factors and application of contour optimization methodology

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Journal of Central South University 2012年第8期19卷 2386-2393页

作者： KIM Seong-rae SUNG Ki-deug lee Dong-woo HUH Sun-chul NEXEN Tire Corporation 30 Yusan-DongYangsan-SiKyungnam 626-230Korea Division of Automotive and Mechanical Engineering Changwon Moonsung University91Doodae-dongChangwon-si Kyungnam 641-771Korea Department of Energy and Mechanical Engineering Institute of Marine IndustryGyeongsang National University Cheondaeguk-Gil 38TongyeongGyeongnam 650-160Korea

Cavity resonance noise of passenger car tires is generated by interacting excitation between a tire structure and the fill gas (air), and generally lies in a frequency range of 200?250 Hz. As such, this noise is strongly perceived and may be a serious source of driver annoyance. Thus, many studies regarding the cavity noise mechanism and its reduction have already been conducted. In this work, a vibro-acoustic coupled analysis was conducted between a tire structure and air cavity. Using this analysis, we can more accurately simulate the tire noise performance in the region of the cavity resonance frequency. An analysis of the effects of variation of tire contour design factors was conducted, using design-of-experiments methods. Finally, a multi-objective optimization was performed using in-house codes to reduce the cavity noise level while minimizing the loss of other performances, such as diminished ride comfort and handling caused by the variations of contour. As a result of this optimization, an optimized contour shape was derived, which satisfied the multi-objective performances.

关键词： tire cavity noise vibro-acoustic coupled analysis finite element method boundary element method (BEM) sensitivity optimization

Diamond machining of sinusoidal grid surface using fast tool servo system for fabrication of hydrophobic surface

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中国有色金属学会会刊：英文版 2012年第S3期22卷 787-792页

作者： Hong LU deug-woo lee Sang-Min lee Jeong-woo PARK Department of Nano Fusion Technology Pusan National University Department of Nano Mechatronics Engineering Pusan National University Department of Mechanical Design Engineering Chosun University

Ultra-precision diamond machining with piezoelectric-assisted fast tool servo (FTS) was used to produce various free-form surfaces.A low cost,rapid and large area fabrication of uniform hydrophobic surface at room temperature which transfers the FTS fabricated sinusoidal grid surface to the flat film with UV-moulding process was described.A piezoelectric-assisted FTS with high band width of 2 kHz,travel range up to 16 μm and the compact mechanism structure was designed for the sinusoidal grid surface machining and the dynamic performance testing of FTS was described in *** results indicate that the dimensions of sinusoidal grid change with the variation of the FTS machining *** properties of UV-moulded surface were evaluated,the best contact angle was measured to be 120.5° on the sinusoidal grid surface with profile wavelength of 350 μm and peak-to-valley amplitude of about 16 μm.

关键词： fast tool servo system diamond turning sinusoidal grid surface UV-moulding contact angle

A DEVELOPMENT OF NANO PROBE FOR ULTRA PRECISION SCRATCHING AND MEASURING

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A DEVELOPMENT OF NANO PROBE FOR ULTRA PRECISION SCRATCHING A...

韩国跨国企业的中国致胜之道——从中国制造到全方位设计研发的战略转变

第七届海内外青年设计与制造科学会议

作者： Jeong woo Park Hyoung Won Kim Cae Moon lee Jong Kweon Park deug woo lee Engineering Research Center （ERC） Pusan National UniversityKorea Engineering Research Center （ERC） Pusan National UniversityKorea Engineering Research Center （ERC） Pusan National UniversityKorea Intelligence ＆ Precision Machinery Research Division Korea Institute of Machinery and Materials （KIMM）Korea Department of Nano System and Process Engineering Pusan National UniversityKorea

＜正＞The nano probe system that can measure precise micro parts or optical parts in nanometer range resolution and scratch in mN contact force as well was demonstrated. The nano probe was originally designed for on-machine measuring applications or one kind of contact type measuring probes on micro/nano CMM system. It should be small size and able to measure surface topography in nanometer scale. We proposed a new concept of nano probe system by applying commercial capacitive displacement sensor, which can measure the displacement of shaft driven by the variation of surface topography. The main structure of nano probe is consisted of three parts, capacitive displacement sensor, porous type air slide, and contact probe part with various tip radiuses. Especially, capacitive displacement sensor was applied to ensure both the fine control of normal measuring force and nanoscale measuring resolutions. The aerostatic porous type air slide guarantees the shaft to slide smoothly with controllable normal force in mN scale and high positioning accuracy. The probe part, in contact with target surface directly, can be applied to micro-to-nano scale scratching as well as measurement of the sample topography by simple tip change. We applied two types of probe tips, a commercial ruby ball with 300pm in radius and MEMS process based lab-made micro diamond tip under 1μm in tip end radius. To evaluate the characteristics of nano probe, on-machine measuring and （100） silicon scratching test was done under the ultra precision 3 axis stage with 10nm resolution.

关键词： Capacitive displacement sensor Nano probe On-machine measuring CMM (Coordinate Measuring Machine) Scratching

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装饰 2007年第12期 33-35页

作者：李德顺清华大学美术学院

韩国的跨国企业在最开始进入中国时.看中了中国的制造成本低廉.将中国变成其一个制造基地,将产品行销到中国以外的市场。但是.随着上世纪末中国经济的突飞猛进.三星、LG及韩国现代汽车都加大了中国市场的产品本土化研发力度,迅速将中国... 详细信息

韩国的跨国企业在最开始进入中国时.看中了中国的制造成本低廉.将中国变成其一个制造基地,将产品行销到中国以外的市场。但是.随着上世纪末中国经济的突飞猛进.三星、LG及韩国现代汽车都加大了中国市场的产品本土化研发力度,迅速将中国培育成韩国跨国企业的巨大市场。从开始的零设计纯制造,到现在的本土化全方位产品研发,韩国跨国企业在中国的本土化设计经历了前所未有的转变。

关键词：零设计纯制造本土化设计研发

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一种高效实现等值线的COM组件

计算机与应用化学 2007年第5期24卷 586-588页

作者：马辉 Tae-Seop Jeong 崔龙哲 deug-Soo Kim 中南民族大学化学与材料科学学院湖北省催化材料科学重点实验室湖北武汉430074 全北国立大学校环境工学科群山国立大学校环境工学科

改进等值线生成方法,提出了颜色填充、包围面积计算、底图操作的新方法,同时利用Visual C++．NET开发COM组件。用于绘制了环评项目中大气污染物浓度的分布等值线图。

关键词：等值线算法颜色填充组件