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World Journal of Clinical Cases 2022年第1期10卷 388-396页

作者： Se Hee choi Youn young Lee Won-Joong Kim Anesthesiology and Pain Medicine Ewha Womans University Mokdong HospitalSeoul 07985South Korea Anesthesiology and Pain Medicine School of MedicineEwha Womans UniversitySeoul 07985South Korea

BACKGROUND Cerebrospinal fluid(CSF)leakage at C1/2 in spontaneous intracranial hypotension(SIH)is *** hematoma(SDH),a serious complication of SIH,may lead to neurological *** report presents a case of SDH after spontaneous C1/2 CSF leakage,which was treated with a targeted epidural blood patch(EBP).CASE SUMMARY A 60-year-old man with no history of trauma was admitted to our hospital with orthostatic headache,nausea,and *** computed tomography imaging revealed bilateral,subacute to chronic *** magnetic resonance imaging(MRI)findings were SDH with dural enhancement in the bilateral cerebral convexity and posterior fossa and mild sagging,suggesting *** the patient underwent burr hole trephination,the patient’s orthostatic headache was *** myelography led to a suspicion of CSF leakage at C1/***,we performed a targeted cervical EBP using an epidural catheter under fluoroscopic *** 5 d after EBP,a follow-up MR myelography revealed a decrease in the interval size of the CSF *** his symptoms improved,the patient still complained of headaches;therefore,we repeated the targeted cervical EBP 6 d after the initial ***,his headache had almost disappeared on the 8th day after the repeated *** Targeted EBP is an effective treatment for SDH in patients with SIH due to CSF leakage at C1/2.

关键词： Cerebrospinal fluid Chronic subdural hematoma Epidural blood patch Myelography Spontaneous intracranial hypotension Case report

Emerging nanoformulation strategies for phytocompounds and applications from drug delivery to phototherapy to imaging

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Bioactive Materials 2022年第8期7卷 182-205页

作者： Hwa Seung Han Song Yi Koo Ki young choi Natural Product Informatics Research Center Korea Institute of Science and Technology(KIST)Gangneung25451Republic of Korea Division of Bio-Medical Science and Technology KIST SchoolUniversity of Science and Technology(UST)Seoul02792Republic of Korea

Over thousands of years,natural bioactive compounds derived from plants(bioactive phytocompounds,BPCs)have been used worldwide to address human health ***,they are a significant resource for drug discovery in the development of modern *** many BPCs have promising biological activities,most of them cannot be effectively utilized in drugs for therapeutic applications because of their inherent limitations of low solubility,structural instability,short half-life,poor bioavailability,and non-specific distribution to *** have utilized emerging nanoformulation(NF)technologies to overcome these limitations as they have demonstrated great potential to improve the solubility,stability,and pharmacokinetic and pharmacodynamic characteristics of *** review exemplifies NF strategies for resolving the issues associated with BPCs and summarizes recent advances in their preclinical and clinical applications for imaging and *** review also highlights how innovative NF technologies play a leading role in next-generation BPC-based drug development for extended therapeutic ***,this review discusses the opportunities to take BPCs with meaningful clinical impact from bench to bedside and extend the patent life of BPC-based medicines with new formulations or application to new adjacent diseases beyond the primary drug indications.

关键词： Natural products Phytocompound Nanoformulation Drug delivery Phototherapy

Paradoxical vocal fold motion masquerading as post-anesthetic respiratory distress:A case report

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World Journal of Clinical Cases 2023年第10期11卷 2349-2354页

作者： Jongyoon Baek Dae-Lim Jee Yoon Seok choi Sang woo Kim Eun Kyung choi Department of Anesthesiology and Pain Medicine Yeungnam University College of MedicineDaegu 42415South Korea Department of Otorhinolaryngology-Head and Neck Surgery Yeungnam University College of MedicineDaegu 42415South Korea Department of Neurosurgery Yeungnam University College of MedicineDaegu 42415South Korea

BACKGROUND Functional vocal cord disorders can be a differential diagnosis for postoperative upper airway obstruction requiring urgent ***,this may be unfamiliar to anesthesiologists who would favor inappropriate airway intervention and increased *** SUMMARY A 61-year-old woman underwent cervical laminectomy,followed by laparoscopic cholecystectomy 10 mo *** adequate reversal of neuromuscular blockade,the patient experienced repetitive respiratory difficulty with inspiratory stridor after *** the second operation,the patient was diagnosed with paradoxical vocal fold motion(PVFM)by an otolaryngologist based on the clinical features and fiberoptic bronchoscopy results,and the patient was successfully *** PVFM should be considered a differential diagnosis if a patient presents with stridor after general anesthesia.

关键词： Anesthesiology Vocal fold Paradoxical motion Postoperative respiratory distress Case report

Increasing sulfur utilization in lithium-sulfur batteries by a Co-MOF-74@MWCNT interlayer

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Journal of Energy Chemistry 2021年第9期30卷 186-193页

作者： SiHyeon Sung Byung Hyuk Kim SeungTaek Lee Sanghyeon choi woo young Yoon Department of Materials Science and Engineering Korea University15GaAnam-dongSungbuk-GuSeoul 136-701Republic of Korea

To improve lithium-sulfur battery performance,Co-MOF-74 has been applied for the first time as an interlayer with multiwalled carbon nanotubes(MWCNTs).Co-MOF-74@MWCNT was synthesized using a solvothermal *** fabrication of Co-MOF-74@MWCNT was confirmed by scanning electron microscopy,X-ray diffraction,thermogravimetric analysis,and Brunauer-Emmett-Teller *** interlayer was fabricated using a filtration *** batteries were prepared using a CoMOF-74@MWCNT interlayer and an MWCNT interlayer and subsequently investigated via cyclic voltammetry ***-MOF-74 promotes a redox reaction and shows a small peak at 1.85 V.A symmetric and full cell test revealed that the Co-MOF-74@MWCNT cell enables a faster redox reaction and higher capacity than that of the MWCNT *** 15 cycles,the Co-MOF-74@MWCNT cell achieved a value of 1112 mAh g^(-1),which is 26% greater than that of the MWCNT cell(880 mAh g^(-1)) at 0.2 *** profile testing showed that the reason for the higher capacity of the Co-MOF-74@MWCNT cell is that it promotes the conversion of Li_(2)S_(2) to Li_(2)*** electrochemical analyses confirmed that the Co-MOF-74@MWCNT interlayer acts not only as a physical and chemical barrier but also promotes the transformation of Li_(2)S_(2) to Li_(2)S.

关键词： Li-S battery Shuttling effect Interlayer Sulfur utilization Co-MOF-74

High efficiency and stable solid-state fiber dye-sensitized solar cells obtained using TiO_(2) photoanodes enhanced with metal organic frameworks

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Journal of Energy Chemistry 2022年第4期31卷 458-466页

作者： Jae Ho Kim Hyun woo Park Sung-Jun Koo Daseul Lee Eunyeong Cho Yong-Ki Kim Myunghun Shin Jin woo choi Hee Jung Lee Myungkwan Song Department of Energy and Electronic Material Korea Institute of Materials Science(KIMS)797 Changwon-daeroSungsan-guChangwonGyeongsangnam-do 51508Republic of Korea Composites Research Division Korea Institute of Materials Science(KIMS)797 Changwon-daeroSungsan-GuChangwonGyeongsangnam-do 51508Republic of Korea School of Electronics and Information Engineering Korea Aerospace UniversityGoyang-cityGyeonggi-do 10540Republic of Korea

Solid-state fiber dye-sensitized solar cells(SS-FDSSCs) have been the subject of intensive attention and development in recent years. Although this field is only in its infancy, metal–organic frameworks(MOFs) are one such material that has been utilized to further improve the power conversion efficiency of solar cells. In this study, MOF-integrated DSSCs were shown to have potential in the development of solar cell devices with efficiency comparable to or better than that of conventional solar cells. The power conversion efficiency(PCE) of SS-FDSSCs was improved by embedding MOF-801 into a mesoporous-TiO_(2)(mp-TiO_(2)) layer, which was used as a photoanode in SS-FDSSCs, which are inherently flexible. The PCE of the MOF-integrated SS-FDSSCs was 6.50%, which is comparable to that of the reference devices(4.19%).The MOF-801 enhanced SS-FDSSCs decreased the series resistance(R_(s)) value, resulting in effective electron extraction with improved short-circuit current density(J_(SC)), while also increasing the shunt resistance(R_(sh)) value to prevent the recombination of photo-induced electrons. The result is an improved fill factor and, consequently, a higher value for the PCE.

关键词： Photoanode Metal organic frameworks Solid-state electrolyte Dye-sensitized solar cells Fiber-shaped solar cells

Large retroperitoneal atypical spindle cell lipomatous tumor,an extremely rare neoplasm:A case report

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World Journal of Clinical Cases 2022年第8期10卷 2584-2590页

作者： Jung-Min Bae Chang-Yeon Jung woo-Sung Yun Joon Hyuk choi Department of Surgery Yeungnam University College of MedicineDaegu 42415South Korea Kyungpook National University School of Medicine Jung-guDaegu 41944Korea Department of Pathology Yeungnam University College of Medicine Nam-guDaegu 42415Korea

BACKGROUND Atypical spindle cell lipomatous tumor(ASLT)is a rare soft tissue neoplasm with a low potential for *** frequently occurs in the limb and limb ***,large retroperitoneal ASLTs are extremely *** was no concrete case report of retroperitoneal *** SUMMARY An 18-year-old woman presented with abdominal pain and a palpable *** computed tomography revealed a large fatty mass that was approximately 30 cm in size and filled the entire abdominal *** excision was *** tumor did not invade the adjacent *** pelvic cavity was then too narrow to dissect *** mass was successfully excised without tumor rupture or adjacent organ ***,the neoplasm was a well-differentiated adipocytic *** staining showed that the spindle cells were positive for CD34 and desmin,in addition to multifocal positivity for S100 *** histological features were consistent with an *** patient’s postoperative course was *** the 12-mo followup,no evidence of recurrence or metastasis was *** To the best of our knowledge,our study is the first concrete report of a large retroperitoneal ASLT in the English *** the large retroperitoneal ASLT located in the pelvic cavity,which made it too narrow and tight to dissect,complete excision is difficult but very important because of recurrence *** large retroperitoneal ASLTs are considered extremely rare,their detection is important for accurate evaluation and *** to their significant rarity,retrospective multicenter case studies are required to determine the clinicopathologic characteristics.

关键词： Neoplasms Retroperitoneal space Spindle cell Case report

AKT regulates IL-1β-induced proliferation and activation of hepatic stellate cells

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BIOCELL 2023年第3期47卷 669-676页

作者： YONGDAE YOON SOONJAE HWANG FATEMA TUJ SAIMA MOON young KIM SOON KOO BAIK young woo EOM Regeneration Medicine Research Center Yonsei University Wonju College of MedicineWonju26426Korea Department of Biochemistry Lee Gil Ya Cancer and Diabetes InstituteGAISTGachon University College of MedicineIncheon21999Korea Cell Therapy and Tissue Engineering Center Yonsei University Wonju College of MedicineWonju26426Korea Department of Internal Medicine Yonsei University Wonju College of MedicineWonju26426Korea

Background:Activated hepatic stellate cells(HSCs)are closely involved in the initiation,perpetuation,and resolution of liver ***-inflammatory cytokine levels are positively correlated with the transition from liver injury to fibrogenesis and contribute to HSC pathophysiology in liver ***:In this study,we investigated the effect of the pro-inflammatory cytokine interleukin(IL)-1βon the proliferation and signaling pathways involved in fibrogenesis in LX-2 cells,an HSC cell line,using western blotting and cell proliferation ***:IL-1βincreased the proliferation rate andα-smooth muscle actin(SMA)expression of LX-2 cells in a dose-dependent *** 1 h after IL-1βtreatment,c-Jun N-terminal kinase(JNK),p38,and nuclear factor-κB(NF-κB)signaling was activated in LX-2 ***,protein kinase B(AKT)phosphorylation and an increase inα-SMA expression were observed in LX-2 *** inhibitor of JNK,p38,or NF-κB decreased cell proliferation,AKT phosphorylation,andα-SMA expression in IL-1β-treated LX-2 ***:These results indicate that JNK,p38,and NF-κB signals converge at AKT phosphorylation,leading to LX-2 activation by IL-1β.Therefore,the AKT signaling pathway can be used as a target for alleviating liver fibrosis by the inflammatory cytokine IL-1β.

关键词： Hepatic stellate cell Interleukin-1β AKT Cell proliferation Fibrosis

Changes on optical coherence tomography angiography and fluorescein angiography in eyes with neovascular age-related macular degeneration

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International Journal of Ophthalmology(English edition) 2022年第11期15卷 1837-1844页

作者： So Min Ahn Mihyun choi Cheolmin Yun Seong-woo Kim Jaeryung Oh Department of Ophthalmology Korea University College of MedicineSeoul 02841Republic of Korea

AIM:lo evaluate the changes on optical coherence tomography angiography(OCTA) and fluorescein angiography(FA) and their correlation in neovascular agerelated macular degeneration(nAMD) before and after intravitreal aflibercept injections(IAIs).METHODS:In 43 treatment-na?ve patients with nAMD,choroidal neovascularization(CNV) in OCTA were morphologically and quantitatively analyzed before and after IAIs to determine whether they are correlated with leakage on FA or *** combining CNV in OCTA and leakage in FA,lesions were characterized as three types:L+C+(with both CNV and leakage),L-C+(with CNV but without leakage),or L+C-lesion(with leakage outside CNV).RESULTS:Before IAI,while 27 eyes had L+C+lesion only,16 eyes had both L+C+and L-C+lesions *** capillaries and anastomosis in CNV were more developed in L+C+lesion,at 86.0% and58.1%,respectively,relative to 9.3% and 9.3% in L-C+lesions(P<0.001).After IAIs in 33 eyes,tiny capillaries and anastomosis were decreased in the lesions with cessation of leakage on FA(P<0.001 and P=0.001,respectively).In quantitative analysis,neovascularization length and numbers of junctions and endpoints were also significantly ***:Leakage on FA is associated with CNV morphology in OCTA and remained so after ***,by carefully assessing the morphological and quantitative changes of CNV in OCTA before and after treatment,activity of nAMD is expected even though CNV on OCTA is not completely matched with fluorescein leakage.

关键词： choroidal neovascularization fluorescein angiography leakage neovascular age-related macular degeneration optical coherence tomography angiography

3D cell-printing of gradient multi-tissue interfaces for rotator cuff regeneration

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Bioactive Materials 2023年第1期19卷 611-625页

作者： Suhun Chae Uijung Yong Wonbin Park Yoo-mi choi In-Ho Jeon Homan Kang Jinah Jang Hak Soo choi Dong-woo Cho Department of Mechanical Engineering Pohang University of Science and Technology77 Cheongam-roNam-guGyeongsangbuk-doPohang37673South Korea EDmicBio Inc. 111 Hoegi-roDongdaemun-guSeoul 02445South Korea Institute for Convergence Research and Education in Advanced Technology Yonsei University50 Yonsei-roSeodaemun-guSeoul03722South Korea Gordon Center for Medical Imaging Department of RadiologyMassachusetts General Hospital&Harvard Medical School14913th StreetBostonMA02114USA Department of Convergence IT Engineering Pohang University of Science and Technology77 Cheongam-roNam-guGyeongsangbuk-doPohang37673South Korea School of Interdisciplinary Bioscience and Bioengineering Pohang University of Science and Technology77 Cheongam-roNam-guGyeongsangbuk-doPohang37673South Korea Department of Orthopaedic Surgery Asan Medical CenterCollege of MedicineUniversity of Ulsan86 Asanbyeongwon-gilSongpa-guSeoul05505South Korea

Owing to the prevalence of rotator cuff(RC)injuries and suboptimal healing outcome,rapid and functional regeneration of the tendon-bone interface(TBI)after RC repair continues to be a major clinical *** the essential role of the RC in shoulder movement,the engineering of biomimetic multi-tissue constructs presents an opportunity for complex TBI reconstruction after RC ***,we propose a gradient cell-laden multi-tissue construct combined with compositional gradient TBI-specific bioinks via 3D cell-printing *** vitro studies demonstrated the capability of a gradient scaffold system in zone-specific inducibility and multi-tissue formation mimicking *** regenerative performance of the gradient scaffold on RC regeneration was determined using a rat RC repair *** particular,we adopted nondestructive,consecutive,and tissue-targeted near-infrared fluorescence imaging to visualize the direct anatomical change and the intricate RC regeneration progression in real time in ***,the 3D cell-printed implant promotes effective restoration of shoulder locomotion function and accelerates TBI healing in *** summary,this study identifies the therapeutic contribution of cell-printed constructs towards functional RC regeneration,demonstrating the translational potential of biomimetic gradient constructs for the clinical repair of multi-tissue interfaces.

关键词： 3D cell-printing Tissue-specific bioink Gradient tissue scaffolds Near-infrared fluorophores Rotator cuff repair

Installing a molecular truss beam stabilizes MOF structures

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npj Computational Materials 2022年第1期8卷 1110-1118页

作者： Hong Ki Kim Jong-Yeong Jung Gyumin Kang Mu-Hyun Baik Eun-young choi Department of Chemistry Korea Advanced Institute of Science and Technology(KAIST)Daejeon34141Republic of Korea Center for Catalytic Hydrocarbon Functionalizations Institute for Basic Science(IBS)Daejeon34141Republic of Korea Korea Science Academy of KAIST 105-47 Baegyanggwanmun-roBusanjin-guBusan47162Republic of Korea

Enhancing the stability and durability of metal-organic frameworks(MOFs)is vital for practical applications because many promising MOF materials suffer from phase transitions and/or structural decompositions with humidity being a particularly damaging *** mechanical engineering,the frame of buildings and furniture can be stabilized significantly by installing a truss *** the same principle,we functionalized the organic component of MOF-5 to contain a carbazole moiety that can act as a molecular truss beam by reaching across the corner and forming a stableπ–πinteraction with a phenyl group on the edge position of the *** structural support enhanced the stability of the MOF substantially,allowing the designed MOF to maintain compositional integrity under steam conditions at 90℃for~5 *** unmodified MOF-5 shows clear signs of structural collapse after~1 h.

关键词： beam moiety durability