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Prenatal and postnatal factors associated with sudden infant death syndrome:an umbrella review of meta-analyses

World Journal of Pediatrics 2024年第5期20卷 451-460页

作者： Tae hyeon Kim hyeri Lee Selin woo hayeon Lee Jaeyu Park Guillaume Fond Laurent Boyer Jong woo hahn Jiseung Kang Dong Keon yon Department of Medicine Kyung Hee University College of MedicineSeoulSouth Korea Center for Digital health Medical Science Research InstituteKyung Hee University College of MedicineSeoulSouth Korea Department of Regulatory Science Kyung Hee UniversitySeoulSouth Korea Department of Biomedical Engineering Kyung Hee UniversityYonginSouth Korea CEReSS-health Service Research and Quality of Life Center Assistance Publique des Hôpitaux de MarseilleAix-Marseille UniversityMarseilleFrance Department of Pediatrics Seoul National University College of MedicineSeoulSouth Korea Department of Pediatrics Seoul National University Bundang HospitalSeongnamSouth Korea Department of Anesthesia Critical Care and Pain MedicineMassachusetts General Hospital14913th StreetRoom 4140CharlestownBostonMAUSA Division of Sleep Medicine Harvard Medical SchoolBostonMAUSA Department of Pediatrics Kyung Hee University Medical CenterKyung Hee University College of Medicine23 Kyungheedae-roDongdaemun-guSeoul02447South Korea Department of Precision Medicine Kyung Hee University College of MedicineSeoulSouth Korea

Background Comprehensive quantitative evidence on the risk and protective factors for sudden infant death syndrome(SIDS)effects is *** investigated the risk and protective factors related to *** We conducted an umbrella review of meta-analyses of observational and interventional studies assessing SIDS-related ***/MEDLINE,Embase,EBSCO,and Google Scholar were searched from inception until January 18,*** extraction,quality assessment,and certainty of evidence were assessed by using A Measurement Tool Assessment Systematic Reviews 2 following PRISMA *** to observational evidence,credibility was graded and classified by class and quality of evidence(CE;convincing,highly suggestive,suggestive,weak,or not significant).Our study protocol was registered with PROSPERO(CRD42023458696).The risk and protective factors related to SIDS are presented as equivalent odds ratios(eORs).Results We identified eight original meta-analyses,including 152 original articles,covering 12 unique risk and protective factors for SIDS across 21 countries/regions and five *** risk factors,including prenatal drug exposure[eOR=7.84(95%CI=4.81–12.79),CE=highly suggestive],prenatal opioid exposure[9.55(95%CI=4.87–18.72),CE=suggestive],prenatal methadone exposure[9.52(95%CI=3.34–27.10),CE=weak],prenatal cocaine exposure[4.38(95%CI=1.95–9.86),CE=weak],prenatal maternal smoking[2.25(95%CI=1.95–2.60),CE=highly suggestive],postnatal maternal smoking[1.97(95%CI=1.75–2.22),CE=weak],bed sharing[2.89(95%CI=1.81–4.60),CE=weak],and infants found with heads covered by bedclothes after last sleep[11.01(95%CI=5.40–22.45),CE=suggestive],were *** the other hand,three protective factors,namely,breastfeeding[0.57(95%CI=0.39–0.83),CE=non-significant],supine sleeping position[0.48(95%CI=0.37–0.63),CE=suggestive],and pacifier use[0.44(95%CI=0.30–0.65),CE=weak],were also *** Based on the evidence,we propose several risk and protecti

关键词： Infant Protective factor Risk factor Sudden infant death syndrome Umbrella review

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Increasing concentrations of dietary threonine,tryptophan,and glycine improve growth performance and intestinal health with decreasing stress responses in broiler chickens raised under multiple stress conditions

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Animal Nutrition 2024年第3期18卷 145-153页

作者： hyun woo Kim Jong hyuk Kim Gi Ppeum han Dong yong Kil Department of Animal Science and Technology Chung-Ang UniversityAnseong-siGyeonggi-do 17546Republic of Korea Department of Animal Science Chungbuk National UniversityCheongju 28644Republic of Korea

The current study aimed to compare the effects of increasing concentrations of dietary threonine(Thr),tryptophan(Trp),and glycine(Gly)on growth performance,stress biomarkers,and intestinal function in broiler chickens under multiple stress *** hundred sixty broiler chickens at 21 d old were randomly allotted to 5 treatments with 8 *** in a positive control(PC)treatment were raised under low stock density(16.9 birds/m2 per cage)with recommended environmental conditions,whereas birds in 4 treatments were subjected to multiple stress conditions:a cyclic heat stress of 30±0.3°C for 10 h and 23±0.2°C for 14 h per day with high stock density(25.3 birds/m2 per cage).A basal diet was assigned to both PC and negative control(NC)*** additional diets were individually formulated to contain double concentrations of digestible Thr,Trp,or Gly+Ser compared with their concentrations in the basal *** experiment lasted for 14 *** showed that NC treatment had less growth performance(Phelial electrical resistance(TEER;Pher corticosterone(CORT)concentrations than PC *** treatment showed the least(Py treatments had less(P=0.026)feather CORT concentrations,but had greater(Phan NC *** conclusion,increasing concentrations of dietary Thr,Trp,or Gly improve the growth performance and intestinal health in broiler chickens with decreasing stress response under multiple stress conditions.

关键词： Broiler chicken Glycine Multiple stress Threonine Tryptophan

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(FeO)_(2)FeBO_(3) nanoparticles attached on interconnected nitrogen-doped carbon nanosheets serving as sulfur hosts for lithium-sulfur batteries

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Frontiers of Materials Science 2024年第2期18卷 75-88页

作者： Junhai Wang huaqiu huang Chen Chen Jiandong Zheng yaxian Cao Sang woo Joo Jiarui huang School of Material and Chemical Engineering Chuzhou UniversityChuzhou 239000China College of Mechanical Engineering Tongling UniversityTongling 244000China Key Laboratory of Functional Molecular Solids of the Ministry of Education College of Chemistry and Materials ScienceAnhui Normal UniversityWuhu 241002China School of Mechanical Engineering Yeungnam UniversityGyeongsanGyeongbuk 38541Republic of Korea

There are still many challenges including low conductivity of cathodes,shuttle effect of polysulfides,and significant volume change of sulfur during cycling to be solved before practical applications of lithium-sulfur(Li-S)*** this work,(FeO)_(2)FeBO_(3) nanoparticles(NPs)anchored on interconnected nitrogen-doped carbon nanosheets(NcNs)were synthesized,serving as sulfur carriers for Li-S batteries to solve such *** have the cross-linked network structure,which possess good electrical conductivity,large specific surface area,and abundant micropores and mesopores,enabling the cathode to be well infiltrated and permeated by the electrolyte,ensuring the rapid electron/ion transfer,and alleviating the volume expansion during the electrochemical *** addition,polar(FeO)_(2)FeBO_(3) can enhance the adsorption of polysulfides,effectively alleviating the polysulfide shuttle *** a current density of 1.0 A·g^(-1),the initial discharging and charging specific capacities of the(FeO)_(2)FeBO_(3)@NCNs-2/S electrode were obtained to be 1113.2 and 1098.3mA·h·g^(-1),*** 1000 cycles,its capacity maintained at 436.8 mA·h·g^(-1),displaying a decay rate of 0.08%per ***,combining NCNs with(FeO)_(2)FeBO_(3) NPs is conducive to the performance improvement of Li-S batteries.

关键词： (FeO)_(2)FeBO_(3) nitrogen-doped carbon nanosheet cathode lithium-sulfurbattery

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“牵手型”早期胃癌关键分子表达特点

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临床与实验病理学杂志 2018年第5期34卷 485-485页

作者： woo h y Bae y S Kim J h 陈昌明方三高福建省三明市第一医院病理科三明365000 福建医科大学附属三明第一医院病理科三明365000

＂牵手型＂腺癌（CRA）是一种罕见的早期胃癌变异型,组织学以腺体不规则融合、低级别细胞异型性、易于向黏膜侧向扩散为特征。与普通分化型腺癌（CDAs）相比,CRA患者相对年轻[（57.3±9.7）岁vs（66.2±7.9）岁],肿瘤较大，与周围非肿... 详细信息

＂牵手型＂腺癌（CRA）是一种罕见的早期胃癌变异型,组织学以腺体不规则融合、低级别细胞异型性、易于向黏膜侧向扩散为特征。与普通分化型腺癌（CDAs）相比,CRA患者相对年轻[（57.3±9.7）岁vs（66.2±7.9）岁],肿瘤较大，与周围非肿瘤性黏膜缺乏对比，边界不清，ESD不易完全切除。

关键词：早期胃癌细胞异型性 CRA

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Tetramic acid-motif natural products from a marine fungus Tolypocladium cylindrosporum FB06 and their anti-Parkinson activities

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Marine Life Science & Technology 2024年第1期6卷 84-92页

作者： yuna Jung Chaesun Kwon Taeyeon Kim Jin woo Lee Min-Kyoo Shin Sang hee Shim Natural Products Research Institute College of PharmacySeoul National UniversitySeoul 08826Republic of Korea College of Pharmacy and Research Institute of Pharmaceutical Sciences Seoul National UniversitySeoul 08826Republic of Korea College of Pharmacy Duksung Women’s UniversitySeoul 01369Republic of Korea

Tetramic acid-containing natural products are attracting significantly increasing attention from biologists and chemists due to their intriguing structures and biological *** the present study,two new tetramic acid alkaloids tolypyridone I(1)and tolypyridone J(2),together with five known ones(3–7),were isolated from cultures of a marine fungus Tolypocladium cylindrosporum FB06 isolate obtained from a marine sediment in Beaufort sea of North *** structures were elucidated using 1D,2D NMR,and *** configurations were established on the basis of 1h coupling constants,ROESy correlations and DP4 *** 2 was isolated as mixtures of rotational isomers with C-3 to C-7 axis between 4-hydroxy-2-pyridone and 1-ethyl-3,5-dimethylcyclohexane,hindering *** our unbiased screening to discover neuroprotective compounds in an in vitro Parkinson’s disease(PD)model,Sh-Sy5y dopaminergic cells were treated with isolated compounds followed by treatment with 1-methyl-4-phenylpyridinium(MPP^(+)),a parkinsonian *** tested compounds,F-14329(7)significantly protected cells from MPP^(+)-induced ***^(+)-mediated cell death is known to be related to the regulation of Bcl-2 family proteins,specifically the down-regulation of anti-apoptotic Bcl-2 and the up-regulation of pro-apoptotic Bax *** with 2 mmol/L of MPP^(+)for 24 h significantly reduced Bcl-2 levels compared to control treated with ***,treatment with F-14329(7)attenuated such *** study demonstrates that tetramic acid-motif compounds could be potential lead compounds for treating PD.

关键词： Tolypocladium cylindrosporum Tetramic acid Tolypyridone Parkinson’s disease

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Applying heteroatom co-doped carbon nanotube for manifesting high performance in the electrochemical reduction of aqueous nitrogen oxide by gold nanoparticles

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Nano Research 2024年第3期17卷 1151-1164页

作者： Jane Chung haibo yin Rong Wang yunlong Wang Junyang Zhang yue Peng Joung woo han Seongyun Ryu Junhua Li State Key Joint Laboratory of Environment Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing 100084China EhS Research Center Samsung Electronics Co.Ltd.Gyeonggi-do 18448Republic of Korea

Electrochemical NO-to-Nh_(3) under ambient conditions could be a viable alternative having advantages in terms of energy consumption and exhaust gas recycling of NO,replacing a traditional ammonia synthesis method of the haber–Bosch *** synthesizing boron(B-)and nitrogen(N-)co-doped carbon nanotube(CNT)based gold(Au)catalysts,B-dopants elevate the conductivity of carbon nanotube by sp2 hybridization on graphene and implant B–N domains within the graphene layer,and result in facilitating the embedding amount of Au accompanied by high dispersibility with low particle *** density functional theory(DFT)calculations elucidate that the electron cloud transmitted from B-dopant to the active site of Au induces the Lewis acidic site,and the O-distal pathway occurs following a spontaneous *** of the electron-deficient B-doping area accompanied by N-defects and B–O edges retains the major valence state of Au as Au^(δ+),and suppresses hydrogen evolution reaction(hER)by repulsing the hindrance of h*.This record exhibits the highest faradaic efficiency(FE)of 94.7%,and Nh_(3) yield rate of 1877.4μg·h^(-1)·mg_(cat)^(-1),which is the optimal yield over energy consumption in the field of the ambient reduction of aqueous NO.

关键词： boron heteroatom nitrogen defect gold nanoparticles valence states of gold electrochemical NO-to-Nh3

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Semicrystalline Unfused Polymer Donors with Backbone halogenation toward Cost-Effective Organic Solar Cells

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Chinese Journal of Chemistry 2024年第7期42卷 752-759页

作者： yuxin Kong Shijie Ju hongmei Qin Min hun Jee Simeng Xia Jiaqi Ren Chao Gao Jianyu yuan Wenyan Su han young woo yuxiang Li School of Materials Science and Engineering Xi'an University of Science and TechnologyXianShaanxi 710054China Department of Chemistry Korea UniversitySeoul 02841Republic of Korea Xi'an Key Laboratory of Liquid Crystal and Organic Photovoltaic Materials State Key Laboratory of Fluorine&Nitrogen ChemicalsXi'an Modern Chemistry Research InstituteXi'anShaanxi 710065China Jiangsu Key Laboratory for Carbon-Based Functional Materials&Devices Institute of Functional Nano&Soft Materials(FUNSOM)Soochow University199 Ren'ai RoadSuzhouJiangsu 215123China

Developing novel unfused building blocks with simple synthesis and low cost is essential to advance and enrich cost-effective poly-mer donors;however,it remains a challenge due to the lack of efficient molecular ***,a class of low-cost and fully unfused polymer donors with precisely regulated backbone planarity via halogenation was designed and synthesized,namely PDTBTBz-2h,PDTBTBz-2F,and *** polymer donors possess a four-step synthesis route with over 80%yield from cheap raw chemicals comparable to existing low-cost polymer donors,such as *** from the planar backbone via in-corporating the F…S non-covalent interactions,PDTBTBz-2F exhibits more robust J-type aggregation in solution and a long-ranged molecular stacking in film relative to PDTBTBz-2h and ***,the systematical study of PDTBTBz-based organic so-lar cells(OSCs)reveals the close relationship between optimized molecular self-assembly and charge separation/transport regarding backbone halogenation when paired with the non-fullerene acceptor(y6-BO-4F).As a result,the photovoltaic devices based on semicrystalline PDTBTBz-2F achieved a promising power conversion efficiency(PCE)of 12.37%.Our work highlighted the influence of backbone halogenation on the molecular self-assembly properties and a potential unfused backbone motif for further developing cost-effective OSCs.

关键词： Low-cost Polymer donors Backbone halogenation Molecular self-assembly Organic solar cells

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Surface-modified Ag@Ru-P25 for photocatalytic CO_(2) conversion with high selectivity over Ch_(4) formation at the solid–gas interface

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Carbon Energy 2024年第1期6卷 182-196页

作者： Chaitanya B.hiragond Sohag Biswas Niket SPowar Junho Lee Eunhee Gong hwapyong Kim hong Soo Kim Jin-woo Jung Chang-hee Cho Bryan M.Wong Su-Il In Department of Energy Science&Engineering Daegu Gyeongbuk Institute of Science and Technology(DGIST)DaeguRepublic of Korea Department of Chemical&Environmental Engineering Materials Science&Engineering ProgramDepartment of ChemistryDepartment of Physics&AstronomyUniversity of California-RiversideRiversideCaliforniaUSA Department of Physics and Chemistry Daegu Gyeongbuk Institute of Science and Technology(DGIST)DaeguRepublic of Korea NiceScience Corporation DaeguRepublic of Korea

Systematic optimization of the photocatalyst and investigation of the role of each component is important to maximizing catalytic activity and comprehending the photocatalytic conversion of CO_(2) reduction to solar fuels.A surface-modified Ag@Ru-P25 photocatalyst with h_(2)O_(2) treatment was designed in this study to convert CO_(2) and h_(2)O vapor into highly selective *** doping followed by Ag nanoparticles(NPs)cocatalyst deposition on P25(TiO_(2))enhances visible light absorption and charge separation,whereas h_(2)O_(2) treatment modifies the surface of the photocatalyst with hydroxyl(–Oh)groups and promotes CO_(2) ***-resonance transmission electron microscopy,X-ray photoelectron spectroscopy,X-ray absorption near-edge structure,and extended X-ray absorption fine structure techniques were used to analyze the surface and chemical composition of the photocatalyst,while thermogravimetric analysis,CO_(2) adsorption isotherm,and temperature programmed desorption study were performed to examine the significance of h_(2)O_(2) treatment in increasing CO_(2) reduction *** optimized Ag1.0@Ru1.0-P25 photocatalyst performed excellent CO_(2) reduction activity into CO,Ch4,and C2h6 with a~95%selectivity of Ch4,where the activity was~135 times higher than that of pristine TiO_(2)(P25).For the first time,this work explored the effect of h_(2)O_(2) treatment on the photocatalyst that dramatically increases CO_(2) reduction activity.

关键词： gas-phase CO_(2) reduction h_(2)O_(2) treatment plasmonic nanoparticles solar fuel photocatalyst surface modification

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Glucose-mediated mitochondrial reprogramming by cholesterol export at TM4SF5-enriched mitochondria-lysosome contact sites

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Cancer Communications 2024年第1期44卷 47-75页

作者： Ji Eon Kim So-young Park Chulhwan Kwak yoonji Lee Dae-Geun Song Jae woo Jung haesong Lee Eun-Ae Shin yangie Pinanga Kyung-hee Pyo Eun hae Lee Wonsik Kim Soyeon Kim Chang-Duck Jun Jeanho yun Sun Choi hyun-woo Rhee Kwang-hyeon Liu Jung Weon Lee Department of Pharmacy College of PharmacySeoul National UniversitySeoulRepublic of Korea Research Institute of Pharmaceutical Sciences College of PharmacySeoul National UniversitySeoulRepublic of Korea BK21 FOUR Community-Based Intelligent Novel Drug Discovery Education Unit College of Pharmacy and Research Institute of Pharmaceutical SciencesKyungpook National UniversityDaeguRepublic of Korea Department of Chemistry Seoul National UniversitySeoulRepublic of Korea College of Pharmacy Chung-Ang UniversitySeoulRepublic of Korea Natural Product Informatics Research Center Korea Institute of Science and Technology(KIST)Gangneung-siGangwon-doRepublic of Korea School of Life Sciences Gwangju Institute of Science and Technology(GIST)GwangjuRepublic of Korea Department of Biochemistry College of MedicineDong-A UniversityBusanRepublic of Korea Global AI Drug Discovery Center College of Pharmacy and Graduate School of Pharmaceutical SciencesEwha Womans UniversitySeoulRepublic of Korea Interdisciplinary Program in Genetic Engineering Seoul National UniversitySeoulRepublic of Korea

Background:Transmembrane 4 L six family member 5(TM4SF5)translocates subcellularly and functions metabolically,although it is unclear how intracellu-lar TM4SF5 translocation is linked to metabolic *** is thus of interests to understand how the traffic dynamics of TM4SF5 to subcellular endosomal membranes are correlated to regulatory roles of ***:here,we explored the metabolic significance of TM4SF5 localization at mitochondria-lysosome contact sites(MLCSs),using in vitro cells and in vivo animal systems,via approaches by immunofluorescence,proximity labelling based proteomics analysis,organelle reconstitution ***:Upon extracellular glucose repletion following depletion,TM4SF5 became enriched at MLCSs via an interaction between mitochondrial FK506-binding protein 8(FKBP8)and lysosomal *** labeling showed molecular clustering of phospho-dynamic-related protein I(DRP1)and certain mitophagy receptors at TM4SF5-enriched MLCSs,leading to mitochondrial fis-sion and ***4SF5 bound NPC intracellular cholesterol transporter 1(NPC1)and free cholesterol,and mediated export of lysosomal cholesterol to mitochondria,leading to impaired oxidative phosphorylation but intact tri-carboxylic acid(TCA)cycle andβ-*** mouse models,hepatocyte Tm4sf5 promoted mitophagy and cholesterol transport to mitochondria,both with positive relations to liver ***:Our findings suggested that TM4SF5-enriched MLCSs regu-late glucose catabolism by facilitating cholesterol export for mitochondrial reprogramming,presumably while hepatocellular carcinogenesis,recapitulating aspects for hepatocellular carcinoma metabolism with mitochondrial repro-gramming to support biomolecule synthesis in addition to glycolytic energetics.

关键词： cholesterol fluorescent imaging glucose catabolism hepatocellular carcinogenesis mem-brane contact sites mitochondria function mitophagy oxidative phosphorylation protein-protein interaction tetraspanin

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Realizing high Thermoelectric Performance in n-Type Se-Free Bi2Te3 Materials by Spontaneous Incorporation of FeTe2 Nanoinclusions

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Energy & Environmental Materials 2024年第4期7卷 344-354页

作者： Jamil Ur Rahman woo hyun Nam yong-Jae Jung Jong ho Won Jong-Min Oh Nguyen Van Du Gul Rahman Víctor M.García-Suárez Ran he Kornelius Nielsch Jung young Cho Won-Seon Seo Jong wook Roh Sang-il Kim Soonil Lee Kyu hyoung Lee hyun Sik Kim Weon ho Shin Leibniz Institute for Solid State and Materials Research Advanced Materials Convergence R&D Division Korea Institute of Ceramic Engineering & Technology Department of Electronic Materials Engineering Kwangwoon University Department of Energy Engineering Dankook University Faculty of Fundamental Science Phenikaa University Department of Physics Quaid-i-Azam University Departamento de Física Universidad de Oviedo Nanomaterials and Nanotechnology Research Center-CINN Department of Materials Science and Engineering Yonsei University School of Nano & Materials Science and Engineering Kyungpook National University Department of Materials Science and Engineering University of Seoul School of Materials Science and Engineering Changwon National University

Bi2Te3-based materials have drawn much attention from the thermoelectric community due to their excellent thermoelectric performance near room ***,the stability of existing n-type Bi2（Te,Se）3materials is still low due to the evaporation energy of Se (37.70 kJ mol-1) being much lower than that of Te (52.55 kJ mol-1).The evaporated Se from the material causes problems in interconnects of the module while degrading the efficiency.

关键词： Bi2Te3 energy harvesting FeTe2 nanoinclusion n-type materials thermoelectric

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