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Nonalcoholic fatty liver disease is associated with coronary artery disease in Koreans

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World Journal of Gastroenterology 2013年第38期19卷 6453-6457页

作者： Dae Hee Choi Sung Joon lee Chang Don Kang Myoung Ok Park Dong Wook Choi Tae Suk Kim wonho lee Byung Ryul Cho Yong Hoon Kim Bong-ki lee Dong Ryeol Ryu Ji Won lee Department of Internal Medicine Kangwon National University School of Medicine Department of Radiology Kangwon National University School of Medicine

AIM:To investigate whether nonalcoholic fatty liver disease(NAFLD)affects coronary artery disease(CAD)and identify candidate ***:Patients who underwent coronary angiography were consecutively *** patients were classified into four groups by coronary artery stenosis:A,insignificant;B,one-vessel disease;C,two-vessel disease;and D,three-vessel *** ultrasonography was performed to determine the presence of a fatty liver and categorize by grade:0,no evidence;1,mild;2,moderate;and 3,*** measured not only known CAD risk factors,but also serum insulin,HOMA-index,adiponectin,interleukin-6,tumor necrosis factor-αand high-sensitivity C-reactive protein ***:Of the 134 patients who met the inclusion criteria,82(61.2%)had ultrasonographically diagnosed *** the 46 patients with CAD,37(80.4%)had evidence of a fatty *** two groups(A vs B-D)were significantly different in terms of age,total cholesterol,triglycerides,low-density lipoprotein levels and fatty *** artery stenosis was strongly associated with fatty liver in a grade-dependent manner(P=0.025).In binary logistic regression,NAFLD was a significant independent predictor of CAD(P=0.03,OR=1.685;95%CI:1.051-2.702).Among the candidate mediators,the serum adiponectin level showed a trend toward lowering based on CAD progression(P=0.071).CONCLUSION:NAFLD is an independent risk factor for CAD in a grade-dependent ***,adiponectin might be related to the pathogenesis of NAFLD.

关键词： Nonalcoholic fatty liver disease Coronary artery disease Coronary angiography Adiponectin Insulin resistance

High-performance 110 kVp hard x-ray detector based on all-crystalline-surface passivated perovskite single crystals

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InfoMat 2024年第8期6卷 97-110页

作者： Juyoung Ko Beomjun Park Jangwon Byun Sandeep Pandey Ajin Jo Joo-Hong lee wonho lee Jin-Wook lee Nam-Gyu Park Man-Jong lee Department of Chemistry Konkuk UniversitySeoulRepublic of Korea Advanced Crystal Material/Device Research Center Konkuk UniversitySeoulRepublic of Korea Health Science Research Center Korea UniversitySeoulRepublic of Korea Department of Nano Engineering and Department of Nano Science and Technology SKKU Advanced Institute of Nanotechnology(SAINT)Sungkyunkwan UniversitySuwonRepublic of Korea SKKU Institute of Energy Science&Technology(SIEST) Sungkyunkwan UniversitySuwonRepublic of Korea Department of Health and Environmental Science Korea UniversitySeoulRepublic of Korea School of Chemical Engineering Center for Antibonding Regulated CrystalsSungkyunkwan UniversitySuwonRepublic of Korea

Halide perovskite single crystals(SCs)have attracted much attention for their application in high-performance x-ray detectors owing to their desirable properties,including low defect density,high mobility–lifetime product(μτ),and long carrier diffusion ***,suppressing the inherent defects in perovskites and overcoming the ion migration primarily caused by these defects remains a *** study proposes a facile process for dipping Cs0.05FA0.9MA0.05PbI3 SCs synthesized by a solution-based inverse temperature crystallization method into a 2-phenylethylammonium iodide(PEAI)solution to reduce the number of defects,inhibit ion migration,and increase x-ray *** to conventional spin coating,this simple dipping process forms a two-dimensional PEA2PbI4 layer on all SC surfaces without further treatment,effectively passivating all surfaces of the inherently defective SCs and minimizing ion *** a result,the PEAI-treated perovskite SC-based x-ray detector achieves a record x-ray sensitivity of 1.3×10^(5)μC Gyair^(-1) cm^(-2) with a bias voltage of 30 V at realistic clinical dose rates of 1–5 mGy s^(-1)(peak potential of 110 kVp),which is 6 times more sensitive than an untreated SC-based detector and 3 orders of magnitude more sensitive than a commercialα-Se-based ***,the PEAI-treatedperovskite SC-based x-ray detector exhibits a low detection limit(73 nGy s^(-1)),improved x-ray response,and clear x-ray images by a scanning method,highlighting the effectiveness of the PEAI dipping approach for fabricating next-generation x-ray detectors.

关键词： 2D PEA2PbI4 layers clinical dose rates perovskite single crystals phenethylammonium iodide(PEAI) surface passivation x-ray sensitivity

Capillary grip-induced stick-slip motion

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Nano Research 2022年第8期15卷 7384-7391页

作者： Sangmin An Manhee lee Bongsu Kim wonho Jhe Department of Physics&Astronomy Seoul National UniversitySeoul 08826Republic of Korea Department of Physics Institute of Photonics and Information TechnologyJeonbuk National UniversityJeonju 54896Republic of Korea Department of Physics Chungbuk National UniversityCheongjuChungbuk 28644Republic of Korea Samsung Advanced Institute of Technology(SAIT) Samsung ElectronicsSuwon 16678Republic of Korea

We present capillary grip-induced stick-slip motion,a nanoscale tribological effect,where the role of a nanoscale confined water meniscus formed between a buckled sharp tip and a glass or mica surface is addressed by shear dynamic force *** obtained the effective elasticity,viscosity,conservative(elastic)and non-conservative(viscous)forces,energy dissipation,and lateral force using small oscillation,amplitude-modulation,and shear-mode quartz tuning fork-atomic force microscopy(QTFAFM).We distinguished the conservative and non-conservative forces by investigating the dependence of normal load and relative humidity,slip length,and stick-slip *** found that the confined nanoscale water enhances the lateral forces via capillary grip-induced stick-slip on a rough surface,resulting in an increase of static lateral force(3-fold for both substrates)and kinetic lateral force(6-fold for glass,3-fold for mica).This work provides quantitative and systematic understanding of nanoscale tribology properties in humid ambient conditions and is thus useful for control of friction as well as characterization of tribology in nanomaterials and nanodevices.

关键词： dynamic force measurement nanoscale water meniscus relative humidity lateral force stick-slip motion

Fabrication and Characterization of Au Nanoparticle-aggregated Nanowires by Using Nanomeniscus-induced Colloidal Stacking Method

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Nano-Micro Letters 2015年第1期7卷 27-34页

作者： Sangmin An wonho Jhe Department of Physics and Astronomy Institute of Applied Physics Seoul National University Center for Nanoscale Science and Technology National Institute of Standards and Technology

We fabricate and characterize Au nanoparticle-aggregated nanowires by using the nano meniscus-induced colloidal stacking method. The Au nanoparticle solution ejects with guidance of nanopipette/quartz tuning fork-based atomic force microscope in ambient conditions, and the stacking particles form Au nanoparticle-aggregated nanowire while the nozzle retracts from the surface. Their mechanical properties with relatively low elastic modulus are in situ investigated by using the same apparatus.

关键词： Au nanoparticle-aggregated nanowire Nanomeniscus-induced colloidal stacking method Atomic force microscope Liquid–solid coexistence phase

Position-resolved Surface Characterization and Nanofabrication Using an Optical Microscope Combined with a Nanopipette/Quartz Tuning Fork Atomic Force Microscope

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Nano-Micro Letters 2014年第1期6卷 70-79页

作者： Sangmin An Baekman Sung Haneol Noh Corey Stambaugh Soyoung Kwon Kunyoung lee Bongsu Kim Qhwan Kim wonho Jhe Center for Nano-Liquid Department of Physics and AstronomySeoul National University National Institute of Standards and Technology

In this work, we introduce position-resolved surface characterization and nanofabrication using an optical microscope(OM) combined with a nanopipette-based quartz tuning fork atomic force microscope(nanopipette/QTF-AFM) system. This system is used to accurately determine substrate position and nanoscale phenomena under ambient conditions. Solutions consisting of 5 nm Au nanoparticles, nanowires, and polydimethylsiloxane(PDMS) are deposited onto the substrate through the nano/microaperture of a pulled pipette. Nano/microscale patterning is performed using a nanopipette/QTF-AFM, while position is resolved by monitoring the substrate with a custom OM. With this tool, one can perform surface characterization(force spectroscopy/microscopy) using the quartz tuning fork(QTF) sensor. Nanofabrication is achieved by accurately positioning target materials on the surface, and on-demand delivery and patterning of various solutions for molecular architecture.

关键词： Surface characterization Nanopipette QTF-AFM Optical microscope

Sorting Gold and Sand(Silica) Using Atomic Force Microscope-Based Dielectrophoresis

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Nano-Micro Letters 2022年第2期14卷 1-11页

作者： Chungman Kim Sunghoon Hong Dongha Shin Sangmin An Xingcai Zhang wonho Jhe Department of Physics and Astronomy Seoul National UniversitySeoul 08826Republic of Korea John A.Paulson School of Engineering and Applied Sciences Harvard UniversityCambridgeMA 02138United States Department of Chemistry and Chemical Engineering Inha UniversityIncheon 22212Republic of Korea Department of Physics Institute of Photonics and Information TechnologyJeonbuk National UniversityJeonju 54896Korea School of Engineering Massachusetts Institute of TechnologyCambridgeMA 02139United States

Additive manufacturing-also known as 3D printing-has attracted much attention in recent years as a powerful method for the simple and versatile fabrication of complicated three-dimensional ***,the current technology still exhibits a limitation in realizing the selective deposition and sorting of various materials contained in the same reservoir,which can contribute significantly to additive printing or manufacturing by enabling simultaneous sorting and deposition of different substances through a single ***,we propose a dielectrophoresis(DEP)-based material-selective deposition and sorting technique using a pipette-based quartz tuning fork(QTF)-atomic force microscope(AFM) platform DEPQA and demonstrate multi-material sorting through a single nozzle in ambient *** used Au and silica nanoparticles for sorting and obtained 95% accuracy for spatial separation,which confirmed the surfaceenhanced Raman spectroscopy(SERS).To validate the scheme,we also performed a simulation for the system and found qualitative agreement with the experimental *** method that combines DEP,pipette-based AFM,and SERS may widely expand the unique capabilities of 3D printing and nano-micro patterning for multi-material patterning,materials sorting,and diverse advanced applications.

关键词： Dielectrophoresis-empowered Pipette/AFM platform On-demand materials sorting Additive 3D printing Multimaterial nano-patterning Nanopipette-based atomic force microscope

Dual‑Atom Nanozyme Eye Drops Attenuate Inflammation and Break the Vicious Cycle in Dry Eye Disease

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Nano-Micro Letters 2024年第6期16卷 439-457页

作者： Dandan Chu Mengyang Zhao Shisong Rong wonho Jhe Xiaolu Cai Yi Xiao Wei Zhang Xingchen Geng Zhanrong Li Xingcai Zhang Jingguo Li Henan Eye Hospital Henan Provincial People’s HospitalPeople’s Hospital of Zhengzhou UniversityZhengzhou 450003People’s Republic of China Department of Ophthalmology Mass Eye and EarMass General BrighamHarvard Medical SchoolBostonMA 02114USA School of Engineering and Applied Sciences Harvard UniversityCambridgeMA 02138USA College of Chemistry Zhengzhou UniversityZhengzhou 450001People’s Republic of China

Dry eye disease(DED)is a major ocular pathology worldwide,causing serious ocular discomfort and even visual *** incidence of DED is gradually increasing with the highfrequency use of electronic *** inflammation is core cause of the DED vicious cycle,reactive oxygen species(ROS)play a pivotal role in the vicious cycle by regulating inflammation from ***,current therapies merely targeting inflammation show the failure of DED ***,a novel dual-atom nanozymes(DAN)-based eye drops are *** antioxidative DAN is successfully prepared by embedding Fe and Mn bimetallic single-atoms in N-doped carbon material and modifying it with a hydrophilic *** in vitro and in vivo results demonstrate the DAN is endowed with superior biological activity in scavenging excessive ROS,inhibiting NLRP3 inflammasome activation,decreasing proinflammatory cytokines expression,and suppressing cell ***,the DAN effectively alleviate ocular inflammation,promote corneal epithelial repair,recover goblet cell density and tear secretion,thus breaking the DED vicious *** findings open an avenue to make the DAN as an intervention form to DED and ROSmediated inflammatory diseases.

关键词： Dry eye disease DAN Dual-atom nanozyme Vicious cycle NLRP3 inflammasome Nanomedicine

Self Consistent Calibration of Detectors and Sources for Hard and Soft X-Ray Diagnostics

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Modern Instrumentation 2014年第3期3卷 13-23页

作者： Danilo Pacella Afra Romano Seung Hun lee Federica Causa Lori Gabellieri wonho Choe ENEA Unità Tecnica Fusione Rome Italy Korea Advanced Institute of Science and Technology Daejeon Korea

X-Ray sources, detectors and optical components are now used in a wide range of applications. What is crucial is the absolute calibration of such devices to permit a quantitative assessment of the system under study. A new X-ray laboratory has been built in Frascati (ENEA) to develop diagnostics for nuclear fusion experiments and study applications of these X-ray techniques in other domains, like new material science, non destructive tests and so on. An in-house developed selfconsistent calibration procedure is described that permits the absolute calibration of sources (X-ray emitted fluxes) and detectors (detection efficiencies) as function of the X-ray photon energy, in the range 2 - 120 keV. The calibration procedure involves the use of an in-house developed code that also predicts the spectral response of any detector in any experimental condition that can be setup in the laboratory. The procedure has been then applied for the calibration and characterisation of gas and solid state imaging detectors, such as Medipix-2, GEM gas detector, CCD camera, Cd-Te C-MOS imager, demonstrating the versatility of the method developed here.

关键词： X-Ray Detector X-Ray Source Absolute Calibration Plasma Physics Diagnostics

乳液法制备有机粘土/白炭黑/丁苯橡胶纳米复合材料的微观结构和动态力学性能

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轮胎工业 2013年第10期33卷 613-617页

作者： Wook-Soo Kim Suk Hee Jang Yong Gu Kang Min Hyun Han Kyu Hyun wonho Kim 肖大玲 Research and Development Division NEXEN TIRE Corporation Department of Chemical Engineering Pusan National UniversitySan 30Jangjeon-Dong 本刊编辑部

由于欧盟标签法的强制实施及高昂的油价，导致许多研究致力于提高轮胎的燃油经济性。众所周知，如果轮胎的滚动阻力下降10％，那么燃油经济性可提高1％～2％。轮胎由胎面、胎侧、钢丝圈、内衬层和胎体组成，1条轮胎约50％的滚动阻力受... 详细信息

由于欧盟标签法的强制实施及高昂的油价，导致许多研究致力于提高轮胎的燃油经济性。众所周知，如果轮胎的滚动阻力下降10％，那么燃油经济性可提高1％～2％。轮胎由胎面、胎侧、钢丝圈、内衬层和胎体组成，1条轮胎约50％的滚动阻力受胎面影响。

关键词：橡胶纳米复合材料动态力学性能微观结构有机粘土白炭黑乳液法燃油经济性丁苯