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Synthesis and structural characterization of lanthanide coordination polymers constructed from a 13-membered macrocycle

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Chinese Science Bulletin 2007年第4期52卷 467-470页

作者： YAO YingMing SHEN Qi wong wing tak Department of Chemistry and Chemical Engineering Dushu Lake Campus Suzhou University Suzhou 215123 China Department of Chemistry The University of Hong Kong Polkfulam Road Hong Kong China

The lanthanide coordination polymers bearing a 13-membered macrocycle, [(13-EDTA-pnOH)H2] were synthesized. The products [Ln(13-EDTA-pnOH)(H2O)2·NO3]n (Ln = Eu(1), Tb(2), Dy(3)) have been obtained by MS, IR and element analyses. The solid-state structure of 1 was established by single-crystal X-ray analysis. The coordination geometry around the central metal atom in complex 1 is a nine-coor-dinated, tricapped-trigonal prism having six donor atoms (two amine nitrogen atoms, two amide oxygen atoms and two carboxymethyl oxygen atoms) from one ligand, one oxygen atom from a neighboring ligand, and two more oxygen atoms from two water molecules. The europium atoms are linked by―Eu―O―C―O―Eu―bridges to form an infinite chain.

关键词：镧系元素复合物配位聚合物官能化大环合成结构表征

多联吡啶钴(Ⅱ)、锰(Ⅱ)配合物的合成及结构

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高等学校化学学报 2000年第1期21卷 5-9页

作者：尹业高张恭启黄永德荆州师范学院化学系荆州434100 香港大学化学系

报道了 3个取代多联吡啶配体 [4-苯基 -2 ,2′∶ 6′,2″-三联吡啶 ( L1) ,4′,4″-二苯基 -2 ,2′∶ 6′,2″∶ 6″,2 -四联吡啶 ( L2 )和 4′,4 -二苯基 -2 ,2′∶ 6′,2″∶ 6″,2 ∶ 6 ,2″″-五联吡啶 ( L3 ) ]的 4个过渡金属配... 详细信息

报道了 3个取代多联吡啶配体 [4-苯基 -2 ,2′∶ 6′,2″-三联吡啶 ( L1) ,4′,4″-二苯基 -2 ,2′∶ 6′,2″∶ 6″,2 -四联吡啶 ( L2 )和 4′,4 -二苯基 -2 ,2′∶ 6′,2″∶ 6″,2 ∶ 6 ,2″″-五联吡啶 ( L3 ) ]的 4个过渡金属配合物[Co( ) ( L 1) 2 ] ( Cl O4) 2 ( CH3 CN) ( 1) ,[Co( ) ( L 2 ) ( Ac O) ( H2 O) ] ( Cl O4) ( 2 ) ,[Mn( ) ( Ac O) ( L 2 ) ( H2 O) ] .( Cl O4) ( 3 ) ,[Co( ) ( L 3 ) ( CH3 CN) ] ( Cl O4) 2 ( 4 ) ]的合成及其晶体结构 .结构分析表明 ,金属离子对配合物的形成有诱导作用 .

关键词：多联吡啶诱导作用钴锰金属有机配合物合成

Effects of ginsenosides on vascular reactivity in rat cerebral and renal arteries

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Effects of ginsenosides on vascular reactivity in rat cerebr...

两岸三地药理学与临床药理学术会议

作者： wong wing-tak LEUNG Fung-ping YUNG Lai-hang wong Ricky Ngok Shun Department of Physiology Chinese University of Hong Kong Department of Biology Hong Kong Baptist University

Objective To investigate possible mechanisms underlying the antioxidant property(1)and the in vitro vasodilator effects(2)of the two ginsenosides,Rb1 and Rg1,in isolated rat renal and cerebral arter- *** Arterial rings were mounted in a multi-channel myograph for recording of isometric *** examine the antioxidant activity,some rings were exposed to a free radical-generating reaction(hypoxan- thine and xanthine oxidase)with and without pre-treatment with *** calcium antagonistic ef- fects were tested on rings contracted by membrane depolarization in elevated extracellular potassium ions,a condition that promoted Cainflux in vascular smooth muscle *** Ginsenosides protected en- dothelial function(endothelial nitric oxide-dependent relaxation)against oxidative stress;(2)ginsenoside Rbl reduced the high K+-induced contractions of both renal and cerebral arteries while ginsenoside Rgl re- laxed the rat cerebral artery but not the renal *** Ginsenosides are vaso-protective via(1) the antioxidant activity which protects endothelial cell function and(2)the inhibition of Ca2+influx through voltage-sensitive Cachannels in vascular smooth *** vasodilator effects may suggest the potential preventive or therapeutic values of ginsenosides against stroke and renal hypertension.

关键词： ginsenosides endothelial cells relaxation

来源： cnki会议评论

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二茂金属共轭大环配体配合物的结构及性质

化学学报 1999年第1期57卷 93-99页

作者：尹业高张恭启黄永德荆州师范高等专科学校化学系荆州434100 香港大学化学系

报道了配体N-(二茂铁基甲基)-1,4,7-氮杂-9-冠-3(L1)和N-(二茂钌基甲基)-1,4,7-氮杂-9-冠-3(L2)的Co(Ⅲ)和Fe(Ⅲ)配合物1～4的合成及电化学性质.配合物[Co(Ⅲ)_2(L1)_2(AcO)_2(OH)](ClO_4)(Ⅰ)_2(1)的晶体结构显示这些配合物具有线型排列的四金属中心结构.电化学研究表明:在这些配合物中,客体金属离子通过分子片断的电子传递作用使二茂金属的金属中心的氧化电位发生正移动.同时,不同二茂金属的取代效应也使相同客体金属离子的氧化电位不同.在两个二茂金属之间由于被大环1,4,7-氮杂-9-冠-3(tacn)和客体金属离子M^(3+)构成的配位部分所分隔没有相互作用,而由μ-AcO^-和μ-OH^-所桥联的两个客体金属离子之间却存在着相互耦合,以致在电化学循环过程中观察到了混合价电化学产物的存在.

关键词：主客体电化学二茂铁二茂钌钴铁配合物

Effects of ginsenosides on vascular reactivity in rat cerebral and renal arteries

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沈阳药科大学学报 2008年第S1期25卷 2-2页

作者： wong wing-tak LEUNG Fung-ping wong Ricky Ngok Shun Department of Physiology Chinese University of Hong Kong Department of Biology Hong Kong Baptist University

Objective To investigate possible mechanisms underlying the antioxidant property(1)and the in vitro vasodilator effects(2)of the two ginsenosides,Rb1 and Rg1,in isolated rat renal and cerebral *** Arterial rings were mounted in a multi-channel myograph for recording of isometric *** examine the antioxidant activity,some rings were exposed to a free radical-generating reaction(hypoxanthine and xanthine oxidase)with and without pre-treatment with *** calcium antagonistic effects were tested on rings contracted by membrane depolarization in elevated extracellular potassium ions,a condition that promoted Ca2+ influx in vascular smooth muscle *** Ginsenosides protected endothelial function(endothelial nitric oxide-dependent relaxation)against oxidative stress;(2)ginsenoside Rb1 reduced the high K+-induced contractions of both renal and cerebral arteries while ginsenoside Rg1 relaxed the rat cerebral artery but not the renal *** Ginsenosides are vaso-protective via(1)the antioxidant activity which protects endothelial cell function and(2)the inhibition of Ca2+ influx through voltage-sensitive Ca2+ channels in vascular smooth *** vasodilator effects may suggest the potential preventive or therapeutic values of ginsenosides against stroke and renal hypertension.

关键词： ginsenosides endothelial cells relaxation

Ligand-Metal Interaction in Transition-Metal Complexes with Tripodal Polyaza Ligands

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Wuhan University Journal of Natural Sciences 1999年第4期4卷 477-481页

作者： YIN Ye gao Department of Chemistry, Jingzhou Teachers College, Jingzhou City, Hubei 434100 HUANG Zu yun  College of Chemistry and Environmental Science , Wuhan University, Wuhan 430072 CHEUNG Kung kai, wong wing tak Department of Chemistry Department of Chemistry Jingzhou Teachers College Jingzhou City Hubei College of Chemistry and Environmental Science Wuhan University Wuhan Department of Chemistry The University of Hong Kong H. K.

Five complexes ([Cu(tpc)] 2+ 1, [Cu(tpa)] 2+ 2, [Co(tpa)] 2+ 3, [Fe(tpa)] 2+ 4 and [Mn(tpa)] 2+ 5) (tpc = N, N', N' tris[(2 pyridyl)methyl] 1,4,7 triaza cyclononane(L1) and tpa = tris... 详细信息

Five complexes ([Cu(tpc)] 2+ 1, [Cu(tpa)] 2+ 2, [Co(tpa)] 2+ 3, [Fe(tpa)] 2+ 4 and [Mn(tpa)] 2+ 5) (tpc = N, N', N' tris[(2 pyridyl)methyl] 1,4,7 triaza cyclononane(L1) and tpa = tris[2 ((2 pyridyl)methyl imino)ethyl]amine(L2)) were synthesized and characterized. The crystal structures of 1, 3 and 4 were determined by X ray crystallography. Electrochemical investigations over two cupric complexes reveal that 2 has a less negative redox potential than that of 1. Electronic spectra of 2, 3, 4 and 5 show that the distinction in metal ion results in a shift of the ligand based π*←π transition.

关键词： Tripodal ploydentate ligands Transition metal Electrochemistry Electron spectra Interaction

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二茂钌共轭大环氮杂冠醚的合成及结构

高等学校化学学报 1999年第12期20卷 1838-1841页

作者：尹业高易长海张恭启黄永德荆州师范学院化学系荆州434100 香港大学化学系

合成并表征了质子化的 N - (二茂钌基甲基 ) - 1,4 ,7-三氮杂 - 9-冠 - 3(1)和 N ,N′,N″-三 - (二茂钌基甲基 ) - 1,4 ,7-三氮杂 - 9-冠 - 3(2 ) .用 X射线衍射法测定了化合物 2的结构 .化合物 2的晶体属 P2 1/ a空间群 .晶胞参数 a=1... 详细信息

合成并表征了质子化的 N - (二茂钌基甲基 ) - 1,4 ,7-三氮杂 - 9-冠 - 3(1)和 N ,N′,N″-三 - (二茂钌基甲基 ) - 1,4 ,7-三氮杂 - 9-冠 - 3(2 ) .用 X射线衍射法测定了化合物 2的结构 .化合物 2的晶体属 P2 1/ a空间群 .晶胞参数 a=1.4 2 85(3) nm,b=1.9888(3) nm,c=1.9133(3) nm;β=10 9.12 (2 )°;V=5.1358(1.0 ) nm3 ;Z=4 .Dc=1.6 6 5g/ cm3 . 1和 2的核磁共振谱表明 ,化合物中取代 Cp环上质子的共振吸收较二茂钌 Cp环上质子的吸收向低场移动 .这表明质子化的 1,4 ,7-三氮杂 - 9冠 - 3对 Cp环上质子具有去屏蔽作用 .化合物 2的电位扫描曲线在 0 .84

关键词：二茂钌核磁共振氮杂冠醚钌金属中心配合物

具有不同类型桥基的双核Cu(Ⅱ)-Schiff碱配合物的合成和晶体结构

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高等学校化学学报 1998年第10期19卷 1546-1550页

作者：尹业高张恭启黄永德荆州师范专科学校化学系香港大学化学系

合成了３个分别以Ｃ２Ｏ２－４（［Ｃｕ２（Ｌ１）２（ｏｘ）］，１），ＡｃＯ－（［Ｃｕ２（ＡｃＯ）（Ｌ２）２］ＢＦ４，２）和酚氧（［Ｃｕ２（Ｌ３）２］（ＣｌＯ４）２，３）为桥基的双核铜配合物，并测定了１的复配合物［Ｃｕ２... 详细信息

合成了３个分别以Ｃ２Ｏ２－４（［Ｃｕ２（Ｌ１）２（ｏｘ）］，１），ＡｃＯ－（［Ｃｕ２（ＡｃＯ）（Ｌ２）２］ＢＦ４，２）和酚氧（［Ｃｕ２（Ｌ３）２］（ＣｌＯ４）２，３）为桥基的双核铜配合物，并测定了１的复配合物［Ｃｕ２（Ｌ１）２（ｏｘ）］·［Ｆｅ（ＯＨ）２（Ｈ２Ｏ）４］ＣｌＯ４·Ｈ２Ｏ（１′）及２和３的晶体结构．Ｘ射线衍射结果表明：１′，２和３分别属于Ｆｄｄｄ，Ｐ２１／ｃ和Ｐ２１／ｃ空间群．晶胞参数：［Ｃｕ２（Ｌ１）２（ｏｘ）］［Ｆｅ（ＯＨ）２（Ｈ２Ｏ）４］ＣｌＯ４·Ｈ２Ｏ，ａ＝２．４３９０（４）ｎｍ，ｂ＝３．０５３８（６）ｎｍ，ｃ＝１．８４９４（６）ｎｍ，α＝β＝γ＝９０．００°；２，ａ＝０．８４７（１）ｎｍ，ｂ＝２．６５４２（８）ｎｍ，ｃ＝１．４１００（６）ｎｍ，β＝９１．３４（６）°；３，ａ＝０．７６４６（３）ｎｍ，ｂ＝１．６９８３（３）ｎｍ，ｃ＝２．４４１７（３）ｎｍ，β＝９７．

关键词：双核铜配合物晶体结构席夫碱三齿

Crosstalk between degradation and bioenergetics: how autophagy and endolysosomal processes regulate energy production

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Neural Regeneration Research 2025年第3期20卷 671-681页

作者： Angelid Pabon Jagannatham Naidu Bhupana Ching-On wong Department of Biological Sciences Rutgers UniversityNewarkNJUSA

Cells undergo metabolic reprogramming to adapt to changes in nutrient availability, cellular activity, and transitions in cell states. The balance between glycolysis and mitochondrial respiration is crucial for energy production, and metabolic reprogramming stipulates a shift in such balance to optimize both bioenergetic efficiency and anabolic requirements. Failure in switching bioenergetic dependence can lead to maladaptation and pathogenesis. While cellular degradation is known to recycle precursor molecules for anabolism, its potential role in regulating energy production remains less explored. The bioenergetic switch between glycolysis and mitochondrial respiration involves transcription factors and organelle homeostasis, which are both regulated by the cellular degradation pathways. A growing body of studies has demonstrated that both stem cells and differentiated cells exhibit bioenergetic switch upon perturbations of autophagic activity or endolysosomal processes. Here, we highlighted the current understanding of the interplay between degradation processes, specifically autophagy and endolysosomes, transcription factors, endolysosomal signaling, and mitochondrial homeostasis in shaping cellular bioenergetics. This review aims to summarize the relationship between degradation processes and bioenergetics, providing a foundation for future research to unveil deeper mechanistic insights into bioenergetic regulation.

关键词： autophagy bioenergetics endolysosome energy production glycolysis metabolic reprogramming mitochondria