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Genomic data and ecological niche modeling reveal an unusually slow rate of molecular evolution in the Cretaceous Eupteleaceae

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Science China(Life Sciences) 2024年第4期67卷 803-816页

作者： Kun-Li Xiang Sheng-Dan Wu Lian Lian Wen-Chuang He Dan peng Huan-Wen peng Xiao-Ni Zhang hong-Lei Li Jia-Yu Xue hong-Yan Shan Gui-Xia Xu Yang Liu Zhi-Qiang Wu Wei Wang State Key Laboratory of Plant Diversity and Specialty Crops Institute of BotanyChinese Academy of SciencesBeijing 100093China Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureKey Laboratory of Synthetic BiologyLaboratory of the Ministry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518120China China National Botanical Garden Beijing 100093China State Key Laboratory of Grassland Agro-Ecosystems and College of Ecology Lanzhou UniversityLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China College of Landscape Architecture and Life Science/Institute of Special Plants Chongqing University of Arts and SciencesChongqing 402160China College of Horticulture Academy for Advanced Interdisciplinary StudiesNanjing Agricultural UniversityNanjing 210095China Fairylake Botanical Garden Shenzhen&Chinese Academy of SciencesShenzhen 518004China

Living fossils are evidence of long-term sustained ecological ***,whether living fossils have little molecular changes remains poorly known,particularly in ***,we have introduced a novel method that integrates phylogenomic,comparative genomic,and ecological niche modeling analyses to investigate the rate of molecular evolution of Eupteleaceae,a Cretaceous relict angiosperm family endemic to East *** assembled a high-quality chromosome-level nuclear genome,and the chloroplast and mitochondrial genomes of a member of Eupteleaceae(Euptelea pleiosperma).Our results show that Eupteleaceae is most basal in Ranunculales,the earliest-diverging order in eudicots,and shares an ancient whole-genome duplication event with the other *** document that Eupteleaceae has the slowest rate of molecular changes in the observed *** unusually low rate of molecular evolution of Eupteleaceae across all three independent inherited genomes and genes within each of the three genomes is in association with its conserved genome architecture,ancestral woody habit,and conserved niche *** findings reveal the evolution and adaptation of living fossil plants through large-scale environmental change and also provide new insights into early eudicot diversification.

关键词： conservation genomics eudicots evolutionary rates niche conservatism phylogenomics

Chemical biology investigation of a triple-action,smart-decomposition antimicrobial booster based-combination therapy against“ESKAPE”pathogens

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Science China Chemistry 2024年第9期67卷 3071-3082页

作者： Min Wang Huangsheng Pu Yangfan Xu Chenxuan Wu Yuanxin Gu Qingyun Cai Guoxing Yin peng Yin Chunhui Zhang Wing-Leung wong Muyang Wan Yugang Bai Xinxin Feng State Key Laboratory of Chem-/Bio-Sensing and Chemometrics Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biologyand School of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China College of Biology Hunan UniversityChangsha 410082China College of Advanced Interdisciplinary Studies&Hunan Provincial Key Laboratory of Novel Nano Optoelectronic Information Materials and Devices National University of Defense TechnologyChangsha 410073China Nanhu Laser Laboratory National University of Defense TechnologyChangsha 410073China Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research(Ministry of Education) College of Chemistry and Chemical EngineeringHunan Normal UniversityChangsha 410081China State Key Laboratory of Chemical Biology and Drug Discovery Department of Applied Biology and Chemical TechnologyThe Hong Kong Polytechnic UniversityHong Kong SAR 999077China Hunan Provincial Key Laboratory of Anti-Resistance Microbial Drugs The Third Hospital of Changsha(The Affiliated Changsha Hospital of Hunan University)Changsha 410015China

The global antibiotic resistance crisis necessitates urgent *** innovative approach involves potentiating antibiotics and non-antibiotic drugs with adjuvants or boosters.A major drawback of these membrane-active boosters is their limited biocompatibility,as they struggle to differentiate between prokaryotic and eukaryotic *** study reports the chemical biology investigation of a dual-action oligoamidine(OA1)booster with a glutathione-triggered decomposition ***1,when combined with other antimicrobial molecules,exhibits a triple-targeting mechanism including cell membrane disruption,DNA targeting,and intracellular enzyme *** multi-targeting mechanism not only enhances the in vitro and in vivo eradication of antibiotic-resistant“ESKAPE”pathogens,but also suppresses the development of bacterial ***,OA1 maintains its activity in bacterial cells by creating an oxidative environment,while it quickly decomposes in mammalian cells due to high glutathione *** mechanistic insights and design principles may provide a feasible approach to develop novel antimicrobial agents and effective anti-resistance combination therapies.

关键词： antimicrobial booster oligoamidine membrane disruption DNA targeting triggered degradation anti-resistance

急性胰腺炎伴肝外門靜脈系統血栓形成1例報告

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镜湖医学 2017年第1期17卷 75-75,29页

作者：黃炳紅朱靜澳門鏡湖醫院腎臟内科中国

急性胰腺炎(Acute pancreatitis,AP)伴肝外門靜脈系統血栓形成是一種少見疾病,但近幾年隨着認識的深入及技術的進步,文獻報導的病例數有所增多,並發現其有一些臨床及影像學特徵。

关键词：血栓形成急性胰腺炎肝外

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腹腔鏡胃十二指腸潰瘍穿孔修補術的臨床研究

镜湖医学 2016年第2期16卷 41-42,49页

作者：黃炳紅崔鳳東澳門鏡湖醫院普通外科澳門

目的探討胃和十二腸潰瘍穿孔患者腹腔鏡手術的臨床療效。方法回顧性分析91例胃十二指腸潰瘍穿孔行手術治療之住院患者的臨床資料。其中54例行腹腔鏡胃十二指腸潰瘍穿孔修補術(腹腔鏡組),37例行開腹胃十二指腸潰瘍穿孔修補術(開腹組),比... 详细信息

目的探討胃和十二腸潰瘍穿孔患者腹腔鏡手術的臨床療效。方法回顧性分析91例胃十二指腸潰瘍穿孔行手術治療之住院患者的臨床資料。其中54例行腹腔鏡胃十二指腸潰瘍穿孔修補術(腹腔鏡組),37例行開腹胃十二指腸潰瘍穿孔修補術(開腹組),比較兩組患者在手術時間、術中出血量、術後胃腸功能恢復時間(肛門排氣時間/腸鳴音恢復時間)及併發症發生率等情况。結果與開腹組比較,腹腔鏡組手術時間較長(P0.05)。結論腹腔鏡胃十二指腸潰瘍穿孔修補術安全可靠,與傳統開腹手術比較創傷小,恢復快。

关键词：腹腔鏡胃十二指腸潰瘍穿孔手術治療

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膽囊十二指腸内瘻致膽石性腸梗阻1例

镜湖医学 2019年第2期19卷 83-83,42页

作者：袁兆霖宋偉黃炳紅澳門鏡湖醫院外科中國

膽囊十二指腸瘻併發膽石性腸梗阻(Gallstoneileus,GI)是一種少見的腸梗阻類型,膽囊十二指腸瘻是膽道内瘻占膽道内瘻的70%~95%[1],1654年Bartolin首次提出GI[2],該病是膽石症的一種罕見併發症,占膽石症患者0.3%~0.4%[2],占腸梗阻患者1%~3... 详细信息

膽囊十二指腸瘻併發膽石性腸梗阻(Gallstoneileus,GI)是一種少見的腸梗阻類型,膽囊十二指腸瘻是膽道内瘻占膽道内瘻的70%~95%[1],1654年Bartolin首次提出GI[2],該病是膽石症的一種罕見併發症,占膽石症患者0.3%~0.4%[2],占腸梗阻患者1%~3%[3]。GI常發病於高齡人群,臨床表現多樣且不典型,診斷困難,併發症和死亡率發生率高[3]。本研究報導1例少見的膽管結石性伴空腸腸梗阻的GI,現報告如下。

关键词： 1例性伴梗阻

Instrumented oscillographic study on impact toughness of an axle steel DZ2 with different tempering temperatures

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International Journal of Minerals,Metallurgy and Materials 2024年第7期31卷 1590-1598页

作者： Shuo Liu peng Zhang Bin Wang Kaizhong Wang Zikuan Xu Fangzhong Hu Xin Bai Qiqiang Duan Zhefeng Zhang Shi-changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China Technology Center Ma'anshan Iron and Steel Co.Ltd.Ma'anshan 243000China

Compared with the conventional Charpy impact test method,the oscillographic impact test can help in the behavioral analysis of materials during the fracture *** this study,the trade-off relationship between the strength and toughness of a DZ2 axle steel at various tempering temperatures and the cause of the improvement in impact toughness was *** tempering process dramatically influenced carbide precipitation behavior,which resulted in different aspect ratios of *** toughness improved along with the rise in tempering temperature mainly due to the increase in energy required in impact crack *** characteristics of the impact crack propagation process were studied through a comprehensive analysis of stress distribution,oscilloscopic impact statistics,fracture morphology,and carbide *** poor impact toughness of low-tempering-temperature specimens was attributed to the increased number of stress concentration points caused by carbide morphology in the small plastic zone during the propagation process,which resulted in a mixed distribution of brittle and ductile fractures on the fracture surface.

关键词： axle steel DZ2 tempering process impact toughness oscillographic impact test impact crack propagation carbides

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微量供油下的线接触副润滑增效分析

中国机械工程 2024年第7期35卷 1205-1211页

作者：李书义郭峰黄柏林金薇梁鹏青岛理工大学机械与汽车工程学院青岛266520 香港城市大学机械工程系中国香港999077

实验发现亲/疏油交替供油的功能润湿表面能提高微量供油下有效润滑的成膜性能。基于此,建立了有限长滚子副润滑模型,分析了交替供油的亲/疏油带宽及工作参数对润滑性能的增强规律。研究发现,微量供油条件下可利用交替供油方式达到线接... 详细信息

实验发现亲/疏油交替供油的功能润湿表面能提高微量供油下有效润滑的成膜性能。基于此,建立了有限长滚子副润滑模型,分析了交替供油的亲/疏油带宽及工作参数对润滑性能的增强规律。研究发现,微量供油条件下可利用交替供油方式达到线接触副润滑增效的目的,但供油交替变换使接触区润滑性能不稳定,且润滑增效作用会受功能表面亲/疏油带宽和卷吸速度的影响。

关键词：线接触副微量润滑功能表面供油

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Food-derived bio-functional peptides for the management of hyperuricemia and associated mechanism

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Food Science and Human Wellness 2024年第4期13卷 1767-1786页

作者： Yanxin Wang Mingxia Ma Yumeng Huang Siqing Fan Jie peng Shiming Li Xiurong Su Yanbo Wang Chenyang Lu State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products and School of Marine Science Ningbo UniversityNingbo 315211China School of Food and Health Beijing Technology and Business UniversityBeijing 100048China Department of Food Science Rutgers UniversityNew BrunswickNJ 08901USA College of Life Sciences Huanggang Normal UniversityHuanggang 438000China Food Safety Key Laboratory of Zhejiang Province School of Food Science and BiotechnologyZhejiang Gongshang UniversityHangzhou 310018China

Hyperuricemia,a metabolic disorder related to uric acid metabolism dysregulation,has become a common metabolic disease worldwide,due to changes in lifestyle and dietary *** recent years,owing to their high activity and few adverse effects,food-derived active peptides used as functional foods against hyperuricemia have attracted increasing *** article aims to focus on the challenge associated with peptide-specific preparation methods development,functional components identification,action mechanism(s)clarification,and bioavailability *** current review proposed recent advances in producing the food-derived peptides with high anti-hyperuricemia activity by protein source screening and matched enzymatic hydrolysis condition adjusting,increased the knowledge about strategies to search antihyperuricemia peptides with definite structure,and emphasized the necessity of combining computer-aided approaches and activity *** addition,novel action mechanism mediated by gut microbiota was discussed,providing different insights from classical ***,considering that little attention was paid previously on the structure-activity relationships of anti-hyperuricemia peptides,we collected the sequences from published studies and make a preliminary summary about the structure-activity relationships,which in turn provided guides for enzymatic hydrolysis optimization and bioavailability ***,this article could promote the development,application and commercialization of food-derived anti-hyperuricemia peptides in the future.

关键词： Hyperuricemia Peptide Enzyme hydrolysis Mechanism Structure-activity relationship Bioavailability

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胆道纤维化的发生发展与治疗

中华消化外科杂志 2024年第7期23卷 989-1000页

作者：赵进玉林延延岳平姚佳米宁宁李麻图付文康高龙 Azumi Suzuki peng F wong Kiyohito Tanaka Rungsun Rerknimitr Henrik H Junger Tan T Cheung Emmanuel Melloul Nicolas Demartines Joseph W Leung 袁金秋 Hans J Schlitt 孟文勃兰州大学第一临床医学院兰州730030 兰州大学第一医院普通外科兰州730030 浜松医学中心消化科日本浜松432-8002 詹姆斯库克大学医院血管外科英国米德尔斯堡TS43BW 京都第二红十字医院消化科日本京都602-8031 朱拉隆功国王纪念医院胃肠内镜卓越中心泰国曼谷10330 雷根斯堡大学医学中心外科德国雷根斯堡93053 香港大学外科学系中国香港999077 洛桑大学医院内脏外科瑞士洛桑CH-1015 加州大学戴维斯分校医学中心和萨克拉门托退伍军人医学中心胃肠肝病科美国萨克拉门托95817 中山大学附属第七医院临床研究中心深圳518107

胆道纤维化(BF)是病理性胆道损伤修复的结果,主要表现为胆管壁的增厚硬化和管腔的进行性狭窄,最终可能导致胆道梗阻、胆汁性肝硬化、肝衰竭、肝胆恶性肿瘤等严重不良结局。目前的研究将BF描述为某些胆管病的病理特征,对其病因、病理生... 详细信息

胆道纤维化(BF)是病理性胆道损伤修复的结果,主要表现为胆管壁的增厚硬化和管腔的进行性狭窄,最终可能导致胆道梗阻、胆汁性肝硬化、肝衰竭、肝胆恶性肿瘤等严重不良结局。目前的研究将BF描述为某些胆管病的病理特征,对其病因、病理生理、分子机制和治疗缺乏系统总结。BF是胆道系统普遍存在但容易被忽略的疾病状态,可能通过病理性胆道损伤后的异常修复机制促进肝胆疾病的发生和进展,笔者结合国内外最新研究进展,综述BF的概念、临床表现、病因、发病机制和治疗策略,为临床医师提供参考。

关键词：胆道疾病纤维化胆管反应病因信号通路治疗