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Genomic data and ecological niche modeling reveal an unusually slow rate of molecular evolution in the Cretaceous Eupteleaceae

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Science China(Life Sciences) 2024年第4期67卷 803-816页

作者： Kun-Li Xiang Sheng-Dan Wu Lian Lian Wen-Chuang He Dan peng Huan-Wen peng Xiao-Ni Zhang hong-Lei Li Jia-Yu Xue hong-Yan Shan Gui-Xia Xu Yang Liu Zhi-Qiang Wu Wei Wang State Key Laboratory of Plant Diversity and Specialty Crops Institute of BotanyChinese Academy of SciencesBeijing 100093China Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureKey Laboratory of Synthetic BiologyLaboratory of the Ministry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518120China China National Botanical Garden Beijing 100093China State Key Laboratory of Grassland Agro-Ecosystems and College of Ecology Lanzhou UniversityLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China College of Landscape Architecture and Life Science/Institute of Special Plants Chongqing University of Arts and SciencesChongqing 402160China College of Horticulture Academy for Advanced Interdisciplinary StudiesNanjing Agricultural UniversityNanjing 210095China Fairylake Botanical Garden Shenzhen&Chinese Academy of SciencesShenzhen 518004China

Living fossils are evidence of long-term sustained ecological ***,whether living fossils have little molecular changes remains poorly known,particularly in ***,we have introduced a novel method that integrates phylogenomic,comparative genomic,and ecological niche modeling analyses to investigate the rate of molecular evolution of Eupteleaceae,a Cretaceous relict angiosperm family endemic to East *** assembled a high-quality chromosome-level nuclear genome,and the chloroplast and mitochondrial genomes of a member of Eupteleaceae(Euptelea pleiosperma).Our results show that Eupteleaceae is most basal in Ranunculales,the earliest-diverging order in eudicots,and shares an ancient whole-genome duplication event with the other *** document that Eupteleaceae has the slowest rate of molecular changes in the observed *** unusually low rate of molecular evolution of Eupteleaceae across all three independent inherited genomes and genes within each of the three genomes is in association with its conserved genome architecture,ancestral woody habit,and conserved niche *** findings reveal the evolution and adaptation of living fossil plants through large-scale environmental change and also provide new insights into early eudicot diversification.

关键词： conservation genomics eudicots evolutionary rates niche conservatism phylogenomics

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Chemical biology investigation of a triple-action,smart-decomposition antimicrobial booster based-combination therapy against “ESKAPE” pathogens

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Science China Chemistry 2024年第9期67卷 3071-3082页

作者： Min Wang Huangsheng Pu Yangfan Xu Chenxuan Wu Yuanxin Gu Qingyun Cai Guoxing Yin peng Yin Chunhui Zhang Wing-Leung wong Muyang Wan Yugang Bai Xinxin Feng State Key Laboratory of Chem-/Bio-Sensing and Chemometrics Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biologyand School of Chemistry and Chemical Engineering Hunan University College of Biology Hunan University College of Advanced Interdisciplinary Studies & Hunan Provincial Key Laboratory of Novel Nano Optoelectronic Information Materials and Devices National University of Defense Technology Nanhu Laser Laboratory National University of Defense Technology Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education) College of Chemistry and Chemical Engineering Hunan Normal University State Key Laboratory of Chemical Biology and Drug Discovery Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic University Hunan Provincial Key Laboratory of Anti-Resistance Microbial Drugs The Third Hospital of Changsha (The Affiliated Changsha Hospital of Hunan University)

The global antibiotic resistance crisis necessitates urgent solutions. One innovative approach involves potentiating antibiotics and non-antibiotic drugs with adjuvants or boosters. A major drawback of these membrane-active boosters is their limited biocompatibility, as they struggle to differentiate between prokaryotic and eukaryotic membranes. This study reports the chemical biology investigation of a dual-action oligoamidine(OA1) booster with a glutathione-triggered decomposition mechanism. OA1, when combined with other antimicrobial molecules, exhibits a triple-targeting mechanism including cell membrane disruption, DNA targeting, and intracellular enzyme inhibition. This multi-targeting mechanism not only enhances the in vitro and in vivo eradication of antibiotic-resistant “ESKAPE” pathogens, but also suppresses the development of bacterial resistance. Furthermore, OA1 maintains its activity in bacterial cells by creating an oxidative environment, while it quickly decomposes in mammalian cells due to high glutathione levels. These mechanistic insights and design principles may provide a feasible approach to develop novel antimicrobial agents and effective anti-resistance combination therapies.

关键词： antimicrobial booster oligoamidine membrane disruption DNA targeting triggered degradation anti-resistance

Instrumented oscillographic study on impact toughness of an axle steel DZ2 with different tempering temperatures

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International Journal of Minerals,Metallurgy and Materials 2024年第7期31卷 1590-1598页

作者： Shuo Liu peng Zhang Bin Wang Kaizhong Wang Zikuan Xu Fangzhong Hu Xin Bai Qiqiang Duan Zhefeng Zhang Shi-changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China Technology Center Ma'anshan Iron and Steel Co.Ltd.Ma'anshan 243000China

Compared with the conventional Charpy impact test method,the oscillographic impact test can help in the behavioral analysis of materials during the fracture *** this study,the trade-off relationship between the strength and toughness of a DZ2 axle steel at various tempering temperatures and the cause of the improvement in impact toughness was *** tempering process dramatically influenced carbide precipitation behavior,which resulted in different aspect ratios of *** toughness improved along with the rise in tempering temperature mainly due to the increase in energy required in impact crack *** characteristics of the impact crack propagation process were studied through a comprehensive analysis of stress distribution,oscilloscopic impact statistics,fracture morphology,and carbide *** poor impact toughness of low-tempering-temperature specimens was attributed to the increased number of stress concentration points caused by carbide morphology in the small plastic zone during the propagation process,which resulted in a mixed distribution of brittle and ductile fractures on the fracture surface.

关键词： axle steel DZ2 tempering process impact toughness oscillographic impact test impact crack propagation carbides

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Food-derived bio-functional peptides for the management of hyperuricemia and associated mechanism

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Food Science and Human Wellness 2024年第4期13卷 1767-1786页

作者： Yanxin Wang Mingxia Ma Yumeng Huang Siqing Fan Jie peng Shiming Li Xiurong Su Yanbo Wang Chenyang Lu State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products and School of Marine Science Ningbo UniversityNingbo 315211China School of Food and Health Beijing Technology and Business UniversityBeijing 100048China Department of Food Science Rutgers UniversityNew BrunswickNJ 08901USA College of Life Sciences Huanggang Normal UniversityHuanggang 438000China Food Safety Key Laboratory of Zhejiang Province School of Food Science and BiotechnologyZhejiang Gongshang UniversityHangzhou 310018China

Hyperuricemia,a metabolic disorder related to uric acid metabolism dysregulation,has become a common metabolic disease worldwide,due to changes in lifestyle and dietary *** recent years,owing to their high activity and few adverse effects,food-derived active peptides used as functional foods against hyperuricemia have attracted increasing *** article aims to focus on the challenge associated with peptide-specific preparation methods development,functional components identification,action mechanism(s)clarification,and bioavailability *** current review proposed recent advances in producing the food-derived peptides with high anti-hyperuricemia activity by protein source screening and matched enzymatic hydrolysis condition adjusting,increased the knowledge about strategies to search antihyperuricemia peptides with definite structure,and emphasized the necessity of combining computer-aided approaches and activity *** addition,novel action mechanism mediated by gut microbiota was discussed,providing different insights from classical ***,considering that little attention was paid previously on the structure-activity relationships of anti-hyperuricemia peptides,we collected the sequences from published studies and make a preliminary summary about the structure-activity relationships,which in turn provided guides for enzymatic hydrolysis optimization and bioavailability ***,this article could promote the development,application and commercialization of food-derived anti-hyperuricemia peptides in the future.

关键词： Hyperuricemia Peptide Enzyme hydrolysis Mechanism Structure-activity relationship Bioavailability

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急性胰腺炎伴肝外門靜脈系統血栓形成1例報告

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镜湖医学 2017年第1期17卷 75-75,29页

作者：黃炳紅朱靜澳門鏡湖醫院腎臟内科中国

急性胰腺炎(Acute pancreatitis,AP)伴肝外門靜脈系統血栓形成是一種少見疾病,但近幾年隨着認識的深入及技術的進步,文獻報導的病例數有所增多,並發現其有一些臨床及影像學特徵。

关键词：血栓形成急性胰腺炎肝外

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腹腔鏡胃十二指腸潰瘍穿孔修補術的臨床研究

镜湖医学 2016年第2期16卷 41-42,49页

作者：黃炳紅崔鳳東澳門鏡湖醫院普通外科澳門

目的探討胃和十二腸潰瘍穿孔患者腹腔鏡手術的臨床療效。方法回顧性分析91例胃十二指腸潰瘍穿孔行手術治療之住院患者的臨床資料。其中54例行腹腔鏡胃十二指腸潰瘍穿孔修補術(腹腔鏡組),37例行開腹胃十二指腸潰瘍穿孔修補術(開腹組),比... 详细信息

目的探討胃和十二腸潰瘍穿孔患者腹腔鏡手術的臨床療效。方法回顧性分析91例胃十二指腸潰瘍穿孔行手術治療之住院患者的臨床資料。其中54例行腹腔鏡胃十二指腸潰瘍穿孔修補術(腹腔鏡組),37例行開腹胃十二指腸潰瘍穿孔修補術(開腹組),比較兩組患者在手術時間、術中出血量、術後胃腸功能恢復時間(肛門排氣時間/腸鳴音恢復時間)及併發症發生率等情况。結果與開腹組比較,腹腔鏡組手術時間較長(P0.05)。結論腹腔鏡胃十二指腸潰瘍穿孔修補術安全可靠,與傳統開腹手術比較創傷小,恢復快。

关键词：腹腔鏡胃十二指腸潰瘍穿孔手術治療

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微量供油下的线接触副润滑增效分析

中国机械工程 2024年第7期35卷 1205-1211页

作者：李书义郭峰黄柏林金薇梁鹏青岛理工大学机械与汽车工程学院青岛266520 香港城市大学机械工程系中国香港999077

实验发现亲/疏油交替供油的功能润湿表面能提高微量供油下有效润滑的成膜性能。基于此,建立了有限长滚子副润滑模型,分析了交替供油的亲/疏油带宽及工作参数对润滑性能的增强规律。研究发现,微量供油条件下可利用交替供油方式达到线接... 详细信息

实验发现亲/疏油交替供油的功能润湿表面能提高微量供油下有效润滑的成膜性能。基于此,建立了有限长滚子副润滑模型,分析了交替供油的亲/疏油带宽及工作参数对润滑性能的增强规律。研究发现,微量供油条件下可利用交替供油方式达到线接触副润滑增效的目的,但供油交替变换使接触区润滑性能不稳定,且润滑增效作用会受功能表面亲/疏油带宽和卷吸速度的影响。

关键词：线接触副微量润滑功能表面供油

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HiFAST:An HIdata calibration and imaging pipeline for FAST

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Science China(Physics,Mechanics & Astronomy) 2024年第5期67卷 182-199页

作者： Yingjie Jing Jie Wang Chen Xu Ziming Liu Qingze Chen Tiantian Liang Jinlong Xu Yixian Cao Jing Wang Huijie Hu Chuan-peng Zhang Qi Guo Liang Gao Mei Ai Hengqian Gan Xuyang Gao Jinlin Han Ligang Hou Zhipeng Hou peng Jiang Xu Kong Fujia Li Zerui Liu Li Shao Hengxing Pan Jun Pan Lei Qian Jinghai Sun Ningyu Tang Qingliang Yang Bo Zhang Zhiyu Zhang Ming Zhu National Astronomical Observatories Chinese Academy of SciencesBeijing 100012China Institute for Frontiers in Astronomy and Astrophysics Beijing Normal UniversityBeijing 02206China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China Guizhou Radio Astronomical Observatory Guizhou UniversityGuiyang 55000China Max Planck Institute for Extraterrestrial Physics Garching 85748Germany Kavli Institute for Astronomy and Astrophysics Peking UniversityBeijing 100871China Institute of Computational Cosmology Department of PhysicsUniversity of DurhamDurham DHI 3LEUK CAS Key Laboratory of FAST National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China Deep Space Exploration Laboratory/Department of Astronomy University of Science and Technology of ChinaHefei 230026China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China Astrophysics Department of PhysicsUniversity of OxfordOxford OX/3RHUK College of Earth Sciences Guilin University of TechnologyGuilin 541004China Department of Physics Anhui Normal UniversityWuhu 241002China School of Astronomy and Space Science Nanjing UniversityNanjing 210023China Key Laboratory of Modern Astronomy and Astrophysics Nanjing UniversityNanjing 20023China

The Five-hundred-meter Aperture Spherical radio Telescope(FAST)has the largest aperture and a 19-beam L-band receiver,making it powerful for investigating the neutral hydrogen atomic gas(HI)in the *** present HiFAST(https://***),a dedicated,modular,and self-contained calibration and imaging pipeline for processing the H?data of *** pipeline consists of frequency-dependent noise diode calibration,baseline fitting,standing wave removal using an FFT-based method,flux density calibration,stray radiation correction,and gridding to produce data *** modules can be combined as needed to process the data from most FAST observation modes:tracking,drift scanning,On-The-Fly mapping,and most of their *** HiFAST,the root-mean-square(RMS)noises of the calibrated spectra from all 19 beams were only slightly(~5%)higher than the theoretical *** results for the extended source M33 and the point sources are consistent with the results from *** moment maps(0,1 and 2)of M33 agree well with the results from the Arecibo Galaxy Environment Survey(AGES)with a fractional difference of less than 10%.For a common sample of 221 sources with signal-to-noise ratio S/N>10 from the Arecibo Legacy Fast ALFA(ALFALFA)survey,the mean value of fractional difference in the integrated flux density,Sint,between the two datasets is approximately 0.005%,with a dispersion of 15.4%.Further checks on the integrated flux density of 23 sources with seven observations indicate that the variance in the flux density of the source with luminous objects(Sint>2.5 Jy km s-1)is less than 5%.Our tests suggest that the FAST telescope,with the efficient,precise,and user-friendly pipeline HiFAST,will yield numerous significant scientific findings in the investigation of the H?in the universe.

关键词： fractional luminous correction

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膽囊十二指腸内瘻致膽石性腸梗阻1例

镜湖医学 2019年第2期19卷 83-83,42页

作者：袁兆霖宋偉黃炳紅澳門鏡湖醫院外科中國

膽囊十二指腸瘻併發膽石性腸梗阻(Gallstoneileus,GI)是一種少見的腸梗阻類型,膽囊十二指腸瘻是膽道内瘻占膽道内瘻的70%~95%[1],1654年Bartolin首次提出GI[2],該病是膽石症的一種罕見併發症,占膽石症患者0.3%~0.4%[2],占腸梗阻患者1%~3... 详细信息

膽囊十二指腸瘻併發膽石性腸梗阻(Gallstoneileus,GI)是一種少見的腸梗阻類型,膽囊十二指腸瘻是膽道内瘻占膽道内瘻的70%~95%[1],1654年Bartolin首次提出GI[2],該病是膽石症的一種罕見併發症,占膽石症患者0.3%~0.4%[2],占腸梗阻患者1%~3%[3]。GI常發病於高齡人群,臨床表現多樣且不典型,診斷困難,併發症和死亡率發生率高[3]。本研究報導1例少見的膽管結石性伴空腸腸梗阻的GI,現報告如下。

关键词： 1例性伴梗阻