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Rapid testing methods for food contaminants and toxicants

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Journal of Integrative Agriculture 2015年第11期14卷 2243-2264页

作者： Jiachi Chiou Arthur ho hon Leung Hang Wai Lee Wing-tak wong Department of Applied Biology and Chemical Technology Food Safety and Technology Research CenterThe Hong Kong Polytechnic University Shenzhen Key Laboratory for Food Biological Safety Control Food Safety and Technology Research CentreThe Hong Kong Polytechnic University Shenzhen Research Institute

Food safety is one of the major concerns in every country regardless of the economic and social development. The frequent occurrence of food scandals in the world has led the Chinese government to implement several strategies to fortify the food supply system to a high food safety standard. This relies heavily on laboratory testing services but conventional methods for detection of food contaminants and toxicants are limited by sophisticated sample preparation procedures, long analysis time, large instruments and professional personnel to meet the increasing demands. In this review, we have incorporated most of the current and potential rapid detection methods for many notorious food contaminants and toxicants including microbial agents, toxic ions, pesticides, veterinary drugs and preservatives, as well as detection of genetically modified food genes and adulterated edible oil. Development of rapid, accurate, easy-to-use and affordable testing methods could urge food handlers and the public to actively screen for food contaminants and toxicants instead of passively relying on monitoring by the government examination facility. This review also provides several recommendations including how to encourage the public to engage in the food safety management system and provide optimal education and financial assistance that may improve the current Chinese food safety control system.

关键词： rapid testing food contaminants and toxins microbial agents pesticides veterinary drugs preservatives formaldehyde nitrite nitrate test strips

Prevalence, correlates, attitude and treatment seeking of erectile dysfunction among type 2 diabetic Chinese men attending primary care outpatient clinics

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Asian Journal of Andrology 2014年第5期16卷 755-760,I0010页

作者： Wai hon Lo Sau Nga Fu Carlos King ho wong Ee San Chen Department of Family Medicine and Primary Health Care Kowloon West Cluster Hospital Authority Hong Kong China Department of Family Medicine and Primary Care Li Ka Shing Faculty of Medicine University of Hong Kong Hong Kong China Department of Linguistics School of Humanities University of Hong Kong Hong Kong China

To investigate the prevalence, correlates, attitude and treatment seeking behavior of erectile dysfunction （ED） in type 2 diabetes mellitus （T2DM） patients in the primary care setting, a multi-center cross-sectional survey using a structured anonymous self-administered questionnaire was performed in 10 general outpatient clinics. Of the 603 subjects （91% response rate）, the prevalence of ED men, as defined by the International Index of Erectile Function, was 79.1%. Most subjects had mild ED （28.9%）, followed by mild-to-moderate ED （27.9%）, then moderate ED （13.4%） and severe ED （9%）. Nearly 55% of those with ED did not consider themselves as having ED. Less than 10% of them had ever sought medical treatment, although 76.1% of them wished to receive management from doctor（s） should they be diagnosed with ED. They considered the most important management from doctors to be clinical assessment （41.7%）, followed by management of potential underlying cause （37.8%）, referral to specialist （27.5%）, education （23.9%）, prescription of phosphodiesterase type 5 inhibitors （16.9%） and referral to ~：ounseling service （6.7%）. The prevalence of ED was strongly associated with subjects who thought they had ED （odds ratio （OR） = 90.49 （20.00-409.48, P 〈 0.001）） and were from the older age group （OR = 1.043 （1.011-1.076, P = 0.008））. In conclusion, ED is highly prevalent among T2DM men. The majority of them wanted management from doctors should they have ED, but only a minority would actually voice out the request. Screening of ED among T2DM men using structural questionnaire allowed the diagnosis of more than half of the ED cases, which otherwise would have gone undiagnosed.

关键词： diabetes mellitus erectile dysfunction prevalence risk factors

The genus Pythium in Taiwan,China(1)-a synoptic review

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Frontiers in Biology 2009年第1期4卷 15-28页

作者： hon-Hing ho Department of Biology State University of New YorkNew PaltzNY 12561USA

The genus Pythium,with slightly over 280 described species,has been classified traditionally with other filamentous,coenocytic,sporangia-producing fungi as“Phycomyetes”.however,with recent advances in chemical,ultrastructural and molecular studies,Pythium *** now considered as“fungus-like organisms”or“pseudo-fungi”and are placed in the Kingdom Chromista or Kingdom Straminopila,distinct from the true fungi of the Kingdom Fungi or Kingdom *** are widely distributed throughout the world as soil saprophytes or plant *** of the warm moist maritime climate,Taiwan,China,is especially rich in Pythium *** date,48 species of Pythium have been reported from Taiwan,China,with the dominant species being ***,***,***,***,*** and *** is no definite geographical distribution of Pythium *** Taiwan,*** nine species of Pythium have proven to be plant pathogens attacking a wide variety of woody and herbaceous plants primarily causing pre-and post-emergence seedling damping-off,root rot,stem rot and rotting of fruits,tubers and ginger rhizomes,resulting in serious economic *** most important plant pathogenic species include *** and ***,which are most active during the hot and wet summer months;whereas ***,***,*** and *** cause the greatest damage in the cool *** Pythium *** non-specific pathogens,infecting mainly juvenile or succulent *** review attempts to assess the taxonomic position of the genus Pythium and provide details of the historical development of the study of Pythium as pathogens in Taiwan,China,causing diseases of sugarcane,trees,vegetables,fruits,specialty crops and flowering plants,as well as measures to control these *** special note is the introduction of the S-H mixture which,when used as soil amendment,effectively controls many soil-borne Pythium diseases during the ear

关键词： Pythiaceae oomycetes Chromista Straminolia plant pathogens soil-borne disease saprophytes mycoparasites biodiversity

SMA molecular line survey towards the massive star-forming region G10.6-0.4in W31complex

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Research in Astronomy and Astrophysics 2018年第11期18卷 29-42页

作者： Wai-ho wong Tao An Key Laboratory of Radio Astronomy Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China University of Chinese Academy of Sciences Beijing 100049China

Line surveys of complex molecules with millimeter and sub-millimeter telescopes are important for probing the physical and chemical environments of massive star forming regions(MSFRs).We present a molecular line survey with the Submillimeter Array(SMA) in the frequency ranges of 220.3–222.3 GHz and 230.3–232.3 GHz toward G10.6-0.4, the brightest star forming core in the W31 complex. Ninety-nine transitions from 22 molecular species and their isotopologues are identified. The moment 0 images of typical molecules show a compact core which is concentrated at the continuum peak position. Based on the local thermodynamic equilibrium assumption, the molecular line data are modeled. The rotational temperatures of those molecular species range from 96 to 178 K and their column densities range from 2.0×1014to 3.7×1017cm-2. The observational data suggest that all complex molecules are located in a warm environment. Chemical environments of the molecules are discussed. We compared molecular abundances and gas temperatures in G10.6-0.4 with those in other MSFRs, and found that gas temperatures and fractional abundances of specific molecules in G10.6-0.4 are similar to the typical MSFR W51 North, suggesting that there are similar physical and chemical environments in these two MSFRs.

关键词： stars: formation ISM: abundances ISM: individual objects: G10.6-0.4 ISM: molecules radio lines: ISM

Luminescent cyclometalated iridium(Ⅲ) dipyridoquinoxaline indole complexes as biological probes

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Science China Chemistry 2010年第10期53卷 2091-2098页

作者： LO Kenneth Kam-Wing LEUNG Arthur ho-hon Department of Biology and Chemistry City University of Hong Kong

Four luminescent cyclometalated iridium(Ⅲ) dipyridoquinoxaline complexes appended with an indole moiety [Ir(N^C)2(N^N)] (PF6) (HN^C = 2-phenylpyridine, Hppy; N^N = 2-(N-(2-(indole-3-acetamido)ethyl)aminocarbonyl)dipyrido[3,2-f:2′,3′-h]quinox- aline, dpqC2indole (1a), N^N = 2-(N-(6-(indole-3-acetamido)hexyl)aminocarbonyl)dipyrido[3,2-f:2′,3′-h]quinoxaline, dpqC6indole (1b); HN^C = 7,8-benzoquinoline, Hbzq, N^N = dpqC2indole (2a), N^N = dpqC6indole (2b)) have been synthesized and characterized. Upon irradiation, all the complexes displayed moderately intense and long-lived luminescence under ambient condi-tions and in 77 K glass. On the basis of the photophysical data, the emission of the complexes has been assigned to an excited state of triplet metal-to-ligand charge-transfer (3MLCT) ((dπ(Ir)→π*(N^N)) character. Cyclic voltammetric studies revealed indole-based and iridium-based oxidations at ca. +1.10 V and +1.24 V vs. SCE, respectively, and ligand-based reductions at ca. -1.07 to-2.29 V vs. SCE. The interactions of the complexes with an indole-binding protein, bovine serum albumin (BSA), have been examined by emission titrations.

关键词： binding indole iridium luminescence probes

Effective Common Chinese Herbal Medicines Used in Treating Chronic Cholecystitis with Liver-Gallbladder Dampness-Heat Syndrome: A Review of Clinical Studies in the Past 10 Years

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World Journal of Traditional Chinese Medicine 2023年第1期9卷 8-20页

作者： Desmond Wei Kang Tee hon Foong wong Centrefor Complementary and Alternative Medicine International Medical UniversityKuala LumpurMalaysia

The objective of the study is to identify the effective common Chinese herbal medicines used in treating chronic cholecystitis with liver-gallbladder dampness-heat syndrome(CCLGDHS) through reviewing relevant clinical studies published in the past 10 years. Data were collected from Science Direct and Chinese National Knowledge Infrastructure. Data screening was carried out for the abstracts and full texts of the data. The top 15 Chinese herbal medicines with the highest occurring frequency were selected, statistically analyzed, and classified by their medicinal properties, actions, and indications according to the Chinese Pharmacopoeia 2015 edition. The top 15 effective common Chinese herbal medicines comprise Chai Hu, Huang Qin, Jin Qian Cao, Bai Shao, Yin Chen, Yu Jin, Chuan Lian Zi, Yan Hu Suo, Zhi Shi, Ban Xia, Bai Zhu, Pu Gong Ying, Gan Cao, Zhi Zi, and Qing Pi. The predominant natures were cold, cool, and warm. This combination can clear stagnant heat, warm Yang, and regulate Qi dynamics. In addition, bitter, pungent, and sweet were the predominant flavors. They can clear dampness-heat, regulate Qi dynamics to relieve cramps and pain, as well as tonify the deficiency. Along with entering the liver and gallbladder meridians, these herbal medicines also entered the spleen, stomach, and lung meridians to prevent potential disease transmission. The combinatorial medicinal actions of the effective common Chinese herbal medicine highlight the importance of the holistic concept of traditional Chinese medicine when treating CCLGDHS. In addition, the inclusion of activating blood to promote blood circulation, relieving cramps and alleviating pain, and tonifying the spleen and stomach represents a new finding in the treatment principle for CCLGDHS.

关键词： Chronic cholecystitis common Chinese herbal medicines liver-gallbladder dampness-heat syndrome traditional Chinese medicine treatment

Recent Developments of Genomic Research in Soybean

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Journal of Genetics and Genomics 2012年第7期39卷 317-324页

作者： Ching Chan Man-Wah Li Fuk-Ling wong hon-Ming Lam State Key Laboratory of Agrobiolechnology and School of Life Sciences The Chinese University of Hong Kong

Soybean is an important cash crop with unique and important traits such as the high seed protein and oil contents, and the ability to perform symbiotic nitrogen fixation. A reference genome of cultivated soybeans was established in 2010, followed by whole-genome re-sequencing of wild and cultivated soybean accessions. These efforts revealed unique features of the soybean genome and helped to understand its evolution. Mapping of variations between wild and cultivated soybean genomes were perfo^aned. These genomic variations may be related to the process of domestication and human selection. Wild soybean germplasms exhibited hiigh genomic diversity and hence may be an important source of novel genes/alleles. Accumulation of genomic data will help to refine genetic maps and expedite the identification of functional genes. In this review, we summarize the major findings from the whole-genome sequencing projects and discuss the possible impacts on soybean researches and breeding programs. Some emerging areas such as transcriptomic and epigenomic studies will be introduced. In addition, we also tabulated some useful bioinformatics tools that will help the mining of the soybean genomic data.

关键词： Evolution Genome Soybean

Healthcare Services Demand in Post-disaster Settings:The 2014 Earthquake in Ludian County,Yunnan Province,China

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International Journal of Disaster Risk Science 2016年第4期7卷 445-449页

作者： ho Ting wong Sijian Li School of Nursing The Hong Kong Polytechnic University Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences

Healthcare relief teams dispatched to rural areas often face difficulties due to limited initial and ongoing health information in the affected *** present study investigated patterns of healthcare service demand for a rural displaced population in a post-disaster *** weeks after the 2014 Ludian County earthquake,the Institute for Disaster Management and Reconstruction(IDMR) at Sichuan University and hong Kong Polytechnic University organized a disaster nursing team to support the rural community in Longtoushan,at the epicenter of the earthquake.A cross-sectional,records-based study of 2484 records obtained from a temporary hospital in Longtoushan(for the period of 14 September-1 October 2014) was *** daily number of records by patients' sociodemographic characteristics and medical diagnoses were plotted on a time series graph to explore the temporal change during the study *** indicate that healthcare service demand from younger age groups was higher than that of the older adult *** major health problems were observed:respiratory disease,skin problems,and ear,eye,and throat(EET) *** of these very real health problems are chronic issues that require long-term *** are not health issues directly related to the disaster emergency *** disaster relief nursing teams were selected on the basis of their ability to cope primarily with traumatic disaster-related *** existing practice of teaming up disaster relief professions might not be *** better understand the healthcare needs of a displaced population,short- and long-term planning is *** will allow disaster response professionals to better organize and deploy healthcare personnel to manage the above-listed problems in a postdisaster situation.

关键词： China Earthquake disaster Healthcare services demand Post-disaster healthcare

Deep learning based radiomics for gastrointestinal cancer diagnosis and treatment:A minireview

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World Journal of Gastroenterology 2022年第45期28卷 6363-6379页

作者： Pak Kin wong In Neng Chan Hao-Ming Yan Shan Gao Chi hong wong Tao Yan Liang Yao Ying Hu Zhong-Ren Wang hon ho Yu Department of Electromechanical Engineering University of MacaoTaipa 999078MacaoChina School of Clinical Medicine China Medical UniversityShenyang 110013Liaoning ProvinceChina Department of Gastroenterology Xiangyang Central HospitalAffiliated Hospital of Hubei University of Arts and ScienceXiangyang 441021Hubei ProvinceChina Faculty of Medicine Macao University of Science and TechnologyTaipa 999078MacaoChina School of Mechanical Engineering Hubei University of Arts and ScienceXiangyang 441053Hubei ProvinceChina Shenzhen Institute of Advanced Technology Chinese Academy of SciencesShenzhen 518055Guangdong ProvinceChina Department of Gastroenterology Kiang Wu HospitalMacao 999078China

Gastrointestinal(GI)cancers are the major cause of cancer-related mortality *** imaging is an important auxiliary means for the diagnosis,assessment and prognostic prediction of GI *** is an emerging and effective technology to decipher the encoded information within medical images,and traditional machine learning is the most commonly used *** advances in deep learning technology have further promoted the development of *** the field of GI cancer,although there are several surveys on radiomics,there is no specific review on the application of deep-learning-based radiomics(DLR).In this review,a search was conducted on Web of Science,PubMed,and Google Scholar with an emphasis on the application of DLR for GI cancers,including esophageal,gastric,liver,pancreatic,and colorectal ***,the challenges and recommendations based on the findings of the review are comprehensively analyzed to advance DLR.

关键词： Radiomics Deep learning Gastrointestinal cancer Medical imaging