检索结果-南通市图书馆

Unsynchronized butyrophilin molec.l.s dictate cancer c.l. evasion of Vγ9Vδ2 T-c.l. killing

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

c.l.ular & Molec.l.r Immunology 2024年第4期21卷 362-373页

作者： Zeguang Wu Qiezhong lamao Meichao Gu Xuanxuan Jin Ying liu Feng Tian Ying Yu Pengfei Yuan Shuaixin Gao Thomas S.Fulford Adam P.Uldrich catherine c.l.wong Wensheng Wei Biomedic.l.Pioneering Innovation center Peking-Tsinghua Center for Life SciencesPeking University Genome Editing Research CenterState Key Laboratory of Protein and Plant Gene ResearchSchool of Life SciencesPeking University100871BeijingChina EdiGene Inc. Life Science ParkChangping District102206BeijingChina center for Precision Medicine Multi-Omics Research Peking University Health Science CenterPeking University100191BeijingChina Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity The University of MelbourneParkvilleVIC3010Australia cancer Immunology Program Peter MacCallum Cancer CentreMelbourneVICAustralia State Key laboratory for complex Severe and Rare DiseasesClinical Research InstitutePeking Union Medical College HospitalChinese Academy of Medical Science&Peking Union Medical CollegePeking-Tsinghua Center for Life Sciences100871BeijingChina

Vγ9Vδ2 T c.l.s are specialized effector c.l.s that have gained prominence as immunotherapy agents due to their ability to target and kill c.l.s with altered pyrophosphate *** our effort to understand how cancer c.l.s evade the c.l.-killing activity of Vγ9Vδ2 T c.l.s,we performed a comprehensive genome-sc.l. cRISPR screening of cancer *** found that four molec.l.s belonging to the butyrophilin(BTN)family,specific.l.y BTN2A1,BTN3A1,BTN3A2,and BTN3A3,are critic.l.y important and play unique,nonoverlapping roles in fac.l.tating the destruction of cancer c.l.s by primary Vγ9Vδ2 T *** coordinated function of these BTN molec.l.s was driven by synchronized gene expression,which was regulated by IFN-γsignaling and the RFX ***,an enzyme c.l.ed QPc.l.was shown to play a key role in modifying the N-terminal glutamine of these BTN proteins and was found to be a crucial factor in Vγ9Vδ2 T c.l. killing of cancer *** our research,we offer a detailed overview of the functional genomic mechanisms that underlie how cancer c.l.s escape Vγ9Vδ2 T ***,our findings shed light on the importance of the harmonized expression and function of gene family members in modulating T-c.l. activity.

关键词： Butyrophilin Vγ9Vδ2 T-c.l. cancer-specific immune evasion Glutaminyl-peptide cyclotransferase-like Pyrophosphate metabolite Immunotherapy

langmuir-Schaefer Film Investigation and Density Functional Theory Band Gap c.l.ulations of c.l.x[n]arene-Para-Aminobenzoic Acid for Drug Nanosensor Application

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Wuhan University of Technology(Materials Science) 2024年第5期39卷 1311-1318页

作者： wong Yeong Yi F l Supian A Radzwan M Musa N F N Abd Karim Department of Physics Sultan Idris Education UniversityTanjong Malim 35900Malaysia Department of chemistry Sultan Idris Education UniversityTanjong Malim 35900Malaysia

c.l.x[n]arenes was utilized to detect PABA,the primary sunscreen *** study investigates the interaction of c.l.x[4]arene(c4),c.l.x[6]arene(c6),and PABA using the langmuir method and first-principle density functional theory(DFT).Using the langmuir-Schaefer(lS)technique,an ultrathin film composed of c.l.x[n]arenes and their complexes with PABA was deposited on various *** on the langmuir study,the PABA molec.l. was bonded to the lower rims of both c4 and c6 with the host-guest ratio of 1:*** of the lS films formed were then characterized by ultravioletvisible spectroscopy(UV-Vis),Fourier-transform infrared spectroscopy(FTIR)and carbon,hydrogen,nitrogen,sulfur elemental analyzer(cHNS).The band gap reduction obtained in the DFT study denotes the charge transfer interaction with promising reactivity between the c.l.x[n]arenes and *** sensing of PABA by c4 and c6 is successful based on the formation of bonding between them due to the hosts’effective trapping *** outcomes of this study could be applied to drug delivery systems for future pharmaceutic.l.and medic.l.applications.

关键词： c.l.x[n]arenes band gap density functional theory langmuir-Schaefer PABA sensor

Superior antibody and membrane protein‑specific T‑c.l. responses to coronaVac by intradermal versus intramusc.l.r routes in adolescents

在线全文

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2024年第4期20卷 353-370页

作者： Jaime S.Rosa Duque Samuel M.S.cheng carolyn A.cohen Daniel leung Xiwei Wang Xiaofeng Mu Yuet chung Tsun Ming lau Manni Wang Wenyue Zhang Yanmei Zhang Howard H.W.wong leo c.H.Tsang Sara chaothai Tsz chun Kwan John K.c.l. Karl c.K.chan leo l.H.luk Jenson c.H.Ho Wing Yan li Amos M.T.lee Jennifer H.Y.lam Sau Man chan Wilfred H.S.wong Issan Y.S.Tam Masashi Mori Sophie A.Valkenburg Malik Peiris Wenwei Tu Yu lung lau Department of Paediatrics and Adolescent Medicine The University of Hong KongHong KongChina School of Public Health The University of Hong KongHong KongChina HKU‑Pasteur Research Pole School of Public HealthThe University of Hong KongHong KongChina Research Institute for Bioresources and Biotechnology Ishikawa Prefectural UniversityNonoichiJapan Department of Microbiology and Immunology Peter Doherty Institute for Infectionand ImmunityUniversity of MelbourneMelbourneVICAustralia center for Immunology and Infection c2i Hong KongChina

Background Optimising the immunogenicity of cOVID-19 vaccines to improve their protection against disease is *** dosing by intradermal(ID)administration has been shown to be equally immunogenic as intramusc.l.r(IM)administration for several vaccines,but the immunogenicity of ID inactivated whole severe acute respiratory syndrome coronavirus 2(SARS-coV-2)at the full dose is *** study(NcT04800133)investigated the superiority of antibody and T-c.l. responses of full-dose coronaVac by ID over IM administration in *** Participants aged 11–17 years received two doses of IM or ID vaccine,followed by the 3rd dose 13–42 days *** and c.l.ular immunogenicity outcomes were measured post-dose 2(IM-cc versus ID-cc)and post-dose 3(IMccc versus ID-ccc).Doses 2 and 3 were administered to 173 and 104 adolescents,*** Spike protein(S)immunoglobulin G(IgG),S-receptor-binding domain(RBD)IgG,S IgG Fcγreceptor IIIa(FcγRIIIa)-binding,SNM[sum of individual(S),nucleocapsid protein(N),and membrane protein(M)peptide pool]-specific interleukin-2(Il-2)+cD4^(+),SNM-specific Il-2^(+)cD8^(+),S-specific Il-2^(+)cD8^(+),N-specific Il-2^(+)cD4^(+),N-specific Il-2^(+)cD8^(+)and M-specific Il-2^(+)cD4^(+)responses fulfilled the superior and non-inferior criteria for ID-cc compared to IM-cc,whereas IgG avidity was *** ID-ccc,S-RBD IgG,surrogate virus neutralisation test,90%plaque reduction neutralisation titre(PRNT90),PRNT50,S IgG avidity,S IgG FcγRIIIa-binding,M-specific Il-2^(+)cD4^(+),interferon-γ+cD8^(+)and Il-2^(+)cD8^(+)responses were superior and non-inferior to *** estimated vaccine efficacies were 49%,52%,66%and 79%for IM-cc,ID-cc,IM-ccc and ID-ccc,*** ID groups reported more loc.l.mild adverse *** This is the first study to demonstrate superior antibody and M-specific T-c.l. responses by ID inactivated SARScoV-2 vaccination and serves as the basis for future research to improve the

关键词： coronaVac coronavirus disease 2019 Immunity Intradermal Vaccine

limosilactobac.l.us mucosae FZJTZ26M3 prevents NAFlD in mice through modulation of lipid metabolism and gut microbiota dysbiosis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年第3期13卷 1589-1601页

作者： Danting Dang Bowen li Mengfan Ding RPaul Ross catherine Stanton Jianxin Zhao Bo Yang Wei chen State Key laboratory of Food Science and Resources Jiangnan UniversityWuxi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China International Joint Research center for Probiotics&Gut Health Jiangnan UniversityWuxi 214122China APc Microbiome Ireland University College CorkCork T12 YT20Ireland Teagasc Food Research centre MooreparkFermoyCork T12 YT20Ireland National Engineering Research center for Functional Food Jiangnan UniversityWuxi 214122China

lactobac.l.us are considered promising therapeutic methods for nonalcoholic fatty liver disease(NAFlD).The effects of two strains of ltmosilactobac.l.us mucosae on NAFlD were investigated in this ***-old male c57Bl/6J mice were divided into 4 groups(n=8 per group,control,Model,FZJTZ26M3,FGSYc17l3).*** FZJTZ26M3 reduced the mice 's body weight,liver weight,and adipose tissue weight after 12 weeks of *** to serum analysis,total cholesterol,triac.l.lycerol,and low-density lipoprotein cholesterol significantly decreased after *** FZJTZ26M3 *** pathology showed that *** FZJTZ26M3 was effective to ameliorate lipid deposition in NAFlD ***,the expression of the gene related to lipid metabolism in the liver and adipose tissue was analyzed,and the results indicated that *** FZJTZ26M3 could alleviate NAFlD by regulating lipid ***,the results of 16S rRNA gene sequencing revealed a drop in the relative abundance of Ruminococcaceae,which is linked to inflammation,but the relative abundance of a potential probiotic Akkermansia significantly increased after *** FZJTZ26M3 ***,*** FZJTZ26M3 could be a candidate to prevent NAFlD.

关键词： limosilactobac.l.us mucosae Nonalcoholic fatty liver disease(NAFlD) Probiotic lipid metabolism Gut microbiota

Empiric.l.model for fusion cross sections of ca-induced reactions

在线全文

学校读者我要写书评

暂无评论

chinese Physics c 2024年第3期48卷 126-132页

作者： Reddi Rani.l N.Sowmya K.N Sridhar H c.Manjunatha M.M.Armstrong Arasu Department of Physics St.Joseph's College(Autonomous)Affiliated to Bharathidasan UniversityTiruchirappalli620002TNIndia Department of Physics Govt.First.Grade CollegeChikkaballapur-562101KarnatakaIndia Department of Physics Govt.First.Grade CollegeMalur-563160KarnatakaIndia Department of Physics Govt.First.Grade CollegeDevanahalli-562110KarnatakaIndia

A new empiric.l.formula for the astrophysic.l.S-factor has been suggested as a function of the coulomb interaction parameter,center of mass energy,and barrier *** 22 fusion reactions with ^(40,48)ca as projectiles were considered for different targets,leading to compound nuclei with atomic and mass numbers varying between 40≤Z≤≤Z≤112 and 88≤A≤27888≤A≤278,*** fusion cross-sections have been estimated using the geometric factor,the Gamow-Sommerfield factor,and the empiric.l.formula for the *** study's findings showed better agreement with those of available experiments when compared to wong's *** present work leads to a smaller standard deviation value than wong's formula when used to correlate the experimental data of c.l.ium-induced fusion ***'s formula provides a good approximation of fusion cross-sections when the center of mass energy is below the fusion barrier when compared to above the fusion barrier.

关键词： fusion cross-sections wong formula Gamow-Sommerfield-factor Geometric-factor S-factor

Prevalence and risk factors for impaired renal function among Asian patients with nonalcoholic fatty liver disease

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 241-248页

作者： chao Sun George Boon-Bee Goh Wan-cheng chow Wah-Kheong chan Grace lai-Hung wong Wai-Kay Seto Yi-Hsiang Huang Han-chieh lin I-cheng lee Hye Won lee Seung Up Kim Vincent Wai-Sun wong Jian-Gao Fan center for Fatty liver Disease Department of GastroenterologyXinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai Key Lab of Pediatric Gastroenterology and NutritionShanghai 200092China Department of Gastroenterology&Hepatology Singapore General HospitalSingaporeSingapore Gastroenterology and Hepatology Unit Department of MedicineFaculty of MedicineUniversity of MalayaKuala LumpurMalaysia Department of Medicine and Therapeutics and State Key laboratory of Digestive Disease The Chinese University of Hong KongHong KongChina Department of Medicine The University of Hong KongHong KongChina Institute of clinic.l.Medicine National Yang Ming Chiao Tung University School of MedicineTaipeiTaiwanChina Division of Gastroenterology and Hepatology Taipei Veterans General HospitalTaipeiTaiwanChina Fac.l.y of Medicine National Yang Ming Chiao Tung University School of MedicineTaipeiTaiwanChina Department of Internal Medicine Yonsei University College of MedicineSeoulKorea

Background:Nonalcoholic fatty liver disease(NAFlD)is associated with impaired renal function,and both diseases often occur alongside other metabolic ***,the prevalence and risk factors for impaired renal function in patients with NAFlD remain *** objective of this study was to identify the prevalence and risk factors for renal impairment in NAFlD ***:All adults aged 18-70 years with ultrasound-diagnosed NAFlD and transient elastography examination from eight Asian centers were enrolled in this prospective *** fibrosis and cirrhosis were assessed by FibroScan-aspartate aminotransferase(FAST),Agile 3+and Agile 4 *** renal function and chronic kidney disease(cKD)were defined by an estimated glomerular filtration rate(eGFR)with value ofl/min/1.73 m^(2) andl/min/1.73 m^(2),respectively,as estimated by the cKD-Epidemiology c.l.aboration(cKD-EPI)***:Among 529 included NAFlD patients,the prevalence rates of impaired renal function and cKD were 37.4%and 4.9%,*** multivariate analysis,a moderate-high risk of advanced liver fibrosis and cirrhosis according to Agile 3+and Agile 4 scores were independent risk factors for cKD(Pcreased fasting plasma glucose(FPG)and blood pressure were significantly associated with impaired renal function after controlling for the other components of metabolic syndrome(Pcompared with patients with normoglycemia,those with prediabetes[FPG≥5.6 mmol/l or hemoglobin A1c(HbA1c)≥5.7%]were more likely to have impaired renal function(Pconclusions:Agile 3+and Agile 4 are reliable for identifying NAFlD patients with high risk of *** glycemic control in the prediabetic stage might have a potential renoprotective role in these patients.

关键词： Nonalcoholic fatty liver disease Impaired renal function Agile 3+ Agile 4 Metabolic syndrome

Distribution of atrial cardiomyopathy markers and association with atrial fibrillation detected after ischaemic stroke in the SAFAS study

在线全文

学校读者我要写书评

暂无评论

Stroke & Vasc.l.r Neurology 2024年第2期9卷 165-173,I0426,I0427页

作者： Romain Didier lucie Garnier Gauthier Duloquin Alexandre Meloux Audrey Sagnard Mathilde Graber Geoffrey Dogon Karim Benali Thibaut Pommier Gabriel laurent catherine Vergely Yannick Bejot charles Guenancia cardiology CHU Dijon BourgogneDijonFrance Dijon Stroke Registry Department of NeurologyUniversity Hospital Centre DijonDijonFrance PEc 2 Universitéde BourgogneDijonFrance cardiology CHU Saint EtienneSaint EtienneFrance

Background Atrial cardiomyopathy(Ac)is an emerging concept explaining the pathophysiology of cardioembolic strokes in absence of atrial fibrillation(AF).A definition based on the presence of electric.l.abnormality(P-wave terminal force in lead V1(PTFV1)>5000µV×ms),N-Terminal pro-B-type natriuretic peptide(NT pro BNP)>250pg/ml and/or indexed left atrial diameter(lADI)>3cm/m^(2)is currently tested in the ARcADIA(AtRial cardiopathy and Antithrombotic Drugs In prevention After cryptogenic stroke)*** set out to estimate the prevalence of Ac as defined in the ARcADIA trial,its determinants and its association with AF detected after stroke(AFDAS).Methods Stepwise screening for silent Atrial Fibrillation After Stroke(SAFAS)study prospectively included 240 ischaemic stroke *** markers were complete for 192 of them and 9 were not included in this analysis because AF had been diagnosed on *** A total of 183 patients were analysed,of whom 57%(104 patients)met the Ac criteria(79 NT-proBNP,47 PTFV1,4 lADI).In the multivariate logistic regression,c reactive protein>3mg/l(OR(95%cI)2.60(1.30 to 5.21),p=0.007)and age(OR(95%cI)1.07(1.04 to 1.10),ply associated with *** 6 months of follow-up,AFDAS was detected in 33%of Ac patients and in 14%of the remaining ones(p=0.003).However,Ac was not independently associated with AFDAS,contrary to left atrial volume index(>34ml/m^(2),OR 2.35(cI 1.09 to 5.06)p=0029).conclusion Ac as defined in ARcADIA is mostly based on NT pro BNP elevation(76%of patients)and is associated with age and ***,Ac was not independently associated with AFDAS at *** ARcADIA trial,which compares aspirin to apixaban in patients with embolic strokes of undetermined source with Ac markers and must,therefore be analysed in the light of these limitations.

关键词： atrial cardiomyopathy prevention

Proteomics research of SARS-coV-2 and cOVID-19 disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Medic.l.Review 2022年第4期2卷 427-445页

作者： Nan Zhang Siyuan Wang catherine c.l.wong Department of Medic.l.Research center State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingP.R.China Department of Radiation Onc.l.gy College of MedicineThe Ohio State UniversityColumbusOHUSA center for cancer Metabolism Comprehensive Cancer CenterThe Ohio State UniversityColumbusOHUSA Department of Medic.l.Research center State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College Hospital(Dongdan Campus)Chinese Academy of Medical Sciences&Peking Union Medical CollegeNo.1 Shuaifuyuan WangfujingDongcheng DistrictBeijing 100730P.R.China Tsinghua University-Peking University Joint center for life Sciences Tsinghua UniversityBeijing 100084P.R.China

currently,coronavirus disease 2019(cOVID-19)is still spreading in a global sc.l.,exerting a massive health and socioeconomic *** insights into the molec.l.r functions of the viral proteins and the pathogenesis of this infectious disease are urgently *** this review,we comprehensively describe the proteome of severe acute respiratory syndrome coronavirus 2(SARS-coV-2)and summarize their protein interaction map with host *** the protein interaction network between the virus and the host,a total of 787 host prey proteins that appeared in at least two studies or were verified by co-immunoprecipitation *** with 29 viral proteins,a network of 1762 proximal interactions were *** also review the proteomics results of cOVID-19 patients and proved that SARS-coV-2 hijacked the host’s translation system,post-translation modification system,and energy supply system via viral proteins,resulting in various immune disorders,multiple cardiomyopathies,and cholesterol metabolism diseases.

关键词： cOVID-19 disease proteomics research SARS-coV-2 particles

含二硫化硒洗发水对中-重度头皮脂溢性皮炎外用糖皮质激素/水杨酸治疗后的疗效维持作用

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中华皮肤科杂志 2024年第5期57卷 483-484页

作者： Philippe Massiot Pasc.l.Reygagne corinne chagnoleau leila Kanoun-copy Florence Pouradier Geneviève loussouarn catherine Queille-Roussel Hussein Jouni Delphine Kerob l'Oréal Research and Innovation Saint-Ouen France. centre Sabouraud Hôpital Saint-Louis 1 avenue Claude-Vellefaux 75010 Paris France. cPcAD Hôpital l'Archet Nice France. l'Oréal Research and Innovation Aulnay-sous-Bois France. cosmetic Active International Levallois-Perret France.

脂溢性皮炎是一种慢性炎症性皮肤病,好发于头皮、面部和躯干等皮脂腺分布丰富的部位。头皮脂溢性皮炎主要表现为红斑和片状鳞屑,程度从轻度鳞屑到弥漫性大片黏着性鳞屑不等,伴有明显的瘙痒,并容易反复发作。目前认为脂溢性皮炎的发生与... 详细信息

脂溢性皮炎是一种慢性炎症性皮肤病,好发于头皮、面部和躯干等皮脂腺分布丰富的部位。头皮脂溢性皮炎主要表现为红斑和片状鳞屑,程度从轻度鳞屑到弥漫性大片黏着性鳞屑不等,伴有明显的瘙痒,并容易反复发作。目前认为脂溢性皮炎的发生与亲脂性马拉色菌定植增加以及遗传、环境和全身健康状况等因素相关,上述因素共同导致皮脂腺代谢活动异常、皮脂成分改变、表皮屏障功能障碍,最终加重炎症反应。

关键词：头皮脂溢性皮炎二硫化硒洗发水亲脂性炎症反应马拉色菌皮脂腺黏着性