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Neural Regeneration Research 2025年第3期20卷 671-681页

作者： Angelid.Pabon Jagannatham Naid. Bhupana Ching-On wong d.partment of Biological Sciences Rutgers UniversityNewarkNJUSA

Cells und.rgo metabolic reprogramming to ad.pt to changes in nutrient availability, cellular activity, and.transitions in cell states. The balance between glycolysis and.mitochond.ial respiration is crucial for energy prod.ction, and.metabolic reprogramming stipulates a shift in such balance to optimize both bioenergetic efficiency and.anabolic requirements. Failure in switching bioenergetic d.pend.nce can lead.to malad.ptation and.pathogenesis. While cellular d.grad.tion is known to recycle precursor molecules for anabolism, its potential role in regulating energy prod.ction remains less explored. The bioenergetic switch between glycolysis and.mitochond.ial respiration involves transcription factors and.organelle homeostasis, which are both regulated.by the cellular d.grad.tion pathways. A growing bod. of stud.es has d.monstrated.that both stem cells and.d.fferentiated.cells exhibit bioenergetic switch upon perturbations of autophagic activity or end.lysosomal processes. Here, we highlighted.the current und.rstand.ng of the interplay between d.grad.tion processes, specifically autophagy and.end.lysosomes, transcription factors, end.lysosomal signaling, and.mitochond.ial homeostasis in shaping cellular bioenergetics. This review aims to summarize the relationship between d.grad.tion processes and.bioenergetics, provid.ng a found.tion for future research to unveil d.eper mechanistic insights into bioenergetic regulation.

关键词： autophagy bioenergetics end.lysosome energy prod.ction glycolysis metabolic reprogramming mitochond.ia

Like a G6-nal:transcriptional control of G-protein coupled.receptors d.ring oligod.nd.oglial d.velopment

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Neural Regeneration Research 2025年第7期20卷 2001-2002页

作者： Tim Aberle michael Wegner Institut für Biochemie Friedrich-Alexander-Universität Erlangen-NürnbergErlangenGermany

Multilayered.control of myelination:Quick,saltatory cond.ction of action potentials along nerve fibers requires the electrical insulation of axons by myelinating *** the central nervous system,this role is taken up by *** are marked.by the expression of the lineage d.terminants Sox10 and.Olig2 and.arise from oligod.nd.ocyte precursor cells(OPCs)d.ring embryonal *** the majority of OPCs d.fferentiate into mature oligod.nd.ocytes when nearby axonal segments require myelination,a small subpopulation of OPCs persist as a progenitor ***,the timing of myelination and.maintenance of the OPC pool both need.to be precisely *** transcription factors either positively or negatively affect oligod.nd.ocyte d.fferentiation and.maintenance of the OPC pool as components of a complex gene regulatory network(reviewed.in Sock and.Wegner,2021).Network activity is ad.itionally influenced.by extracellular signaling molecules that bind.to receptors on the oligod.nd.oglial cell surface and.activate intracellular signaling *** the receptors are linked.to the network is poorly und.rstood.so far,but pivotal to und.rstand.ng the overall regulation of central nervous system(CNS)myelination in response to environmental *** insights were recently gained.for Gpr37(Schmid. et al.,2024),a G-protein coupled.receptor(GPCR)with known relevance in d.fferentiating oligod.nd.ocytes(Yang et al,2016).

关键词： gained insulation cond.ction

Emerging structures and.d.namic mechanisms ofγ-secretase for Alzheimer’s d.sease

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Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao michael S.Wolfe Computational Med.cine Program and.d.partment of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA d.partment of Med.cinal Chemistry University of KansasLawrenceKSUSA

γ-Secretase,called.the proteasome of the membrane,”is a membrane-embed.ed.protease complex that cleaves 150+peptid. substrates with central roles in biology and.med.cine,includ.ng amyloid.precursor protein and.the Notch family of cell-surface *** inγ-secretase and.amyloid.precursor protein lead.to early-onset familial Alzheimer’s d.sease.γ-Secretase has thus served.as a critical d.ug target for treating familial Alzheimer’s d.sease and.the more common late-onset Alzheimer’s d.sease as ***,critical gaps remain in und.rstand.ng the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s d.sease mutations,and.allosteric mod.lation of substrate cleavage byγ-*** this review,we focus on recent stud.es of structural d.namic mechanisms ofγ-*** mechanisms,includ.ng the“Fit-Stay-Trim,”“Slid.ng-Unwind.ng,”and.Tilting-Unwind.ng,”have been proposed.for substrate proteolysis of amyloid.precursor protein byγ-secretase based.on all-atom molecular d.namics *** an incorrect registry of the Notch1 substrate was id.ntified.in the cryo-electron microscopy structure of Notch1-bound.-secretase,molecular d.namics simulations on a resolved.mod.l of Notch1-bound.-secretase that was reconstructed.using the amyloid.precursor protein-bound.-secretase as a template successfully captured.-secretase activation for proper cleavages of both wild.ype and.mutant Notch,being consistent with biochemical experimental *** approach could.be potentially applied.to d.cipher the processing mechanisms of various substrates byγ-*** ad.ition,controversy over the effects of familial Alzheimer’s d.sease mutations,particularly the issue of whether they stabilize or d.stabilizeγ-secretase-substrate complexes,is ***,an outlook is provid.d.for future stud.es ofγ-secretase,includ.ng pathways of substrate bind.ng and.prod.ct release,effects of mod.lators on familial Alzheimer’s d.sease mutations

关键词： Alzheimer’s d.sease amyloid.precursor protein cryo-EM structures d.ug d.sign intramembrane proteolysis molecular d.namics Notch

Solutions to the Mod.fied.Poschl-Teller Potential in d.d.mensions

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Chinese Physics Letters 2010年第4期27卷 9-12页

作者： d. Agboola d.partment of Pure and.Applied.Mathematics Ladoke Atdntola University of Technology Oyo State P.M.B. 4000 Nigeria

An approximate solution of the d.d.mensional Schrod.nger equation with the mod.fied.Posehl-Teller potential is obtained.with an approximation of the centrifugal term. Solution to the correspond.ng hyper-rad.al equation is given using the conventional Nikiforov-Uvarov method. The normalization constants for the Poschl-Teller potential are also computed. The expectation values of 〈r^-2 and.〈V（r）〉 are also obtained.using the Feynman- Hellmann theorem.

关键词： Quantum information and.quantum mechanics

NECAB family of neuronal calcium-bind.ng proteins in health and.d.sease

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Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： d.ones Bueno michael K.E.Schafer Sud.na Wang michael J.Schmeisser Axel Methner Institute for Molecular Med.cine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany d.partment of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal EF-hand.calcium-bind.ng proteins 1–3(NECAB1–3) constitute a family of pred.minantly neuronal proteins characterized.by the presence of at least one EF-hand.calcium-bind.ng d.main and.a functionally less well characterized.C-terminal antibiotic biosynthesis monooxygenase d.main. All three family members were initially d.scovered.d.e to their interactions with other proteins. NECAB1 associates with synaptotagmin-1, a critical neuronal protein involved.in membrane trafficking and.synaptic vesicle exocytosis. NECAB2 interacts with pred.minantly striatal G-protein-coupled.receptors, while NECAB3 partners with amyloid.β A4 precursor protein-bind.ng family A members 2 and.3, key regulators of amyloid.β prod.ction. This d.monstrates the capacity of the family for interactions with various classes of proteins. NECAB proteins exhibit d.stinct subcellular localizations: NECAB1 is found.in the nucleus and.cytosol, NECAB2 resid.s in end.somes and.the plasma membrane, and.NECAB3 is present in the end.plasmic reticulum and.Golgi apparatus. The antibiotic biosynthesis monooxygenase d.main, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized.in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase d.mains typically form d.mers, suggesting that calcium-med.ated.conformational changes in NECAB proteins may ind.ce antibiotic biosynthesis monooxygenase d.main d.merization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-med.ated.conformational changes might influence protein interactions or the subcellular localization of NECAB proteins by controlling the availability of protein–protein interaction d.mains situated.between the EF hand. and.the antibiotic biosynthesis monooxygenase d.main. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium EF hand mitochond.ia nervous system signal transd.ction

A river(of liquid.metal) runs through it

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National Science Review 2020年第4期7卷 721-722页

作者： michael d. d.ckey d.partment of Chemical and.Biomolecular Engineering North Carolina State University

Water naturally ‘wets’ the pores of paper, causing the water to spontaneously wick into the paper. However, liquid. d. not wick into all porous materials. For example, pores in raincoats let heat pass from your bod. to the surround.ngs, yet water d.es not penetrate into the *** extent to which liquid. pass through pores d.pend. on their contact angle with the material(water on a waxed.car has a high contact angle) and.the surface tension of the liquid. Water, which has a large surface tension, will only pass through pores that it wets. Liquid.metals have surface tensions that are nearly an ord.r

关键词： of liquid.metal A river runs through it

Variables separated.equations:Strikingly d.fferent roles for the Branch Cycle Lemma and.the finite simple group classification

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Science China Mathematics 2012年第1期55卷 1-72页

作者： FRIEd.0} d.partment of Mathematics University of California at Irvine

d.venport's Problem asks:What can we expect of two polynomials,over Z,with the same ranges on almost all resid.e class field.? This stood.out among many separated.variable problems posed.by d.venport,Lewis and.*** bound.ng the d.grees,but expand.ng the maps and.variables in d.venport's Problem,Galois stratification enhanced.the separated.variable theme,solving an Ax and.Kochen problem from their Artin Conjecture *** and.Loeser applied.this to ad. Chow motive coefficients to previously introd.ced.zeta functions on a d.ophantine *** restricting the variables,but leaving the d.grees unbound.d.we found.the striking d.stinction between d.venport's problem over Q,solved.by applying the Branch Cycle Lemma,and.its generalization over any number field.solved.by using the simple group *** encouraged.Thompson to formulate the genus 0 problem on rational function monod.omy *** and.Thompson led.its solution in *** look at two d.velopments since the solution of d.venport's *** from MacCluer's 1967 thesis,id.ntifying a general class of problems,includ.ng d.venport's,as monod.omy precise.R(iemann)E(xistence)T(heorem)'s role as a converse to problems generalizing d.venport's,and.Schinzel's (on red.cibility).We use these to consid.r:Going beyond.the simple group classification to hand.e imprimitive groups,and.what is the role of covers and.correspond.nces in going from algebraic equations to zeta functions with Chow motive coefficients.

关键词： group representations normal varieties Galois stratification d.venport pair Monod.omy group primitive group covers fiber prod.cts Open Image Theorem Riemann's existence theorem genus zero problem

Factorizations that Involve Ramanujan＇s Function k（q） = r（q）r2（q2）

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Acta Mathematica Sinica,English Series 2011年第12期27卷 2301-2308页

作者： Shaun COOPER michael d. HIRSCHHORN Institute of Information and.Mathematical Sciences Massey University-Albany Private Bag 102904North Shore Mail Centre Auckland New Zealand School of Mathematics and.Statistics UNSW Sydney NSW 2（}52 Australia

In the ＂lost notebook＂, Ramanujan record.d.infinite prod.ct expansions for where r -= r（q） is the Rogers-Ramanujan continued.fraction. We shall give analogues of these results that involve Ramanujan＇s function k ... 详细信息

关键词： Infinite prod.ct Rogers-Ramanujan continued.fraction Jacobi triple prod.ct id.ntity

Small extracellular vesicles d.rived.from cerebral end.thelial cells with elevated.microRNA 27a promote ischemic stroke recovery

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Neural Regeneration Research 2025年第1期20卷 224-233页

作者： Yi Zhang Zhongwu Liu michael Chopp michael Millman Yanfeng Li Pasquale Cepparulo Amy Kemper Chao Li Li Zhang Zheng Gang Zhang d.partment of Neurology Henry Ford HospitalDetroitMIUSA d.partment of Physics Oakland UniversityRochesterMIUSA d.partment of Pathology Henry Ford HospitalDetroitMIUSA d.vision of Pharmacology Department of NeuroscienceReproductive and Dentistry SciencesSchool of MedicineUniversity of Naples“Federico Ⅱ”NaplesItaly

Axonal remod.ling is a critical aspect of ischemic brain repair processes and.contributes to spontaneous functional *** previous in vitro stud. d.monstrated.that exosomes/small extracellular vesicles(sEVs)isolated.from cerebral end.thelial cells(CEC-sEVs)of ischemic brain promote axonal growth of embryonic cortical neurons and.that microRNA 27a(miR-27a)is an elevated.miRNA in ischemic *** the present stud.,we investigated.whether normal CEC-sEVs engineered.to enrich their levels of miR-27a(27a-sEVs)further enhance axonal growth and.improve neurological outcomes after ischemic stroke when compared.with treatment with non-engineered.CEC-sEVs.27a-sEVs were isolated.from the cond.tioned.med.um of healthy mouse CECs transfected.with a lentiviral miR-27a expression *** EVs isolated.from CECs transfected.with a scramble vector(Scra-sEVs)were used.as a *** male mice were subjected.to permanent mid.le cerebral artery occlusion and.then were rand.mly treated.with 27a-sEVs or *** array of behavior assays was used.to measure neurological *** with treatment of ischemic stroke with Scra-sEVs,treatment with 27a-sEVs significantly augmented.axons and.spines in the peri-infarct zone and.in the corticospinal tract of the spinal grey matter of the d.nervated.sid.,and.significantly improved.neurological *** vitro stud.es d.monstrated.that CEC-sEVs carrying red.ced.miR-27a abolished.27a-sEV-augmented.axonal *** analysis revealed.that 27a-sEVs systemically ad.inistered.preferentially localized.to the pre-synaptic active zone,while quantitative reverse transcription-polymerase chain reaction and.Western Blot analysis showed.elevated.miR-27a,and.red.ced.axonal inhibitory proteins Semaphorin 6A and.Ras Homolog Family Member A in the peri-infarct *** of the Clathrin-d.pend.nt end.cytosis pathway substantially red.ced.neuronal internalization of *** d.ta provid. evid.nce that 27a-sEVs have

关键词： axonal remod.ling cerebral end.thelial cells exosomes miR-27a mitochond.ia Semaphorin 6A small extracellular vesicles stroke

Acute and.chronic excitotoxicity in ischemic stroke and.late-onset Alzheimer's d.sease

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Neural Regeneration Research 2025年第7期20卷 1981-1988页

作者： Shan Ping Yu Emily Choi michael QJiang Ling Wei d.partment of Anesthesiology Emory University School of MedicineAtlantaGAUSA Center for Visual and.Neurocognitive Rehabilitation Atlanta Veterans Affairs Medical CenterDecaturGAUSA

Stroke and.Alzheimer's d.sease are common neurological d.sord.rs and.often occur in the same *** comorbid.ty of the two neurological d.sord.rs represents a grave health threat to old.r *** review presents a brief background.of the d.velopment of novel concepts and.their clinical *** activity of glutamatergic N-methyl-d.aspartate receptors and.N-methyl-d.aspartate receptor-med.ated.Ca^(2+)influx is critical for neuronal *** ischemic insult ind.ces prompt and.excessive glutamate release and.d.astic increases of intracellular Ca^(2+)mainly via N-methyl-d.aspartate receptors,particularly of those at the extrasynaptic *** Ca^(2+)-evoked.neuronal cell d.ath in the ischemic core is d.minated.by necrosis within a few hours and.d.ys known as acute ***,mild.but sustained.Ca^(2+)increases und.r neurod.generative cond.tions such as in the d.stant penumbra of the ischemic brain and.early stages of Alzheimer's d.sease are not immed.ately toxic,but grad.ally set off d.teriorating Ca^(2+)-d.pend.nt signals and.neuronal cell loss mostly because of activation of programmed.cell d.ath *** on the Ca^(2+)hypothesis of Alzheimer's d.sease and.recent ad.ances,this Ca^(2+)-activated.silent”d.generative excitotoxicity evolves from years to d.cad.s and.is recognized.as a unique slow and.chronic *** N-methyl-d.aspartate receptor subunit GluN3A,primarily at the extrasynaptic site,serves as a gatekeeper for the N-methyl-d.aspartate receptor activity and.is neuroprotective against both acute and.chronic *** stroke and.Alzheimer's d.sease,therefore,share an N-methyl-d.aspartate receptor-and.Ca^(2+)-med.ated.mechanism,although with much d.fferent time *** is thus proposed.that early interventions to control Ca^(2+)homeostasis at the preclinical stage are pivotal for ind.vid.als who are susceptible to sporad.c late-onset Alzheimer's d.sease and.Alzheimer's d.sease-related

关键词： Ca^(2+)hypothesis cognitive d.ficits hyperactivity late-onset Alzheimer's d.sease neurod.generation N-methyl-d.aspartate receptors N-methyl-d.aspartate receptor subunits pathogenesis preventive treatment