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MicroRNA miR-252-5p regulates the Notch signaling pathway by targeting Rab6 in Drosophila wing development

Insect Science 2023年第5期30卷 1431-1444页

作者： Do-Hwan Lim Min-seok choi Ji won Jeon Young Sik Lee School of Systems Biomedical Science Soongsil UniversitySeoulRepublic of Korea College of Life Sciences and Biotechnology Korea UniversitySeoulRepublic of Korea Institute of Animal Molecular Biotechnology Korea UniversitySeoulRepublic of Korea

The Notch signaling pathway plays a central role in the development of various ***,dysregulation of microRNAs(miRNAs),which are crucial regulators of gene expression,can disrupt signaling pathways at all stages of *** Notch signaling is involved in wing development in Drosophila,the mechanism underlying miRNA-based regulation of the Notch signaling pathway is ***,we report that loss of Drosophila miR-252 increases the size of adult wings,whereas the overexpression of miR-252 in specific compartments of larval wing discs leads to patterning defects in the adult *** miR-252 overexpression-induced wing phenotypes were caused by aberrant Notch signaling with intracellular accumulation of the full-length Notch receptor during development,which could be due to defects in intracellular Notch trafficking associated with its recycling to the plasma membrane and autophagy-mediated ***,we identified Rab6 as a direct target of miR-252-5p;Rab6 encodes a small Ras-like GTPase that regulates endosomal trafficking *** with this finding,RNAi-mediated downregulation of Rab6 led to similar defects in both wing patterning and Notch ***,co-overexpression of Rab6 completely rescued the wing phenotype associated with miR-252 overexpression,further supporting that Rab6 is a biologically relevant target of miR-252-5p in the context of wing ***,our data indicate that the miR-252-5p-Rab6 regulatory axis is involved in Drosophila wing development by controlling the Notch signaling pathway.

关键词： Drosophila miR-252-5p Notch signaling Rab6 wing development

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Understanding the physical metallurgy of the CoCrFeMnNi high-entropy alloy:an atomistic simulation study

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npj Computational Materials 2018年第1期4卷 662-670页

作者： won-Mi choi Yong Hee Jo seok Su Sohn Sunghak Lee Byeong-Joo Lee Department of Material Science and Engineering Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea

Although high-entropy alloys(HEAs)are attracting interest,the physical metallurgical mechanisms related to their properties have mostly not been clarified,and this limits wider industrial applications,in addition to the high alloy *** clarify the physical metallurgical reasons for the materials phenomena(sluggish diffusion and micro-twining at cryogenic temperatures)and investigate the effect of individual elements on solid solution hardening for the equiatomic CoCrFeMnNi HEA based on atomistic simulations(Monte Carlo,molecular dynamics and molecular statics).A significant number of stable vacant lattice sites with high migration energy barriers exists and is thought to cause the sluggish *** predict that the hexagonal close-packed(hcp)structure is more stable than the face-centered cubic(fcc)structure at 0 K,which we propose as the fundamental reason for the micro-twinning at cryogenic *** alloying effect on the critical resolved shear stress(CRSS)is well predicted by the atomistic simulation,used for a design of non-equiatomic fcc HEAs with improved strength,and is experimentally *** study demonstrates the applicability of the proposed atomistic approach combined with a thermodynamic calculation technique to a computational design of advanced HEAs.

关键词： alloy alloying entropy

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Pediatric schwannoma of the tongue:A case report and review of literature

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World Journal of Clinical Cases 2021年第24期9卷 7212-7217页

作者： Chang Bin Yun Young-Mo Kim Jeong-seok choi Ji won Kim Department of Otorhinolaryngology-Head and Neck Surgery Inha University College of MedicineIncheon 22212South Korea

BACKGROUND Neurogenic tumors account for about ten percent of all tumors of childhood,and benign tumor originating from Schwann cells is rare in peripheral *** of the tongue is quite rare in *** SUMMARY We present the case of an 8-year-old male with schwannoma in the anterolateral *** mass was slow-growing for one year with no pain and *** underwent transoral mass excision under general *** examination revealed a smooth surfaced,17 mm×14 mm×7 mm sized,encapsulated nodule with a clear resection *** of the tongue was confirmed by the pathological *** reported no motor or sensory change,such as dysgeusia or paresthesia,or phonation difficulty during postoperative 12 mo *** Schwannoma of the tongue is a rare benign neoplasm in *** a painless firm mass is encountered in the tongue of a child,solid tumors like schwannoma should be considered in the differential diagnosis.

关键词： Schwannoma Tongue Child Pediatric Neurogenic Tumor Case report

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Visualization of flow structures inside a conical spouted bed by electrical capacitance volume tomography

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Particuology 2019年第1期17卷 15-25页

作者： Hoon Chae Park Hang seok choi Department of Environmental Engineering Yonsei UniversityWonju 26493Republic of Korea

Electrical capacitance volume tomography (ECVT) was conducted to measure instantaneous gas–solid flow structures in a conical spouted bed. The sensor has 24 electrodes/channels and was used to make three-dimensional measurements of the solid volume fraction. Flow structures in the conical spouted bed were analyzed using quantitative ECVT images. Three-dimensional images of gas–solid flow structures and time-averaged vertical and radial solid volume fraction profiles are presented. Different fluidization regimes in spouted beds were characterized by analyzing pressure fluctuation signals and ECVT images. ECVT was shown to be robust and powerful for the three-dimensional visualization and quantitative measurement of a gas–solid fluidization system.

关键词： Conical spouted bed Electrical capacitance volume tomography Multiphase flow

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Shape-controlled Pt nanocubes directly grown on carbon supports and their electrocatalytic activity toward methanol oxidation

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Science Bulletin 2017年第13期62卷 943-949页

作者： Hee Jin Kim Bibi Ruqia Mi Sung Kang Su Bin Lim Ran choi Ki Min Nam won seok Seo Gaehang Lee Sang-Il choi Department of Chemistry and Green-Nano Materials Research Center Kyungpook National University Department of Chemistry KAIST Department of Chemistry Mokpo National University Department of Chemistry Sogang University Korea Basic Science Institute(KBSI) and University of Science and Technology

Synthesis of shape-controlled Pt nanocrystals is substantial and important for enhancing chemical and electrochemical ***,the removal of capping agents,shape-controlling chemicals,on Pt surfaces is essential prior to conducting the catalytic *** we report a facile one-pot synthesis of Pt nanocubes directly grown on carbon supports(Pt nanocubes/C) with modulating the kinetic reaction factors for shaping the nanocrystals,but without adding any capping agents for preserving the clean Pt ***-dispersed Pt nanocubes/C shows enhanced activity and long-term stability toward methanol oxidation reaction compared to the commercial Pt/C catalyst.

关键词： Platinum Nanocube Shape-control Kinetic product Methanol oxidation

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Gene editing particle system as a therapeutic approach for drug-resistant colorectal cancer

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Nano Research 2020年第6期13卷 1576-1585页

作者： Jee-Yeon Ryu You Jung choi Eun-Jeong won Emmanuel Hui Ho-Shik Kim Young-seok Cho Tae-Jong Yoon Laboratory of Nanopharmacy College of PharmacyResearch Institute of Pharmaceutical Science and Technology(RIPST)Ajou UniversitySuwon16499Republic of Korea Division of Gastroenterology Department of Internal MedicineSeoul St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul06591Republic of Korea Moogene Medi Co. Ltd.Seongnam13488Republic of Korea

The epidermal growth factor receptor(EGFR)pathway plays an important role in the progression of colorectal cancer(CRC).Anti-EGFR drugs based on antibodies have been widely used for treating CRC through inducing the cell death ***,the majority of CRC patients will inevitably develop drug-resistance during anti-EGFR drug treatment,which is mainly caused by a point mutation in the KRAS *** developed a nanoliposomal(NL)particle containing the Cas9 protein and a single-guide RNA(sgRNA)complex(Cas9-RNP),for genomic editing of the KRAS *** NL particle is composed of bio-compatible lipid compounds that can effectively encapsulate *** modifying the NL particle to include the appropriate antibody,it can specifically recognize EGFR expressing CRC and effectively deliver the gene-editing *** conditions of NL treatment were optimized using a KRAS mutated CRC in vivo mouse *** with KRAS-mutated CRC showed drug resistance against cetuximab,a therapeutic antibody *** treating the mice with the KRAS gene-editing NL particles,the implanted tumors showed a dramatic decrease in *** results demonstrated that this genomic editing complex has great potential as a therapeutic carrier system for the treatment of drug-resistant cancer caused by a point mutation.

关键词： nanoliposome clustered regularly interspaced short palindromic repeat and associated Cas9 nuclease(CRISPR/Cas9) KRAS mutation drug-resistance colorectal cancer

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Inhomogeneous lithium-storage reaction triggering the inefficiency of all-solid-state batteries

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Journal of Energy Chemistry 2022年第3期31卷 226-236,I0008页

作者： Jaeyoung Kim wontae Lee Jangwhan seok Eunkang Lee Woosung choi Hyunyoung Park Soyeong Yun Minji Kim Jun Lim won-Sub Yoon Department of Energy Science Sungkyunkwan UniversitySuwon 16419South Korea Pohang Accelerator Laboratory Pohang University of Science and TechnologyPohang 37673South Korea

All-solid-state batteries offer an attractive option for developing safe lithium-ion *** the various solid-state electrolyte candidates for their applications,sulfide solid electrolytes are the most suitable owing to their high ionic conductivity and facile ***,their performance is extensively lower compared with those of conventional liquid electrolyte-based batteries mainly because of interfacial reactions between the solid electrolytes and high capacity ***,the kinetic evolution reaction in the composite cathode of all-solid-state lithium batteries has not been actively ***,electrochemical analyses were performed to investigate the differences between the organic liquid electrolyte-based battery and all-solid-state battery *** with electrochemical analyses and synchrotron-based in situ and ex situ X-ray analyses,it was confirmed that inhomogeneous reactions were due to physical *** contacted and/or isolated active material particles account for the inhomogeneously charged regions,which further intensify the inhomogeneous reactions during extended cycles,thereby increasing the polarization of the *** study highlighted the benefits of electrochemo-mechanical integrity for securing a smooth conduction pathway and the development of a reliable homogeneous reaction system for the success of solid-state batteries.

关键词： Liquid electrolyte lithium batteries All-solid-state lithium batteries Ni-rich cathode Synchrotron-based X-ray techniques Inhomogeneous reaction

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Evaluation of anti-tubercular activity of linolenic acid and conjugatedlinoleic acid as effective inhibitors against Mycobacterium tuberculosis

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Asian Pacific Journal of Tropical Medicine 2016年第2期9卷 121-125页

作者： won Hyung choi Department of Biomedical Science and Department of Medical Zoology Kyung Hee University School of Medicine

Objective: To evaluate a new pharmacological activity/effect of linolenic acid(α- and γ-form) and conjugated-linoleic acid(CLA) causing antibacterial activity against Mycobacterium tuberculosis(Mtb). Methods: The anti-Mtb activity/effect of linolenic acid and CLA were determined using different anti-Mtb indicator methods such as resazurin microtiter assay(REMA) and MGIT 960 system assay. The Mtb was incubated with various concentrations(12.5–200) μg/m L of the compounds and anti-Mtb first-line drugs for 5 d in the REMA, and for 3 wk in MGIT 960 system assay. Results: Linolenic acid and CLA obviously indicated their anti-Mtb activity/effect by strongly inhibiting the growth/proliferation of Mtb in a dosedependent manner in the REMA and the MGIT 960 system assay. Interestingly, linolenic acid and CLA consistently induced anti-Mtb activity/effect by effectively inhibiting the growth/proliferation of Mtb in MGIT 960 system for 21 d with a single-treatment, and their minimum inhibitory concentrations were measured as 200 μg/m L respectively. Conclusions: These results demonstrate that linolenic acid and CLA not only have effective anti-Mtb activity/properties, but also induce the selective-anti-Mtb effects by strongly inhibiting and blocking the growth/proliferation of Mtb through a new pharmacological activity/action. Therefore, this study provides novel perspectives for the effective use of them and the potential that can be used as potent anti-Mtb candidate drugs, as well as suggests the advantage of reducing the cost and/or time for developing a new/substantive drug by effectively repurposing the existing drugs or compounds as one of new strategies for the global challenge of tuberculosis.

关键词： MGIT 960 system Tuberculosis Drug susceptibility testing γ-linolenic acid

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Prediction accuracy of reservoir break flood simulation model using finite volume method and UAV

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International Journal of Agricultural and Biological Engineering 2020年第6期13卷 7-15页

作者： Jeongbae Jeon won choi Spatial Information Research Institute Korea Land and Geospatial Infomatix CorporationKorea Land and Geospatial Infomatix CorporationJeollabuk-doSouth Korea Department of Rural Systems Engineering Global Smart Farm Convergence MajorResearch Institute of Agriculture and Life SciencesSeoul National UniversitySeoul 08826South Korea

Methods for producing high-resolution digital topographic maps using an unmanned aerial vehicle(UAV),and 3D fluid dynamics simulation to estimate the flooded areas caused by a collapsed reservoir,were proposed in this *** UAV flight path for photographing damaged areas was divided into two sections considering the drone flight time and overlapping range of the images in the x-and *** metadata taken by the drone were transferred into world coordinates by tracking the key features of the photographs of nearby areas using a 3D rotation *** point cloud data with a 3D space were extracted from the registered images,and a digital surface map(DSM)was produced using a point cloud classification geometric mapping *** amend the serious elevation errors caused by natural or artificial obstacles,a kriging interpolation method was used to reproduce the DSM.A transient computational simulation that considers both the complex geometric topology and hydrodynamic energy of flowing water was conducted using FLOW-3D software to deal with an renormalization group(RNG)turbulence *** flooded areas calculated through visual reading using images taken by the UAV were compared with the 3D simulation results for *** flooded areas estimated through the simulation were approximately 18.3%larger than those found by visual *** flows were mainly observed in obstacles or curved areas of the stream,and the differences in the water depth could be further ***,the villagers confirmed that the flooded areas were much greater than what was seen through the visual ***,the combination of UAV surveying and the 3D simulation method based on the RNG turbulence model is recommended to accurately estimate flooded areas,and it will support an administrative policy aimed at minimizing the economic costs of damage caused by future reservoir collapses.

关键词： reservoir failure flooded area finite volume method unmanned aerial vehicle photogrammetric survey digital surface model

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Interplay between Plants and Microbial Communities:Insights from Holobionts and Environmental Interactions

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Phyton-International Journal of Experimental Botany 2024年第10期93卷 2519-2534页

作者： Sejin choi Ho-seok Lee Department of Biology College of SciencesKyung Hee UniversitySeoul02447Republic of Korea Center for Genome Engineering Institute for Basic ScienceDaejeon34126Republic of Korea

Plants interact with a complex network of microorganisms,forming a dynamic holobiont that is crucial for their health,growth,and *** interconnected system is deeply influenced by environmental factors,which modulate the relationships within the plant *** environmental drivers such as light,temperature,and moisture can alter the balance of these interactions,impacting plant immunity,resilience,and overall *** traditional disease triangle model,which emphasizes plant-pathogen-environment interactions,is enhanced by incorporating the role of the microbiome,revealing how microbial communities contribute to disease *** review highlights the importance of shifting focus from studying plants in isolation to embracing an integrated approach that accounts for the intricate interactions between plants,microbes,and their surrounding *** these interactions is pivotal as we explore new approaches,including advanced sequencing technologies and microbiome engineering,to optimize plant-microbe relationships for improved crop *** insights are vital for developing sustainable agricultural practices to address the impacts of climate change and other environmental challenges.

关键词： Holobiont disease triangle plant-associated microbiome temperature moisture circadian clock

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