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Characterization of hidden rules linking symptoms and selection of acupoint using an artificial neural network model

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Frontiers of Medicine 2019年第1期13卷 112-120页

作者： won-mo jung In-Soo Park Ye-Seul Lee Chang-Eop Kim Hyangsook Lee Dae-Hyun Hahm Hi-Joon Park Bo-Hyoung Jang Younbyoung Chae Department of Science in Korean Medicine Graduate SchoolKyung Hee UniversitySeoul 130-701Republic of Korea Acupuncture & Meridian Science Research Center College of Korean MedicineKyung Hee UniversitySeoul 130-701Republic of Korea Department of Physiology College of Korean MedicineGachon UniversitySeoul 131-120Republic of Korea Department of Physiology School of MedicineKyung Hee UniversitySeoul 130-701Republic of Korea Department of Preventive Medicine College of Korean MedicineKyung Hee UniversitySeoul 130-701Republic of Korea

Comprehension of the medical diagnoses of doctors and treatment of diseases is important to understand the underlying principle in selecting appropriate *** pattern recognition process that pertains to symptoms and diseases and informs acupuncture treatment in a clinical setting was explored. A total of 232 clinical records were collected using a Charting Language program. The relationship between symptom information and selected acupoints was trained using an artificial neural network (ANN). A total of 11 hidden nodes with the highest average precision score were selected through a tenfold cross-validation. Our ANN model could predict the selected acupoints based on symptom and disease information with an average precision score of 0.865 (precision, 0.911;recall, 0.811). This model is a useful tool for diagnostic classification or pattern recognition and for the prediction and modeling of acupuncture treatment based on clinical data obtained in a real-world setting. The relationship between symptoms and selected acupoints could be systematically characterized through knowledge discovery processes, such as pattern identification.

关键词： acupuncture indication neural network pattern identification prediction

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CHARACTERISTICS OF ACUPUNCTURE POINTS COMBINATIONS BASED ON THREE DIFFERENT PATTERN IDENTIFICATION SYSTEM IN THE DONG UI BO GAM

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Journal of Integrative Medicine 2014年第3期 305-305页

作者： won-mo jung Tae-Hyung Lee Younbyoung Chae Department of Brain Cognitive Engineering Korea University Acupuncture and Meridian Science Research Center Kyung Hee University

Dong Ui Bo Gam literally means "Mirror of Eastern Medicine" and it was on the UNESCO’s Memory of the World Programme in *** is composed of five chapters, and one of them is the Nae Gyeong chapter describing about internal bodily *** of important features of this chapter is that this chapter explains symptoms or diseases based on three different pattern identification *** study intends to review the acupuncture and moxibustion(AM) methods found in Dong Ui Bo Gam with consideration on how the AM methods are utilized based on three pattern identification systems, and to visualize how the features of acupoints are recognized in Dong Ui Bo *** extracted acupoints information from their usage for clinical symptoms or *** describing symptoms and diseases were analyzed using keywords of three pattern identification *** these two processes, we obtained bipartite relationships between acupoints and keywords of three pattern identification *** adjacency matrix presenting the relationship, we defined a characteristic of each acupoint using the keywords by quantifying the relationships with a Term Frequency-Inverse Document Frequency(TF-IDF).We analyzed 728 sentences describing what acupoints can be used to 114 clinical ***, we extracted 496 individual keywords illustrating causes of clinical symptoms or ***, each keyword was categorized into 25 specific concepts of the three pattern identification ***, the characteristics of 115 acupoints were presented by TF-IDF values of 25 *** top 5 acupoints with high TF-IDF were PC6, GB43, BL38, LR8, and CV7 for the internal organs pattern/SP5, ST40, KI1, TE6, and SP2 for the internal or external damages pattern/LU7, ST36, GV20, HT7, and CV12 for the five body constituent elements *** acupoints can be linked to the three pattern identification *** visualization of bipartite relationships between acupoints and t

关键词： CHARACTERISTICS OF ACUPUNCTURE POINTS COMBINATIONS BASED ON THREE DIFFERENT PATTERN IDENTIFICATION SYSTEM IN THE DONG UI BO GAM IDF

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Implicit Function Theorem and Its Application to a Ulam's Problem for Exact Differential Equations

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Acta Mathematica Sinica,English Series 2010年第11期26卷 2085-2092页

作者： Soon-mo jung Mathematics Section College of Science and TechnologyHong-Ik University

We prove a global version of the implicit function theorem under a special condition and apply this result to the proof of a modified Hyers-Ulam-Rassias stability of exact differential equations of the form, g（x, y）... 详细信息

关键词： Implicit function theorem Ulam's problem Hyers-Ulam-Rassias stability exact differ-ential equation potential function

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On an Asymptotic Behavior of Exponential Functional Equation

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Acta Mathematica Sinica,English Series 2006年第2期22卷 583-586页

作者： Soon-mo jung Mathematics Section College of Science and Technology Hong-Ik University

The stability problems of the exponential （functional） equation on a restricted domain will be investigated, and the results will be applied to the study of an asymptotic property of that equation. more precisely, the following asymptotic property is proved： Let X be a real （or complex） normed space. A mapping f ： X → C is exponential if and only if f（x ＋ y） - f（x）f（y） → 0 as ｜｜x｜｜＋｜｜y｜｜ → ∞ under some suitable conditions.

关键词： Exponential equation Stability Superstability

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monitoring continuous k-nearest neighbor queries in the hybrid wireless network

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Journal of Zhejiang University-Science C(Computers and Electronics) 2011年第3期12卷 213-220页

作者： Young-mo Kwon HaRim jung Yon Dohn CHUNG Department of Computer Science and Engineering Korea UniversitySeoul 136-713Korea

In a mobile/pervasive computing environment,one of the most important goals of monitoring continuous spatial queries is to reduce communication cost for *** work uses many cellular wireless connections,which would easily become the performance bottleneck of the overall *** paper introduces a novel continuous kNN query monitoring method to reduce communication cost in the hybrid wireless network,where the moving objects in the wireless broadcasting system construct the ad-hoc *** results prove the efficiency of the proposed method,which leverages the wireless broadcasting channel as well as the WiFi link to alleviate the burden on the cellular uplink communication cost.

关键词： Continuous kNN query monitoring Ad-hoc networks Wireless broadcasting systems

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Hybrid Friction Stir Welding of High-carbon Steel

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Journal of Materials Science & Technology 2011年第2期27卷 127-130页

作者： Don-Hyun Choi Chang-Yong Lee Byung-Wook Ahn jung-Hyun Choi Yun-mo Yeon Keun Song Seung-Gab Hong won-Bae Lee Ki-Bong Kang Seung-Boo jung School of Advanced Materials Science and Engineering Sungkyunkwan University 300 Cheoncheon-dongJangan-guSuwonGyeonggi-do 440-746South Korea Department of Mechanical Engineering Korea Advanced Institute of Science and Technology 335 GwahangnoYuseong-guDaejeon 305-701South Korea Department of Advanced Materials Application Suwon Science College 9-10Botong-liJeongnam-myeonHwasungGyeonggi-do 445-742South Korea Technical Research Lab POSCO Corp.Goedong-dongNam-guPohangGyeongbuk790-785South Korea

A high-carbon steel joint,SK5（0.84 wt% C）,was successfully welded by friction stir welding（FSW）,both without and with a gas torch,in order to control the cooling rate during *** welding,the weld zone comprised gray and black regions,corresponding to microstructural variation：a martensite structure and a duplex structure of ferrite and cementite,*** volume fraction of the martensite structure and the Vickers hardness in the welds were decreased with the using of the gas torch,which was related with the lower cooling rate.

关键词： Friction stir welding High-carbon steel Transformation Martensite

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Sex-dependent difference in the effect of metformin on colorectal cancer-specific mortality of diabetic colorectal cancer patients

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World Journal of Gastroenterology 2017年第28期23卷 5196-5205页

作者： jung won Park Jin Ha Lee Ye Hyun Park Soo jung Park Jae Hee Cheon won Ho Kim Tae Il Kim Department of Internal Medicine and Institute of Gastroenterology Yonsei University College of Medicine Cancer Prevention Center Yonsei University College of Medicine

To assess factors associated with the higher effect of metformin on mortality in diabetic colorectal cancer (CRC) patients, since the factors related to the effectiveness of metformin have not been identified *** January 2000 and December 2010, 413 patients diagnosed with both stage 3/4 CRC and diabetes mellitus were identified. Patients’ demographics and clinical characteristics were analyzed. The effect of metformin on CRC-specific mortality and the interactions between metformin and each adjusted factor were *** follow-up duration was median 50 mo (range: 1-218 mo). There were 85 deaths (45.9%) and 72 CRC-specific deaths (38.9%) among 185 patients who used metformin, compared to 130 total deaths (57.0%) and 107 CRC-specific deaths (46.9%) among 228 patients who did not use metformin. In multivariate analysis, survival benefit associated with metformin administration was identified (HR = 0.985, 95%CI: 0.974-0.997, P = 0.012). Interaction test between metformin and sex after adjustment for relevant factors revealed that female CRC patients taking metformin exhibited a significantly lower CRC-specific mortality rate than male CRC patients taking metformin (HR = 0.369, 95%CI: 0.155-0.881, P = 0.025). Furthermore, subgroup analysis revealed significant differences in CRC-specific mortality between the metformin and non-metformin groups in female patients (HR = 0.501, 95%CI: 0.286-0.879, P = 0.013) but not male patients (HR = 0.848, 95%CI: 0.594-1.211, P = 0.365). There were no significant interactions between metformin and other adjusted factors on CRC-specific *** showed a strong sex-dependent difference in the effect of metformin on CRC-specific mortality in advanced stage CRC patients with diabetes.

关键词： Colorectal cancer Metformin Survival Sex

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Complete remission of advanced hepatocellular carcinoma by radiofrequency ablation after sorafenib therapy

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World Journal of Gastroenterology 2015年第8期21卷 2568-2572页

作者： jung Gil Park Soo Young Park Hye won Lee Division of Gastroenterology and Hepatology Department of Internal Medicine CHA University Gumi CHA Medical Center Division of Gastroenterology and Hepatology Department of Internal Medicine School of Medicine Kyungpook National University Department of Pathology School of Medicine Kyungpook National University

Sorafenib,a potent multikinase inhibitor,lead to a significant improvement in progression free survival and overall survival in patients with advanced hepatocellular carcinoma(HCC).Though sorafenib has proven its efficacy in advanced stage HCC,there are limitedreports on the role of sorafenib allowing for curative treatment by *** herein report a case of advanced HCC with vascular invasion,which showed treatment response by sorafenib therapy as to allow for radiofrequency ablation as curative *** patient was followed-up for 6 mo without recurrence with continued sorafenib therapy.

关键词： Hepatocellular carcinoma Radiofrequency ablation S

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Enrichment by air classification of indium components from In-containing scrap powders scraped by sand-blasting chamber shields of sputter coaters

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Rare Metals 2010年第1期29卷 1-8页

作者： Sungkyu Lee Soo-Bok Jeong Hang-Chul jung Hyun Seon Hong Yongseung Yun Sang mo Woo Plant Engineering Center Institute for Advanced Engineering633-2 Goan-ri Baegam-myeon Cheoin-gu Yongin-si Gyeonggi-do 449-863 Korea Division of Chemical and Materials Engineering Ajou University 5 Wonchon Youngtong Suwon Gyeonggi-do 443-749 Korea Minerals and Materials Processing Division Korea Institute of Geo-science and Mineral Resources (KIGAM) 30 Gajeong-dong Yuseong-gu Daejeon 305-350 Korea Plant Engineering Center Institute for Advanced Engineering633-2 Goan-ri Baegam-myeon Cheoin-gu Yongin-siGyeonggi-do 449-863 Korea 9 Digit Co. Ltd. 20BL-10L Namdong Industrial Complex428-9 Nonhyeon-dong Namdong-gu Incheon 405-848 Korea

Raw scrap powders containing 10 wt.% In were recovered by sand-blasting chamber shields of sputter coaters and used as a sole source of indium components for both sieving and air-classification. Sieving was performed first as a feasibility test, and enrichment of indium component was possible up to 19 wt.% with a mesh size of 635. With this experimental basis, the raw scrap powders were air-classified into 12 lots according to the revolution per minute （r/min） of a single horizontally arranged classifying wheel： 4000, 6000, 8000, 10000, 12000, and 14000 r/rain. The particle cut size varied from 56 to 5 μm with turbo wheel speeds corresponding to 4000 to 14000 r/min, respectively, and enrichment of indium component was possible in fine overflow fractions at all turbo wheel speeds while the indium components were not concentrated in all of the coarse underflow fractions. The grade of the indium components became higher with decreasing particle size of the air-classified scrap powders, with the highest grade obtained in the fine overflow fraction with a turbo wheel speed of 14000 r/min. The amount of indium in the fine overflow fractions varied between 15.9 wt.% and 31.5 wt.%. All in all, the grade or purity of the indium component improved rather significantly from 15.9 wt.% to 31.5 wt.% by air-classification, but this also resulted in overall decrease in recovery rate from 99.33% to 49.64%. Therefore, enrichment and separation of indium should be optimized for maximum recovery and grade of the indium components, which can be used as raw materials in the subsequent electro-refining processes.

关键词： indium air-classification recycling indium tin oxide gas-cyclone dry dispersion

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HOS1 Facilitates the Phytochrome B-Mediated Inhibition of PIF4 Function during Hypocotyl Growth in Arabidopsis

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molecular Plant 2017年第2期10卷 274-284页

作者： Ju-Heon Kim Hyo-Jun Lee Jae-Hoon jung Sangmin Lee Chung-mo Park Department of Chemistry Seoul National University Seoul 08826 Korea Sainsbury Laboratory University of Cambridge Cambridge CB2 1LR UK Plant Genomics and Breeding Institute Seoul National University Seoul 08826 Korea These authors contributed equally to this article Present address: SK Innovation Daejeon 34124 Korea

Upon exposure to light, developing seedlings undergo photomorphogenesis, as illustrated by inhibition of hypocotyl elongation, cotyledon opening, and leaf greening. During hypocotyl photomorphogenesis, light signals are sensed by multiple photoreceptors, among which the red/far-red light-sensing phytochromes have been extensively studied. However, it is not fully understood how the phytochromes modulate hypo- cotyl growth. Here, we demonstrated that HIGH EXPRESSION OF OSmoTICALLY RESPONSIVE GENES 1 （HOS1）, which is known to either act as E3 ubiquitin ligase or affect chromatin organization, inhibits the transcriptional activation activity of PHYTOCHROME INTERACTING FACTOR 4 （PIF4）, a key transcrip- tion factor that promotes hypocotyl growth. Consistent with the negative regulatory role of HOSl in hypo- cotyl growth, HOSl-defective mutants exhibited elongated hypocotyls in the light. Notably, phyB induces HOS1 activity in inhibiting PIF4 function. Taken together, these observations provide a molecular basis for the phyB-mediated suppression of hypocotyl growth in Arabidopsis.

关键词： photomorphogenesis hypocotyl growth phytochrome signaling HOS1 PIF4

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