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Simultaneous laparoscopic and arthroscopic excision of a huge juxta-articular ganglionic cyst compressing the sciatic nerve:A case report

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World Journal of Clinical Cases 2022年第25期10卷 9028-9035页

作者： won-ku choi Jong-Sung Oh Sun-Jung Yoon Department of Obstetrics and Gynecology Medical SchoolJeonbuk National UniversityResearch Institute of Clinical Medicine of Jeonbuk National UniversityJeonju 54907South Korea Department of Orthopedic Surgery Medical SchoolJeonbuk National UniversityResearch Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University HospitalJeonju 54907South Korea

BACKGROUND A large ganglionic cyst extending from the hip joint to the intrapelvic cavity through the sciatic notch is a rare space-occupying lesion associated with compressive lower-extremity neuropathy.A cyst in the pelvic cavity compressing the intrapelvic-sciatic nerve is easily missed in the diagnostic process because it usually presents as atypical symptoms of an extraperitoneal-intrapelvic *** present a case of a huge ganglionic cyst that was successfully excised laparoscopically and endoscopically by a gynecologist and an orthopedic *** SUMMARY A 52-year-old woman visited our hospital complaining of pain and numbness in her left buttock while *** pain began 3 years ago and worsened,while the numbness in the left lower extremity lasted 1 *** was diagnosed and unsuccessfully treated at several tertiary referral centers many years *** resonance imaging revealed a suspected paralabral cyst(5 cm×5 cm×4.6 cm)in the left hip joint,extending to the pelvic cavity through the greater sciatic *** CA-125 and CA19-9 tumor marker levels were within normal ***,the cyst was compressing the sciatic ***,endoscopic and laparoscopic neural decompression and mass excision were performed simultaneously.A laparoscopic examination revealed a tennis-ball-sized cyst filled with gelatinous liquid,stretching deep into the hip *** excisional biopsy performed in the pelvic cavity and deep gluteal space confirmed the accumulation of ganglionic cysts from the hip joint into the extrapelvic intraperitoneal *** Intra-or extra-sciatic nerve-compressing lesion should be considered in cases of sitting pain radiating down the ipsilateral lower *** large juxta-articular ganglionic cyst was successfully treated simultaneously using laparoscopy and arthroscopy.

关键词： Paralabral cyst Ganglion cyst Intrapelvic sciatic nerve compression syndrome Deep gluteal syndrome Hip joint Laparoscopy Case report

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Co-operative roles of IL-4Rαand IL-13Rα1 in the progression of ovarian carcinomas and the survival of ovarian carcinoma patients

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Cancer Communications 2023年第7期43卷 850-854页

作者： won ku choi Usama Khamis Hussein Asmaa Gamal Ahmed Junyue Zhang Kyoung Min Kim Ae Ri Ahn Ho Sung Park See-Hyoung Park Dong Hyu Cho Kyu Yun Jang Department of Obstetrics and Gynecology Jeonbuk National University Medical SchoolJeonjuRepublic of Korea Department of Pathology Jeonbuk National University Medical SchoolJeonjuRepublic of Korea Faculty of Science Beni-Suef UniversityBeni-SuefEgypt School of Biomedical Informatics The University of Texas Health Science Center at HoustonHoustonTexasUSA Faculty of Postgraduate Studies and Advanced Sciences Beni-Suef UniversityBeni-SuefEgypt Department of Orthopedic Surgery Jeonbuk National University Medical SchoolJeonjuRepublic of Korea Department of Bio and Chemical Engineering Hongik UniversitySejongRepublic of Korea Research Institute of Clinical Medicine of Jeonbuk National University JeonjuRepublic of Korea Biomedical Research Institute of Jeonbuk National University Hospital JeonjuRepublic of Korea

Dear Editor,Recently,there has been a rise in interest in the roles of cytokines and cytokine receptors in malignant human *** receptors,especially typeⅡinterleukin-4 receptor(IL-4R),have recently been examined as novel therapeutic targets of human cancers[1-3].The typeⅡIL-4R complex is composed of IL-4Rαand interleukin-13 receptorα1(IL-13Rα1),and the expression of IL-4Rαand IL-13Rα1 was higher in cancer tissues compared with normal counterpart tissues[3,4].

关键词： operative patients cytokines

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Apolipoprotein A-I binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration

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Neural Regeneration Research 2025年第5期20卷 1414-1415页

作者： Sinwoo Hwang Seunghwan choi Soo-Ho choi Keun-Young Kim Yury I.Miller won-Kyu Ju Hamilton Glaucoma Center and Shiley Eye Institute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA Department of Medicine University of California San DiegoLa JollaCAUSA National Center for Microscopy and Imaging Research Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA

Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs *** to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more *** primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.

关键词： irreversible pass primarily

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Therapeutic potential of exercise-hormone irisin in Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1555-1564页

作者： Eunhee Kim Rudolph ETanzi Se Hoon choi Genetics and Aging Research Unit MassGeneral Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolCharlestownMAUSA McCance Center for Brain Health Massachusetts General HospitalBostonMAUSA

Irisin is a myokine that is generated by cleavage of the membrane protein fibronectin type Ⅲ domain-containing protein 5(FNDC5) in response to physical exercise. Studies reveal that irisin/FNDC5 has neuroprotective functions against Alzheimer's disease, the most common form of dementia in the elderly, by improving cognitive function and reducing amyloid-β and tau pathologies as well as neuroinflammation in cell culture or animal models of Alzheimer's disease. Although current and ongoing studies on irisin/FNDC5 show promising results, further mechanistic studies are required to clarify its potential as a meaningful therapeutic target for alleviating Alzheimer's disease. We recently found that irisin treatment reduces amyloid-β pathology by increasing the activity/levels of amyloid-β-degrading enzyme neprilysin secreted from astrocytes. Herein, we present an overview of irisin/FNDC5's protective roles and mechanisms against Alzheimer's disease.

关键词： Alzheimer's disease exercise fibronectin typeⅢdomain-containing protein 5(FNDC5) irisin

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Acute and chronic excitotoxicity in ischemic stroke and late-onset Alzheimer's disease

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Neural Regeneration Research 2025年第7期20卷 1981-1988页

作者： Shan Ping Yu Emily choi Michael QJiang Ling Wei Department of Anesthesiology Emory University School of MedicineAtlantaGAUSA Center for Visual and Neurocognitive Rehabilitation Atlanta Veterans Affairs Medical CenterDecaturGAUSA

Stroke and Alzheimer's disease are common neurological disorders and often occur in the same *** comorbidity of the two neurological disorders represents a grave health threat to older *** review presents a brief background of the development of novel concepts and their clinical *** activity of glutamatergic N-methyl-D-aspartate receptors and N-methyl-D-aspartate receptor-mediated Ca^(2+)influx is critical for neuronal *** ischemic insult induces prompt and excessive glutamate release and drastic increases of intracellular Ca^(2+)mainly via N-methyl-D-aspartate receptors,particularly of those at the extrasynaptic *** Ca^(2+)-evoked neuronal cell death in the ischemic core is dominated by necrosis within a few hours and days known as acute ***,mild but sustained Ca^(2+)increases under neurodegenerative conditions such as in the distant penumbra of the ischemic brain and early stages of Alzheimer's disease are not immediately toxic,but gradually set off deteriorating Ca^(2+)-dependent signals and neuronal cell loss mostly because of activation of programmed cell death *** on the Ca^(2+)hypothesis of Alzheimer's disease and recent advances,this Ca^(2+)-activated“silent”degenerative excitotoxicity evolves from years to decades and is recognized as a unique slow and chronic *** N-methyl-D-aspartate receptor subunit GluN3A,primarily at the extrasynaptic site,serves as a gatekeeper for the N-methyl-D-aspartate receptor activity and is neuroprotective against both acute and chronic *** stroke and Alzheimer's disease,therefore,share an N-methyl-D-aspartate receptor-and Ca^(2+)-mediated mechanism,although with much different time *** is thus proposed that early interventions to control Ca^(2+)homeostasis at the preclinical stage are pivotal for individuals who are susceptible to sporadic late-onset Alzheimer's disease and Alzheimer's disease-related

关键词： Ca^(2+)hypothesis cognitive deficits hyperactivity late-onset Alzheimer's disease neurodegeneration N-methyl-D-aspartate receptors N-methyl-D-aspartate receptor subunits pathogenesis preventive treatment

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Laser-assisted deposition of Cu bumps for microelectronic packaging

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中国有色金属学会会刊：英文版 2012年第S3期22卷 683-687页

作者： won-Seok choi Joohan KIM Department of Nano IT Fusion Program Seoul National University of Science and Technology Department of Mechanical and Automotive Engineering Seoul National University of Science and Technology

Cu bump was transferred using a focused laser pulse for microelectronic *** Nd:YAG laser pulse (maximum energy of 500 mJ;wavelength of 1064 nm;fluences of 0.4-2.1 kJ/cm2) was irradiated on a sacrificial absorption layer with copper *** focused laser beam induced plasma between the semi-transparent donor slide and the sacrificial layer,causing a shock *** shock wave pressure pushed the Cu layer and transferred material to deposit a bump on substrate.A beam-shaper was used to produce uniform pressure at the interface to reduce fragmentation of the transferred material on the *** calculated shock wave pressure with respect to laser fluence was 1-3 GPa.A Cu bump of diameter of 200 μm was successfully deposited at laser fluence of 0.6 kJ/cm *** pressure control at the sacrificial layer using a laser pulse was critical to produce a bump with less *** technique can be applied to forming Cu bump for an interconnecting process in electronics.

关键词： laser induced forward transfer bump deposition Nd:YAG pulsed laser micro system packaging beam shaping

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Journal of Materials Science & Technology 2022年第16期111卷 99-110页

作者： Vioni Dwi Sartika won Seok choi Gwanghyo choi Jaewook Han Sung-Jin Chang won-Seok Ko Blazej Grabowski Pyuck-Pa choi Department of Materials Science and Engineering Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea Gangwon Regional Division Korea Institute of Industrial TechnologyGangwon 25440Republic of Korea Division of Measurement and Analysis National Nanofab CenterDaejeon 34141Republic of Korea School of Materials Science and Engineering University of UlsanUlsan 44610Republic of Korea Institute for Materials Science University of StuttgartPfaffenwaldring 5570569 StuttgartGermany

We report laser cladding of pure titanium on a CoCrMo alloy using directed energy *** electron microscopy,the microstructural evolution upon varying the process parameters,especially laser power and powder feed rate,was investigated in relation to crack *** layers showing dilution rates of more than 5%contained cracks due to the formation of the brittle Co_(2)Ti intermetallic *** observed cracks could be ascribed to a mismatch in thermal expansion and a resulting stress of more than 440 MPa acting on the Co_(2)Ti phase,as determined by density functional theory and ***,an excess laser energy caused chemical inhomogeneity and unmelted Ti powder particles,while a deficient laser energy resulted in a lack of *** cracks nor partially melted powders were observed for a powder feed rate of 3 g/min and a laser power of 225–300 W,for which the dilution rate was minimized to less than 5%.For such samples,the cladding layers comprised pureα-Ti and a uniform CoT i interface with Co_(2)Ti islands.

关键词： Additive manufacturing Dissimilar metal joining Titanium Cobalt-based alloy

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Evaluation of anti-tubercular activity of linolenic acid and conjugatedlinoleic acid as effective inhibitors against Mycobacterium tuberculosis

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Asian Pacific Journal of Tropical Medicine 2016年第2期9卷 121-125页

作者： won Hyung choi Department of Biomedical Science and Department of Medical Zoology Kyung Hee University School of Medicine

Objective: To evaluate a new pharmacological activity/effect of linolenic acid(α- and γ-form) and conjugated-linoleic acid(CLA) causing antibacterial activity against Mycobacterium tuberculosis(Mtb). Methods: The anti-Mtb activity/effect of linolenic acid and CLA were determined using different anti-Mtb indicator methods such as resazurin microtiter assay(REMA) and MGIT 960 system assay. The Mtb was incubated with various concentrations(12.5–200) μg/m L of the compounds and anti-Mtb first-line drugs for 5 d in the REMA, and for 3 wk in MGIT 960 system assay. Results: Linolenic acid and CLA obviously indicated their anti-Mtb activity/effect by strongly inhibiting the growth/proliferation of Mtb in a dosedependent manner in the REMA and the MGIT 960 system assay. Interestingly, linolenic acid and CLA consistently induced anti-Mtb activity/effect by effectively inhibiting the growth/proliferation of Mtb in MGIT 960 system for 21 d with a single-treatment, and their minimum inhibitory concentrations were measured as 200 μg/m L respectively. Conclusions: These results demonstrate that linolenic acid and CLA not only have effective anti-Mtb activity/properties, but also induce the selective-anti-Mtb effects by strongly inhibiting and blocking the growth/proliferation of Mtb through a new pharmacological activity/action. Therefore, this study provides novel perspectives for the effective use of them and the potential that can be used as potent anti-Mtb candidate drugs, as well as suggests the advantage of reducing the cost and/or time for developing a new/substantive drug by effectively repurposing the existing drugs or compounds as one of new strategies for the global challenge of tuberculosis.

关键词： MGIT 960 system Tuberculosis Drug susceptibility testing γ-linolenic acid

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Prediction accuracy of reservoir break flood simulation model using finite volume method and UAV

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International Journal of Agricultural and Biological Engineering 2020年第6期13卷 7-15页

作者： Jeongbae Jeon won choi Spatial Information Research Institute Korea Land and Geospatial Infomatix CorporationKorea Land and Geospatial Infomatix CorporationJeollabuk-doSouth Korea Department of Rural Systems Engineering Global Smart Farm Convergence MajorResearch Institute of Agriculture and Life SciencesSeoul National UniversitySeoul 08826South Korea

Methods for producing high-resolution digital topographic maps using an unmanned aerial vehicle(UAV),and 3D fluid dynamics simulation to estimate the flooded areas caused by a collapsed reservoir,were proposed in this *** UAV flight path for photographing damaged areas was divided into two sections considering the drone flight time and overlapping range of the images in the x-and *** metadata taken by the drone were transferred into world coordinates by tracking the key features of the photographs of nearby areas using a 3D rotation *** point cloud data with a 3D space were extracted from the registered images,and a digital surface map(DSM)was produced using a point cloud classification geometric mapping *** amend the serious elevation errors caused by natural or artificial obstacles,a kriging interpolation method was used to reproduce the DSM.A transient computational simulation that considers both the complex geometric topology and hydrodynamic energy of flowing water was conducted using FLOW-3D software to deal with an renormalization group(RNG)turbulence *** flooded areas calculated through visual reading using images taken by the UAV were compared with the 3D simulation results for *** flooded areas estimated through the simulation were approximately 18.3%larger than those found by visual *** flows were mainly observed in obstacles or curved areas of the stream,and the differences in the water depth could be further ***,the villagers confirmed that the flooded areas were much greater than what was seen through the visual ***,the combination of UAV surveying and the 3D simulation method based on the RNG turbulence model is recommended to accurately estimate flooded areas,and it will support an administrative policy aimed at minimizing the economic costs of damage caused by future reservoir collapses.

关键词： reservoir failure flooded area finite volume method unmanned aerial vehicle photogrammetric survey digital surface model

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Indigenous parasitoids as effective natural enemies of Phyllocnistis citrella(Lepidoptera:Gracillariidae)in Korea

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Journal of Forestry Research 2017年第1期28卷 183-187页

作者： Sanghyeob Lee Da-Som Kim Il-Kwon Kim Chung-won choi Rokyeon Hwang Deok-Seo ku Bong-Kyu Byun Department of Plant Biotechnology and Plant Engineering Research Institute Sejong UniversitySeoul 05006Republic of Korea Department of Biological Science and Biotechnology Hannam University461-6 Jeonmin-dongYuseong-guDaejeon 34054Republic of Korea Division of Forest Biodiversity Korea National ArboretumPocheon 11186Republic of Korea Citrus Research Institute SeogwipoJeju 63607Republic of Korea The Science Museum of Natural Enemies Geochang 50147Republic of Korea

This study is aimed to investigate the occurrence of Phyllocnistis citrella Stainton （citrus leafminer; CLM）, which has recently caused increasing damage to citrus farms in southern South Korea, and its natural enemies, which can act as biological control agents. In the present study, CLM monitoring using sex pheromone traps were conducted in the major citrus farms in the Jeju region in South Korea. Also a survey of parasites was carried out to detect the effective control agent for CLM. During the investigation from 2011 to 2015, a relatively large number of adult CLM （2,386,990） were observed in the sex pheromone traps. The mean annual occurrence of CLM was 477,398, which showed an increasing trend with the increase in temperature. A survey of parasites was conducted in November 2015. Six parasites were found, of which, Quadrastichus sp. and Sympiesis sp. showed the highest rates of parasitism. The mean rate of parasitism during the survey period was 3.97 %. We discovered four new species of parasites of CLM in South Korea.

关键词： CLM Biological control. Parasitoid Korea

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