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Synergetic effects of shock waves with polydeoxyribonucleotides on rotator cuff tendon tear in a rabbit model

BIOCELL 2021年第3期45卷 527-536页

作者： DONG HAN kim DONG RAK Kwon gi-YOUNG PARK YONG SUK MOON Department of Rehabilitation Medicine Catholic University of Daegu School of MedicineDaegu42472South Korea Department of Anatomy Catholic University of Daegu School of MedicineDaegu42472South Korea

This work aimed to investigate the synergetic therapeutic effects of polydeoxyribonucleotides(PDRN)combined with extracorporeal shock waves therapy(ESWT)and the effects of the therapy according to ESWT sequences on a chronic traumatic full-thickness rotator cuff tear(RCT)in rabbit *** this purpose,thirty-two rabbits were randomly allocated into 4 *** excision was made to create a 5-mm sized full-thickness RCT right proximal to the insertion site on the *** 6 weeks,4 different procedures(normal saline,Group 1;PDRN injection,Group 2;PDRN injection before ESWT,Group 3;PDRN injection after ESWT,Group 4)were *** injection and radial type ESWT were each performed 4 times per *** morphology,Immunohistochemistry,and motion analysis were performed at 4 weeks after *** parameters including tear size,Masson’s trichrome(MT)staining,anti-collagen 1 monoclonal antibody immunostaining(COL-1),proliferating cell nuclear antigen(PCNA),vascular endothelial growth factor(VEGF),anti-platelet endothelial cell adhesion molecule-1 polyclonal antibody(PECAM-1),and motion analysis,were significantly greater in Group 2,Group 3,and Group 4 than in Group *** Group 4,all parameters were significantly greater than in Group 2,and parameters including MT staining,COL-1,PCNA,PECAM-1,and fast walking time were significantly greater than Group *** were no significant differences between Group 2 and Group *** study demonstrated that PDRN injection alone and combined with ESWT were more effective than control treatment and applying ESWT before PDRN injection was also shown to yield better outcomes in parameters including angiogenesis,cell proliferation,and fast walking time in a rabbit model with chronic traumatic full-thickness ***,the application of ESWT before PDRN injection could be recommended for optimal outcomes of the conservative treatments when the patients with full-thickness RCT are not suitable in surgical treatment

关键词： Shoulder Rotator cuff Polydeoxyribonucleotides Extracorporeal shock waves

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Texture tailoring and bendability improvement of rolled AZ31 alloy using {10-12} twinning: The effect of precompression levels

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Journal of Magnesium and Alloys 2019年第4期7卷 648-660页

作者： Jong Un Lee Ye Jin kim Sang-Hoon kim Jeong Hun Lee Min-Seong kim Shi-Hoon Choi Byoung gi Moon Young Min kim Sung Hyuk Park School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Republic of Korea Ulsan Regional Division Korea Institute of Industrial TechnologyUlsan 44413Republic of Korea Department of Printed Electronics Engineering Sunchon National UniversitySuncheonJeonnam 57922Republic of Korea Implementation Research Division Korea Institute of Materials ScienceChangwon 51508Republic of Korea

In this study,the texture of a rolled Mg alloy is effectively modified through the application of precompression and subsequent annealing treatment,leading to a remarkable improvement in the bending formability of the alloy at room *** induces lattice reorientation through{10-12}twinning,and annealing treatment reduces the stored strain energy of the precompressed material,which results in the formation of a stable grain structure with two dominant texture *** an increase in precompression,the tensile strain in the outer region of the bending samples is accommodated to a greater extent due to more pronounced{10-12}twinning and basal *** a result,the bending formability of the material at room temperature improves with greater *** variation in microstructure,texture,and bending behavior in relation to the degree of precompression is discussed in detail.

关键词： Magnesium Bending Formability Twinning Texture

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Hydrangeae Dulcis Folium Attenuates Physical Stress by Supressing ACTH-Induced Cortisol in Zebrafish

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Chinese Journal of Integrative Medicine 2020年第2期26卷 130-137页

作者： Junyoung Oh Dong Hyun kim gi-young kim Eun-Jin Park Jong Hoon Ryu Ji Wook Jung Se Jin Park Gwang-Woo kim Seungheon Lee Department of Marine Life Science College of Ocean ScienceJeju National UniversityJeju(63243)Republic of Korea Departme nt of Medicinal Biotech no logy College of Health SciencesDong-A UniversityBusan(604-714)Republic of Korea Department of Food Bioengineering Jeju National UniversityJeju(63243)Republic of Korea Institute of Convergence BioHealth Dong-A UniversityBusan(604-714)Republic of Korea Department of Oriental Pharmaceutical Science College of PharmacyKyung Hee UniversityHoeki-dongDongdaemoon・KuSeoul(130-701)Republic of Korea Kyung Hee East-West Pharmaceutical Research Institute College of PharmacyKyung Hee UniversityHoeki-dongDongdaemoorvKuSeoul(130-701)Republic of Korea Department of Herbal Medicinal Pharmacology College of Herbal Bio-industryDaegu Haany UniversityYugok-dongGyeongsan(712-715)Republic of Korea School of Natural Resources and Environmental Sciences Kangwon National UniversityChuncheon(24341)Republic of Korea Marine Bio Con verge nee Center Gangneung Science&In dustry Promotion AgencyGangneung(25440)Republic of Korea

Objective:To determine the effects of Hydrangeae Dulcis Folium(EHDF)on physical stress,changes in the whole-body cortisol level and behaviour in zebrafish(Danio rerio).Methods:One hundred and seventy-four fish were randomly divided into 4[adrenocorticotropin hormone(ACTH)challenge test:4 fish per group]or 6 groups(behavioural test:10–12 fish per group,whole-body cortisol:4 fish per group).Net handling stress(NHS)was used to induce physical *** were treated with vehicle or EHDF(5–20 mg/L)for 6 min before they were exposed to *** then,fish were sacrificed for collecting body fluid from whole-body or conducted behavioural tests,including novel tank test and open field test,and were evaluated to observe anxiety-like behaviours and *** addition,to elucidate the mode of action of the anti-stress effects of EHDF,ACTH(0.2 IU/g,i.p.)challenge test was ***:The increased anxiety-like behaviours in novel tank test and open field test under stress were prevented by treatment with EHDF at 5–20 mg/L(P<0.05).Moreover,compared with the unstressed group,which was not treated with NHS,the whole-body cortisol level was significantly increased by treatment with NHS(P<0.05).Compared with the NHS-treated stressed control group,pre-treatment with EHDF at concentrations of 5–20 mg/L for 6 min significantly prevented the NHS-increased whole-body cortisol level(P<0.05).In addition,ACTH challenge test showed that EHDF completely blocked the effects of ACTH on cortisol secretion(P<0.05).Conclusion:EHDF may be a good antistress candidate and its mechanism of action may be related to its positive effects on cortisol release.

关键词： net handling stress zebrafish Hydrangeae Dulcis Folium whole-body cortisol behavioural tests

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High prevalence of osteoporosis in patients with gastric adenocarcinoma following gastrectomy

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World Journal of Gastroenterology 2007年第48期13卷 6492-6497页

作者： Jung Sub Lim Sang Bum kim Ho-Yoon Bang gi Jeong Cheon Jong-Inn Lee Department of Pediatrics Korea Cancer Center Hospital Department of Surgery Korea Cancer Center Hospital Department of Nuclear Medicine Korea Cancer Center Hospital

AIM： To evaluate the prevalence and predictive factors of osteoporosis in patients with gastric adenocarcinoma alter gastrectomy.METHODS： The study included 133 patients diagnosed with gastric adenocarcinoma but who did not undergo prior diagnostic work-up for osteoporosis. Bone mineral density （BMD） was measured by dual-energy X-ray absorptiometry （DXA） and vertebral deformity was assessed by plain X-rays. We evaluated the effects of age, sex, body mass index （BMI）, anemia, back pain, vertebral deformity, tumor staging, reconstruction type, and past medical history to determine predictive factors of osteoporosis in these patients.RESULTS： The prevalence of osteoporosis in the lumbar spine was 38.3% （male, 28.9%; female, 54.0%）, and 15.0% in the femoral neck （male, 10.8%; female, 22.0%）. The vertebral deformity rate was 46.6% （male, 43.4%; female, 52.0%）. Age, BMI and hemoglobin correlated with BMD （P 〈 0.01）. In males, anemia and age 〉 64 years were independent predictive factors of osteoporosis in multivariate analysis. In females, back pain was an independent factor for osteoporosis.CONCLUSION： The results of this study revealed that prevalence of osteoporosis and vertebral bone deformity rate were high in gastric cancer patients, regardless of post-gastrectomy duration and operation type. Early diagnosis and a proper management plan must be established in these patients.

关键词： Gastric adenocarcinoma Gastrectomy Bone mineral density Osteoporosis Vertebral deformity Anemia Back pain

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Assessment of pathogens and risk factors associated with bloodstream infection in the year after pediatric liver transplantation

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World Journal of Gastroenterology 2022年第11期28卷 1159-1171页

作者： Yeong Eun kim Ho Jung Choi Hye-Jin Lee Hyun Ju Oh Mi Kyoung Ahn Seak Hee Oh Jung-Man Namgoong Dae Yeon kim won Kyoung Jhang Seong Jong Park Dong-Hwan Jung Deok Bog Moon gi-won Song gil-Chun Park Tae-Yong Ha Chul-Soo Ahn Ki-Hun kim Shin Hwang Sung Gyu Lee Kyung Mo kim Department of Pediatrics Asan Medical Center Children's HospitalUniversity of Ulsan College of MedicineSeoul 05505South Korea Division of Pediatric Surgery Department of SurgeryAsan Medical Center Children's HospitalUniversity of Ulsan College of MedicineSeoul 05505South Korea Division of Hepatobiliary Surgery and Liver Transplantation Department of SurgeryAsan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea

BACKGROUND Bloodstream infection(BSI)is one of the most significantly adverse events that can occur after liver transplantation(LT)in *** To analyze the profile of BSI according to the postoperative periods and assess the risk factors after pediatric *** Clinical data,collected from medical charts of children(n=378)who underwent primary LT,were retrospectively *** primary outcome considered was BSI in the first year after *** and multivariate analyses were performed to identify risk factors for BSI and respective odds ratios(ORs).RESULTS Of the examined patients,106(28%)experienced 162 episodes of pathogen-confirmed BSI during the first year after *** were 1.53±0.95 episodes per children(mean±SD)among BSIcomplicated patients with a median onset of 0.4 mo *** most common pathogenic organisms identified were Coagulase-negative staphylococci,followed by Enterococcus *** Streptococcus *** half(53%)of the BSIs were of unknown *** analysis demonstrated that young age(≤1.3 year;OR=2.1,P=0.011),growth failure(OR=2.1,P=0.045),liver support system(OR=4.2,P=0.008),and hospital stay of>44 d(OR=2.3,P=0.002)were independently associated with BSI in the year after *** BSI was frequently observed in patients after pediatric LT,affecting survival *** profile of BSI may inform clinical treatment and management in high-risk children after LT.

关键词： Bloodstream infection Liver transplantation Children Pathogens

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Aqueous extract of Protaetia brevitarsis larvae increases mTOR-mediated growth rate in zebrafish larvae

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Asian Pacific Journal of Tropical Biomedicine 2023年第8期13卷 339-347页

作者： Jayasingha Arachchige Chathuranga Chanaka Jayasingha Kyoung Tae Lee Yung Hyun Choi gi-Young kim Department of Marine Life Science Jeju National UniversityJeju 63243Republic of Korea Forest Bioresources Department Forest Microbiology DivisionNational Institute of Forest ScienceSuwon 16631Republic of Korea Department of Biochemistry College of Korean MedicineDong-Eui UniversityBusan 47227Republic of Korea

Objective:To evaluate the effects of an aqueous extract of Protaetia brevitarsis(AEPB)on the growth of zebrafish and preosteoblast MC3T3-E1 ***:The effects of AEPB on the linear growth and the expression of growth-related genes in zebrafish and MC3T3-E1 cells were assessed using various molecular ***,the involvement of the mammalian target of rapamycin(mTOR)pathway in AEPB-induced growth was investigated by employing the mTOR inhibitor ***:AEPB administration led to a significant and dose-dependent increase in zebrafish larvae growth over ***,AEPB treatment upregulated the expression of growth hormone-1(GH-1),insulin-like growth factor-1(IGF-1),growth hormone receptor-1(GHR-1),and cholecystokinin-a(CCKA)in ***,AEPB stimulated the expression and release of IGF-1 and accelerated mTOR expression in MC3T3-E1 *** addition,rapamycin hindered AEPB-induced linear growth in zebrafish larvae and suppressed the expression of growth-promoting genes by inhibiting mTOR ***:AEPB shows growth-promoting effects by upregulating growth-related genes and activating the mTOR signaling *** investigations are warranted to elucidate its mechanisms of action and explore its potential application in the development of growth-enhancing supplements for various purposes.

关键词： Protaetia brevitarsis Growth rate Growth hormone Insulin-like growth factor mTOR MC3T3-E1

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A Cu-Pd alloy catalyst with partial phase separation for the electrochemical CO_(2) reduction reaction

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Journal of Energy Chemistry 2024年第6期93卷 8-15,I0001页

作者： Gyeong Ho Han Jung Yong Seo Minji Kang Myung-gi Seo Youngheon Choi Soo Young kim Sang Hyun Ahn School of Chemical Engineering and Material Science Chung-Ang UniversitySeoul 06974Republic of Korea Lotte Chemical Institute of Technology Daejeon 34110Republic of Korea Department of Materials Science and Engineering Korea UniversitySeoul 02841Republic of Korea

Cu catalysts can convert CO_(2) through an electrochemical reduction reaction into a variety of useful carbon-based ***,this capability provides an obstacle to increasing the selectivity for a single ***,we report a simple fabrication method for a Cu-Pd alloy catalyst for use in a membrane electrode assembly(MEA)-based CO_(2) electrolyzer for the electrochemical CO_(2) reduction reaction(ECRR)with high selectivity for CO *** the composition of the Cu-Pd alloy catalyst was fabricated at 6:4,the selectivity for CO increased and the production of multi-carbon compounds and hydrogen is *** a Cu-Pd alloy catalyst with 6:4 ratio as the cathode of the MEAbased CO_(2) electrolyzer showed a CO faradaic efficiency of 92.8%at 2.4 V_(cell).We assumed that these results contributed from the crystal planes on the surface of the Cu-Pd *** phases of the Cu-Pd alloy catalyst were partially separated through annealing to fabricate a catalyst with high selectivity for CO at low voltage and C_(2)H_4 at high *** results of CO-stripping testing confirmed that when Cu partially separates from the lattice of the Cu-Pd alloy,the desorption of~*CO is suppressed,suggesting that C-C coupling reaction is favored.

关键词： Cu-Pd catalyst Electrodeposition Electrochemical carbon dioxide reduction Partial phase separation Membrane electrode assembly-based electrolyzer

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Intrauterine midgut volvulus without malrotation:Diagnosis from the 'coffee bean sign'

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World Journal of Gastroenterology 2008年第9期14卷 1456-1458页

作者： Jun Seok Park Seong Jae Cha Beom Gyu kim Yong Seok kim Yoo Shin Choi In Taik Chang Gwang Jun kim Woo Seok Lee gi Hyeon kim Department of Surgery College of MedicineChung-Ang University Seoul 156-755Korea Department of Obstetrics and Gynecology College of Medicine Chung-Ang UniversityKorea Department of Radiology College of Medicine Chung-Ang University Seoul 156-755Korea

Fetal midgut volvulus is quite rare, and most cases are associated with abnormalities of intestinal rotation or fixation. We report a case of midgut volvulus without malrotation, associated with a meconium pellet, during the gestation period. This 2.79 kg, 33-wk infant was born via a spontaneous vaginal delivery caused by preterm labor. Prenatal ultrasound showed dilated bowel loops with the appearance of a 'coffee bean sign'. This patient had an unusual presentation with a distended abdomen showing skin discoloration. An emergency laparotomy revealed a midgut volvulus and a twisted small bowel, caused by complicated meconium ileus. Such nonspecific prenatal radiological signs and a low index of suspicion of a volvulus during gestation might delay appropriate surgical management and result in ischemic necrosis of the bowel. Preterm labor, specific prenatal sonographic findings (for example, the coffee bean sign) and bluish discoloration of the abdominal wall could suggest intrauterine midgut volvulus requiring prompt surgical intervention.

关键词： Midgut volvulus Coffee bean sign Meconium ileus

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Transanal excision of a malignant fibrous histiocytoma of anal canal:A case report and literature review

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World Journal of Gastroenterology 2008年第9期14卷 1459-1462页

作者： Beom Gyu kim In Taik Chang Jun Seok Park Yoo Shin Choi gi Hyeon kim Eon Sub Park Chang Hwan Choi Department of Surgery College of MedicineChung-Ang University Seoul 156-755Korea Department of Radiology College of MedicineChung-Ang University Seoul 156-755Korea Department of Pathology College of MedicineChung-Ang University Seoul 156-755 Korea Department of Internal Medicine College of Medicine Chung-Ang UniversitySeoul 156-755Korea

Malignant fibrous histiocytoma, which is composed of spindle-shaped cells arranged in a pleomorphic and storiform pattern, is rarely found in the colorectum. Although complete surgical excision remains the main stem of therapy, an optimal treatment strategy according to the stage has not been elucidated. We report a case of a 63-year-old woman with an ulcerative lesion in the anorectal junction and a final diagnosis of malignant fibrous histiocytoma. We introduced an access for transanal local excision and adjuvant radiotherapy because the patient refused abdominoperineal resection. No local recurrences or distant metastases were observed 15 mo after the operation. To our knowledge, this is the first case reported in the English literature of a malignant fibrous histiocytoma treated with the transana local excision and adjuvant radiotherapy. This report showed that this approach is selectively reserved for early-stage malignant fibrous histiocytoma and for those patients who refuse radical surgery because of the risk in a permanent colostomy.

关键词： Malignant fibrous histiocytoma Anorectal junction Transanal local excision

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Treatment of hepatocellular carcinoma with portal venous tumor thrombosis: A comprehensive review

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World Journal of Gastroenterology 2016年第1期22卷 407-416页

作者： Kichang Han Jin Hyoung kim gi-Young Ko Dong Il Gwon Kyu-Bo Sung Department of Radiology and Research Institute of Radiology Asan Medical CenterUniversity of Ulsan College of Medicine

The natural history of hepatocellular carcinoma(HCC)with portal vein tumor thrombosis(PVTT)is dismal(approximately 2-4 mo),and PVTT is reportedly found in 10%-40%of HCC patients at *** to the Barcelona Clinic Liver Cancer(BCLC)Staging System(which is the most widely adopted HCC management guideline),sorafenib is the standard of care for advanced HCC(i.e.,BCLC stage C)and the presence of PVTT is included in this ***,sorafenib treatment only marginally prolongs patient survival and,notably,its therapeutic efficacy is reduced in patients with *** this context,there have been diverse efforts to develop alternatives to current standard systemic chemotherapies or combination treatment *** date,many studies on transarterial chemoembolization,3-dimensional conformal radiotherapy,hepatic arterial chemotherapy,and transarterial radioembolization report better overall survival than sorafenib therapy alone,but their outcomes need to be verified in future prospective,randomized controlled studies in order to be incorporated into current treatment ***,combination strategies have been applied to treat HCC patients with PVTT,with the hope that the possible synergistic actions among different treatment modalities would provide promising *** narrative review describes the current status of the management options for HCC with PVTT,with a focus on overall survival.

关键词： Hepatocellular carcinoma Portal vein tumorthrombosis Sorafenib Transarterial chemoembolization Transarterial radioembolization Hepatic arterial chemotherapy Radiotherapy

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