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Advances in Atmospheric Sciences 2013年第2期30卷 263-279页

作者： jae-Gyoo lee Ming XUE Department of Atmospheric Environmental Sciences Kangnung National University Center for Analysis and Prediction of Storms Norman OKUSA School of Meteorology University of OklahomaNorman OKUSA

A 24-h simulation with the Advanced Regional Prediction System （ARPS） nonhydrostatic model is performed for the heavy snowfall event of 3-4 February 1998 along the eastern coast of Korean Peninsula; the results are used to understand the snowfall process, including why the precipitation maxima formed along the Yeongdong coastal region rather than over the mountain slope and ridge top during. The numerical simulation with a 4-kin horizontal grid spacing and 43 levels reproduces very well the narrow snowband located off the eastern Korean coast, away from, instead of over, the Yeongdong coastal mountain range. The general evolution of the snowband agrees quite well with radar observations, while the water-equivalent precipitation amount agrees reasonably well with radar precipitation estimate. The simulation results clearly show that the snow band developed due to the lifting by a coastal front that developed because of the damming of cold air against the eastern slope of the coastal mountain range. The damming was enhanced by the advection of cold air by a tow-level mountain-parallel jet from the north, formed due to geostrophic adjustment as the on-shore upslope air was decelerated by the mountain blocking. As the onshore flow weakened later due to synoptic-scale flow pattern change, the cold front propagated off shore and the precipitation dissipated.

关键词： coastal snowfall cold air damming orographic precipitation

Proton pump inhibitor administration delays rebleeding after endoscopic gastric variceal obturation

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World Journal of Gastroenterology 2014年第45期20卷 17127-17131页

作者： won Seok Jang Hyun Phil Shin Joung Ⅱ lee Kwang Ro Joo jae Myung Cha Jung won Jeon Jun Uk Lim Department of Internal Medicine College of Medicine Kyung Hee University

AIM: To clarify the efficacy of proton pump inhibitors (PPIs) after endoscopic variceal obturation (EVO) with N-butyl-2-cyanoacrylate.

关键词： Cirrhosis Endoscopic variceal obturation N-butyl-2-cyanoacrylate Proton pump inhibitor Rebleeding interval

Influence of tool deflection on micro channel pattern of 6:4 brass with rectangular tool

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中国有色金属学会会刊：英文版 2009年第B9期19卷 164-170页

作者： Tae-Jin JE Kang-won lee Sang-Cheon PARK jae-Gu KIM Doo-Sun CHOI Kyoung-Taik PARK Kyung-Hyun WHANG Nano Mechanical Systems Research Division Korea Institute of Machinery & Materials (KIMM)

Machining experiment of micro channel structure with 6:4 brass was carried out by shaping process using a single crystal diamond tool. FEM simulation using solid cantilever beam model was analyzed. In result of experiment, tool deflection is observed as machining characteristics through result of experiments such as surface roughness, cutting force and burr formations. And the influence of tool deflection is experimentally proved.

关键词：金刚石工具挠度通道模式黄铜矩形实验证明加工特性有限元模拟

Safety and efficacy of transradial coronary angiography and intervention in patients older than 80 years： from the Korean Transradial Intervention Prospective Registry

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Journal of Geriatric Cardiology 2017年第2期14卷 81-86页

作者： Hoyoun won Wang Soo lee Sang-Wook Kim Byung Ryul Cho Young Jin Youn Young-Hyo Lim Min-Ho lee jae-Hwan lee Seung-Woon Rha Cardiovascular & Arrhythmia Center Chung-Ang University Hospital Chung-Ang University College of Medieine Seoul South Korea Division of Cardiology Kangwon National University Hospital Chuncheon South Korea Division of Cardiology Yonsei University Wonju College of Medicine Wonju South Korea Division of Cardiology College of Medicine Hanyang University Seoul South Korea Department of Cardiology Soonchunhyang University College of Medicine Seoul South Korea Department of Cardiology Chungnam National University Hospital Daejeon South Korea Department of Cardiology Korea University Guro Hospital Seoul South Korea

Background Radial artery access for coronary procedures is a safe and beneficial technique. However, elderly patients have been considered as a higher risk group of access site related complications compared to younger patients. This study was conducted to investigate the feasibility and safety oftransradial coronary angiography or intervention in the elderly. Methods A total of 6132 patients from Korean Transradial Intervention Prospective Registry at 20 centers were analyzed. Patients were divided into the non-elderly group （n = 5667） and the elderly （_〉 80 years） group （n = 465）. Using propensity score matching, the elderly group （n = 465） was compared with one-to-one matched the non-elderly group （n = 465）. Results After propensity score matching, mean age was 64.3 ＋ 10.3 years in the non-elderly group and 83.5 -4- 3.3 years in the elderly group. There was no difference of procedural characteristics, procedural and fluoroscopic times. Access site cross-over rate was not different between the non-elderly group and elderly group （7.5% vs. 6.2%, P = 0.074）. Bleeding compli- cations occurred similarly in two groups （2.6% of the non-elderly group vs. 1.9% of the elderly group, P -~ 0.660）. Access site complications were 1.9% of the non-elderly group and 0.9% of the elderly group （P = 0.263）. Both of in hospital death and cardiovascular death for one year were also similar between two groups. Conclusions Transradial angiography or intervention was safe and feasible in elderly patients. Complication rates and clinical outcomes in elderly patients were comparable with those in non-elderly patients.

关键词： The elderly patients Transmdial coronary angiography Transradial coronary intervention

Short-circuit Current Characteristics of Wind Generators

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电力系统自动化 2012年第8期36卷 110-114页

作者： Seung-jae lee Myeon-Song CHOI Department of Electrical Engineering Myongji University

To study the effects of wind generators on distribution system protection,the short-circuit current(SCC) characteristics of wind generators is *** there are many researches on the issue,a clear agreement has not been reached so *** SCC characteristics for different wind generators are *** simulation is performed in the same system integrated with different kinds of wind generators,and their results are compared with those reported in IEEE *** detection possibility by overcurrent relay(OCR)is discussed based on the simulation results.

关键词：风力发电机组短路电流电流特性配电系统 PSCAD 过流继电器 IEEE 通过检测

Sinkihwan-gamibang ameliorates puromycin amino nucleoside-induced nephrotic syndrome

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Chinese Journal of Natural Medicines 2022年第3期20卷 177-184页

作者： lee Hyeon Kyoung Jang Youn jae Na Se won Kim Hye Yoom Han Bywig Hyuk lee Yun Jung lee Ho Sub Yoon Jung Joo Kang Dae Gill Hanbang Cardio-Renal Syndrome Research Center Wonkwang UniversityJeollabukdo 54538Republic of Korea College of Oriental Medicine and Professional Graduate School of Oriental Medicine Wonkwang UniversityJeollabukdo 54538Republic of Korea

Nephrotic syndrome(NS)is a kidney disease characterized by hypertriglyceridemia,massive proteinuria,hypo-albuminemia and peripheral ***-gamibang(SKHGMB)was recorded in a traditional Chinese medical book named“Bangyakhappyeon(方藥合編)”and its three prescriptions Sinkihwan,Geumgwe-sinkihwan,and Jesaeng-sinkihwan belong to *** study confirmed the effect of SKHGMB on renal dysfunction in an NS model induced by puromycin aminonucleoside(PAN).The experimental NS model was induced in male Sprague Dawley(SD)rats through injection of PAN(50 mg·kg^(-1))via the femoral *** not only reduced the size of the kidneys increased due to PAN-induced NS,but also decreased proteinuria and *** addition,SKHGMB significantly ameliorated creatinine clearance,creatinine,and blood urea *** relieved glomeruli dilation and tubules fibrosis in the glomeruli of the NS *** inhibited the protein and mRNA levels of the NLRP3 inflammasome including NLRP3,ASC,and pro-caspase-1 in NS *** reduced the protein and mRNA levels of fibrosis regulators in NS *** results indicated that SKHGMB exerts protective effects against renal dysfunction by inhibiting of renal inflammation and fibrosis in NS rats.

关键词： Sinkihwan-gamibang Puromycin aminonucleoside Nephrotic syndrome Renal dysfunction NLRP3 inflammasome Fibrosis

Safety of acupotomy in a real-world setting:A prospective pilot and feasibility study

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Journal of Integrative Medicine 2022年第6期20卷 514-523页

作者： Sang-Hoon Yoon Chan-Young Kwon Hee-Geun Jo jae-Uk Sul Hyangsook lee Jiyoon won Su Jin Jeong Jun-Hwan lee Jungtae leem Chung-Yeon Korean Medicine Clinic Gangnam-guSeoul 06224Republic of Korea Department of Oriental Neuropsychiatry Dong-eui University College of Korean MedicineBusanjin-guBusan 47340Republic of Korea Department of Herbal Pharmacology College of Korean MedicineGachon University1342 Seongnamdae-roSujeong-guSeongnam 13120Republic of Korea Department of Korean Rehabilitation Medicine Dongshin University Korean Medicine HospitalGwangju 61619Republic of Korea Acupuncture and Meridian Science Research Center Kyung Hee UniversityDongdaemun-guSeoul 02447Republic of Korea Department of Science in Korean Medicine Graduate SchoolKyung Hee UniversityDongdaemun-guSeoul 02447Republic of Korea KM Science Research Division Korea Institute of Oriental MedicineDaejeon 34054Republic of Korea Department of Statistics Support Medical Science Research InstituteKyung Hee University Medical CenterDongdaemun-guSeoul 02447Republic of Korea Clinical Medicine Division Korea Institute of Oriental MedicineYuseong-guDaejeon 34054Republic of Korea Korean Medicine Life Science University of Science&Technology(UST)Campus of Korea Institute of Oriental MedicineYuseong-guDaejeon 34054Republic of Korea College of Korean Medicine Wonkwang UniversityIksanJeollabuk-do54538Republic of Korea

Objective:Acupotomy is a modern acupuncture method that includes modern surgical *** acupotomy is relatively more invasive than filiform acupuncture treatment,it is important to establish the safety profile of this *** justify further large-scale prospective observational studies,this preliminary study was performed to assess the feasibility of the approach and investigate the safety profile and factors potentially associated with adverse events(AEs).Methods:This was a prospective pilot study that assessed the feasibility of a large-scale forthcoming safety study on acupotomy treatment in a real-world *** feasibility(call response rate,dropout rate,response rate for each variable and recruitment per month)and safety profile(incidence,type,severity and causality of AEs,and factors potentially associated with AEs)were ***:A total of 28 participants joined the study from January to May 2018.A follow-up assessment was achieved in 258(1185 treatment points)out of 261 sessions(1214 treatment points).The response rate via telephone on the day after treatment was 87.3%.There were 8 systemic AEs in all the sessions(8/258;3.11%)and 27 local AEs on the total points treated(27/1185;2.28%).Severe AEs did not *** AE and local AE occurrence were associated with blade width and the number of needle stimulations per treatment ***:The findings suggest that it could be feasible to analyze the safety of acupotomy in a realworld ***,the primary data on some relevant AEs could be *** are planning large-scale prospective studies based on these *** registration:Clinical Research Information Service(CRIS)KCT0002849(https://***/cris/search/***/11487).

关键词： Acupotomy Acupuncture Safety Adverse effects Observational study Traditional Chinese medicine

Remote induction of in situ hydrogelation in a deep tissue,using an alternating magnetic field and superparamagnetic nanoparticles

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Nano Research 2018年第11期11卷 5997-6009页

作者： Hwangjae lee Guru Karthikeyan Thirunavukkarasu Semin Kim jae Young lee School of Materials Science and Engineering Gwangju Institute of Science and Technology Gwongju 51005 Republic of Korea Department of Biomedical Science and Engineering Gwangju Institute of Science and Technology Gwangju 61005 Repubfic of Korea

In situ hydrogelation systems, such as transdermal polymerization, allow for external control over the gelation processes in a minimally invasive way. Recently, a novel system consisting of near-infrared (NIR) light and plasmonic nanomaterials was demonstrated to cause in vivo transdermal gelation. However, NIR light is not sufficient for gelation induction in deep tissues owing to its limited penetration into tissues. To overcome this problem, here we developed an alternating magnetic field (AMF)-inducible hydrogelation system with superparamagnetic iron oxide nanoparticles (SPIONs), by which a deep-tissue–penetrating AMF can induce heat generation in the SPIONs and temperature elevation (≥ 43 °C), leading to initiation of thermal polymerization of poly(ethylene glycol) diacrylate. The feasibility of our AMF-inducible hydrogelation was successfully demonstrated using thick porcine muscle tissues (> 2 cm), whereas the NIR light–based hydrogelation system could induce gelation only in tissues thinner than several millimeters. Cell viability assays indicated cytocompatibility of the AMF-inducible hydrogelation for cell encapsulation and delivery. In vivo hydrogelation in rat muscle tissues further validated in situ hydrogelation in deep muscle tissues of a living animal. This AMF-inducible hydrogelation system may overcome the conventional problems of depth limitation and should extend the applicable area of on-demand injectable hydrogel systems for tissue engineering and drug delivery applications.

关键词： hydrogelation alternating magnetic field superparamagnetic nanoparticles hydrogel tissue engineering cell delivery

Drug Transport Microdevice Mimicking an Idealized Nanoscale Bio-molecular Motor

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Journal of Bionic Engineering 2011年第4期8卷 455-463页

作者： jae Hwan lee Ramana M. Pidaparti Department of Mechanical Engineering Virginia Commonwealth University Richmond VA 23284 USA

Molecular motors are nature＇s nano-devices and the essential agents of movement that are an integral part of many living organisms. The supramolecular motor, called Nuclear Pore Complex （NPC）, controls the transport of all cellular material be- tween the cytoplasm and the nucleus that occurs naturally in biological cells of many organisms. In order to understand the design characteristics of the NPC, we developed a microdevice for drug/fluidic transport mimicking the coarse-grained repre- sentation of the NPC geometry through computational fluid dynamic analysis and optimization. Specifically, the role of the central plug in active fluidic/particle transport and passive transport （without central plug） was investigated. Results of flow rate, pressure and velocity profiles obtained from the models indicate that the central plug plays a major role in transport through this biomolecular machine. The results ofthis investigation show that fluidic transport and flow passages are important factors in designing NPC based nano- and micro-devices for drug delivery.

关键词： molecular motors nuclear pore complex geometry design simulation

Broadband Light Source for Wavelength-Division Multiple Access Passive Optical Network

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光学学报 2003年第S1期23卷 389-390页

作者： Tae-won Oh Jin-Serk Baik jae-Ho Song Chang-Hee lee Dept. of Electrical Engineering Korea Advanced Institute of Science and Technology 373-1 Guseong-dong Yuseong-gu Daejeon 305-701 Korea Novera Optics Korea Inc. 62-1 Hwaam-dong Yuseong-gu Daejeon 305-718 Korea

We demonstrated a unified two-band broadband light source based on erbium-doped fiber. The proposed scheme generates high output power at both bands and saves doped-fiber and pump lasers.

关键词： Passive Optical Network Multiple Access output power light source