检索结果-南通市图书馆

Dietary fat-associated osteoarthritic chondrocytes gain resistance to lipotoxicity through PKCK2/STAMP2/FSP27

在线全文

学校读者我要写书评

暂无评论

Bone Research 2018年第3期6卷 238-251页

作者： Sung won Lee Jee Hyun Rho Sang Yeob Lee won tae chung Yoo Jin Oh Jung Ha Kim Seung Hee Yoo Woo Young Kwon Ju Yong Bae Su Young Seo Hokeun Sun Hye Young Kim Young Hyun Yoo Department of Rheumatology Dong-A University College of Medicine Department of Anatomy and Cell Biology Dong-A University College of Medicine and Mitochondria Hub Regulation Center Department of Microbiology Dong-A University College of Medicine Department of Statistics Pusan National University

Free fatty acids(FFAs), which are elevated with metabolic syndrome, are considered the principal offender exerting lipotoxicity. Few previous studies have reported a causal relationship between FFAs and osteoarthritis pathogenesis. However, the molecular mechanism by which FFAs exert lipotoxicity and induce osteoarthritis remains largely unknown. We here observed that oleate at the usual clinical range does not exert lipotoxicity while oleate at high pathological ranges exerted lipotoxicity through apoptosis in articular chondrocytes. By investigating the differential effect of oleate at toxic and nontoxic concentrations, we revealed that lipid droplet(LD) accumulation confers articular chondrocytes, the resistance to lipotoxicity. Using high fat diet-induced osteoarthritis models and articular chondrocytes treated with oleate alone or oleate plus palmitate, we demonstrated that articular chondrocytes gain resistance to lipotoxicity through protein kinase casein kinase 2(PKCK2)—six-transmembrane protein of prostate 2(STAMP2)—and fat-specific protein 27(FSP27)-mediated LD accumulation. We further observed that the exertion of FFAs-induced lipotoxicity was correlated with the increased concentration of cellular FFAs freed from LDs, whether FFAs are saturated or not. In conclusion, PKCK2/STAMP2/FSP27-mediated sequestration of FFAs in LD rescues osteoarthritic chondrocytes. PKCK2/STAMP2/FSP27 should be considered for interventions against metabolic OA.

关键词： osteoarthritis remains articular chondrocytes

A Framework for Enhancing Privacy and Anonymity in Blockchain-Enabled IoT Devices

在线全文

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2024年第3期78卷 4263-4282页

作者： Muhammad Saad Muhammad Raheel Bhutta Jongik Kim tae-Sun chung Department of Artificial Intelligence Ajou UniversitySuwon443-749Korea Department of Electrical and Computer Engineering University of Utah Asia CampusIncheon21985Korea Department of Artificial Intelligence Chungnam National UniversityDaejeon34134Korea

With the increase in IoT(Internet of Things)devices comes an inherent challenge of *** the world today,privacy is the prime concern of every *** one’s privacy and keeping anonymity throughout the system is a desired functionality that does not come without inevitable trade-offs like scalability and increased complexity and is always exceedingly difficult to *** challenge is keeping confidentiality and continuing to make the person innominate throughout the *** address this,we present our proposed architecture where we manage IoT devices using blockchain *** proposed architecture works on and off blockchain integrated with the closed-circuit television(CCTV)security camera fixed at the rental *** this framework,the CCTV security camera feed is redirected towards the owner and renter based on the smart contract *** entity(owner or renter)can see the CCTV security camera feed at one *** is no third-party dependence except for the CCTV security camera deployment *** contributions include the proposition of framework architecture,a novel smart contract algorithm,and the modification to the ring signatures leveraging an existing cryptographic *** are made based on different systems’security and key management *** an empirical study,our proposed algorithm performed better in key generation,proof generation,and verification *** comparing similar existing schemes,we have shown the proposed architectures’*** now,we have developed this system for a specific area in the real ***,this system is scalable and applicable to other areas like healthcare monitoring systems,which is part of our future work.

关键词： Privacy anonymity blockchain IoT smart contracts

Simultaneous intrahepatic and subgaleal hemorrhage in antiphospholipid syndrome following anticoagulation therapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2013年第38期19卷 6494-6499页

作者： In-Chul Park Yang-Hyun Baek Sang-Young Han Sung-Wook Lee won-tae chung Sung-won Lee Sang-Hyeon Kang Duk-Song Cho Division of Gastroenterology and Hepatology Department of Internal MedicineCollege of MedicineDong-A University

Warfarin is a widely used *** differences in drug response,a narrow therapeutic range and the risk of bleeding render warfarin difficult to use *** 18-year-old woman with antiphospholipid syndrome received long-term warfarin therapy for a recurrent deep vein *** years later,she developed right flank *** diagnosed intrahepatic and subgaleal hemorrhages secondary to anticoagulation *** stopping oral anticoagulation,a follow-up computed tomography showed improvement in the *** restarting warfarin because of a recurrent thrombosis,the intrahepatic hemorrhage *** decided to start clopidogrel and hydroxychloroquine instead of *** patient has not developed further recurrent thrombotic or bleeding *** hemorrhage is a very rare complication of warfarin,and our patient experienced intrahepatic and subgaleal hemorrhage although she did not have any risk factors for bleeding or instability of the international normalized ratio control.

关键词： Warfarin Liver Subgaleal Hemorrhage Antiphospholipid syndrome

Recent progress and future research directions for electrochromic zinc-ion batteries

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第3期90卷 220-232,I0007页

作者： tae Gwang Yun Byungil Hwang Jun Young Cheong Department of Molecular Science and Technology Ajou UniversitySuwon 16499Republic of Korea School of Integrative Engineering Chung-Ang UniversitySeoul 06974Republic of Korea Bavarian Center for Battery Technology(Bay Batt)and Department of Chemistry University of Bayreuth95447 BayreuthGermany

In recent times,future energy storage systems demand a multitude of functionalities beyond their traditional energy storage *** line with this technological shift,there is active research and development of electrochromic-energy storage systems designed to visualize electrochemical charging and discharging *** conventional electrochromic-energy storage devices primarily integrated supercapacitors,known for their high power density,to enable rapid color ***,the low energy density of supercapacitors restricts overall energy storage capacity,acting as a significant barrier to expanding the application range of such *** this review,we introduce electrochromic zinc(Zn)-ion battery systems,which effectively overcome the limitation of low energy density,and provide illustrative examples of their applicability across diverse *** many recent research works are present for electrochromic Zn-ion batteries,little review has so far taken *** objective is to discuss on the current progress and future directions for electrochromic Zn-ion batteries,which are applicable for wearable electronics applications and energy storage *** review provides an initial milestone for future researchers in electrochromic energy storage and zinc-ion batteries,which will lead to a stream of future works related to them.

关键词： Electrochromic Zn-ion battery Flexible Transition metal oxide Conductive polymer

Statistical Downscaling for Multi-Model Ensemble Prediction of Summer Monsoon Rainfall in the Asia-Pacific Region Using Geopotential Height Field

在线全文

学校读者我要写书评

暂无评论

Advances in Atmospheric Sciences 2008年第5期25卷 867-884页

作者：祝从文 chung-Kyu PARK Woo-Sung LEE won-tae YUN Chinese Academy of Meteorological Sciences Asia-Pacific Economic Cooperation Climate Center (APCC) Busan Republic of Korea Canadian Centre for Climate Modelling and Reanalysis Victoria BC Canada Korea Meteorological Administration Seoul Republic of Korea

The 21-yr ensemble predictions of model precipitation and circulation in the East Asian and western North Pacific （Asia-Pacific） summer monsoon region （0°-50°N, 100° 150°E） were evaluated in nine different AGCM, used in the Asia-Pacific Economic Cooperation Climate Center （APCC） multi-model ensemble seasonal prediction system. The analysis indicates that the precipitation anomaly patterns of model ensemble predictions are substantially different from the observed counterparts in this region, but the summer monsoon circulations are reasonably predicted. For example, all models can well produce the interannual variability of the western North Pacific monsoon index （WNPMI） defined by 850 hPa winds, but they failed to predict the relationship between WNPMI and precipitation anomalies. The interannual variability of the 500 hPa geopotential height （GPH） can be well predicted by the models in contrast to precipitation anomalies. On the basis of such model performances and the relationship between the interannual variations of 500 hPa GPH and precipitation anomalies, we developed a statistical scheme used to downscale the summer monsoon precipitation anomaly on the basis of EOF and singular value decomposition （SVD）. In this scheme, the three leading EOF modes of 500 hPa GPH anomaly fields predicted by the models are firstly corrected by the linear regression between the principal components in each model and observation, respectively. Then, the corrected model GPH is chosen as the predictor to downscale the precipitation anomaly field, which is assembled by the forecasted expansion coefficients of model 500 hPa GPH and the three leading SVD modes of observed precipitation anomaly corresponding to the prediction of model 500 hPa GPH during a 19-year training period. The cross-validated forecasts suggest that this downscaling scheme may have a potential to improve the forecast skill of the precipitation anomaly in the South China Sea, western North Pacific and the East Asia

关键词： summer monsoon precipitation multi-model ensemble prediction statistical downscaling forecast

M1-polarized macrophage-derived cellular nanovesicle-coated lipid nanoparticles for enhanced cancer treatment through hybridization of gene therapy and cancer immunotherapy

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第7期14卷 3169-3183页

作者： Ha Eun Shin Jun-Hyeok Han Seungyong Shin Ga-Hyun Bae Boram Son tae-Hyung Kim Hee Ho Park Chun Gwon Park Wooram Park Department of Integrative Biotechnology Sungkyunkwan University(SKKU)SuwonGyeonggi 16419Republic of Korea Deparment of Inteligent Precision Healthcare Convergence SKKUSuwonGyeonggi 16419Republic of Korea Department of MetaBioHealth SKKU Institute for ConvergenceSKKUSuwonGyeonggi 16419Republic of Korea Department of Bioengineering Hanyang UniversitySeoul 04763Republic of Korea Department of Integrative Engineering Chung-Ang UniversitySeoul 06974Republic of Korea Department of Biomedical Engineering SKKUSuwonGyeonggi 16419Republic of Korea Korea Institute of Science and Technology(KIST) Seoul 02792Republic of Korea

Optimum genetic delivery for modulating target genes to diseased tissue is a major obstacle for profitable gene *** nanoparticles(LNPs),considered a prospective vehicle for nucleic acid delivery,have demonstrated efficacy in human use during the COVID-19 *** study introduces a novel biomaterial-based platform,M1-polarized macrophage-derived cellular nanovesicle-coated LNPs(M1-C-LNPs),specifically engineered for a combined gene-immunotherapy approach against solid *** dual-function system of M1-C-LNPs encapsulates Bcl2-targeting siRNA within LNPs and immune-modulating cytokines within M1 macrophage-derived cellular nanovesicles(M1-NVs),effectively facilitating apoptosis in cancer cells without impacting T and NK cells,which activate the intratumoral immune response to promote granule-mediating killing for solid tumor *** retention within tumor was observed upon intratumoral administration of M1-C-LNPs,owing to the presence of adhesion molecules on M1-NVs,thereby contributing to superior tumor growth *** findings represent a promising strategy for the development of targeted and effective nanoparticle-based cancer genetic-immunotherapy,with significant implications for advancing biomaterial use in cancer therapeutics.

关键词： Genetic-immunotherapy M1 macrophage-derived cellular nanovesicles Lipid nanoparticles(LNPs) Gene therapy siRNA Cancer immunotherapy Solid tumor Tumor microenvironment(TME)

Modified analogue forecasting in the hidden Markov frameworkfor meteorological droughts

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Technological Sciences) 2019年第1期62卷 151-162页

作者： CHEN Si chung GunHui KIM Byung Sik KIM tae-Woong Department of Civil and Environmental Engineering Hanyang University Department of Civil Engineering Hoseo University Department of Urban Environmental Disaster Prevention Engineering Kangwon National University

An analogue method(AM) is a nonparametric approach that has been applied to predict the future states of a dynamic system by following the evolution of the analogues in the historical archive. In this study, we proposed a hidden Markov model(HMM)framework for a modified analogue forecasting(MAF) approach for meteorological droughts in Korea. The unobservable(hidden) state process in the framework aims to model the underlying drought state, while the observation process was formed from the time series of the standardized precipitation index(SPI) as a drought index. Within the framework, the likelihood estimator was used as the measure of similarity between past SPI analogues and current data. The MAF approach was conducted on the selected analogues to make forecasts at lead times of one and three months. The proposed model was applied to five selected stations in Korea using the SPI data from 1973 to 2016. The forecasting performance of the proposed model was tested during the validation period(2003–2016) using several statistical criteria and it was compared to a persistence-based benchmark model. The results showed significant improvement in the forecasting capacity, and satisfactory performance for numerical SPI forecasting and categorical drought forecasting. The results also suggested that the proposed model was able to provide useful information for determining future drought categories for early drought warning with a lead time of up to three months.

关键词： modified analogue forecasting hidden Markov model meteorological drought standardized precipitation index

Helicobacter pylori in middle ear of children with otitis media with effusion

在线全文

学校读者我要写书评

暂无评论

中华医学杂志(英文版) 2011年第24期124卷 4275-4278页

作者： PARK Chul-won chung Jae-ho MIN Hyun-jung KIM Kyung-rae tae Kyung CHO Seok-hyun LEE Seung-hwan Department of Otolaryngology-Head and Neck Surgery School of MedicineHanyang UniversitySeoulKorea

Background Otitis media with effusion(OME) is a common pediatric disease,but its pathogenesis remains uncertain. The relationship between OME and Helicobacter pylori(HP) is currently being studied,and a relationship has not yet been *** purpose of this study was to show that a relationship does exist between HP and OME. Methods The study consisted of 60 patients who were diagnosed with OME and had ventilation tube insertions with or without an *** study included an additional 30 patients who had only received an adenoidectomy without being diagnosed with *** effusion samples were analyzed with polymerase chain reaction(PCR) and the campylobacter-like organism(CLO) *** adenoid tissue samples were analyzed with the CLO test. Results Eighteen patients among the 60 patients(30%) tested positive for *** the cases with adenoids,15.6%of the OME patients and 13.3%of the adenoidectomy only patients were positive for *** were no differences between the prevalence of HP in the adenoids of OME patients and the patients without OME. Conclusion HP can be considered one of the causes of OME.

关键词： Helicobacter pylori otitis media effusion

Intestinal Behet's disease appearing during treatment with adalimumab in a patient with ankylosing spondylitis

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2013年第32期19卷 5389-5392页

作者： Sook Hee chung Soo Jung Park Sung Pil Hong Jae Hee Cheon tae Il Kim won Ho Kim Department of Internal Medicine and Institute of Gastroenterology Yonsei University College of Medicine

Behet’s disease(BD)is a chronic inflammatory disease affecting multiple organ systems,such as the skin,joints,blood vessels,central nervous system,and gastrointestinal *** BD is characterized by intestinal ulcerations and gastrointestinal *** medical treatment of intestinal BD includes corticosteroids and *** have been several reports of tumor necrosis factor-α (TNF-α)blockers being successful in treatment of refractory intestinal ***,we report on a patient who was diagnosed with intestinal BD despite treatment with the fully humanized TNF-α blocker(adalimumab)for underlying ankylosing *** patient achieved clinical remission and complete mucosal healing through the addition of a steroid and azathioprine to the adalimumab regimen.

关键词： Intestinal Behet's disease Tumor necrosis factor-α Adalimumab