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Bacterial peptide deformylase inhibitor PMT analogs inhibit cancer cell growth by interacting with human peptide deformylase

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Chinese Science Bulletin 2014年第32期59卷 4274-4282页

作者： won-Je Kim Woo Sung Son Kyoung-seok Ryu Seung-Kyu Lee Kwang-Hyun choi Jong-Sun Lee Bong-Jin Lee College of Pharmacy Seoul National University Seoul 151-742Korea College of Pharmacy CHA University SeongnamGyeonggi-do 487-010 Korea Division of Magnetic Resonance Korea Basic Science InstituteOchang Campus Seoul Chungcheongbuk-Do 363-883 Korea Promeditech Ltd Seoul National University Seoul 151-742Korea

Potent inhibitors of human peptide deformylase(HsPDF)were screened using known PMT analog inhibitors of bacterial peptide ***-three species of PMT analogs that are non-peptidyl bacterial PDF inhibitors like actinonin were selected using virtual screening *** species out of 43 that could bind to HsPDF were selected and their antitumor activities were *** them,four species(PMT-172,PMT-173,PMT-199,and PMT-201)showed excellent growth inhibition of cancer cell in the MTT ***-PMT binding was confirmed through a1H-CPMG-T2filter NMR experiment leading to a significant change in peak intensity for PMT-172 and *** results suggest that PMT analogs could possibly interact with HsPDF and be a novel anticancer drug candidate.

关键词：相互作用抑制剂类似物 PMT 癌细胞类肽细胞生长细菌

Clinical course of sub-centimeter-sized nodules detected during surveillance for hepatocellular carcinoma

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World Journal of Gastroenterology 2012年第21期18卷 2654-2660页

作者： Yang won Min Geum-Youn Gwak Min Woo Lee Moon seok choi Joon Hyoek Lee Kwang Cheol Koh Seung Woon Paik Byung Chul Yoo Department of Medicine Samsung Medical Center Sungkyunkwan University School of MedicineSeoul 135-710 South Korea Department of Radiology Samsung Medical Center Sungkyunkwan University School of MedicineSeoul 135-710 South Korea

AIM: To evaluate the outcome of sub-centimeter-sized nodules (SCSNs) detected during surveillance for hepatocellular carcinoma (HCC) in patients at risk. METHODS: We retrospectively analyzed a total of 142 patients with liver cirrhosis or chronic hepatitis B or C without a prior history of HCC in whom a SCSN was detected during HCC surveillance. We calculated the rate of HCC development from SCSNs in the study population and analyzed the differences in the baseline clinical characteristics and imaging features between the patients with SCSNs that eventually developed into HCC and patients with SCSNs that did not develop into ***: During 667 person-years of follow-up, HCC developed in 33 patients. The calculated HCC development rate was 4.9% per year. The cumulative one-, two-, three- and five-year HCC development rates were 5.6%, 10.6%, 14.1% and 20.4%, respectively. Upon baseline comparison, the HCC group was older (54.4 ± 8.3 years vs 48.9 ± 9.4 years; P = 0.003) and had lower albumin levels (3.56 ± 0.58 g/dL vs 3.84 ± 0.55 g/dL; P = 0.012) and higher baseline alpha-fetoprotein (AFP) levels (8.5 ng/mL vs 5.4 ng/mL; P = 0.035) compared to the non-HCC group. Nodule pattern and initial radiologic diagnosis also differed between the two groups. Multivariate analysis revealed that age [P = 0.012, odds ratio (OR) =1.075, 95% confidence interval (CI) =1.016-1.137], sex (P = 0.009, OR = 3.969, 95% CI: 1.403-11.226), and baseline AFP level (P = 0.024, OR = 1.039, 95% CI: 1.005-1.073) were independent risk factors for developing HCC. CONCLUSION: The overall risk of HCC development in patients with SCSNs is similar to that in liver cirrhosis patients. Patients with these risk factors need to be closely monitored during follow-up.

关键词： Chronic liver disease Hepatocellular carcinoma Risk factor Sub-centimeter-sized nodule

Increased risk of atrial fibrillation in patients with inflammatory bowel disease: A nationwide population-based study

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World Journal of Gastroenterology 2019年第22期25卷 2788-2798页

作者： You-Jung choi Eue-Keun choi Kyung-Do Han Jiesuck Park Inki Moon Euijae Lee won-seok Choe So-Ryoung Lee Myung-Jin Cha Woo-Hyun Lim Seil Oh Department of Internal Medicine Seoul National University HospitalSeoul 03080South Korea Department of Biostatistics College of MedicineThe Catholic University of KoreaSeoul 03083South Korea Department of Internal Medicine Seoul National University Boramae Medical CenterSeoul 07061South Korea

BACKGROUND Inflammatory bowel disease (IBD), a chronic inflammatory disease of the gastrointestinal tract, could play a role in the pathophysiology of atrial fibrillation (AF). AIM To investigate the association between IBD and AF development. METHODS We performed a population-based cohort study using records in the Korean National Health Insurance Services database between 2010 and 2014. A total of 37696 patients with IBD (12349 with Crohn’s disease and 25397 with ulcerative colitis) were identified. The incidence rate of newly diagnosed AF in patients with IBD was compared with that in a 3 times larger cohort of 113088 age- and sex-matched controls without IBD. RESULTS During 4.9 ± 1.3 years of follow-up, 1120 patients newly diagnosed with AF (348 in the IBD group and 772 in controls) were identified. After adjustments using multivariable Cox proportional hazards, patients with IBD were at a 36%[95% confidence interval (CI) 20%-54%] higher risk of AF than controls. The association between IBD and the development of AF was stronger in younger than in older patients. Patients without cardiovascular risk factors showed a higher risk of AF primarily. Additionally, patients receiving immun-omodulators [Hazard ration (HR) 1.46, 95%CI 1.31-1.89], systemic corticosteroids (HR 1.37, 95%CI 1.10-1.71), or biologics agents (HR 2.38, 95%CI 1.51-3.75) were at higher risk of AF than patients without them. CONCLUSION IBD significantly increased the risk of AF, and the impact of IBD on developing AF was in patients with moderate to severe disease.

关键词： Atrial fibrillation Inflammatory bowel disease Colitis, Ulcerative Crohn's disease

Computational design of Mg alloys with minimal galvanic corrosion

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Journal of Magnesium and Alloys 2022年第7期10卷 1972-1980页

作者： Krishnamohan Thekkepat Hyung-Seop Han Ji-won choi Seung-Cheol Lee Eul Sik Yoon Guangzhe Li Hyun-Kwang seok Yu-Chan Kim Jae-Hun Kim Pil-Ryung Cha Indo-Korea Science and Technology Center JakkurBangalore 560065India Division of Nano&Information Technology KIST SchoolKorea University of Science and TechnologySeoul 02792Republic of Korea Electronic Materials Research Center Korea Institute of Science and TechnologySeoul 02792Republic of Korea Center for Biomaterials Biomedical Research InstituteKorea Institute of Science and TechnologySeoul 02792Republic of Korea Department of Plastic and Reconstructive Surgery Korea University College of MedicineSeoul 02841Republic of Korea Division of Bio-Medical Science and Technology KIST SchoolKorea University of Science and TechnologySeoul 02792Republic of Korea School of Advanced Materials Engineering Kookmin UniversitySeoul 02707Republic of Korea

Formation of galvanic cells between constituent phases is largely responsible for corrosion in Mg-based *** develop a methodology to calculate the electrochemical potentials of intermetallic compounds and alloys using a simple model based on the Born-Haber *** electrochemical potentials are used to predict and control the formation of galvanic cells and minimize *** demonstrate the applicability of our model by minimizing galvanic corrosion in Mg-3wt%Sr-x Zn alloy by tailoring the Zn *** methodology proposed in this work is applicable for any general alloy system and will facilitate efficient design of corrosion resistant alloys.

关键词： Galvanic corrosion First-principles Cluster expansion Thermodynamics Modeling Magnesium alloys

Enhanced performance of solution-processed carbon nanotube transparent electrodes in foldable perovskite solar cells through vertical separation of binders by using eco-friendly parylene substrate

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Carbon Energy 2024年第7期6卷 83-93页

作者： Unsoo Kim Jeong-seok Nam Jungjin Yoon Jiye Han Mansoo choi Il Jeon Department of Mechanical Engineering Seoul National UniversitySeoulRepublic of Korea Global Frontier Center for Multiscale Energy Systems Seoul National UniversitySeoulRepublic of Korea Frontier Energy Solution SeoulRepublic of Korea Department of Nano Engineering Department of Nano Science and TechnologySKKU Advanced Institute of Nanotechnology(SAINT)Sungkyunkwan University(SKKU)SuwonRepublic of Korea Department of Materials Science and Engineering Pennsylvania State UniversityUniversity ParkPennsylvaniaUSA

The successful utilization of an eco-friendly and biocompatible parylene-C substrate for high-performance solution-processed double-walled carbon nanotube(CNT)electrode-based perovskite solar cells(PSCs)was *** the use of a novel inversion transfer technique,vertical separation of the binders from the CNTs was induced,rendering a stronger p-doping effect and thereby a higher conductivity of the *** resulting foldable devices exhibited a power conversion efficiency of 18.11%,which is the highest reported among CNT transparent electrode-based PSCs to date,and withstood more than 10,000 folding cycles at a radius of 0.5 mm,demonstrating unprecedented mechanical ***,solar modules were fabricated using entirely laser scribing processes to assess the potential of the solution-processable nanocarbon ***,this is the only one to be processed entirely by the laser scribing process and to be biocompatible as well as eco-friendly among the previously reported nonindium tin oxide-based perovskite solar modules.

关键词： double-walled carbon nanotubes parylene substrates perovskite modules perovskite solar cells solution-processable electrodes surfactant removal

Extraction and clipping repair of a chicken bone penetrating the gastric wall

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World Journal of Gastroenterology 2008年第12期14卷 1955-1957页

作者： Jin-Soo Kim Hyung-Keun Kim Young-seok Cho Hiun-Suk Chae Chang-Whan Kim Byung-Wook Kim Sok-won Han Kyu-Yong choi Department of Internal Medicine College of Medicine The Catholic University of Korea Uijeongbu St. Mary's Hospital Gyeonggi-do 480-717 Korea Department of Internal Medicine College of Medicine The Catholic University of Korea Holy Family Hospital Gyeonggi-do 420-717 Korea Department of Internal Medicine College of Medicine The Catholic University of Korea Our lady of Mercy Hospital Gyeonggi-do 420-717 Korea

We report a case of gastric penetration caused by accidental ingestion of a chicken bone in a 42-year old woman with a partially wearing denture. Three days ago, she accidentally swallowed several lumps of poorly-chewed chicken. Physical examination disclosed mild tenderness in the periumbilical area. Abdominal Computed tomography (CT) showed a suspicious penetration or perforation of the stomach wall measuring about 3 cm, by a linear radiopaque material at the lesser curvature of the antrum. The end of a chicken bone was very close to but did not penetrate the liver. Endoscopic examination revealed a chicken bone that penetrated into the prepyloric antrum. The penetrating chicken bone was removed with grasping forceps. Five endoscopic clips were applied immediately at the removal site and the periumbilical pain resolved promptly. After removal of the chicken bone, the patient was treated with conservative care for three days, after which she was completely asymptomatic and discharged without complication. To treat gastric penetration by a foreign body, endoclipping can be a useful method in patients with no signs or symptoms of peritoneal irritation.

关键词： Gastric penetration Chicken bone Hemoclip

Prolapse gastropathy syndrome may be a predictor of pathologic acid reflux

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World Journal of Gastroenterology 2008年第36期14卷 5601-5605页

作者： Jin-Soo Kim Hyung-Keun Kim Young-seok Cho Hiun-Suk Chae Byung-Wook Kim Jin-Il Kim Sok-won Han Kyu-Yong choi Department of Internal Medicine College of Medicine The Catholic University of Korea Uijeongbu St. Mary's Hospital Gyeonggi-do 480-717 South Korea Department of Internal Medicine College of Medicine The Catholic University of Korea Uijeongbu St. Mary’s Hospital Gyeonggi-do 480-717 South Korea Department of Internal Medicine College of Medicine The Catholic University of Korea Our Lady of Mercy Hospital Gyeonggi-do 403-720 South Korea Department of Internal Medicine College of Medicine The Catholic University of Korea Yeoeuido St. Mary’s Hospital Seoul 150-713 South Korea Department of Internal Medicine College of Medicine The Catholic University of Korea Holy Family Hospital Gyeonggi-do 420-717 South Korea

AIM： To assess the occurrence of gastric acid reflux into the esophagus in endoscopically confirmed prolapse gastropathy syndrome （PGS）. METHODS： Using ambulatory esophageal pH measurement （BRAVOTM wireless esophageal pH monitoring system）, twenty-six patients with PGS were compared with twenty-one patients with erosive esophagitis （EE） as controls. We assessed several reflux parameters, including the percentage of total time at pH 〈 4, and the DeMeester score. RESULTS： There were no statistical differences between the PGS group and the EE group as to mean age, sex ratio and pH recording time. The EE group showed more severe reflux than the PGS group, as evaluated in terms of the longest duration of reflux, the number of reflux episodes, the number of reflux episodes lasting 〉 5 min, the total time with pH 〈 4 during acid reflux episodes, and the DeMeester score, but none of these parameters showed statistically significant difference. Although 53.8% （14/26） of the PGS group and 76.2% （16/22） of the EE group demonstrated pathologic acid reflux （DeMeester score 〉 14.72）, there was no statistically significant difference between the two groups in the incidence of pathologic acid reflux （P = 0.11）. CONCLUSION： There was no statistically significant difference in pathologic acid reflux between the PGS and EE group. These data suggest that endoscopically diagnosed PGS might be a predictor of pathologic acid reflux.

关键词： Prolapse gastropathy syndrome Pathologic acid reflux Erosive esophagitis Ambulatory esophageal pH monitoring Retching

Fe-based high-entropy alloy with excellent mechanical properties enabled by nanosized precipitates and heterogeneous grain distribution

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Journal of Materials Science & Technology 2024年第14期181卷 71-81页

作者： Heechan Jung Sangwon Lee Taehyeok Kang Alireza Zargaran Pyuck-Pa choi seok Su Sohn Department of Materials Science and Engineering Korea UniversitySeoul 02841Republic of Korea Department of Materials Science and Engineering Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea Graduate Institute of Ferrous and Energy Materials Technology Pohang University of Science and TechnologyPohang 37673Republic of Korea

High-entropy alloys(HEAs)consisting of CoCrFeNiAlTi systems,with a face-centered cubic(FCC)matrix reinforced by ordered L12 precipitates,have demonstrated exceptional strength-ductility ***,the current compositional design of HEAs heavily relies on high Ni and Co contents,compro-mising the balance between properties and ***,it is crucial to optimize the cost-performance trade-offby fine-tuning the range of Fe,Co,and Ni,while maintaining excellent strength-ductility *** this study,we propose a novel Fe-based HEA with nanosized precipitates and a heteroge-neous grain distribution,achieving a strength-ductility combination comparable to state-of-the-art Ni-or Co-based *** alloy benefits from both precipitation hardening and hetero-deformation-induced strengthening attributed to the heterogeneous grain distribution,resulting in excellent yield strength of 1433 MPa,tensile strength of 1599 MPa,and ductility of 22%.The microstructural evolution and its in-fluence on mechanical properties are unraveled with respect to the observation of precipitate-dislocation interaction and hetero-deformation-induced stress(HDI stress)*** study suggests that the challenge of balancing properties and cost can be addressed through optimized compositional and mi-crostructural design.

关键词： High-entropy alloys Precipitation Heterogeneous microstructure Mechanical property HDI stress

Effects of inter-electrode insertion on the performance and thermal flow fields of a hollow-electrode plasma torch

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Plasma Science and Technology 2020年第1期22卷 33-44页

作者： In-Mok YANG Jun-seok NAM Min-Kyu choi Jun-Ho SEO Shi-Young YANG Department of Applied Plasma Engineering Chonbuk National UniversityJeonju 54896Republic of Korea Graduate School of Flexible&Printable Electronics Chonbuk National UniversityJeonju 54896Republic of Korea

The effects of lntcr-ckxttxxk insertion on the performance of a hollow--electrode plasma torch have been investigated by numerical *** results revealed that when inter-dcctrodes arc inserted,the arc voltages and plasma powers increase due to the increase in the arc *** addition,it was predicted that thermal efficiency can be improved with the increase in plasma power by injecting plasma gases through the gaps between *** unique effects of inter-electrode insertion arc a result of the plasma temperatures adjusting themselves to increase arc voltages when the arc column is contracted radially by increasing gas-flow rate or decreasing inter-electrcxk diameter.

关键词： hollow-electrode plasma torch inter-electrodes numerical analysis torch performance