检索结果-南通市图书馆

Pharmacology & Pharmacy 2011年第1期2卷 17-30页

作者： Ram Achuthanandam Dorie Makropoulos Laura Johns Amy Volk Kerry Brosnan Jin Lu wojciech Krzyzanski Peter J. Bugelski 不详

CNTO 530 and darbepoetin-a are long lived erythropoietin receptor agonists (ERAs). Clinically, anemia of chronic disease (ACD) is associated with increased expression of tumor necrosis factor-a (TNF-a) and mice transgenic for human TNF-a develop ACD. The purpose of this investigation was to compare the effects of these agents in a murine model of ACD. Human TNF-a expressing (Tg 197) mice were administered a single subcutaneous dose of CNTO 530 or darbepoetin-a and the pharmacodynamic response in bone marrow spleen and peripheral blood evaluated. RBC life span and reticulocyte age distribution were also evaluated. CNTO 530 induced a dose responsive increase in reticulocytes, RBCs and Hgb in both wild type and Tg197 mice. Although the reticulocyte response was similar to wild types, the RBC and Hgb response to CNTO 530 in Tg197 mice was blunted. There was no statistically significant difference in RBC life span with either compound. Darbepoetin-α caused a greater peak in % dead Pro/basophilic erythroblasts, greater peak EMH in the spleen and a greater increase in reticulocyte maturation time. In contrast, despite a similar peak increase, CNTO 530 caused a more sustained response of reticulocyte, EMH, RBC and Hgb, consistent with increased exposure. In conclusion, CNTO 530 and darbepoetin-a increased RBC and hemoglobin in a murine model of ACD. Compared to darbepoetin-a, CNTO 530 had a more sustained effect, consistent with increased exposure.

关键词： Fusion Protein Recombinant Flow Cytometry Erythropoiesis

Laparoscopy-assisted percutaneous endoscopic gastrostomy enables enteral nutrition even in patients with distorted anatomy

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World Journal of Gastroenterology 2013年第43期19卷 7696-7700页

作者： Adam Hermanowicz Ewa Matuszczak Marta Komarowska Elzbieta Jarocka-Cyrta Jerzy Wojnar wojciech Debek Konrad Matysiak Stanislaw Klek Department of Pediatric Surgery Medical University of Bialystok15-001 BialystokPoland Department of Gastroenterology and Oncology and Plastic Surgery Medical University of Poznan60-015 PoznańPoland General and Oncology Surgery Unit Stanley Dudrick’s Memorial Hospital32-050 SkawinaPoland

AIM:To analyzed whether laparoscopy-assisted percutaneous endoscopic gastrostomy(PEG)could be a valuable option for patients with complicated ***:A retrospective analysis of twelve patients(seven females,five males;six children,six young adults;mean age 19.2 years)with cerebral palsy,spastic quadriparesis,severe kyphoscoliosis and interposed organs and who required enteral nutrition(EN)due to starvation was *** all patients,standard PEG placement was impossible due to distorted *** the patients qualified for the laparoscopyassisted PEG ***:In all twelve patients,the laparoscopy-assisted PEG was successful,and EN was introduced four to six hours after the PEG *** were no complications in the perioperative period,either technical or *** the patients were discharged from the hospital and were then effectively fed using bolus ***:Laparoscopy-assisted PEG should become the method of choice for gastrostomy tube placement and subsequent EN if PEG placement cannot be performed safely.

关键词： Percutaneous endoscopic gastrostomy Laparoscopy-assisted percutaneous endoscopic gastrostomy Severe kyphosis Malnutrition Interposed organs

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波兰国家馆

建筑实践 2010年第5期 58-59页

作者： wojciech Kakowski Marcin Mostafa Natalia Paszkowska

在波兰国家馆的设计中,波兰民间剪纸的基调始终贯穿着整个主题。在表现手法上,建筑师将其表达为应用于建筑装饰、语言之中的基础美学语法。这座将产生丰富视觉体验的

关键词：国家馆波兰

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不能忘却的纪念

建筑实践 2015年第1期 12-19页

作者：李莹 Pawel Paniczko Photoroom Juha Salminen wojciech Krynskii

1970年12月7日.华沙一个很寻常的冬日,阴湿寒冷.万木萧疏.德国前总理勃兰特在华沙犹太隔离区起义纪念碑(The Memorial to the Warsaw Ghetto Uprising)前献花后.突然下跪为在纳粹德国侵略期间被杀害的死难者默哀.“华沙之跪“的瞬间被... 详细信息

1970年12月7日.华沙一个很寻常的冬日,阴湿寒冷.万木萧疏.德国前总理勃兰特在华沙犹太隔离区起义纪念碑(The Memorial to the Warsaw Ghetto Uprising)前献花后.突然下跪为在纳粹德国侵略期间被杀害的死难者默哀.“华沙之跪“的瞬间被永远定格于历史的影像中。44年后.就在起义纪念碑后方.崭新的波兰犹太人历史博物馆揭下神秘的面纱.向世人缓缓讲述漫漫历史长河中犹太人的前世今生。其实.波兰犹太人历史博物馆项目早在上个世纪90年代中期便开始筹备.经过多年的论证与商

关键词：建筑师纪念碑主入口博物馆建筑体量犹太人玻璃幕墙勃兰特希伯来文立面设计拉丁文玻璃相

Endoscopic submucosal dissection for the treatment of neoplastic lesions in the gastrointestinal tract

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World Journal of Gastroenterology 2013年第12期19卷 1953-1961页

作者： Andrzej Biaek Anna Wiechowska-Kozowska Jan Pertkiewicz Katarzyna Karpińska wojciech Marlicz Piotr Milkiewicz Teresa Starzyńska Gastroenterology Department Pomeranian Medical University Department of Endoscopy Ministry of Internal Affairs Hospital Endotherapy Ltd Cell Pathology Department Pomeranian Medical University Liver Unit Pomeranian Medical University

AIM: To investigate the indications, resection rate, and safety of endoscopic submucosal dissection (ESD) for neoplastic lesions in the gastrointestinal tract at a European referral center. METHODS: We carried out a retrospective analysis of the ESD procedures performed in our center for mucosal neoplastic and submucosal lesions of the gastrointestinal tract. The duration of the procedure, en bloc and complete (R0) resection rates, and complication rates were evaluated. Variables were reported as mean ± SD or simple proportions. Univariate analysis and comparisons of procedure times and resection rates were performed using Mann-Whitney U tests, or χ2 tests for dichotomous ***: Between 2007 and 2011, ESD was performed in a total of 103 patients (46.7% male, mean age 64.0 ± 12.7 years). The indications for the procedure were epithelial tumor (n = 54), submucosal tumor (n = 42), or other (n = 7). The total en bloc resection rate was 90.3% (93/103) and R0 resection rate 80.6% (83/103). The median speed of the procedure was 15.0 min/cm2 . The complete resection rate was lower for submucosal tumors arising from the muscle layer (68%, 15/22, P < 0.05). Resection speed was quicker for submucosal tumors localized in the submucosal layer than for lesions arising from the muscularis propria layer (8.1 min/cm 2 vs 17.9 min/cm 2 , P < 0.05). The R0 resection rate and speed were better in the last 24 mo (90.1%, 49/54 and 15.3 min/cm 2 ) compared to the first 3 years of treatment (73.5%, 36/49, P < 0.05 and 22.0 min/cm2 , P < 0.05). Complications occurred in 14.6% (n = 15) of patients, including perforation in 5.8% (n = 6), pneumoperitoneum in 3.9% (n = 4), delayed bleeding in 1.9% (n = 2), and other in 2.9% (n = 3). Only one patient with delayed perforation required surgical treatment. During the mean follow-up of 26 ± 15.3 mo, among patients with R0 resection, recurrence occurred in one patient (1.2%).CONCLUSION: ESD is an effective and safe method for resection of

关键词： Endoscopic submucosal dissection Gastrointestinal neoplasms Gastrointestinal stromal tumors Treatment

Mutations of TP53 Gene and Oxidative Stress in Alzheimer’s Disease Patients

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Advances in Alzheimer's Disease 2014年第1期3卷 24-32页

作者： Jolanta Dorszewska Agata Rozycka Anna Oczkowska Jolanta Florczak-Wyspianska Michal Prendecki Mateusz Dezor Izabela Postrach Pawel P.Jagodzinski wojciech Kozubski Laboratory of Neurobiology Department of NeurologyPoznan University of Medical SciencesPoznanPoland Department of Biochemistry and Molecular Biology Poznan University of Medical SciencesPoznanPoland Chair and Department of Neurology Poznan University of Medical Sciences10Fredry Str.61-701 PoznanPoland

Alzheimer’s disease (AD) leads to the generation of β-amyloid (Aβ), which may damage DNA and thus lead to apoptosis induction by the p53 pathway. Dysfunction of the p53 protein may then be connected with the development of AD. Studies were conducted on 28 AD patients and 30 non-AD controls. Analysis of TP53 mutations in exon 7 was performed on DNA isolated from whole blood and biochemical parameters in the peripheral lymphocytes of these individuals. Our study showed a silent mutation TP53 C708T (21%) [p TP53 C748A (4%) only in the AD patients. Moreover, in AD patients with the TP53 C748A mutation, the level of 8-oxo-2’- deoxyguanosine (8-oxo2dG) was more than 5 times higher than the average level in this study group. In AD patients with the wild-type TP53 gene, the level of 8-oxo2dG was correlated with the level of protein p53 (R = +0.7388, p TP53 (p TP53 (C748A, C708T) may be associated with pathogenesis of AD.

关键词： TP53 8-oxo2dG p53 OGG1 AD

Skin 11β-hydroxysteroid dehydrogenase type 1 enzyme expression regulates burn wound healing and can be targeted to modify scar characteristics

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Burns & Trauma 2023年第1期11卷 32-45页

作者： Kevin H.-Y.Tsai Huaikai Shi Roxanne J.Parungao Sina Naficy Xiaotong Ding Xiaofeng Ding Jonathan J.Hew Xiaosuo Wang wojciech Chrzanowski Gareth G.Lavery Zhe Li Andrea C.Issler-Fisher Jun Chen Qian Tan Peter K.Maitz Mark S.Cooper Yiwei Wang Adrenal Steroid Group ANZAC Research InstituteConcord HospitalThe University of SydneySydneyNSW 2137Australia Burns and Reconstructive Surgery Research Group ANZAC Research InstituteConcord HospitalThe Uni-versity of SydneySydneyNSW 2137Australia School of Chemical and Biomolecular Engineering The University of SydneySydneyNSW 2006Australia Jiangsu Provincial Engineering Research Centre of TCM External Medication Development and Application Nanjing University of Chinese MedicineNanjingJiangsu210023China Department of Burns and Plastic Surgery Nanjing Drum Tower Hospital Clinical CollegeNanjing University of Chinese MedicineNanjingJiangsu210008China Heart Research Institute The University of SydneySydneyNSW 2006Australia Sydney Nano Institute Sydney Pharmacy SchoolFaculty of Medicine and HealthThe University of SydneySydneyNSW2006Australia Department of Biosciences Centre for Healthy Ageing and Understanding DiseaseNottingham Trent UniversityNG14BUUK Burns and Reconstructive Surgery Unit Concord Repatriation General HospitalSydneyNSW 2137Australia

Background:Excessive scarring and fibrosis are the most severe and common complications of burn *** exposure to high levels of glucocorticoids detrimentally impacts on skin,leading to skin thinning and impaired wound *** can generate active glucocorticoids locally through expression and activity of the 11β-hydroxysteroid dehydrogenase type 1 enzyme(11β-HSD1).We hypothesised that burn injury would induce 11β-HSD1 expression and local glucocorticoid metabolism,which would have important impacts on wound healing,fibrosis and *** additionally proposed that pharmacological manipulation of this system could improve aspects of post-burn ***:Skin 11β-HSD1 expression in burns patients and mice was *** impacts of 11β-HSD1 mediating glucocorticoid metabolism on burn wound healing,scar formation and scar elas-ticity and quality were additionally examined using a murine 11β-HSD1 genetic knockout ***-release scaffolds containing therapeutic agents,including active and inactive glucocorticoids,were developed and pre-clinically tested in mice with burn ***:We demonstrate that 11β-HSD1 expression levels increased substantially in both human and mouse skin after burn injury.11β-HSD1 knockout mice experienced faster wound healing than wild type mice but the healed wounds manifested significantly more collagen deposition,tensile strength and stiffness,features characteristic of excessive *** of slow-release prednisone,an inactive glucocorticoid,slowed the initial rate of wound closure but significantly reduced post-burn scarring via reductions in inflammation,myofibroblast generation,collagen production and scar ***:Skin 11β-HSD1 expression is a key regulator of wound healing and scarring after burn *** of an inactive glucocorticoid capable of activation by local 11β-HSD1 in skin slows the initial rate of wound closure but significantlyimproves scar characteristics po

关键词： Wound healing Burn injury Scarring Skin 11β-HSD1 11β-HSD1 knockout Glucocorticoid metabolism Polycaprolactone scaffold Drug delivery

Mn^(5+)-activated Ca_(6)Ba(PO_(4))_(4)O near-infrared phosphor and its application in luminescence thermometry

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Light(Science & Applications) 2022年第10期11卷 2463-2475页

作者： Miroslav D.Dramicanin Lkasz Marciniak Sanja Kuzman wojciech Piotrowski Zoran Ristic Jovana Perisa Ivana Evans Jelena Mitric Vesna Dordevic Nebojsa Romcevic Mikhail G.Brik Chong-Geng Ma School of Optoelectronic Engineering&CQUPT-BUL Innovation Institute Chongqing University of Posts and TelecommunicationsChongqing 400065PR China Centre of Excellence for Photoconversion Vinca Institute of Nuclear Sciences-National Institute of the Republic of SerbiaUniversity of BelgradeP.O.Box 522Belgrade 11001Serbia Institute of Low Temperature and Structure Research Polish Academy of SciencesOkólna 250-422 WroclawPoland Department of Chemistry Durham UniversityDurham DH13LEUK Institute of Physics University of BelgradePregrevica 11811080 BelgradeSerbia Institute of Physics University of TartuTartu 50411Estonia Department of Theoretical Physics Jan D?ugosz UniversityCzestochowa PL 42200Poland Academy of Romanian Scientists Ilfov Str.No.3050044 BucharestRomania

The near-infrared luminescence of Ca_(6)Ba(PO_(4))_(4)O∶Mn^(5+)is demonstrated and *** excited into the broad and strong absorption band that spans the 500-1000 nm spectral range,this phosphor provides an ultranarrow(FWHM=5 nm)emission centered at 1140 nm that originates from a spin-forbidden ^(1)E → ^(3)A_(2) transition with a 37.5%internal quantum efficiency and an excited-state lifetime of about 350 μ*** derived the crystal field and Racah parameters and calculated the appropriate Tanabe-Sugano diagram for this *** found that 1E emission quenches due to the thermally-assisted cross-over with the ^(3)T_(2) state and that the relatively high Debye temperature of 783 K of Ca_(6)Ba(PO_(4))_(4)O facilitates efficient *** Ca_(6)Ba(PO_(4))_(4)O also provides efficient yellow emission of the Eu^(2+)dopant,we calculated and explained its electronic band structure,the partial and total density of states,effective Mulliken charges of all ions,elastic constants,Debye temperature,and vibrational ***,we demonstrated the application of phosphor in a luminescence intensity ratio thermometry and obtained a relative sensitivity of 1.92%K^(-1) and a temperature resolution of 0.2 K in the range of physiological temperatures.

关键词： spectra. luminescence excited

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波兰西里西亚大学CINiBA图书馆

现代装饰 2013年第2期 66-73页

作者： Dariusz Herman Piotr Smierzewski wojciech Subalski 谢作标 HS99

早在2002年，波兰西里西亚大学发起了一次新图书馆的设计竞赛，这座新图书馆将担负起世界级科研工作的重任。在获得建筑许可证之后，获奖方案稍稍做了修改，即保留原有图书馆外观的前提下新加入卡托维兹经济大学收藏的图书，突出了图书... 详细信息

早在2002年，波兰西里西亚大学发起了一次新图书馆的设计竞赛，这座新图书馆将担负起世界级科研工作的重任。在获得建筑许可证之后，获奖方案稍稍做了修改，即保留原有图书馆外观的前提下新加入卡托维兹经济大学收藏的图书，突出了图书馆设计的灵活性。科学信息中心和学术图书馆（波兰语首字母缩写：CINiBA）紧跟大学校园恢复工作的步伐，将于未来几年内完工。

关键词：大学校园图书馆波兰西亚设计竞赛科研工作恢复工作信息中心

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Probabilistic Approach to Rough Set Theory

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南昌工程学院学报 2006年第2期25卷 47-47页

作者： wojciech Ziarko Computer Science Department University of Regina Regina Saskatchewan S4S 0A2 Canada

The presentation introduces the basic ideas and investigates the probabilistic approach to rough set theory. The major aspects of the probabilistic approach to rough set theory to be explored during the presentation are: the probabilistic view of the approximation space, the probabilistic approximations of sets, as expressed via variable precision and Bayesian rough set models, and probabilistic dependencies between sets and multi-valued attributes, as expressed by the absolute certainty gain and expected certainty gain measures,*** probabilis-tic dependency measures allow for representation of subtle stochastic associations between *** also allow for more comprehensive evaluation of rules computed from data and for computation of attribute reduct, core and significance factors in probabilistic decision *** will be shown that the probabilistic dependency measure-based attribute reduction techniques are also extendible to hierarchies of decision *** presentation will include computational examples to illustrate pre-sented concepts and to indicate possible practical applications.

关键词： rough set theory decision tables comprehensive evaluation attribute reduction

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