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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2018年第1期19卷 65-70页

作者： wojciech SZCZESNY Magdalena KULIGOWSKA-PRUSINSKA Stanislaw DABROWIECKI Jakub SZMYTKOWSKI Adrian RESLINSKI Maciej SLUPSKI Ludwik Rydygier College of Medicine in Bydgoszcz Nicolaus Copernicus University in Torun Bydgoszcz Poland

Purpose： Metalloproteinases are a key component of the pathogenesis of abdominal hernias. Obesity is considered a risk factor in herniogenesis and hernia recurrence. The aim of this study was to evaluate the serum concentrations of metalloproteinase-2（MMP-2）, MMP-9, MMP-13, and adiponectin in morbidly obese and nonoverweight controls. Materials and methods： The participants were recruited from among patients undergoing bariatric and non-bariatric surgery and divided into two groups： I（body mass index（BMI）≥35 kg/m^2, n=40） and II（BMI〈25 kg/m^2, n=30）. Serum concentrations of MMP-2, MMP-9, MMP-13, and adiponectin were measured using enzyme-linked immunosorbent assay（ELISA）. Results： A statistically significant difference between groups was observed for MMP-2 concentration. The median MMP-9 concentration was higher in the obese group, but the difference was not statistically significant. Median MMP-13 concentrations did not differ between groups. Serum adiponectin concentration was insignificantly higher in the non-obese group. Conclusions： The elevated serum MMP-2 and MMP-9 concentrations in obese individuals may be related to the higher incidence of incisional hernias in this population.

关键词： Metalloproteinase Adiponectin Obesity Incisional hernia

In vitro and in vivo degradation behavior of Mg-0.45Zn-0.45Ca(ZX00)screws for orthopedic applications

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Bioactive Materials 2023年第10期28卷 132-154页

作者： Diana C.Martinez Anna Dobkowska Romy Marek Hanna Cwieka Jakub Jaroszewicz Tomasz Płocinski Crtomir Donik Heike Helmholz Berengere Luthringer-Feyerabend Berit Zeller-Plumhoff Regine Willumeit-Romer wojciech Swięszkowski Biomaterials Group Materials Design DivisionFaculty of Materials Science and EngineeringWarsaw University of TechnologyWołoska 14102-507WarsawPoland Department of Orthopedics and Traumatology Medical University of GrazAuenbruggerplatz 58036GrazAustria Institute of Metallic Biomaterials Helmholtz-Zentrum Hereon GmbH21502GeesthachtGermany Department of Physics and Chemistry of Materials Institute of Metals and TechnologyUniversity of Ljubljan1Lepi Pot 11SI-1000Ljubljan1Slovenia

Magnesium (Mg) alloys have become a potential material for orthopedic implants due to their unnecessary implant removal, biocompatibility, and mechanical integrity until fracture healing. This study examined the in vitro and in vivo degradation of an Mg fixation screw composed of Mg-0.45Zn-0.45Ca (ZX00, in wt.%). With ZX00 human-sized implants, in vitro immersion tests up to 28 days under physiological conditions, along with electrochemical measurements were performed for the first time. In addition, ZX00 screws were implanted in the diaphysis of sheep for 6, 12, and 24 weeks to assess the degradation and biocompatibility of the screws in vivo. Using scanning electron microscopy (SEM) coupled with energy dispersive X-ray spectroscopy (EDX), micro-computed tomography (μCT), X-ray photoelectron spectroscopy (XPS), and histology, the surface and cross-sectional morphologies of the corrosion layers formed, as well as the bone-corrosion-layer-implant interfaces, were analyzed. Our findings from in vivo testing demonstrated that ZX00 alloy promotes bone healing and the formation of new bone in direct contact with the corrosion products. In addition, the same elemental composition of corrosion products was observed for in vitro and in vivo experiments;however, their elemental distribution and thicknesses differ depending on the implant location. Our findings suggest that the corrosion resistance was microstructure-dependent. The head zone was the least corrosion-resistant, indicating that the production procedure could impact the corrosion performance of the implant. In spite of this, the formation of new bone and no adverse effects on the surrounding tissues demonstrated that the ZX00 is a suitable Mg-based alloy for temporary bone implants.

关键词： Magnesium alloys Biodegradable implants Microstructure Electron microscopy Corrosion layers

Physico-chemical and biological evaluation of doxycycline loaded into hybrid oxide-polymer layer on Ti-Mo alloy

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Bioactive Materials 2020年第3期5卷 553-563页

作者： Alicja Kazek-Kęsik Agnieszka Nosol Joanna Płonka MonikaŚmiga-Matuszowicz Sebastian Student Monika Brzychczy-Włoch Małgorzata Krok-Borkowicz Elżbieta Pamuła wojciech Simka Faculty of Chemistry Silesian University of TechnologyB.Krzywoustego Street 644-100GliwicePoland Biotechnology Centre Silesian University of TechnologyKrzywoustego 8 Street44-100GliwicePoland Faculty of Chemistry Silesian University of TechnologyM.Strzody 9 Street44-100GliwicePoland Department of Systems Biology and Engineering Faculty of Automatic ControlElectronics and Computer ScienceSilesian University of TechnologyAkademicka 16 Street44-100GliwicePoland Department of Microbiology Jagiellonian University Medical CollegeCzysta 18 Street31-121KrakowPoland Faculty of Materials Science and Ceramics AGH University of Science and TechnologyMickiewicza Av.3030-059KrakowPoland

Oxide-polymer coatings were formed on the surface of the vanadium-free Ti–15Mo titanium *** Ti alloy surface was modified by the plasma electrolytic oxidation process,and then,the polymer layer of a poly(D,Llactide-co-glycolide)with doxycycline was *** polymer evenly covered the porous oxide layer and filled some of the ***,the microstructure of the polymer surface was completely different from that of the PEO *** surface morphology,roughness and microstructure of the polymer layer were examined by scanning electron microscopy(SEM)and a confocal *** results confirmed the effectiveness of polymer and doxycycline deposition in their stable chemical *** drug analysis was performed by highperformance liquid *** 1H NMR technique was used to monitor the course of hydrolytic degradation of *** was shown that the PLGA layer is hydrolysed within a few weeks,and the polyglycolidyl part of the copolymer is hydrolysed to glycolic acid as first and much faster than the polylactide one to lactic *** paper presents influence of different microstructures on the biological properties of modified titanium *** and bacterial adhesion tests were evaluated using osteoblast-like MG-63 cells and using the reference *** and *** *** results showed that the optimum concentration of doxycycline was found to inhibit the growth of the bacteria and that the layer is still cytocompatible.

关键词： Biomaterials Titanium alloy Plasma electrolytic oxidation Oxide-polymer hybrid coatings Doxycycline

Applications of High Frequency Eddy Current Technology for Material Characterization of Thin Coatings

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材料科学与工程（中英文A版） 2016年第4期6卷 185-191页

作者： Oliver Bruchwald wojciech Frackowiak Wilfried Reimche Hans Jurgen Maier Institut fiir Werkstoffkunde Leibniz Universitat Hannover D-30823 Garbsen Germany

Magnesium implant degradation provides immunomodulatory and proangiogenic effects and attenuates peri-implant fibrosis in soft tissues

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Bioactive Materials 2023年第8期26卷 353-369页

作者： Heithem Ben Amara Diana C.Martinez Furqan A.Shah Anna Johansson Loo Lena Emanuelsson Birgitta Norlindh Regine Willumeit-Römer Tomasz Plocinski wojciech Swieszkowski Anders Palmquist Omar Omar Peter Thomsen Department of Biomaterials Institute of Clinical SciencesSahlgrenska AcademyUniversity of GothenburgGothenburgSweden Biomaterials Group Materials Design DivisionFaculty of Materials Science and EngineeringWarsaw University of TechnologyWarsawPoland Institute of Metallic Biomaterials Helmholtz-Zentrum HereonGeesthachtGermany

Implants made of magnesium(Mg)are increasingly employed in patients to achieve osteosynthesis while degrading in *** Mg implants and Mg^(2+)have been suggested to possess anti-inflammatory properties,the clinically observed soft tissue inflammation around Mg implants is ***,using a rat soft tissue model and a 1-28 d observation period,we determined the temporo-spatial cell distribution and behavior in relation to sequential changes of pure Mg implant surface properties and Mg^(2+)*** to nondegradable titanium(Ti)implants,Mg degradation exacerbated initial *** of Mg degradation products at the tissue-implant interface,culminating at 3 d,actively initiated chemotaxis and upregulated mRNA and protein immunomodulatory markers,particularly inducible nitric oxide synthase and toll-like receptor-4 up to 6 d,yet without a cytotoxic *** vascularization was demonstrated morphologically,preceded by high expression of vascular endothelial growth *** transition to appropriate tissue repair coincided with implant surface enrichment of Ca and P and reduced peri-implant Mg^(2+)*** implants revealed a thinner fibrous encapsulation compared with *** detailed understanding of the relationship between Mg material properties and the spatial and time-resolved cellular processes provides a basis for the interpretation of clinical observations and future tailoring of Mg implants.

关键词： Magnesium Biodegradable implants Inflammation Foreign-body reaction Gene expression Neovascularization

Robust static output feedback based ILC design with finite frequency specifications for batch processes with time-varying uncertainties

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Robust static output feedback based ILC design with finite f...

Influence of Biopreparations on Maiden Growth of Sour Cherry （Prunus cerasus L.） in Organic Nursery- Preliminary Results

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作者： Shoulin Hao Tao Liu wojciech Paszke Key Laboratory of Intelligent Control and Optimization for Industrial Equipment of Ministry of Education Dalian University ofTechnology Institute of Advanced Control Technology Dalian University of Technology Institute of Automation Electronic and Electrical Engineering University of Zielona Góra

For industrial batch processes with time-varying uncertainties, a robust output feedback based iterative learning control（ILC） design is proposed by introducing finite frequency specifications, based on only the output measurement. The integral of output tracking error in the time domain is incorporated into the ILC updating law to improve the tracking performance from batch to batch. Based on the generalized Kalman-Yakubovich-Popov lemma, robust stability of the resulting closed-loop ILC system along both time and batch directions is analyzed in the repetitive system framework. The corresponding ILC law can be determined from the established tractable linear matrix inequality conditions. Moreover, it is shown that the obtained stability condition can also guarantee the bounded output tracking error and system input in the presence of time-and/or batch-varying uncertainties. An illustrative example from the literature is adopted to demonstrate the effectiveness of the proposed design.

关键词： Batch process time-varying uncertainties iterative learning control output feedback finite frequency range specification

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Journal of Life Sciences 2013年第11期7卷 1179-1184页

作者： Zygmunt Stanislaw Grzyb wojciech Piotrowski Lidia Sas Paszt Pawel Bielicki Department of Pomology Research Institute of Horticulture Pomologiczna 18 Skierniewice 96-100 Poland

A study was conducted in an organic nursery in 2010 and 2011 on the maiden growth of sour cherry cultivars ＂Debreceni Botermo＂ and ＂Sabina＂ grafted on Mahaleb cherry seedlings （Prunus mahaleb L.）. The young trees were grown at a spacing of 25 cm × 1.0 m on a podzolic soil. The study focused on the differences in diameter and height of the maiden stock, the branch number, lateral shoots in the crown and their length, among treatments with various bioproducts applied to the maidens once or twice, such as granulated manure, Micosat, Humus UP （humus cultivated）, Humus Active ＋ Aktywit PM （positive microorganisms）, BioFeed Amin, BioFeed Quality, Tytanit and Vinassa. The control maidens were not fertilized at all, or fertilized with NPK （nitrogen, potassium, phosphorus）. The first time when these products were applied in the nursery was mid-May, and the second time was one month later. Repeating the application of humic preparations （vermiculites） and a formulation containing mycorrhizal fungi （Micosat） gave better results than applying them only once, but in the case of BF Quality and the preparation Tytanit treating the plants for the second time did not increase their growth vigour compared to the plants treated only once. And the effectiveness of the biopreparations was different for the treated cultivars changed.

关键词： Maiden cherry bioproduct nursery application

The Quality of Sour Cherry Maidens Fertilized with Various Biopreparations in an Organic Nursery

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Journal of Life Sciences 2013年第4期7卷 400-409页

作者： Zygmunt Stanistaw Grzyb wojciech Piotrowski Lidia Sas Paszt Pawet Bielicki Department of Pomology Research Institute of Horticulture Skierniewice 96-100 Poland

The study was conducted in an organic nursery of sour cherry cultivars ＂Debreceni Botermo＂ and ＂Sabina＂ in the years 2010 and 2011. Cherry trees grafted on Mahaleb （Prunus mahaleb L.） seedlings were grown at a spacing of 25 crn × 1.0 m. In the nursery, an assessment was carried out of the effect of various biopreparations on such growth characteristics as the thickness and height of the maidens, the formation of lateral shoots and the total increase in their length. The control trees were not treated at all, but fertilized with an NPK fertilizer only （second control）. To stimulate growth, use was made of granular manure, mycorrhizal fungi in the form of the preparation Micosat, humic preparations or so-called vermicomposts （Humus UP, Humus Active）, extracts of marine algae （BF Quality） and of terrestrial plants （BF Arnin）, a product derived from yeast （Vinassa） and Tytanit. The specific biological effects of the preparations used in the sour cherry nursery for each morphological feature are presented in this paper in graphical form. A beneficial effect on the increase in the number of lateral shoots and the increase in their length was produced by the use of such products as： Micosat, Humus UP, Humus Active ＋ Aktywit PM and Vinassa. The most effective in this respect was BF Amin.

关键词： Bioproducts organic nursery sour cherry maidens quality maidens.

<i>Clostridium bifermentans</i>c as an Aero-Tolerant Exponent of Strictly Anaerobe Genera

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Advances in Microbiology 2014年第4期4卷 216-224页

作者： Katarzyna Leja Kamila Myszka Mariola Olkowicz wojciech Juzwa Katarzyna Czaczyk Department of Biotechnology and Food Microbiology Poznan University of Life Sciences Poznan Poland

Strictly anaerobic bacteria in the evolutionary way formed some mechanisms of oxygen tolerance. These changes enable strictly anaerobic bacteria existing in natural environment in which avoiding oxygen is not possible. Clostridium bifermentans is described as a strictly anaerobe species;however, in the literature, there is some information about its oxygen tolerance. Thus, in this work, the level of C. bifermentans aero-tolerance, its mechanisms, and the ability to metabolite production in presence of oxygen in cultivation medium were investigated. It was found out that C. bifermentans is able to survive in the presence of oxygen. Moreover, they are able to utilize oxygen and product metabolites when the level of oxygen is below 10%. In bacteria cells superoxide dismutase was detected.

关键词： C. bifermentans Microaerophilic Oxygen Tolerance

Effect of Some Bioproducts on Winter Mortality of Grafted Buds and the Number of Maiden Fruit Trees Produced in an Organic Nursery

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Journal of Life Sciences 2013年第3期7卷 282-288页

作者： Zygmunt Stanistaw Grzyb wojciech Piotrowski Pawet Bielicki Lidia Sas Paszt Department of Pomology Research Institute of Horticulture

In an organic nursery, various bioproducts were used to stimulate plant growth： Fertigo （granulated bovine manure）, Micosat, Humus UP （humic acids microbiologically enriched）, Humus Active ＋ Aktywit PM （beneficial microorganisms）, BioFeed Amin, BioFeed Quality, Tytanit, and Vinassa. One of the aims of the study was to determine the effect of these products on the ability of grafted buds of apple and sour cherry cultivars to survive the winter. Losses resulting from the freezing of buds during winter dormancy were calculated as the difference between the number of buds deemed to have taken in autumn and the number of live buds that began to develop properly in the spring of the following year. In autumn, the number of maiden trees obtained in each fertilization combination was also determined in the same nursery. The greatest tendency to die in winter was shown by apple and sour cherry buds in those combinations in which the rootstocks were supplied with a mineral fertilizer with NPK components, and the smallest where humic preparations （so-called vermiculites） were used. The type of fertilizer had an indirect influence not only on the number of grafted buds that died in winter as a result of freezing, but also on the final number of maiden trees obtained from a given area of the nursery.

关键词： Bio-products organic nursery grafted buds mortality maiden trees.