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Investigation of the immune effects of Scutellaria baicalensis on blood leukocytes and selected organs of the chicken＇s lymphatic system

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Journal of Animal Science and Biotechnology 2017年第3期8卷 601-612页

作者： Bozena Kroliczewska Stanislaw Graczyk Jaroslaw Kroliczewski Aleksandra Pliszczak-Krol Dorota Mista wojciech zawadzki Department of Animal Physiology and Biostructure Faculty of Veterinary Medicine Wroclaw University of Environmental and Life Sciences C.K Norwida 31 50-375 Wrodaw Poland Department of Immunology Pathophysiology and Veterinary Preventive Medicine Faculty of Veterinary Medicine Wrodaw University of Environmental and Life Sciences Wrodaw Poland Department of Chemical Biology Faculty of Biotechnology University of Wroclaw Fryderyka Joliot-Curie 14a 50-383 Wroclaw Poland

Background： The health of chickens and the welfare of poultry industry are central to the efforts of addressing global food security. Therefore, it is essential to study chicken immunology to maintain and improve its health and to find novel and sustainable solutions. This paper presents a study on investigation of the effect of Scutellaria baicalensis root（SBR） on the immune response of broiler chicken, especially on lymphocytes and heterophils reactivity, regarding their contribution to the development of immunity of the ***： The 121-day-old Hubbard Hi-Y male broiler hybrids were randomly assigned to four treatment groups,three SBR supplemented groups（0.5, 1.0, and 1.5% of SBR） and one control group. Each treatment was replicated five times with six birds per replicate pen in a battery brooder. Blood was collected after 3-（rd） and 6-（th）wk of the experiment, and hemoglobin and hematocrit values were determined, as well as total leukocyte count and differential count were performed. Nitroblue tetrazolium test and phagocytosis assay as nonspecific immune parameters and humoral immune responses to the antigenic challenge by sheep red blood cells were ***, the ability of peripheral blood lymphocytes to form radial segmentation（RS） of their nuclei was *** weight and relative weight of spleen, liver, and bursa of Fabricius were ***： Results showed that mean heterophile/lymphocyte ratio increased in the SBR groups compared to the control group and the blood of the chickens showed lymphocytic depletion. The results also demonstrated that the relative weight of bursa of Fabricius and spleen in groups fed with SBR significantly decreased compared to the control group. This study also showed that the addition of SBR significantly inhibited the formation of RS of nuclei compared to some cytotoxic ***： We found that SBR supplementation should be carefully evaluated when given to poultry. The excess intake of

关键词： Development of immune organs Leukocyte Lymphatic system Radial segmentation Scutellaria baicalensis Toxic effect

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A review on Eph/ephrin,angiogenesis and lymphangiogenesis in gastric,colorectal and pancreatic cancers

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Chinese Journal of Cancer Research 2017年第4期29卷 303-312页

作者： julia rudno-rudzińska wojciech kielan ewelina frejlich krzysztof kotulski wojciech hap krzysztof kurnol przemyslaw dzierzek marcin zawadzki agnieszka haloń 2-nd department of general and oncological surgery wroclaw medical universityBorowska 21350-556 WrodawPoland pathology department wroclaw medical universityBorowska 21350-556 WrodawPoland

Erythroprotein-producing human hepatocellular carcinoma receptors （Eph receptors） compose a subfamily of transmembrane protein-tyrosine kinases receptors that takes part in numerous physiological and pathological processes. Eph family receptor-interacting proteins （Ephrins） are ligands for those receptors. Eph/ephrin system is responsible for the cytoskeleton activity, cell adhesion, intercellular connection, cellular shape as well as cell motility. It affects neuron development and functioning, bone and glucose homeostasis, immune system and correct function of enterocytes. Moreover Eph/ephrin system is one of the crucial ones in angiogenesis and lymphangJogenesis. With such a wide range of impact it is clear that disturbed function of this system leads to pathology. Eph/ephrin system is involved in carcinogenesis and cancer progression. Although the idea of participation of ephrin in carcinogenesis is obvious, the exact way remains unclear because of complex bi-directional signaling and cross-talks with other pathways. Further studies are necessary to find a new target for treatment.

关键词： Epldephrin system lymphangiogenesis angiogenesis gastric cancer colon cancer pancreatic cancer

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Preparation,Characterization and Catalytic Activity of Palladium Nanoparticles Embedded in the Mesoporous Silica Matrices

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World Journal of Nano Science and Engineering 2012年第3期2卷 117-125页

作者： Nadiia A.Ivashchenko wojciech Gac Valentyn A.Tertykh Viktor V.Yanishpolskii Sergei A.Khainakov Alla V.Dikhtiarenko Sylwia Pasieczna-Patkowska Witold zawadzki Chuiko Institute of Surface Chemistry of National Academy of Sciences of Ukraine KyivUkraine Faculty of Chemistry Maria Curie-Skłodowska UniversityLublinPoland Department of Organic and Inorganic Chemistry Faculty of ChemistryUniversity of OviedoOviedoSpain

Novel in-situ reduction approach was applied for the synthesis of palladium nanoparticles in the pores of mesoporous silica materials with grafted siliconhydride groups. Matrices possessing different structural properties (MCM-41, SBA-15 and Silochrom) were used. Samples were studied by nitrogen adsorption-desorption method, low-angle X-ray diffraction, transmission electron microscopy (TEM) and FT-IR/PAS spectroscopy. The temperature-programmed oxidation (TPO) and reduction (TPR) methods were applied to examine reducibility of palladium species. Palladium containing catalysts were tested in methane oxidation reaction. It was demonstrated that relatively large pores in SBA-15 type silica facilitated formation of well-dispersed palladium nanoparticles confined in the pores channels. In the case of MCM-41 support, metallic palladium nanoparticles were formed on the external surface. The obtained materials showed high catalytic activity. Lower activity of the samples containing small crystallites located in the pore volume at high temperatures was related to worse accessibility of active sites to the reation mixture.

关键词： Palladium Nanoparticles Siliconhydride Groups Mesoporous Ordered Silica MCM-41 SBA-15 Palladium-Containing Nanocomposites Methane Oxidation

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