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Safety of intrathecal injection of Wharton's jellyderived mesenchymal stem cells in amyotrophic lateral sclerosis therapy

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Neural Regeneration Research 2019年第2期14卷 313-318页

作者： Monika Barczewska Mariusz Grudniak Stanis?aw Maksymowicz Tomasz Siwek Tomasz O?dak Katarzyna Jezierska-Wo?niak Dominika G?adysz wojciech Maksymowicz Department of Neurology and Neurosurgery School of Medicine Collegium Medicum-University of Warmia and Mazury in Olsztyn University Clinical Hospital in Olsztyn Instytut Terapii Komórkowych w Olsztynie(Cell Therapies Institute FamiCord Group) Polski Bank Komórek Macierzystych (PBKM FamiCord Group) Department of Psychology Clinical Logopedics and Social Science in Medicine Faculty of Health Sciences Collegium Medicum-University of Warmia and Mazury in Olsztyn Department of Neurology and Neurosurgery Laboratory of Regenerative Medicine School of Medicine Collegium Medicum-University of Warmia and Mazury in Olsztyn

Animal experiments have confirmed that mesenchymal stem cells can inhibit motor neuron apoptosis and inflammatory factor expression and increase neurotrophic factor expression. Therefore, mesenchymal stem cells have been shown to exhibit prospects in the treatment of amyotrophic lateral sclerosis. However, the safety of their clinical application needs to be validated. To investigate the safety of intrathecal injection of Wharton's jelly-derived mesenchymal stem cells in amyotrophic lateral sclerosis therapy, 43 patients(16 females and 27 males, mean age of 57.3 years) received an average dose of 0.42 × 106 cells/kg through intrathecal administration at the cervical, thoracic or lumbar region depending on the clinical symptoms. There was a 2 month interval between two injections. The adverse events occurring during a 6-month treatment period were evaluated. No adverse events occurred. Headache occurred in one case only after first injection of stem cells. This suggests that intrathecal injection of Wharton's Jelly-derived mesenchymal stem cells is well tolerated in patients with amyotrophic lateral sclerosis. This study was approved by the Bioethical Committee of School of Medicine, University of Warmia and Mazury in Olsztyn, Poland(approval No. 36/2014 and approval No. 8/2016). This study was registered with the ***(identifier: NCT02881476)on August 29, 2016.

关键词： amyotrophic lateral sclerosis stem cells therapy intrathecal injections Wharton's jelly-derived mesenchymal stem cells adverse events safety cerebrospinal fluid neural regeneration

Comparative Transcriptomics of Early Meiosis in Arabidopsis and Maize

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Journal of Genetics and Genomics 2014年第3期41卷 139-152页

作者： Stefanie Dukowic-Schulze Anthony Harris Junhua Li Anitha Sundararajan Joann Mudge Ernest F.Retzel wojciech P.Pawlowski Changbin Chen Department of Horticultural Science University of Minnesota College of Life Sciences Henan Normal University National Center for Genome Resources Department of Plant Breeding and Genetics Cornell University

Though sexually reproductive plants share the same principle and most processes in meiosis, there are distinct features detectable. To address the similarities and differences of early meiosis transcriptomes from the dicot model system Arabidopsis and monocot model system maize, we performed comparative analyses of RNA-seq data of isolated meiocytes, anthers and seedlings from both species separately and via orthologous genes. Overall gene expression showed similarities, such as an increased number of reads mapping to unannotated features, and differences, such as the amount of differentially expressed genes. We detected major similarities and differences in functional annotations of genes up-regulated in meiocytes, which point to conserved features as well as unique features. Transcriptional regulation seems to be quite similar in Arabidopsis and maize, and we could reveal known and novel transcription factors and cis- regulatory elements acting in early meiosis. Taken together, meiosis between Arabidopsis and maize is conserved in many ways, but displays key distinctions that lie in the patterns of gene expression.

关键词： Meiosis Transcriptome RNA-seq Meiocytes Arabidopsis Maize

Super Strong and Tough Elastomers Enabled by Sacrificial Segregated Network

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Chinese Journal of Polymer Science 2021年第3期39卷 377-386,I0008页

作者： Yong Zhu Lai-Yun Wei Xuan Fu Jun-Qi Zhang Ling-Min Kong Guang-Su Huang Jin-Rong wi State Key Laboratory of Polymer Materials Engineering College of Polymer Science and EngineeringSichuan UniversityChengdu 610065China

The integration of high strength and toughness concurrently is a vital requirement for elastomers from the perspective of long-term durability and reliability. Unfortunately, these properties are generally conflicting in artificial materials. In the present work, we propose a facile strategy to simultaneously toughen and strengthen elastomers by constructing 3 D segregated filler network via a simple latex mixing *** as-fabricated elastomers are featured by a microscopic 3 D interconnected segregated network of rigid graphene oxide(GO) nanosheets and a continuous soft matrix of sulfur vulcanized natural rubber(NR). We demonstrate that the interconnected segregated filler network ruptures preferentially upon deformation, and thus is more efficient in energy dissipation than the dispersed filler network. Therefore, the segregated filler network exhibits better reinforcing effects for the rubber matrix. Moreover, the excellent energy dissipating ability also contributes to the outstanding crack growth resistance through the release of concentrated stress at the crack tip. As a result, the strength, toughness and fatigue resistance of the nanocomposites are concurrently enhanced. The methodology in this work is facile and universally applicable, which may provide new insights into the design of elastomers with both extraordinary static and dynamic mechanical performance for practical applications.

关键词： Elastomers Nanocomposites Segregated network Sacrificial bonds Mechanical properties

Engineering Geometric Electrodes for Electric Field-Enhanced High-Performance Flexible In-Plane Micro-Supercapacitors

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Energy & Environmental Materials 2023年第4期6卷 114-120页

作者： Jihong Kim Sung Min wi Jong-Guk Ahn Sangjun Son Hee Young Lim Yeonsu Park Hye Ji Eun Jong Bae Park Hyunseob Lim Sangyeon Pak A-Rang Jang Young-Woo Lee Department of Energy Engineering Soonchunhyang UniversityAsan 31538Korea Department of Chemistry Gwangju Institute of Science and TechnologyGwangju 61005Korea Jeonju Centre Korea Basic Science InstituteJeonju 54907Korea Prof.S.Pak School of Electronic and Electrical Engineering Hongik UniversitySeoul 04066Korea Division of Electrical Electronic and Control EngineeringKongju National UniversityCheonan 31080Korea

In plane micro-supercapacitors that are miniaturized energy storage components have attracted significant attention due to their high power densities for various ubiquitous and sustainable device systems as well as their facile integration on various flexible/wearable *** implement the micro-supercapacitors in various practical applications that can accompany solid state or gel electrolyte and flexible substrates,ions must be readily transported to electrodes for achieving high power ***,we show large enhancement in electrochemical properties of flexible,inplane micro-supercapacitor using sharp-edged interdigitated electrode design,which was simply fabricated through direct laser scribing *** sharp-edged electrodes allowed strong electric field to be induced at the corners of the electrode fingers which led to the greater accumulation of ions near the surface of electrode,significantly enhancing the energy storage performance of *** electric field-enhanced in-plane micro-supercapacitor showed the volumetric energy density of 1.52 Wh L^(−1)and the excellent cyclability with capacitive retention of 95.4%after 20000 *** further showed various practicability of our sharp-edged design in micro-supercapacitors by showing circuit applicability,mechanical stability,and air *** results present an important pathway for designing electrodes in various energy storage devices.

关键词： electric field enhancement flexible energy storage device microsupercapacitors sharp electrodes

THE TRANSFORMED NONPARAMETRIC FLOOD FREQUENCY ANALYSIS

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Journal of Computational Mathematics 1994年第4期12卷 330-338页

作者： Kaz Adamowski(Department of Civil Engineering University of Ottawa, Ottawa, Canada)wojciech Feluch(Institute of Environmental Engineering , Technical University of Warsaw, Warsaw, Poland) University of Ottawa 加拿大 Technical University of Warsaw 波兰

The nonparametric kernel estimation of probability density function (PDF) pro-vides a uniform and accurate estimate of flood frequency-magnitude ***, the kernel estimate has the disadvantage that the smoothing factor h is estimate empirically and is not locally adjusted, thus possibly resulting in deteri oration of density estimate when PDF is not smooth and is heavy-tailed. Such a problem can be alleviate by estimating the density of a transformed random vari able, and then taking the inverse transform. A new and efficient circular transform is proposed and investigated in this paper

关键词： TRT Res THE TRANSFORMED NONPARAMETRIC FLOOD FREQUENCY ANALYSIS

Ultra-long-working-distance spectroscopy of single nanostructures with aspherical solid immersion microlenses

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Light(Science & Applications) 2020年第1期9卷 1561-1571页

作者： Aleksander Bogucki Lukasz Zinkiewicz Magdalena Grzeszczyk wojciech Pacuski Karol Nogajewski Tomasz Kazimierczuk Aleksander Rodek Jan Suffczynski Kenji Watanabe Takashi Taniguchi Piotr Wasylczyk Marek Potemski Piotr Kossacki Faculty of Physics University of Warsawul.Pasteura 502-093 WarsawPoland National Institute for Materials Science TsukubaIbaraki 305-0044Japan Laboratoire National des Champs Magnetiques Intenses CNRS-UJF-UPS-INSAavenue des Martyrs 2538042 GrenobleFrance

In light science and applications,equally important roles are played by efficient light emitters/detectors and by the optical elements responsible for light extraction and *** latter should be simple,cost effective,broadband,versatile and compatible with other components of widely desired micro-optical ***,they should also operate without high-numerical-aperture ***,we demonstrate that all these requirements can be met with elliptical microlenses 3D printed on top of light ***,the microlenses we propose readily form the collected light into an ultra-low divergence beam(half-angle divergence below 1°)perfectly suited for ultra-longworking-distance optical measurements(600mm with a 1-inch collection lens),which are not accessible to date with other spectroscopic *** microlenses can be fabricated on a wide variety of samples,including semiconductor quantum dots and fragile van der Waals heterostructures made of novel two-dimensional materials,such as monolayer and few-layer transition metal dichalcogenides.

关键词： versatile latter optics

Carbon sink potential and allocation in above-and below-ground biomass in willow coppice

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Journal of Forestry Research 2021年第1期32卷 349-354页

作者： Marcin Pietrzykowski Bartłomiej Woś PawełTylek Dariusz Kwaśniewski Tadeusz Juliszewski Józef Walczyk Justyna Likus-Cieślik wojciech Ochał Sylwester Tabor Department of Ecology and Silviculture Faculty of ForestryUniversity of Agriculture in KrakowAl.29 Listopada 4631-425 KrakówPoland Department of Forest Work Mechanization Faculty of ForestryUniversity of Agriculture in KrakowAl.29 Listopada 4631-425 KrakówPoland Institute of Agricultural Engineering and Informatics Faculty of Production and Power EngineeringUniversity of Agriculture in Krakowul.Balicka 116B30-149 KrakówPoland Institute of Machinery Management Ergonomics and Production ProcessesFaculty of Production and Power EngineeringUniversity of Agriculture in Krakowul.Balicka 116B30-149 KrakówPoland Department of Biometry and Forest Productivity Faculty of ForestryUniversity of Agriculture in KrakowAl.29 Listopada 4631-425 KrakówPoland

This research estimates carbon sink and allocation in above-and below-ground biomass of a 12-year-old willow coppice plantation on fl uvisol soil near the Vistula River(southern Poland).The plantation showed high C sink potential and sequestration rates.C sequestration by aboveground biomass was estimated at 10.8 Mg C ha^−1 a^−*** in coarse roots was estimated at 1.5 Mg C ha^−1 a^−1 and in fi ne roots at 1.2 Mg C ha^−1 a^−*** C sequestered(above-ground biomass,coarse roots and fi ne roots)was estimated at 13.5 Mg C ha^−1 a^−*** results confi rm the potential of fast-growing plantations of willow to mitigate,over a short time span,the eff ects of high CO 2 concentrations.

关键词： willow coppice Biomass Roots Carbon sequestration

MICROSTRUCTURAL EVOLUTION AND CONTROL IN SUPERALLOY FORGINGS

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Acta Metallurgica Sinica(English Letters) 1996年第6期9卷 437-442页

作者： R.Noel, D. Furrer, G. Shen and J. Lemsky(Ladish Co., Inc., P.O. Box 8902, Cudahy, wi 53110-8902, USA Ladish Co. Inc. Cudahy United States

Optimum properties of high temperature superalloys are derived from interactions of the composition,thermomechanical deformation, and heat ***-base alloys contain a variety of alloying elements in a large number of combinations to produce various desired effects. The general characteristics of any specific nickelbase superalloy is determined by *** control of the microstructure in wrought processed superalloys can further influence the resultant component *** relationship between microstructure and properties is key in advanced design and manufacture of turbine engine components, and requires extensive alloy and process characterization to achieve desired *** forging methods have been developed and employed throughout the years to process superalloy *** forging, Press forging,and advanced isothermal press forging equipment and processes have been designed and manufactured to process speciality metals which often have very narrow processing *** processes have also been introduced into turbine engine applications,which result in a hybrid of resultant structures and *** such speciality,combination process is the Ladish Iso Con process which utilizes isothermal forging and conventional forging to achieve unique properties not matched by any other single *** utilizes forging presses for conventional forging, hot-die forging and for isothermal forging, in addition to hammers and ring rolling mills for wrought *** wide range of equipment allows flexibility in process design and *** in temperature, strain and strain rate have been shown to significantly influence resultant grain sizes and *** are being developed to allow forging processes and specific forging parameters to be evaluated and optimized with regard to final microstructure before shop triale are required. Sophisticated finite element method (FEM) models are allowin

关键词： forging process modeling microstructure

Study on Fluid Shear Flow on Osteoblast-like Cells in Their Tensile Loading Experiments

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Chinese Journal of Biomedical Engineering(English Edition) 2006年第1期15卷 36-46页

作者： TENG Wei-zhong WU Wenzhou CHEN Wei-wi Institute of Applied Mechanics Taiyuan University of Technology Taiyuan 030024 China Academy of Physics and Technology Engineering GuangXi University Nanning 530005 China Institute of Applied Mechanics Taiyuan University of Technology Taiyuan 030024 China Institute of Applied Mechanics Taiyuan University of Technology Taiyuan 030024 China

In vitro cell loading experiments are used to investigate stimulation of strain to cellular proliferation. As the flowing conditions of culture fluid in loading systems has been little known, strictly people can not detect the influence of strain to cellular proliferation exactly because shear flow can enhance cell proliferation either. Based on the working principle and cyclic loading parameters, we simplify Navier-Stokes equation to describe the flow of culture fluid on substrates of uniaxial and equi-biaxial flat tensile loading systems and four point bending system. with approximate solutions, the distributions of velocity field and wall shear flow to cells are gained. Results show: shear flows are zero in the middle (or fixed point or line) of substrate for all systems, and they get larger proportionally to distance from middle and substrate elongate; the shear flow on the substrate of four point bending system is much greater than those of others. This shear flow in four point bending system, confirmed by Owan, I., et al with OPN mRNA increase in their experiment, could cause more influence to osteoblast-like cells than that caused by strain. We estimate the average magnitude of shear stress in Owan’s device, the results are consistent with other experimental data about shear flow. In conclusion our study makes it possible to differentiate the influence of strain on cellular proliferation to that of shear flow in loading experiments with the devices mentioned above quantitatively.

关键词： Uniaxial/equi-biaxial flat tensile loading system Four-point bending system Velocity field Shear flow