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Atrophy of the left dorsolateral prefrontal cortex is associated with poor performance in verbal fluency in elderly poststroke women

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Neural Regeneration Research 2013年第4期8卷 346-356页

作者： Yang-Kun Chen Wei-Min Xiao Defeng Wang Lin Shi winnie cw chu Vincent CT Mok Ka Sing Wong Gabor S Ungvari Wai Kwong Tang Department of Neurology Dongguan People's Hospital Department of Diagnostic Radiology and Organ Imaging the Chinese University of Hong Kong Department of Medicine and Therapeutics the Chinese University of Hong Kong Graylands Hospital School of Psychiatry & Clinical NeurosciencesUniversity of Western AustraliaPerth 6005Australia Department of Psychiatry the Chinese University of Hong Kong

This study aimed to investigate the association between atrophy in the prefrontal cortex with executive function and verbal fluency in elderly male and female patients poststroke. Thirty elderly female patients with non-aphasic ischemic stroke aged -〉 60 years and 30 age-matched non-aphasic male patients with ischemic stroke were recruited. Automatic magnetic resonance imaging segmentation was used to assess the volume of the whole prefrontal cortex, along with its subdivisions： anterior cingulate cortex, orbitofrontal cortex and dorsolateral prefrontal cortex. The Semantic Verbal Fluency Test was administered at 3 and 15 months poststroke. At 3 months poststroke, left dorsolateral prefrontal cortex volume was significantly correlated with Verbal Fluency Test score in female patients only （partial coefficient = 0.453, P = 0.045）, after controlling for age, education, diabetes, neurological deficit, white matter lesions volume, as well as the location and volume of infarcts. At 15 months poststroke, there remained a significant association between the left dorsolateral prefrontal cortex volume and Verbal Fluency Test （partial coefficient = 0.661, P = 0.001） and between the left prefrontal cortex volume and Verbal Fluency Test （partial coefficient = 0.573, P = 0.004） in female patients after the same adjustments. These findings indicate that atrophy of the left dorsolateral prefrontal cortex contributes to the impairment of verbal fluency in elderly female patients with stroke. Sex differences may be present in the neuropsychological mechanisms of verbal fluency impairment in patients with stroke.

关键词： neural regeneration neuroimaging brain atrophy verbal fluency executive function stroke sex differences prefrontal cortex dorsolateral prefrontal cortex magnetic resonance imaging grants-supported paper photographs-containing paper neuroregeneration

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The combined role of MRI prostate and prostate health index in improving detection of significant prostate cancer in a screening population of Chinese men

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Asian Journal of Andrology 2023年第6期25卷 674-679页

作者： Peter KF Chiu Thomas YT Lam Chi-Fai Ng Jeremy YC Teoh Carmen CM Cho Hiu-Yee Hung Cindy Hong Monique J Roobol winnie cw chu Samuel YS Wong Joseph JY Sung SH Ho Urology Centre Department of SurgeryThe Chinese University of Hong KongHong Kong SARChina The Jockey Club School of Public Health and Primary Care The Chinese University of Hong KongHong Kong SARChina Department of Imaging and Interventional Radiology The Chinese University of Hong KongHong Kong SARChina Erasmus MC Cancer Institute Erasmus Medical UniversityRotterdam 3015The Netherlands Lee Kong Chian School of Medicine Nanyang Technological UniversitySingapore 308232Singapore

Using prostate-specific antigen(PSA)for prostate cancer(PCa)screening led to overinvestigation and overdiagnosis of indolent *** aimed to investigate the value of prostate health index(PHI)and magnetic resonance imaging(MRI)prostate in an Asian PCa screening *** aged 50–75 years were prospectively recruited from a community-based PSA screening *** with PSA 4.0–10.0 ng ml^(−1) had PHI result *** prostate was offered to men with PSA 4.0–50.0 ng ml−1.A systematic prostate biopsy was offered to men with PSA 4.0–9.9 ng ml^(−1) and PHI≥35,or PSA 10.0–50.0 ng ml^(−1).Additional targeted prostate biopsy was offered if they had PI-RADS score≥*** significant PCa(csPCa)was defined as the International Society of Urological Pathology(ISUP)grade group(GG)≥2 or ISUP GG 1 with involvement of≥30%of total systematic *** total,12.8%(196/1536)men had PSA≥4.0 ng ml^(−1).Among 194 men with PSA 4.0–50.0 ng ml^(−1),187(96.4%)received MRI *** them,28.3%(53/187)had PI-RADS≥3 ***,7.0%(107/1536)men were indicated for biopsy and 94.4%(101/107)men received *** the men received biopsy,PCa,ISUP GG≥2 PCa,and csPCa was diagnosed in 42(41.6%),24(23.8%),and 34(33.7%)men,*** with PSA/PHI pathway in men with PSA 4.0–50.0 ng ml^(−1),additional MRI increased diagnoses of PCa,ISUP GG≥2 PCa,and csPCa by 21.2%(from 33 to 40),22.2%(from 18 to 22),and 18.5%(from 27 to 32),*** benefit of additional MRI was only observed in PSA 4.0–10.0 ng ml^(−1),and the number of MRI needed to diagnose one additional ISUP GG≥2 PCa was 20 in PHI≥35 and 94 in PHI<*** them,45.4%(89/196)men with PSA≥4.0 ng ml^(−1) avoided unnecessary biopsy with the use of PHI and MRI.A screening algorithm with PSA,PHI,and MRI could effectively diagnose csPCa while reducing unnecessary *** benefit of MRI prostate was mainly observed in PSA 4.0–9.9 ng ml^(−1) and PHI≥35 *** was an important risk stratification step for PCa

关键词： magnetic resonance imaging prostate prostate cancer prostate health index prostate-specific antigen screening

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A preliminary validation of the Brief COPE instrument for assessing coping strategies among people living with HIV in China

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Infectious Diseases of Poverty 2015年第1期4卷 334-343页

作者： Xiao-you Su Joseph TF Lau winnie WS Mak KC Choi Tie-jian Feng Xi Chen chu-liang Liu Jun Liu De Liu Lin Chen Jun-min Song Yan Zhang Guang-lu Zhao Zhang-ping Zhu Jin-quan Cheng Chinese Academy of Medical Sciences&Peking Union Medical College BeijingChina JC School of Public Health and Primary Care The Chinese University of Hong KongCUHK Shenzhen Research InstituteShenzhenChina Department of Psychology The Chinese University of Hong KongHong KongChina. Shenzhen Chronic Disease Hospital ShenzhenChina Hunan Province CDC HengyangChina Hengyang City CDC HengyangHunan ProvinceChina The 5th Hospital HengyangHunan ProvinceChina Shenzhen CDC ShenzhenChina The 3rd Hospital HengyangHunan ProvinceChina

Background:The Brief COPE instrument has been utilized to conduct research on various populations,including people living with HIV(PLWH).However,the questionnaire constructs when applied to PLWH have not been subjected to thorough factor ***:A total of 258 PLWH were recruited from two provinces of *** answered questions involving the scales of three instruments:the Brief COPE,the Perceived Social Support Scale,and the Perceived Discrimination Scale for *** factor analysis(CFA)and exploratory factor analysis(EFA)were ***:The CFA found a poor goodness of fit to the *** subsequent EFA identified six preliminary factors,forming subscales with Cronbach’s alphas,which ranged from 0.61 to *** correlation coefficients between the subscales and measures of perceived social support and perceived discrimination were reported,giving preliminary support to the validity of the new empirical factor ***:This study showed that the original factor structure of the Brief COPE instrument,when applied to PLWH in China,did not fit the ***,the Brief COPE should be applied to various populations and cultures with *** new factor structure established by the EFA is only preliminary and requires further validation.

关键词： People living with HIV Brief COPE Confirmatory factor analysis Explanatory factor analysis Perceived Social Support Scale Perceived Discrimination Scale for PLWH China

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Four cancer cases after esophageal atresia repair: Time to start screening the upper gastrointestinal tract

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World Journal of Gastroenterology 2018年第9期24卷 1056-1062页

作者： Floor WT Vergouwe Madeleine Gottrand Bas PL Wijnhoven Hanneke IJsselstijn Guillaume Piessen Marco J Bruno René MH Wijnen Manon cw Spaander Department of Gastroenterology and Hepatology Erasmus MC University Medical Center Department of Pediatric Surgery Erasmus MC University Medical Center - Sophia Children's Hospital Department of Pediatrics Jeanne de Flandre Children’s Hospital - Univ.Lille CHU Lille Department of Surgery Erasmus MC University Medical Center Department of Digestive and Oncological Surgery Claude Huriez Hospital - Univ.Lille CHU Lille

Esophageal atresia(EA) is one of the most common congenital digestive malformations and requires surgical correction early in life. Dedicated centers have reported survival rates up to 95%. The most frequent comorbidities after EA repair are dysphagia(72%) and gastroesophageal reflux(GER)(67%). Chronic GER after EA repair might lead to mucosal damage, esophageal stricturing, Barrett's esophagus and eventually esophageal adenocarcinoma. Several long-term follow-up studies found an increased risk of Barrett's esophagus and esophageal carcinoma in EA patients, both at a relatively young age. Given these findings, the recent ESPGHAN-NASPGHAN guideline recommends routine endoscopy in adults born with EA. We report a series of four EA patients who developed a carcinoma of the gastrointestinal tract: three esophageal carcinoma and one colorectal carcinoma in a colonic interposition. These cases emphasize the importance of lifelong screening of the upper gastrointestinal tract in EA patients.

关键词： Adenocarcinoma Esophageal atresia Esophageal cancer Screening Barrett’s esophagus Squamous cell carcinoma

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Bioenergetic alteration in gastrointestinal cancers:The good,the bad and the ugly

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World Journal of Gastroenterology 2023年第29期29卷 4499-4527页

作者： Yu-De chu chun-Wei Chen Ming-Wei Lai Siew-Na Lim Wey-Ran Lin Liver Research Center Linkou Chang Gung Memorial HospitalTaoyuan 333TaiwanChina Department of Gastroenterology and Hepatology Linkou Chang Gung Memorial HospitalTaoyuan 333TaiwanChina Department of Pediatrics Linkou Chang Gung Memorial HospitalTaoyuan 333TaiwanChina Department of Neurology Linkou Chang Gung Memorial HospitalTaoyuan 333TaiwanChina Department of Medicine Chang Gung UniversityTaoyuan 333TaiwanChina

Cancer cells exhibit metabolic reprogramming and bioenergetic alteration,utilizing glucose fermentation for energy production,known as the Warburg ***,there are a lack of comprehensive reviews summarizing the metabolic reprogramming,bioenergetic alteration,and their oncogenetic links in gastrointestinal(GI)***,the efficacy and treatment potential of emerging anticancer drugs targeting these alterations in GI cancers require further *** review highlights the interplay between aerobic glycolysis,the tricarboxylic acid(TCA)cycle,and oxidative phosphorylation(OXPHOS)in cancer cells,as well as hypotheses on the molecular mechanisms that trigger this *** role of hypoxia-inducible transcription factors,tumor suppressors,and the oncogenetic link between hypoxia-related enzymes,bioenergetic changes,and GI cancer are also *** review emphasizes the potential of targeting bioenergetic regulators for anti-cancer therapy,particularly for GI *** the potential of targeting bioenergetic regulators for GI cancer therapy,the review categorizes these regulators into aerobic glycolysis/lactate biosynthesis/transportation and TCA cycle/coupled *** also detail various anti-cancer drugs and strategies that have produced pre-clinical and/or clinical evidence in treating GI cancers,as well as the challenges posed by these *** we highlight that understanding dysregulated cancer cell bioenergetics is critical for effective treatments,although the diverse metabolic patterns present challenges for targeted *** research is needed to comprehend the specific mechanisms of inhibiting bioenergetic enzymes,address side effects,and leverage high-throughput multi-omics and spatial omics to gain insights into cancer cell heterogeneity for targeted bioenergetic therapies.

关键词： Energy metabolism Mitochondria Hypoxia Oxidative phosphorylation Glycolysis Gastrointestinal neoplasms

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青少年特发性脊柱侧凸胸椎形态学的MRI测量及临床意义

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中华外科杂志 2009年第4期47卷 293-296页

作者：朱锋邱勇王斌杨晓恩朱昭颖郑振耀南京大学医学院附属鼓楼医院骨科南京210008 香港中文大学医学院矫形外科及创伤学系香港中文大学威尔斯亲王医院影像学及临床诊断学系

目的通过磁共振成像（MRI）观察青少年特发性脊柱侧凸（AIS）和正常同年龄组青少年胸椎的形态学差异，探讨其临床意义。方法胸椎轻度侧凸（MS）组患者10例（Cobb角15°～39°），胸椎中度侧凸（SS）组患者10例（Cobb角40°～75°）。另... 详细信息

目的通过磁共振成像（MRI）观察青少年特发性脊柱侧凸（AIS）和正常同年龄组青少年胸椎的形态学差异，探讨其临床意义。方法胸椎轻度侧凸（MS）组患者10例（Cobb角15°～39°），胸椎中度侧凸（SS）组患者10例（Cobb角40°～75°）。另选健康青少年10名作为对照（非侧凸组）。所有研究对象均为女性，年龄13～14岁。用1．5T磁共振扫描仪（Sonata，Siemens，Erlanger，德国）对所有研究对象进行全脊柱矢状面扫描，在图像工作站（Easy Vision，Philips Medical Systems，Best，荷兰）上重建脊柱矢状面图像，测量每个胸椎椎体前壁高度，后壁高度，棘突间高度，在横截面测量椎体横径长度，并进行对比分析。结果椎体前后高度、宽度从T1到T12逐渐增加，并呈线性分布，脊柱侧凸组椎体高度普遍〉正常同年龄非侧凸组患者。脊柱侧凸组患者椎体高度横径比值以及脊椎前后高度比值均〉无侧凸组。胸椎侧凸顶椎区T6～T9椎体前方高度、椎体高度横径比值以及脊椎前后高度比值，脊柱侧凸组明显〉非侧凸组，差异均有统计学意义（P〈0．05）。结论AIS胸椎侧凸女性患者胸椎顶椎区存在显著的脊柱生长模式异常，与正常胸椎相比AIS的胸椎更高、并显得更为瘦长。

关键词：脊柱侧凸磁共振成像青少年形态学

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A cis-eQTL in NSUN2 promotes esophageal squamous-cell carcinoma progression and radiochemotherapy resistance by mRNA-m^(5)C methylation

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Signal Transduction and Targeted Therapy 2022年第9期7卷 3190-3193页

作者： Xiangjie Niu Linna Peng Weiling Liu chuanwang Miao Xinjie Chen Jiahui chu Xinyu Yang Wen Tan Chen Wu Dongxin Lin Department of Etiology and Carcinogenesis National Cancer Center/National Clinical Research Center/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeiingChina CAMS Key Laboratory of Genetics and Genomic Biology Chinese Academy of Medical Sciences and Peking Union Medical CollegeBejingChina Jiangsu Collaborative Innovation Center for Cancer Personalized Medicine Nanjing Medical UniversityNanjingChina

Dear Editor,Esophageal squamous cell carcinoma(ESCC)has poor prognosis because of the difficulty in early detection and low sensitivity of advanced disease to radiochemotherapy.1,2 ESCC presents a high proportion of primary resistance to radiochemotherapy,2which may be due to certain individual genetic *** quantitative trait loci(eQTLs)as proximal and continuous cellular phenotypes have been shown to be helpful to determine how genetic variants may influence phenotype.

关键词： chemotherapy squamous esophageal

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Effect of Strontium Ion on the Growth and Second-Harmonic Generation Properties of GdCa_(4)O(BO_(3))_(3) Crystal

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Chinese Physics Letters 2001年第1期18卷 63-64页

作者： ZHANG Shu-Jun CHENG Zhen-Xiang LIU Jun-Hai HAN Jian-Ru WANG Ji-Yang SHAO Zong-Shu CHEN Huan-chu State Key Laboratory of Crystal Materials Shandong UniversityJi'nan 250100

Large sized and optical quality GdCa_(4)O(BO_(3))_(3)(GdCOB)crystal with calcium partially substituted by strontium(Sr)ions was grown for the first *** x-ray powder diffraction shows that the Sr ion has an effect on the cell parameters of the GdCOB crystal Second-harmonic generation(SHG)experiments were performed on the Sr:GdCOB and GdCOB crystals along the spatial phase-matching *** results show that the cw green laser output power is 1.04 W when the laser diode pump power is 10 W in the Nd:YVO_(4)/Sr:GdCOB intracavity *** the slope efficiency of Nd:YVO_(4) and the fundamental laser in cavity,the intracavity SHG conversion efficiency of the GdCOB crystal is 21%while it is 24%for the Sr:GdCOB crystal,the SHG conversion efficiency is improved by 14%.The effect of the Sr ions on the nonlinearity of the GdCOB crystal is also discussed by using the anion group theory.

关键词： intracavity pump Crystal

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脑卒中伴融合型脑白质病变患者的他汀类药物治疗

脑卒中伴融合型脑白质病变患者的他汀类药物治疗

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2013年全国老年性痴呆与相关疾病学术会议

作者：熊云云 Adrian Wong Margherita Cavalieri Reinhold Schmidt winnie W.C.chu Ka Sing Wong 刘新峰 Vincent Mok 南京军区南京总医院神经内科香港中文大学药物与治疗学系香港教育学院心理学研究部心理健康和老龄化中心

目的:脑白质病变(white matter hyperintensity,WMH)和腔隙性脑梗死是两种脑小血管病。他汀类药物可降低各类脑卒中的复发率,其中包括腔隙性脑梗死。本文旨在研究他汀类药物对脑卒中伴融合型WMH的患者是否存在延缓WMH进展和/或认知功能...

目的:脑白质病变(white matter hyperintensity,WMH)和腔隙性脑梗死是两种脑小血管病。他汀类药物可降低各类脑卒中的复发率,其中包括腔隙性脑梗死。本文旨在研究他汀类药物对脑卒中伴融合型WMH的患者是否存在延缓WMH进展和/或认知功能障碍的作用。方法:研究入组了100例基线MRI上存在融合型WMH的患者,其中81例完成了2年随访。使用MMSE和MDRS I/P量表分别评估总体认知功能和执行功能。比较他汀治疗组和非他汀治疗组WMH体积和认知的变化,同时评估他汀类药物对新发脑梗死灶和新发微出血发生率的影响。结果:他汀治疗组(50例)较非他汀治疗组(31例)的WMH体积进展慢(1.54±4.52cm VS 5.01±6.00 cm,P=0.01)。他汀类药物的使用是WMH体积进展的独立预测因子(β=-0.322,P=-0.010),并与MDRS I/P评分呈正相关(β=0.474,P=0.001),而与MMSE变化无相关性,与新发脑梗死灶和新发微出血无相关性。结论:对于脑卒中伴融合型白质病变的患者,他汀类药物可减缓WMH的进展以及执行功能的下降。

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香港儿童服用低剂量三聚氰胺后肾脏并发症的现况调查研究

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英国医学杂志中文版 2009年第3期12卷 145-148页

作者： Hugh S Lam Pak C Ng winnie C W chu William Wong Dorothy F Y Chan Stella S Ho Ka T Wong Anil T Ahuja Chi K Li 张宁(译) 杨勇(校) Department of Paediatrics The Chinese University of Hong Kong Department of Diagnostic Radiology and Organ Imaging The Chinese University of Hong Kong 首都医科大学北京朝阳医院泌尿外科

目的调查香港儿童服用小剂量三聚氰胺后的肾脏并发症。设计横断面调查方法。机构香港专业评估中心。调查对象根据全港初级医疗保健中心的记录，研究包括3170例（1748例男童，1422例女童）≤12岁、连续1个月或以上服用被三聚氰胺污... 详细信息

目的调查香港儿童服用小剂量三聚氰胺后的肾脏并发症。设计横断面调查方法。机构香港专业评估中心。调查对象根据全港初级医疗保健中心的记录，研究包括3170例（1748例男童，1422例女童）≤12岁、连续1个月或以上服用被三聚氰胺污染奶制品的儿童。主要评估指标是否存在肾结石和血尿。结果 1例儿童存在肾结石，7例儿童肾脏内可疑存在三聚氰胺结晶，应用尿试纸检查发现208例（6．6％）儿童存在血尿。这些儿童在专业评估中心进一步检查后，仅有7．4％的儿童确实存在显微镜下血尿，所以总体儿童血尿出现率低于1％。结论：在曾服用小剂量三聚氰胺的儿童中，没有急性肾功能衰竭或尿路梗阻等严重不良事件发生。我们的研究结果与全港调查一致。即使将7例肾内可疑存在三聚氰胺结晶的患儿包括在内，应用超声检查发现的可疑三聚氰胺相关不良事件发生率也仅为0．2％，且这些患儿尚不需要进一步治疗。应用尿试纸检测是否存在血尿，可能会过高估计血尿的发生率。研究结果提示对于曾服用小剂量三聚氰胺的儿童进行大范围、积极的检查可能并不会得到更多有意义的资料，所以不值得投入更多的经费去进行这种检查。

关键词：肾脏并发症儿童氰胺三聚服用香港低剂量镜下血尿

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