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Myeloid sarcoma as a differential diagnosis of small bowel obstruction

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Case Reports in Clinical Medicine 2013年第2期2卷 173-176页

作者： Bastian Kettler Mahmoud Abbas Bastian Ringe Lothar Hambach Jürgen Klempnauer Michael winkler Hans-Heinrich Kreipe Nikos Emmanouilidis Clinic for General- Abdominal- and Transplant-Surgery Medical School Hannover Hannover Germany Clinic for Haematology Medical School Hannover Hannover Germany Institute for Pathology Medical School Hannover Hannover Germany

We are presenting the case of a 42-year-old ?male patient, who was hospitalized due to an acute small bowel obstruction caused by a tissue mass of the mesentery. The patient reported that he had a history of a testicular tumour. for therapy of intestinal obstruction as well as for diagnostic reasons we decided to perform ?an explorative laparotomy. On histopathological examination the immunohistological staining was positive for myeloperoxidase (MPO) and KP-1 (CD68). Staining was slightly positive for Bcl-2, CD117, CD34, but negative for CD3, CD4, CD5, CD8, CD20, CD30, CD79, Bcl-6 and S-100. This leads to the diagnosis of a myeloid sarcoma. After recovery from surgery and chemotherapy, allogenic bone marrow transplantation was performed. Most intestinal obstructions are caused by postoperative adhesions or hernias and only in rare cases caused by a myeloid sarcoma.

关键词： Myeloid Sarcoma Small Bowel Obstruction

4号染色体短臂微卫星多态性与鼻咽癌相关性的研究

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遗传 2006年第7期28卷 783-790页

作者：郭秀婵 O’BRIEN Stephen J winkler Cheryl SCOTT Kevin HUTCHESON Holli DAVID Victor KESSING Bailey 郑裕明廖建刘彦 GUY de The 曾毅中国疾病预防控制中心病毒病预防控制所北京100052 美国国家癌症研究所基因组多样性研究室 frederickmd21702 广西梧州市肿瘤防治研究所梧州543002 广西苍梧县鼻咽癌防治所苍梧543100 法国巴士德研究所 parisfrance75724

鼻咽癌（NPC）是一种多因素复杂疾病。其发病过程涉及EB病毒慢性感染、环境致癌因素及宿主基因之间的相互作用。在这一过程中，那些宿主基因在EB病毒感染及鼻咽癌的发生发展中起了关键作用仍不清楚。本研究的目的是发现与鼻咽癌发生发... 详细信息

鼻咽癌（NPC）是一种多因素复杂疾病。其发病过程涉及EB病毒慢性感染、环境致癌因素及宿主基因之间的相互作用。在这一过程中，那些宿主基因在EB病毒感染及鼻咽癌的发生发展中起了关键作用仍不清楚。本研究的目的是发现与鼻咽癌发生发展中两个关键步骤相关的遗传变异，即EB病毒持续性感染鼻咽部上皮细胞和鼻咽癌的形成。我们在广西梧州市及苍梧县鼻咽癌高发区收集汉族鼻咽癌患者350例、EB病毒壳抗原IgA抗体阳性者（IgA／VCA＋）288例和EB病毒壳抗原IgA抗体阴性者（IgA／VCA—）346例。对先前鼻咽癌家系研究显示的鼻咽癌易感区4号染色体短臂（4p15．1～q12）进行了微卫星精细扫描，在18Mb的范围内选择34个微卫星标记，包括319个等位基因，对其进行基因分型。比较分析NPC组和IgA／VCA＋组等位基因频率结果显示，9个等位基因与鼻咽癌呈相关，其中5个为易感等位基因（OR=1．51～5．36，P=0．01～0．03），4个为限制性等位基因（OR值为0．3～0．71，P值为0．02～0．045）。比较分析IgA／VCA＋组和IgA／VCA-组及比较所有IgA／VCA＋者（包括NPC患者）和IgA／VCA-者等位基因频率的结果显示，12个等位基因与EB病毒壳抗原IgA抗体持续存在相关，其中3个在两组比较中均呈显著相关。等位基因D4S3241～136（P=0．004，OR=1．9，95％CI=1．2～3．0）和D4S3347-213（P=0．001，OR=1．6，95％CI=1．2～2．1）可增加EB病毒IgA／VCA抗体形成的危险，为易感基因；而等位基因D4S174．202（P=0．001，OR=0．5，95％CI=0．3～0．7）可限制IgA／VCA抗体的形成。但上述结果经多因素比较校正后，均失去相关性。结果不能确定该区域与非家族性鼻咽癌的形成相关，但本研究却提供了进一步发现鼻咽癌相关基因的研究模式。有关4号染色体短臂与EB病毒慢性持续感染及鼻咽癌的形成仍值得进一步深入研究。

关键词：鼻咽癌 4号染色体微卫星相关研究

Multinational corporations and infectious disease: Embracing human rights management techniques

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Infectious Diseases of Poverty 2014年第1期3卷 354-366,353页

作者： Kendyl Salcito Burton H Singer Mitchell G Weiss Mirko S winkler Gary R Krieger Mark Wielga Jürg Utzinger Department of Epidemiology and Public Health Swiss Tropical and Public Health InstituteP.O.BoxCH-4002BaselSwitzerland University of Basel P.O.BoxCH-4003BaselSwitzerland NomoGaia 1900 Wazee StreetSuite 303DenverCO 80202USA Newfields LLCDenverCO 80202USA Emerging Pathogens Institute University of FloridaGainesvilleFL 32610USA

Background:Global health institutions have called for governments,international organisations and health practitioners to employ a human rights-based approach to infectious *** motivation for a human rights approach is clear:poverty and inequality create conditions for infectious diseases to thrive,and the diseases,in turn,interact with social-ecological systems to promulgate poverty,inequity and *** and intergovernmental organisations should be concerned with the control and elimination of these diseases,as widespread infections delay economic growth and contribute to higher healthcare costs and slower processes for realising universal human *** social determinants and economic outcomes associated with infectious diseases should interest multinational companies,partly because they have bearing on corporate productivity and,increasingly,because new global norms impose on companies a responsibility to respect human rights,including the right to ***:We reviewed historical and recent developments at the interface of infectious diseases,human rights and multinational *** investigation was supplemented with field-level insights at corporate capital projects that were developed in areas of high endemicity of infectious diseases,which embraced rights-based disease control ***:Experience and literature provide a longstanding business case and an emerging social responsibility case for corporations to apply a human rights approach to health programmes at global ***,in an increasingly globalised and interconnected world,multinational corporations have an interest,and an important role to play,in advancing rights-based control strategies for infectious ***:There are new opportunities for governments and international health agencies to enlist corporate business actors in disease control and elimination *** offered by the United Nations in 2011 that is widel

关键词： Infectious diseases Human rights Systems-based interventions Multinational corporations Corporate social responsibility

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钙调素与钙通道阻断剂

徐州医科大学学报 1988年第1期 1-10+38-2页

作者： Martin A winkler,Linda M DeWitt,张槐耀美国犹大儿童研究医院生化系田纳西大学医学中心美国犹大儿童研究医院生化系田纳西大学医学中心美国犹大儿童研究医院生化系田纳西大学医学中心

钙离子为重要的细胞信使,其进入细胞通过钙通道,而它在体内发挥生物功能主要是通过钙调素。尽管钙调素具有分布上的遍在性和功能上的多样性,但它活化生化作用迄今只有少数证明是有生理意义的,如肌球蛋白轻链激酶对平滑肌的收缩作用等。... 详细信息

钙离子为重要的细胞信使,其进入细胞通过钙通道,而它在体内发挥生物功能主要是通过钙调素。尽管钙调素具有分布上的遍在性和功能上的多样性,但它活化生化作用迄今只有少数证明是有生理意义的,如肌球蛋白轻链激酶对平滑肌的收缩作用等。本文就钙调素及其拮抗剂和钙通道及其阻断剂的结构,功能和药理作用及关系作了分析和综述。钙通道阻断剂似乎不是通过钙调素产生药理效应的。

关键词：钙通道酚噻嗪慢通道阻断剂对抗药钙调素平滑肌

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妊娠期凝血障碍

德国医学 2001年第4期18卷 235-239页

作者： M.winkler W.Rath 官旭华 frauenklinik.Universitatsklinikumder Rheinisch-Westfalischen Technischen HochschuleRWTH 华中科技大学同济医学院

妊娠期凝血障碍最常见的原因:①大量出血后的稀释性凝血障碍病及不适宜的输液过量,如在产后子宫收缩乏力时;②消耗性凝血障碍病弥漫性血管内凝血(DIC),如胎盘早剥、妊娠高血压病、宫内死胎、败血症(如羊膜感染综合征)或羊水栓塞;③血小... 详细信息

妊娠期凝血障碍最常见的原因:①大量出血后的稀释性凝血障碍病及不适宜的输液过量,如在产后子宫收缩乏力时;②消耗性凝血障碍病弥漫性血管内凝血(DIC),如胎盘早剥、妊娠高血压病、宫内死胎、败血症(如羊膜感染综合征)或羊水栓塞;③血小板减少病和内科疾病的出血素质.Blutgerinnungsstrungen in der

关键词：妊娠期并发症凝血障碍消耗性凝血病弥漫性血管内凝血 DIC

Experience and lessons from health impact assessment guiding prevention and control of HIV/AIDS in a copper mine project,northwestern Zambia

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Infectious Diseases of Poverty 2017年第1期6卷 1023-1033页

作者： Astrid M.Knoblauch Mark J.Divall Milka Owuor Kennedy Nduna Harrison Ng’uni Gertrude Musunka Anna Pascall Jürg Utzinger Mirko S.winkler Swiss Tropical and Public Health Institute P.O.BoxCH-4002 BaselSwitzerland University of Basel P.O.BoxCH-4003 BaselSwitzerland SHAPE Consulting Ltd. GY12 St Peter PortChannel IslandsGuernseyUK Solwezi District Health Management Team 40100 SolweziZambia first Quantum Minerals Limited 10100 LusakaZambia

Background:To avoid or mitigate potential project-related adverse health effects,the Trident copper project in Kalumbila,northwestern Zambia,commissioned a health impact *** was identified a priority health issue based on the local vulnerability to HIV transmission and experience from other mining projects in ***,an HIV/AIDS management plan was developed,including community and workplace interventions,with HIV testing and counselling(HTC)being one of the key *** present trends in HTC data over a 4-year ***:In 13 communities affected by the Trident project,HTC was implemented from 2012 onwards,using rapid diagnostic tests,accompanied by pre-and post-test counselling through trained *** addition,HTC was initiated in the project workforce in 2013,coinciding with the launch of the mine *** uptake and HIV positivity rates were assessed in the study population and linked to demographic factors using regression ***:In total,11,638 community members and 5564 workers have taken up HTC with an increase over *** HIV positivity rate in the community was 3.0%in 2012 and 3.4%in 2015,while positivity rate in the workforce was 5.2%in 2013 and 4.3%in *** showed a significantly higher odds of having a positive test result than males(odds ratio(OR)=1.96,95%confidence interval(CI):1.55-2.50 among women in the community and OR=2.90,95%CI:1.74-4.84 among women in the workforce).HTC users in the 35-49 years age group were most affected by HIV,with an average positivity rate of 6.6%in the community sample and 7.9%in the workforce *** study groups had 4.50 and 4.95 higher odds of being positive,respectively,compared to their younger counterparts(15-24 years).Conclusions:While HTC uptake increased five-fold in the community and almost three-fold in the workplace,the HIV positivity rates were insignificantly higher in 2015 compared to *** data can be used alongside other surveillance data to

关键词： Community health management Health impact assessment HIV Mining Occupational health Sexually transmitted infections Zambia

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Portal vein thrombosis in liver transplantation: radiologic evaluation, risk factors, and occult diagnosis

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Hepatoma Research 2016年第1期2卷 36-41页

作者： Adam Hauch Carl winkler Eric Katz Peter W.Lundberg Mary Killackey Anil S.Paramesh Luis A.Balart Nathan J.Shores Martin Moehlen Ward Miller Douglas P.Slakey Joseph f.Buell Bob H.Saggi Tulane Transplant Institute Tulane University School of MedicineNew OrleansLA 70112USA Department of Gastroenterology Section of HepatologyTulane University School of MedicineNew OrleansLA 70112USA

Aim:Portal vein thrombosis(PVT)in the liver transplant recipient poses many ***,the risk factors and effects on outcomes of PVT are not ***:This study analyzed the experience with PVT in liver transplant program from 2007 to *** included the effectiveness of PVT diagnostics and its risk factors using logistical *** primary endpoints were Kaplan-Meir patient and graft *** secondary endpoints were the length of stay(LOS),transfusion rate,and overall *** predictors of survival were identified using a Cox’s proportional hazards ***:Two hundred and sixteen consecutive liver transplant recipients were examined,and 30(13.8%)had either a total or partial *** hundred and five patients had imaging within 1 year of liver transplantation with only 7(23.3%)of the 30 PVTs identified *** sensitivity(4.8-50%)and negative predictive values(10.5-22.2%)were ***,age significantly predicted PVT[P=0.037/hazard ratio(HR)=0.95].Ninety-day-patient and graft survival for PVT was similar at 6 months,although 1-year survival was significantly lower.“Occult”PVT was not associated with inferior *** for end-stage liver disease score>25(P=0.001,HR=0.49/P=0.004,HR=0.52)and age>60 years(P=0.017,HR=0.64/P=0.013,HR=0.67)were significant predictors of patient and graft *** the transfusion rate was significantly greater with PVT,LOS,and morbidity were ***:Older recipients had a greater likelihood of *** studies were not effective at excluding PVT,and occult diagnosis did not affect the *** was not an independent predictor of mortality or graft loss,but was associated with greater blood loss but not increased LOS or morbidity.

关键词： Advanced age graft survival patient survival post-transplant outcomes resource utilization

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老年人的视力损害:双重负荷?

德国医学 1999年第2期16卷 92-94页

作者： H.-W.Wahl V.Heyl f.Oswald U.winkler 杨红 Deutsches Zentrum für Alternsforschung an der Universitt Heidelberg Bergheimer Str.20D-69115 HeidelbergGermany 同济医科大学附属同济医院

视力障碍和盲目多见于60岁以上的老年人。根据联邦统计局的调查结果,盲人约有70％,而其中90％是晚年盲目。一项来自福来明翰眼科研究中心(framingham Eye Study)的资料显示,老年性白内障是52岁以上人群最常见的眼病,占15.6％,其次是老... 详细信息

视力障碍和盲目多见于60岁以上的老年人。根据联邦统计局的调查结果,盲人约有70％,而其中90％是晚年盲目。一项来自福来明翰眼科研究中心(framingham Eye Study)的资料显示,老年性白内障是52岁以上人群最常见的眼病,占15.6％,其次是老年性黄斑变性,占8.8％,第3位是青光眼(3.3％),第4位是糖尿病视网膜病变(3.1％)。这4种眼病均与年龄有明显的相关性。

关键词：视力障碍老年人发病率双重负荷

Monitoring for Thysanoplusia orichalcea in New Zealand

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Monitoring for Thysanoplusia orichalcea in New Zealand