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Reduced mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor contributes to neurodegeneration in a model of spinal and bulbar muscular atrophy pathology

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neural Regeneration Research 2025年第9期20卷 2655-2666页

作者： yiy.ng Qin Wenzhen Zhu Tingting Guo yiran Zhang Tingting Xing Peng y.n Shihua li Xiao-Jiang li Su y.ng Guangdong Key Laboratory of non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong–HongKong–Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina

Spinal and bulbar muscular atrophy is a neurodegenerative disease caused by extended CAG trinucleotide repeats in the androgen receptor gene,which encodes a ligand-dependent transcription facto *** mutant androgen receptor protein,characterized by polyglutamine expansion,is prone to misfolding and forms aggregates in both the nucleus and cytoplasm in the brain in spinal and bulbar muscular atrophy *** aggregates alter protein-protein interactions and compromise transcriptional *** this study,we reported that in both cultured n2a cells and mouse brain,mutant androgen receptor with polyglutamine expansion causes reduced expression of mesencephalic astrocyte-de rived neurotrophic *** n of mesencephalic astrocyte-derived neurotrophic factor amelio rated the neurotoxicity of mutant androgen receptor through the inhibition of mutant androgen receptor *** down endogenous mesencephalic astrocyte-derived neurotrophic factor in the mouse brain exacerbated neuronal damage and mutant androgen receptor *** findings suggest that inhibition of mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor is a potential mechanism underly.ng neurodegeneration in spinal and bulbar muscular atrophy.

关键词： androgen receptor mesencephalic astrocyte-derived neurotrophic factor mouse model neurodegeneration neuronal loss neurotrophic factor polyglutamine disease protein misfolding spinal and bulbar muscular atrophy transcription factor

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Weakly Supervised Object Localization with Background Suppression Erasing for Art Authentication and Copyright Protection

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Machine Intelligence Research 2024年第1期21卷 89-103页

作者： Chaojie Wu Mingy.ng li y.ng Gao Xiny.n Xie wing W.y.ng Ahmad Musyafa School of Computer Science and Engineering South China University of TechnologyGuangzhou 511442China Guangdong Provincial Key Laboratory of Artificial Intelligence in Medical Image Analysis and Application Guangdong Provincial People's HospitalGuangzhou 510180China

The problem of art forgery and infringement is becoming increasingly prominent,since diverse self-media contents with all kinds of art pieces are released on the Internet every *** art paintings,object detection and localization provide an efficient and ef-fective means of art authentication and copyright ***,the acquisition of a precise detector requires large amounts of ex-pensive pixel-level *** alleviate this,we propose a novel weakly supervised object localization(WSOL)with background su-perposition erasing(BSE),which recognizes objects with inexpensive image-level ***,integrated adversarial erasing(IAE)for vanilla convolutional neural network(Cnn)dropouts the most discriminative region by leveraging high-level semantic ***,a background suppression module(BSM)limits the activation area of the IAE to the object region through a self-guidance ***,in the inference phase,we utilize the refined importance map(RIM)of middle features to obtain class-agnostic loc-alization *** experiments are conducted on paintings,CUB-200-2011 and ILSVRC to validate the effectiveness of our BSE.

关键词： Weakly supervised object localization erasing method deep learning computer vision art authentication and copyright protection

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Dramatical enhancement of circular dichroism in chiral hybrid perovskites via carboxylic hydrogen bond engineering

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Science China Chemistry 2025年

作者： Hang li Xinling li Peng Wang Tingting Zhu Ruiqing li Huang ye yaru Geng Hongliang Dai Junhua Luo State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences University of Chinese Academy of Sciences Fujian College University of Chinese Academy of Sciences College of Chemistry Fuzhou University College of Chemistry and Materials Key Laboratory of Fluorine and Silicon for Energy Materials and Chemistry of Ministry of EducationJiangxi Normal University

Chiral hybrid perovskites （CHPs） have been regarded as promising candidates for developing chiroptoelectronics ***,circular dichroism （CD）,as one of the most important characteristics to evaluate the chiroptical activity,remains at a comparatively low level in CHPs compared to other chiral materials,which hinders the successful applications of CHPs in stateof-the-art ***,exploring new methods for enhancing CD in CHPs is urgently.needed and remains ***,enhanced CD response has been successfully realized via constructing carboxylic hydrogen bonding in chiralachiral mixed cations perovskites （R/S-PPA）2（ABA）PbBr5（2R/2S）(PPA=1-phenylpropylamine,ABA=4-aminobutyric acid).Compared with the prototype （R/S-PPA）PbBr3（1R/1S）,2R/2S provide intimate connections between organic units and inorganic parts via carboxylic hydrogen bonding n–H···O bridge,contributing new chirality transfer paths.A larger inorganic skeletons’helicity in 2R/2S predicts a high degree of chirality ***,2R/2S exhibit significantly enhanced CD response with an anisotropy factor amplified by an order of ***,bright blue circularly polarized luminescence applications are achieved in 2R/*** work systematically investigates the correlation between CD and hydrogen bonding interaction in CHPs,meanwhile providing a new avenue to develop the application potential of chiral materials in chiroptoelectronics.

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Fabrication of Microlens Array and Its Application:A Review

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Chinese Journal of Mechanical Engineering 2018年第1期31卷 10-18页

作者： Wei yuan li-Hua li wing-Bun Lee Chang-yuen Chan State Key Laboratory of Ultra-precision Machining Technology Partner Laboratory in the Hong Kong Polytechnic University Shenzhen Branch of State Key Laboratory of Ultra-precision Machining Technology PolyU Shenzhen Research Institute

Microlens arrays are the key component in the next generation of 3D imaging system, for it exhibits some good optical properties such as extremely large field of view angles, low aberration and distortion, high temporal resolution and infinite depth of field. Although many fabrication methods or processes are proposed for manufacturing such precision component, however, those methods still need to be improved. In this review, those fabrication methods are categorized into direct and indirect method and compared in detail. Two main challenges in manufacturing microlens array are identified: how to obtain a microlens array with good uniformity in a large area and how to produce the microlens array on a curved surface? In order to effectively achieve control of the geometry of a microlens,indirect methods involving the use of 3D molds and replication technologies are suggested. Further development of ultraprecision machining technology is needed to reduce the surface fluctuation by considering the dynamics of machine tool in tool path planning. Finally, the challenges and opportunities of manufacturing microlens array in industry and academic research are discussed and several principle conclusions are drawn.

关键词： Microlens array Ultraprecision machining 3D image system MEMS

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A Multiple Model Approach to Modeling Based on LPF Algorithm

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Journal of Systems Engineering and Electronics 2001年第3期12卷 64-70页

作者： li, n. li, S. Xi, y. Institute of Automation Shanghai Jiaotong University Shanghai 200030 China

Input-output data fitting methods are often used for unknown-structure nonlinear system modeling. Based on model-on-demand tactics, a multiple model approach to modeling for nonlinear systems is presented. The basic idea is to find out, from vast historical system input-output data sets, some data sets matching with the current working point, then to develop a local model using Local Polynomial Fitting (LPF) algorithm. With the change of working points, multiple local models are built, which realize the exact modeling for the global system. By comparing to other methods, the simulation results show good performance for its simple, effective and reliable estimation.

关键词： Algorithms Computer simulation Data structures Input output programs Mathematical models Parameter estimation Polynomials

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In vitro Study on Biodegradable AZ31 Magnesium Alloy Fibers Reinforced PLGA Composite

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Journal of Materials Science & Technology 2013年第6期29卷 545-550页

作者： y.H.Wu n.li y.Cheng y.F.Zheng y.Han Center for Biomedical Materials and Tissue Engineering Academy for Advanced Interdisciplinary StudiesPeking University Department of Materials Science and Engineering College of EngineeringPeking University State Key Laboratory for Mechanical Behavior of Materials Xi'an Jiaotong University

AZ31 magnesium alloy fibers reinforced poly（lactic-co-glycolic acid）（PLGA） composites were prepared and their mechanical property, immersion corrosion behavior and biocompatibility were studied. The tensile test showed that with the addition of AZ31 fibers, the composites had a significant increment in tensile strength and elongation. For the direct cell attachment test, all the cells showed a healthy morphology and spread well on the experimental sample surfaces. The immersion results indicated that pH values of the immersion medium increased with increasing AZ31 fiber contents. All the in vitro experimental results indicated that this new kind of magnesium alloy fibers reinforced PLGA composites show a potential for future biomedical applications.

关键词： Biomaterials Corrosion Polymeric composites AZ31 magnesium fiber

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Suppression of grain boundary migration at cryogenic temperature in an extremely fine nanograined ni-Mo alloy

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Journal of Materials Science & Technology 2020年第22期54卷 65-69页

作者： J.Hu J.X.li y.-n.Shi Sheny.ng national Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Institute of Advanced Materials East China JiaoTong UniversityNanchang 330013China School of Materials Science and Engineering University of Science and Technology of ChinaHefei 230026China

Microindentation creep tests on an electrodeposited extremely fine(4.9 nm) nanograined(ng) ni-14.2 at.% Mo(ni-14.2 Mo) at both room temperature(RT) and liquid nitrogen temperature(LnT) demonstrated that lowering temperature retarded softening in the ng ni-Mo alloy. The obtained strain rate sensitivity at LnT was one order of magnitude lower than that at RT. Microstructural characterization revealed that mechanically-driven grain boundary(GB) migration was greatly suppressed by lowering temperature,which might be ascribed to the presence of solute Mo atoms that significantly retarded coupled GB motion at LnT. Deformation was instead carried by shear bands.

关键词： Extremely fine nanograined metals Mechanically-driven grain boundary migration Cryogenic temperature Shear bands Solute atoms

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High-Speed Friction Stir Welding of T6-Treated B4Cp/6061Al Composite

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Acta Metallurgica Sinica(English Letters) 2020年第1期33卷 67-74页

作者： y.Z.li y.n.Zan Q.Z.Wang B.L.Xiao Z.y.Ma Key Laboratory of nuclear Materials and Safety Assessment Institute of Metal ResearchChinese Academy of Sciences72 Wenhua RoadShenyang 110016China Sheny.ng national Laboratory for Materials Science Institute of Metal ResearchChinese Academy of Sciences72 Wenhua RoadShenyang 110016China University of Science and Technology of China Shenyang 110016China

T6-treated 20 wt% B4 Cp/6061 Al sheets were joined under welding speeds of 400–1200 mm/min by friction stir welding(FSW) with a threaded cermet pin. The macro-defect-free FSW joints could be achieved at high welding speeds up to 1200 mm/min, but larger plunge depth was required at the welding speeds of 800 and 1200 mm/min to eliminate the tunnel defect. In the nugget zone(nZ) of the joints, the B4 C particles were broken up and uniformly redistributed. The nZ exhibited lower hardness than the base metal(BM), and the hardness value almost did not change with increasing welding speed, attributable to the dissolution of precipitates. Compared with the BM, the joints showed lower tensile strength. As the welding speed increased from 400 to 800 mm/min, the joint efficiencies were nearly the same and up to ~ 73%. When the welding speed increased up to 1200 mm/min, the tensile strength significantly decreased, due to the occurrence of kissing bond defect at the bottom of the nZ. With increasing welding speed, the fracture location of the joints transferred gradually from the heat-affected zone to the nZ due to the kissing bond defects.

关键词： Metal-matrix composites Microstructures Mechanical properties Friction stir welding High-speed welding

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Corrosion and cavitation erosion resistance enhancement of cast ni–Al bronze by laser surface melting

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Journal of Iron and Steel Research International 2022年第2期29卷 359-369页

作者： Q.n.Song y.Tong H.L.li H.n.Zhang n.Xu G.y.Zhang y.F.Bao W.liu Z.G.liu y.X.Qiao Engineering Research Center of Dredging Technology of Ministry of Education Hohai UniversityChangzhou213022JiangsuChina College of Mechanical and Electrical Engineering Hohai UniversityChangzhou213022JiangsuChina College of Materials Science and Engineering Jiangsu University of Science and TechnologyZhenjiang212003JiangsuChina

Laser surface melting (LSM) was applied on a cast ni–Al bronze (nAB), which was a crucial material for marine ship propellers. A 720 μm-thick LSM layer with fine equiaxed and dendritic microstructures was obtained. After immersion for 30 days, the corrosion rate of cast nAB was reduced by 25% after LSM. Preferential corrosion occurred and deep corrosion pits appeared at α + κIII microstructure for the cast nAB. LSM nAB underwent general corrosion, and a much more protective film formed on the surface because of the homogenized microstructure. The mass loss of the cast nAB was approximately 2.1 times larger than that of LSM nAB after cavitation erosion (CE) in 3.5 wt.% naCl solution for 5 h. For the two materials, the mechanical impact effect was dominantly responsible for CE damage. Therefore, the improved hardness and homogenized microstructure contributed to the improved CE resistance of LSM nAB. CE destructed the film, shifted the open circuit potential toward a more negative value, and raised the current density by an order of magnitude. Corrosion at the cast eutectoid microstructure and the dendrites of LSM nAB facilitates the degradation under the cavitation attack. CE-corrosion synergy was largely caused by corrosion-enhanced-CE.

关键词： Laser surface melting ni-Al bronze Microstructure Corrosion Cavitation erosion Synergy

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EFFECT OF QUEnCHInG TEMPERATURE On SHAPE MEMORy EFFECT OF Fe-18Mn -5Si-8Cr-4ni ALLOy

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Acta Metallurgica Sinica(English Letters) 1999年第5期12卷 739-742页

作者： Wen, y.H. li, n. Xu, y.G. Tu, M.J. li, y.L. Ma, y.L. Sichuan Univ Chengdu China

The effects of quenching temperature on shape memory effect and microstructure of Fe 18Mn 5Si 8Cr 4ni shape memory alloy have been studied. The results show that both the shape recovery ratio and the recovery strain increased as quenching temperature increased, the amount of stress induced ε martensite in the process of cold work decreased with the increase of quenching temperature, the shape recovery ratio and the recovery strain reached maximum at 650℃, and then decreased rapidly with the further increase of quenching temperature,the stress induced ε martensite wholly disappeared at 1023K. But when the quenching temperature is higher than 1023K, the further increase of quenching temperature had little effect on shape recovery ratio, the amount and size of thermal induced ε martensite would increased with the further increase in quenching temperature. The shape memory effect can be improved by the moderate amount of pre exist ε martensite in the matrix before deforming.

关键词： shape memory alloy shape recovery ratio ,martensite transformation

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