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Superior antibody and membrane protein‑specific T‑cell responses to CoronaVac by intradermal versus intramuscular routes in adolescents

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World Journal of Pediatrics 2024年第4期20卷 353-370页

作者： Jaime S.Rosa Duque Samuel M.S.Cheng Carolyn A.Cohen Daniel Leung Xiwei Wang Xiaofeng Mu Yuet Chung Tsun Ming Lau Manni Wang Wenyue Zhang Yanmei Zhang Howard H.W.wong Leo C.H.Tsang Sara Chaothai Tsz Chun Kwan John K.C.Li Karl C.K.Chan Leo L.H.Luk Jenson C.H.Ho wing Yan Li Amos M.T.Lee Jennifer H.Y.Lam Sau Man Chan Wilfred H.S.wong Issan Y.S.Tam Masashi Mori Sophie A.Valkenburg Malik Peiris Wenwei Tu Yu Lung Lau Department of Paediatrics and Adolescent Medicine The University of Hong KongHong KongChina School of Public Health The University of Hong KongHong KongChina HKU‑Pasteur Research Pole School of Public HealthThe University of Hong KongHong KongChina Research Institute for Bioresources and Biotechnology Ishikawa Prefectural UniversityNonoichiJapan Department of Microbiology and Immunology Peter Doherty Institute for Infectionand ImmunityUniversity of MelbourneMelbourneVICAustralia Center for Immunology and Infection C2i Hong KongChina

Background Optimising the immunogenicity of COVID-19 vaccines to improve their protection against disease is *** dosing by intradermal(ID)administration has been shown to be equally immunogenic as intramuscular(IM)administration for several vaccines,but the immunogenicity of ID inactivated whole severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)at the full dose is *** study(NCT04800133)investigated the superiority of antibody and T-cell responses of full-dose CoronaVac by ID over IM administration in *** Participants aged 11–17 years received two doses of IM or ID vaccine,followed by the 3rd dose 13–42 days *** and cellular immunogenicity outcomes were measured post-dose 2(IM-CC versus ID-CC)and post-dose 3(IMCCC versus ID-CCC).Doses 2 and 3 were administered to 173 and 104 adolescents,*** Spike protein(S)immunoglobulin G(IgG),S-receptor-binding domain(RBD)IgG,S IgG Fcγreceptor IIIa(FcγRIIIa)-binding,SNM[sum of individual(S),nucleocapsid protein(N),and membrane protein(M)peptide pool]-specific interleukin-2(IL-2)+CD4^(+),SNM-specific IL-2^(+)CD8^(+),S-specific IL-2^(+)CD8^(+),N-specific IL-2^(+)CD4^(+),N-specific IL-2^(+)CD8^(+)and M-specific IL-2^(+)CD4^(+)responses fulfilled the superior and non-inferior criteria for ID-CC compared to IM-CC,whereas IgG avidity was *** ID-CCC,S-RBD IgG,surrogate virus neutralisation test,90%plaque reduction neutralisation titre(PRNT90),PRNT50,S IgG avidity,S IgG FcγRIIIa-binding,M-specific IL-2^(+)CD4^(+),interferon-γ+CD8^(+)and IL-2^(+)CD8^(+)responses were superior and non-inferior to *** estimated vaccine efficacies were 49%,52%,66%and 79%for IM-CC,ID-CC,IM-CCC and ID-CCC,*** ID groups reported more local,mild adverse *** This is the first study to demonstrate superior antibody and M-specific T-cell responses by ID inactivated SARSCoV-2 vaccination and serves as the basis for future research to improve the

关键词： CoronaVac Coronavirus disease 2019 Immunity Intradermal Vaccine

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On a non-abelian invariant on complex surfaces of general type Dedicated to Professor Sheng GONG on the occasion of his 75th birthday

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Science China Mathematics 2006年第12期49卷 1897-1900页

作者： CHEUNG wing-Sum wong Bun Department of Mathematics University of Hong Kong Department of Mathematics University of California at Riverside

In this paper,we give certain homotopy and diffeomorphism versions as a generalization to an earlier result due to ***,Bun wong and Stephen *** concerning a local rigidity problem of the tangent bundle over compact su... 详细信息

关键词： Chern numbers complex surfaces of general type coholomogy group local moduli local deformation space Miyaoka-Yau inequality Yau's global rigidity theorem Yau's uniformization theorem.

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Remifentanil mimics cardioprotective effect of ischemic preconditioning via protein kinase C activation in open chest of rats

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Acta Pharmacologica Sinica 2005年第5期26卷 546-550页

作者： Michael G IRWIN tak-ming wong Department of Anesthesiology Department of Physiology the University of Hong Kong Hong Kong China

Aim:To examine whether the protective effect of remifentanil preconditioning（RPC）on postischemic hearts is mediated by protein kinase（PKC）activation incomparison with ischemic preconditioning（IPC）.Methods:Male Sprague-Dawleyrats were anesthetized and their chests were *** experiment was per-formed with chelerythrine（CHE,2mg/kg）,GF109203X（0.05 mg/kg）protein kinaseC（PKC）inhibitors administered before RPC(remifentanil 6μ***-1·min-1×3 cycle)orIPC,*** size（IS）,as a percentage of the area at risk（AAR）,wasdetermined by triphenyltetrazolium ***:In groups subjected to IPCand RPC the IS/AAR were significantly reduced（IS/AAR from 52.7%±5.5% to12.9%±3.4%,P0.05 vs CON）or IPC（CHE+IPC 53.7%±4.3%,GF+IPC54.1%±6.2%,P>0.05 vs CON）.The difference was not significant in any of thehemodynamic parameters between control and treatment groups during ischemiaand ***:Remifentanil confers myocardial protection againstischemic injury through a mechanism that is similar to IPC and involves PKCactivation.

关键词： remifentanil myocardial ischemia preconditioning myocardial reperfusion injury protein kinase C chelerythrine GF109203X

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Socioeconomic Distribution of Health and Health Care Utilization in a New Town in Hong Kong, China

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Biomedical and Environmental Sciences 2004年第2期17卷 234-245页

作者： tak SUN IGNATIUS YU TZE WAI wong Department of Community and Family Medicine the Chinese University of Hong Kong Shatin N. T. Hong Kong SAR ChinaDepartment of Community and Family Medicine the Chinese University of Hong Kong Shatin N. T. Hong Kong SAR China

Objectives To assess the association of socioeconomic indicators with various chronic and acute illnesses and the utilization of public health care in a new town in Hong Kong, China. Methods Illness experience and socioeconomic and demographic data of 7570 residents from 2022 randomly selected households were collected through telephone interviews. The relationships between socioeconomic indicators and illnesses/choice of health care were explored using stepwise logistic regressions after adjusting for sex and age. Results Significant positive associations were noted between low household income and diabetes mellitus, any chronic illnesses among adults and flu among younger subjects; low educational level and accident-related illness among adults; being born in Chinese mainland and flu, any acute illness in adults. For the utilization of public health care, low household income was the most consistent risk factor. Conclusion This study did not demonstrate a unidirectional socioeconomic gradient in healt

关键词： Socioeconomic indicators Health status Health care need Health care utilization

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Modeling the causal regulatory network by integrating chromatin accessibility and transcriptome data

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National Science Review 2016年第2期3卷 240-251页

作者： Yong Wang Rui Jiang wing Hung wong Department of Statistics Department of Biomedical Data ScienceBio-X ProgramStanford University Academy of Mathematics and Systems Science National Center for Mathematics and Interdisciplinary SciencesChinese Academy of Sciences MOE Key Laboratory of Bioinformatics Bioinformatics Division and Center for Synthetic and Systems BiologyTNLISTDepartment of AutomationTsinghua University

Cell packs a lot of genetic and regulatory information through a structure known as chromatin,*** is wrapped around histone proteins and is tightly packed in a remarkable *** express a gene in a specific coding region,the chromatin would open up and DNA loop may be formed by interacting enhancers and ***,the mediator and cohesion complexes,sequence-specific transcription factors,and RNA polymerase Ⅱ are recruited and work together to elaborately regulate the expression *** is in pressing need to understand how the information,about when,where,and to what degree genes should be expressed,is embedded into chromatin structure and gene regulatory *** to large consortia such as Encyclopedia of DNA Elements(ENCODE) and Roadmap Epigenomic projects,extensive data on chromatin accessibility and transcript abundance are available across many tissues and cell *** rich data offer an exciting opportunity to model the causal regulatory ***,we will review the current experimental approaches,foundational data,computational problems,interpretive frameworks,and integrative models that will enable the accurate interpretation of regulatory ***,we will discuss the efforts to organize,analyze,model,and integrate the DNA accessibility data,transcriptional data,and functional genomic regions *** believe that these efforts will eventually help us understand the information flow within the cell and will influence research directions across many fields.

关键词： gene regulatory network open chromatin DNA accessibility transcription factor colocalization statistical model data integration

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The Nano Research Young Innovators Awards in bio-inspired nanomaterials

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Nano Research 2024年第2期17卷 417-425页

作者： Jun Chen Shuotao Wang Department of Bioengineering University of CaliforniaLos AngelesLos AngelesCA 90095USA Key Laboratory of Bio-inspired Materials and Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China

Nano Research Young Innovators(NR45)Awards are designed to acknowledge and celebrate the achievements of young researchers under 45 years of *** individuals have made significant contributions to the field of nanoscience and *** the inaugural NR45 Awards in 2018,the journal's editorial board has recognized over a hundred innovators specializing in nanobiotechnology,nano energy,two-dimensional materials,and *** focus of the 2023 NR45 Awards is on bioinspired nanomaterials,acknowledging thirty-three outstanding young innovators for their extraordinary contributions in developing these materials with applications spanning clean energy,human healthcare,monitoring,and disease treatments,as shown in *** extend our heartfelt congratulations to all the 33 NR45 Awardees in 2023!

关键词： journal materials contributions

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Remarks on two theorems of Qi-Keng Lu

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Science China Mathematics 2008年第4期51卷 773-776页

作者： CHEUNG wing-Sum wong Bun Department of Mathematics University of Hong Kong Department of Mathematics University of California

Two alternate arguments in the framework of intrinsic metrics and measures respectively of part of the proof of a famous theorem due to Qi-Keng Lu on Bergman metric with constant negative holomorphic sectional curvature are presented.A relationship between the Lu constant and the holo- morphic sectional curvature of the Bergman metric is *** recent progress of the Yau’s porblem on the characterization of domain of holomorphy on which the Bergman metric is K(?)hler-Einstein is described.

关键词： Bergman metric holomorphic sectional curvature intrinsic metrics and measures Qi-Keng Lu theorem 32F45 32Q05 32W20

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Spatial-temporal evolution of injection-induced earthquakes in the Weiyuan Area determined by machine-learning phase picker and waveform cross-correlation

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Earth and Planetary Physics 2021年第6期5卷 485-500页

作者： wing Ching Jeremy wong JinPing Zi HongFeng Yang JinRong Su Earth System Science Programme Faculty of ScienceThe Chinese University of Hong KongSha TinHong Kong 999077China Earthquake Monitoring Center Sichuan Earthquake AgencyChengdu 610041China

Anthropogenic induced seismicity has been widely reported and investigated in many regions,including the shale gas fields in the Sichuan basin,where the frequency of earthquakes has increased substantially since the commencement of fracking in late ***,the details of how earthquakes are induced remain poorly understood,partly due to lack of high-resolution spatial-temporal data documenting the evolution of such seismic *** previous studies have been based on a diffusive earthquake catalog constructed by routine ***,however,we have constructed a high resolution catalog using a machine learning detector and waveform *** limited data,this new approach has detected one-third more earthquakes and improves the magnitude completeness of the catalog,illuminating the comprehensive spatial-temporal migration of the emerging seismicity in the target *** of the clusters clearly delineates a potential unmapped fault trace that may have led to the Mw 5.2 in September 2019,by far the largest earthquake recorded in the *** migration of the seismicity also demonstrates a pore-pressure diffusion front,suggesting additional constraints on the inducing mechanism of the *** patterns of the highly clustered seismicity reconcile the causal link between the emerging seismicity and the activity of hydraulic fracturing in the region,facilitating continued investigation of the mechanisms of seismic induction and their associated risks.

关键词： hydraulic fracturing Sichuan Basin machine learning injection-induced earthquake Weiyuan earthquake

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Review of evolution of clinical, training and educational services and research program for autism spectrum disorders in Hong Kong

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Science China(Life Sciences) 2015年第10期58卷 991-1009页

作者： Virginia Chun-Nei wong Cheuk-wing FUNG So-Lun LEE Polly Tsz Yan wong Department of Paediatrics and Adolescent Medicine the University of Hong Kong Queen Mary Hospital

The evolution of a local fragmented model of services for children with autism in Hong Kong emerged gradually over the past three decades with lack of government funding or support. This had been due to increasing number of children with autism being detected and referred for earlier assessment. With increasing pressure from parents due to long waiting time for assessment and training services and the increasing polarization by mass media there had been a gradual increasing public awareness over the past five years. Though still highly fragmented in the availability of services, there is a growing "business model" available in the community due to increasing need and lack of public funding for support. There is a lack of strategic planning for medical diagnostic and management issues in Hong Kong. Our University of Hong Kong based Autism Research Program was pioneered in 1985 based on the increasing load of autism cases referred for assessment for other developmental problems and diagnosed as Autism in the Duchess of Kent Children's Hospital. As the first author has been the staff of the University of Hong Kong, this program flourished as a research based program. The benefits of early identification and intervention of autism spectrum disorder(ASD) had been increasingly recognized, and with the increased public awareness and increasing trend of earlier diagnosis, there has been a continuously high demand from parents for earlier assessment and training for children suspected to have ASD. This model had not received extra funding for this integrated program for research, teaching and training in autism. We had to apply for various donations and grants to support the development of this pioneer program. The research output and organization of forums for public education and awareness are reviewed. The latter part of the paper reports the summary of clinical profile of autism cases(N=1441) assessed from 1985 to 2010 June under the University of Hong Kong. As the waiti

关键词： autism spectrum disorder (ASD) autism Asperger syndrome children

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An efficient method for privacy preserving location queries

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Frontiers of Computer Science 2012年第4期6卷 409-420页

作者： Yubao LIU Xiuwei CHEN Zhan LI Zhijie LI Raymond Chi-wing wong Department of Computer Science Sun Yat-Sen UniversityGuangzhou 510006China Department of Computer Science Jinan UniversityGuangzhou 510632China Department of Computer Science and Engineering The Hong Kong University of Science and TechnologyHong KongChina

Recently, the issue of privacy preserving loca- tion queries has attracted much research. However, there are few works focusing on the tradeoff between location privacy preservation and location query information collection. To tackle this kind of tradeoff, we propose the privacy persevering location query （PLQ）, an efficient privacy pre-serving location query processing framework. This frame- work can enable the location-based query without revealing user location information. The framework can also facilitate location-based service providers to collect some information about the location based query, which is useful in practice. PLQ consists of three key components, namely, the location anonymizer at the client side, the privacy query processor at the server side, and an additional trusted third party connect- ing the client and server. The location anonymizer blurs the user location into a cloaked area based on a map-hierarchy. The map-hierarchy contains accurate regions that are parti- tioned according to real landforms. The privacy query pro- cessor deals with the requested nearest-neighbor （NN） loca- tion based query. A new convex hull of polygon （CHP） algo- rithm is proposed for nearest-neighbor queries using a poly- gon cloaked area. The experimental results show that our al- gorithms can efficiently process location based queries.

关键词： location based service (LBS) privacy preserva- tion nearest-neighbor (NN) location query

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