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Comparison of the reverse bevel versus Franseen type endoscopic ultrasound needle

World Journal of Gastrointestinal Endoscopy 2020年第9期12卷 266-275页

作者： Chi wing chow Syeda Asma Haider Krish Ragunath Guruprasad P Aithal Martin W James Jacobo Ortiz-Fernandez-Sordo Aloysious Dominic Aravinthan Suresh Vasan Venkatachalapathy National Institute for Health Research Nottingham Biomedical Research Centre Nottingham University Hospitals National Health Service Trust and University of NottinghamNottingham NG72UHUnited Kingdom Department of Pathology Nottingham University Hospitals National Health Service TrustNottingham NG72UHUnited Kingdom Nottingham Digestive Diseases Centre School of MedicineUniversity of NottinghamNottingham NG72RDUnited Kingdom National Institute for Health Research Nottingham Biomedical Research Centre Nottingham University Hospitals National Health Service Trust and University of NottinghamNottingham NG27UHUnited Kingdom

BACKGROUND Reverse bevel(RB)needle is widely used for endoscopic ultrasound fine needle biopsy(EUS-FNB).A 3-plane symmetrical needle with Franseen geometry(FG)has recently become *** To compare the clinical efficacy of FG to that of RB *** A retrospective cohort study of all adult patients who underwent EUS-FNB for solid and mixed lesions either with 22G RB needle or 22G FG needle between January 2016 and February 2019 was *** cytology slides were reviewed by an independent gastrointestinal cytopathologist blinded to the needle used and the initial cytology *** primary and secondary outcomes were to assess the sample adequacy using Euro-cytology criteria and the number of cell clusters,*** Two hundred and twenty six procedures were included in the *** needle was used in 128 procedures and FG needle in 98 *** baseline characteristics of both groups were *** multivariable analysis,FG needle(P=0.02)and location of the lesion(P<0.01)were independently associated with adequate ***,the use of FG needle(P=0.04)and the size of the lesion(P=0.02)were independently associated with acquisition of increased number of cell *** FG needle is superior to RB needle in acquiring adequate tissue and attaining higher number of cell clusters for solid and mixed lesions.

关键词： Endoscopic ultrasound Fine needle aspiration Fine needle biopsy Reverse bevel Franseen geometry Tissue acquisition

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The effects of stent porosity on the endovascular treatment of intracranial aneurysms located near a bifurcation

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Journal of Biomedical Science and Engineering 2013年第8期6卷 812-822页

作者： Abraham Yik-Sau Tang Hiu-Ning Chan Anderson Chun-On Tsang Gilberto Ka-Kit Leung Kar-Ming Leung Alfred Cheuk-Hang Yu Kwok-wing chow Department of Mechanical Engineering University of Hong Kong Hong Kong China Department of Neurosurgery Kwong Wah Hospital Hong Kong China Division of Neurosurgery Department of Surgery Li Ka Shing Faculty of Medicine University of Hong Kong Queen Mary Hos-pital Hong Kong China Medical Engineering Program Department of Electrical and Electronic Engineering University of Hong Kong Hong Kong China

Intracranial aneurysm occurs when a cerebral artery develops an abnormal sac-like dilatation, and will cause massive bleeding in the subarachnoid space upon rupture. Endovascular stenting is a minimally invasive procedure in which a flow-diverting stent is deployed to cover the aneurysm neck, thereby restricting blood from entering the aneurysm and reducing the risk of rupture. The stent porosity, a crucial factor determining the intra-aneurysmal hemodynamics following treatment, is investigated by computational fluid dynamics techniques. Based on the computational results, a low porosity stent will dramatically reduce the flow velocity and the flow rate inside the side branch vessel. Conversely, a high porosity stent may not provide adequate flow reduction inside the aneurysm, possibly causing treatment failure. An advisable range of optimal stent porosity would be 60% to 75%, which can drastically reduce the flow rate into the aneurysm while preserving enough blood flow for the side branch vessel. Clinically, deployment of two or more flow-diverting stents may not increase treatment efficacy but can potentially lead to adverse effects due to side-branch hypoperfusion. The present quantitative analysis can also provide practical insight for future stent design.

关键词： Intracranial aneurysm Endovascular Treatment Stent Stent Porosity Computational Fluid Dynamics

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钟乳石的本草考证、品质评价及物相分析

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中国实验方剂学杂志 2024年第21期30卷 203-211页

作者：魏健雄孙媛陈代红王友邵章敏李娟湖北中医药大学药学院武汉430065

该文通过查阅历代本草、医书与经典名方及现代文献,对钟乳石的名称、基原和品质评价等进行系统整理与本草考证,结合对20批样品的物相分析,以期为钟乳石品质评价提供依据。考证表明,清代前的本草多以“石钟乳”之名记载,并有“虚中”“... 详细信息

该文通过查阅历代本草、医书与经典名方及现代文献,对钟乳石的名称、基原和品质评价等进行系统整理与本草考证,结合对20批样品的物相分析,以期为钟乳石品质评价提供依据。考证表明,清代前的本草多以“石钟乳”之名记载,并有“虚中”“夏石”“黄石砂”等;此外,有孔公孽、殷孽、乳床、乳华等别名混用现象,现代多以钟乳石为正名。本草记载的钟乳石与现代碳酸盐类矿物方解石族方解石相符,形状略呈圆锥形或圆柱形,大多有白、灰、黄3种颜色,中心常有孔洞,碳酸钙(CaCO_(3))质量分数在95%以上。历代品质评价包括“鹅翎管”“蝉翼”“明白”“光润”等,更注重光泽;现代评价包括“色白、空心、有亮光,多层纹、断面具闪星状亮光”等特征。扫描电镜下钟乳石可见明显的层纹特征,颗粒大小均匀,而鹅管石呈不规则状;通过不同批次的钟乳石的性状、微性状对比,X射线衍射(XRD)检测和CaCO_(3)含量测定等,不同批次钟乳石药材物相组成大致相似,均以方解石为主,另含镁方解石,“光润”“闪星状亮光多”者CaCO_(3)质量分数相对更高,为其品质评价的关键特征,“色白”可作为品质参考,“层纹”“乳头状突起”可作为药材鉴定特征,与本草考证结果基本一致。该研究结果为矿物类药物的质量评价提供参考,以期更好地指导临床用药和资源合理利用。

关键词：钟乳石品质评价本草考证碳酸钙方解石 X射线衍射(XRD) 物相分析

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Implementing　Higher－Order　Gamma　on　a　Massively　Parallel　computer－A　Case　study

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Journal of Systems Engineering and Electronics 1995年第3期6卷 56-62页

作者： Linpeng Huang Kam wing Ng, Yongqiang sun(Department of Computer Science and EngineeringShanghai Jiao Tong University, Shanghai 200030, P. R. China)(Department of Computer Science, The Chinese University of Hong Kong, Hong Kong) Department of Computer Science and Engineering Shanghai Jiao Tong University Shanghai 200030 P. R. China Department of Computer Science The Chinese University of Hong Kong Hong Kong Department of Computer Science The Chinese University of Hong Kong Hong Kong

Gamma is a kernel programming language with an elegant chemical reaction metaphor in whichprograms are described in terms of multiset rewriting. Gamma formalism allows one to describe analgorithm without introducing artificial sequentiality and leads to the derivation of a parallel solution to agiven problem naturally. However, the difficulty of incorporating control strategies makes Gamma not onlyhard for one to define any sophisticated approaches but also impossible to reach a decent level of efficiencyin any direct implementation. Recently, a higherorder multiset programming paradigm, named higher--order Gamma, is introduced by Metayer to alleviate these problems. In this paper, we investigate the possibility of implementing higherorder Gamma on Maspar, a massively data parallel computer. The results showthat a program written in higher--order Gamma can be transformed naturally toward an efficientimplementation on a real parallel machine.

关键词： Massively Parallel Computation GAMMA programming paradigm

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基于CSP算法的BWB飞机飞控作动系统架构设计

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液压与气动 2024年第2期48卷 165-173页

作者：杨建忠杨洪利孙晓哲中国民航大学安全科学与工程学院天津300300

针对翼身融合(Blended wing Body,BWB)飞机舵面数量多且每个舵面承担两轴或三轴多种功能,可选的动力源和作动器类型多样,导致飞控作动系统架构设计困难的问题,研究分析了BWB飞机飞控作动系统架构安全性设计原则和技术约束,采用约束满足... 详细信息

针对翼身融合(Blended wing Body,BWB)飞机舵面数量多且每个舵面承担两轴或三轴多种功能,可选的动力源和作动器类型多样,导致飞控作动系统架构设计困难的问题,研究分析了BWB飞机飞控作动系统架构安全性设计原则和技术约束,采用约束满足问题(Constraint Satisfaction Problem,CSP)算法为BWB飞机进行飞控作动系统架构设计,对飞控作动系统架构进行变量V、值域D以及约束C建模分析,设计回溯算法对飞控作动系统架构进行筛选,在1049种候选飞控作动系统架构中,用时不到7 min,为飞机筛选出符合安全性设计原则和技术约束的飞控作动系统架构,比其他文献中的初步筛选算法用时更短,且缩短了设计周期。

关键词： BWB飞机飞控作动系统架构设计 CSP算法

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Review on ultra-lightweight flapping-wing nano air vehicles:Artificial muscles,flight control mechanism,and biomimetic wings

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Chinese Journal of Aeronautics 2023年第6期36卷 63-91页

作者： Liang WANG Bifeng SONG Zhongchao sun Xiaojun YANG School of Aeronautics Northwestern Polytechnical UniversityXi'an 710072China Research&Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518057China Yangtze River Delta Research Institute Northwestern Polytechnical UniversityTaicang 215400China

Flying insects are capable of flapping their wings to provide the required power and control forces for flight.A coordinated organizational system including muscles,wings,and control architecture plays a significant role,which provides the sources of inspiration for designing flapping-wing *** recent years,due to the development of micro-and meso-scale manufacturing technologies,advances in components technologies have directly led to a progress of smaller Flapping-wing Nano Air Vehicles(FWNAVs)around gram and sub-gram scales,and these air vehicles have gradually acquired insect-like locomotive strategies and *** paper will present a selective review of components technologies for ultra-lightweight flapping-wing nano air vehicles under 3 g,which covers the novel propulsion methods such as artificial muscles,flight control mechanisms,and the design paradigms of the insect-inspired wings,with a special focus on the development of the driving technologies based on artificial muscles and the progress of the biomimetic *** challenges involved in constructing such small flapping-wing air vehicles and recommendations for several possible future directions in terms of component technology enhancements and overall vehicle performance are also discussed in this *** review will provide the essential guidelines and the insights for designing a flapping-wing nano air vehicle with higher performance.

关键词： Actuators Artificial muscle Biomimetic wings Flapping wing Flight control mechanism Nano Air Vehicles(NAVs)

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Application of a PCA-DBN-based surrogate model to robust aerodynamic design optimization

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Chinese Journal of Aeronautics 2020年第6期33卷 1573-1588页

作者： Jun TAO Gang sun Liqiang GUO Xinyu WANG Department of Aeronautics&Astronautics Fudan UniversityShanghai 200433China Department of Mechanical&Aerospace Engineering University of CaliforniaIrvine 92697USA

An efficient method employing a Principal Component Analysis(PCA)-Deep Belief Network(DBN)-based surrogate model is developed for robust aerodynamic design optimization in this *** order to reduce the number of design variables for aerodynamic optimizations,the PCA technique is implemented to the geometric parameters obtained by parameterization *** the purpose of predicting aerodynamic parameters,the DBN model is established with the reduced design variables as input and the aerodynamic parameters as output,and it is trained using the k-step contrastive divergence *** established PCA-DBN-based surrogate model is validated through predicting lift-to-drag ratios of a set of airfoils,and the results indicate that the PCA-DBN-based surrogate model is reliable and obtains more accurate predictions than three other surrogate *** the efficient optimization method is established by embedding the PCA-DBN-based surrogate model into an improved Particle Swarm Optimization(PSO)framework,and applied to the robust aerodynamic design optimizations of Natural Laminar Flow(NLF)airfoil and transonic *** optimization results indicate that the PCA-DBN-based surrogate model works very well as a prediction model in the robust optimization processes of both NLF airfoil and transonic *** employing the PCA-DBN-based surrogate model,the developed efficient method improves the optimization efficiency obviously.

关键词： Aerodynamic design optimization Deep neural networks Particle swarm optimization Principal component analysis Surrogate model

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Rational design of platinum(Ⅱ)complexes with orthogonally oriented triazolyl ligand with emission enhancement characteristics for cancer chemotherapy in vivo

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Science China Chemistry 2023年第10期66卷 2878-2884页

作者： Yeye Ai Zherui Zhang Yuexuan Fei Ruirong Ye Angela Sin-Yee Law Zong-Wan Mao Junqiu Liu Yongguang Li Vivian wing-Wah Yam Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education College of Material Chemistry and Chemical EngineeringHangzhou Normal UniversityHangzhou 311121China Institute of Molecular Functional Materials State Key Laboratory of Synthetic Chemistry and Department of ChemistryThe University of Hong KongHong KongChina School of Chemistry Sun Yat-Sen UniversityGuangzhou 510275China State Key Laboratory of Supramolecular Structure and Materials Jilin UniversityChangchun 130012China

The mitochondria are essential for tumorigenesis and have been regarded as important targets in cancer ***,the mitochondria-targeted platinum(Ⅱ)complexes have been *** introduction of the triazole group with larger steric hindrance through post-click reaction converts the hybridization of carbon from sp to sp^(2),endowing the complexes with an orthogonally oriented ligand with restricted rotation and emission enhancement *** of the triazolyl ligand has led to platinum(Ⅱ)complexes that can efficiently enter cancer cells and selectively accumulate in mitochondria,leading to significant enhancement in *** vivo anti-cancer investigations have demonstrated their distinct antitumor efficacy in substantial inhibition of tumor growth in breast cancer mice through dissipation of mitochondrial membrane potential,inducing apoptosis of tumor cell with negligibly systemic cytotoxicity.

关键词： platinum(Ⅱ)complexes post-click reaction emission enhancement mitochondria-targeting antitumor

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基于CFD方法的民用飞机缩比飞行试验尺度效应研究

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空气动力学学报 2024年第8期42卷 77-83,I0002页

作者：陈恺吴大卫孙宇辰陈石程攀毛昆上海飞机设计研究院上海201210

缩比飞行试验在民用飞机的研制过程中日益受到重视,其尺度效应影响评估是设计缩比飞行试验工况的基础,也是确认飞行数据适用性的关键。基于几何和动力学相似准则,针对某民用飞机及其缩比验证机设计分析工况组,采用计算流体力学方法研究... 详细信息

缩比飞行试验在民用飞机的研制过程中日益受到重视,其尺度效应影响评估是设计缩比飞行试验工况的基础,也是确认飞行数据适用性的关键。基于几何和动力学相似准则,针对某民用飞机及其缩比验证机设计分析工况组,采用计算流体力学方法研究相似准则参数(马赫数Ma、雷诺数Re、弗劳德数Fr)对气动载荷、典型气动导数及弹性变形的影响。研究结果表明,在动力学相似时,验证机与原型机间的气动特性差异主要来源于马赫数,雷诺数影响较小;当原型机以中低马赫数(Ma<0.5)飞行时,此时马赫数压缩效应不明显,验证机与原型机具有近似的展向与弦向载荷分布特征,典型稳定导数及操纵导数差异约10%,在控制律设计鲁棒性范围内;进一步保持质量与刚度分布相似时,机翼翼尖扭转变形差异不超过0.5°,挠度差异不超过0.5%,在工程上属于可接受的范围。

关键词：缩比验证飞行相似准则尺度效应气动特性机翼弹性变形

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当代世界文化危机、回归传统与中国的儒学复兴运动

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文化发展论丛 2017年第1期 44-70页

作者：周启荣美国伊利诺州立大学香槟分校东亚语言文化系、历史系

21世纪无疑是全球史新一章的开始,而揭开这一章序幕的是两个影响全球的历史事件：第一个是＂中国的崛起＂,第二个是＂西方文明的回落＂。这两个事件同样导致中国与西方国家的＂回归传统＂运动。虽然中国与西方国家都要求回到自己的文化... 详细信息

21世纪无疑是全球史新一章的开始,而揭开这一章序幕的是两个影响全球的历史事件：第一个是＂中国的崛起＂,第二个是＂西方文明的回落＂。这两个事件同样导致中国与西方国家的＂回归传统＂运动。虽然中国与西方国家都要求回到自己的文化＂传统＂,但是两者所要回归的＂传统＂差异甚大。当代中国的传统文化复兴运动的对象是历史人文主义的传统文化,尤其是儒家思想与价值。西方希望＂去世俗化＂,要求回到独一神道主义的宗教传统。本文旨在分析在全球的文化危机中,中国与西方如何重新回到建构的＂传统＂中找寻应对时代危机的方法,通过两个过程的比较来探讨当代儒学复兴的全球史意义。中国能够成功地回归儒家传统将为世界提供一个稳定的磐石。

关键词：中国传统文化儒学复兴西方文明危机去世俗化基督教

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