检索结果-南通市图书馆

Diagnostic yield of small bowel capsule endoscopy depends on the small bowel transit time

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2012年第13期18卷 1502-1507页

作者： Jessie Westerhof Jan J Koornstra Reinier A Hoedemaker wim J Sluiter Jan H Kleibeuker Rinse K Weersma Department of Gastroenterology and Hepatology University Medical Center GroningenUniversity of GroningenPO Box 300019700 RBGroningenThe Netherlands

AIM： To investigate whether the small bowel transit time （SBTT） influences the diagnostic yield of capsule endoscopy （CE）. METHODS： Six hundred and ninety-one consecutive CE procedures collected in a database were analyzed. SBTT and CE findings were recorded. A running mean for the SBl-I- was calculated and correlated to the diagnostic yield with a Spearman＇s correlation test. Subgroup anal- yses were performed for the various indications for the procedure. RESULTS： There was a positive correlation between the diagnostic yield and SBT1- （Spearman＇s rho 0.58, P 〈 0.01）. Positive correlations between diagnostic yield and SB-FI-were found for the indication obscure gastro- intestinal bleeding （r = 0.54, P 〈 0.01）, for polyposis and carcinoid combined （r = 0.56, P 〈 0.01） and for the other indications （r = 0.90, P 〈0.01）, but not for suspected Crohn＇s disease （r = -0.40） CONCLUSION： The diagnostic yield in small bowel capsule endoscopy is positively correlated with the small bowel transit time. This is true for all indications except for suspected Crohn＇s disease.

关键词： Capsule endoscopy Small bowel transit time Diagnostic yield

Hemolysis results in impaired intestinal microcirculation and intestinal epithelial cell injury

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2011年第2期17卷 213-218页

作者： Sebastiaan J Hanssen Tim Lubbers Caroline M Hodin Frits W Prinzen wim A Buurman Michael J Jacobs Department of Surgery Maastricht University Medical Center Cardiovascular Research Institute Maastricht Maastricht University Medical Center European Vascular Center Aachen-Maastricht Department of Vascular SurgeryUniversity Hospital Aachen Nutrition and Toxicology Research Institute Maastricht Maastricht University Medical Center Department of Physiology Maastricht University Medical Center

AIM:To study the effect of circulating cell-free oxy-hemoglobin(FHb) on intestinal microcirculation and intestinal epithelial injury in a rat model. METHODS:To induce elevated intravascular circulating FHb,male Sprague-Dawley rats received water or FHb *** changes in jejunum,ileum and colon were evaluated using fluorescent *** injury was quantified as plasmatic release of ileal lipid binding protein(iLBP) and verified by histological analysis of the ileum. RESULTS:Water and FHb infusions resulted,when compared with saline infusion,in reduced intestinal microcirculation(after 30 min P<0.05,or better;after 60 min FHb infusion P<0.05 for jejunum and colon) .Circulating FHb levels correlated significantly with release of iLBP(Spearman r=0.72,P=0.0011) .Epithelial cell injury of the villi was histologically observed after water and FHb infusions. CONCLUSION:This study shows that circulating FHb leads to a reduction in intestinal microcirculatory blood flow with marked injury to intestinal epithelial cells. These data support the hypothesis that circulating FHb contributes to the development of intestinal injury.

关键词： Hemoglobin Microcirculation Organ injury Vasoconstriction

Belgium experience in disaster victim identification applied in handling terrorist attack at Brussels Airport 2016

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Forensic Sciences Research 2020年第3期5卷 223-231页

作者： Francois Beauthier wim Van de Voorde Philippe Lefevre Jean-Pol Beauthier Medicolegal and Forensic Anthropology Unit Laboratory of AnatomyBiomechanics and OrganogenesisFaculty of MedicineUniversite libre de BruxellesBruxellesBelgium Forensic Biomedical Sciences Department of Imaging and PathologyUniversity of LeuvenBelgium

The Belgian disaster victim identification(DVI)team is involved in many investigations in our ***,this specialized team of the federal police oversees searching for and investigating criminally buried dead bodies,identification of unknown putrefied corpses,and *** Belgian DVI team also assists with the identification of victims of mass disasters(natural,accidental,and mass murders).In this article,we consider the contributions of different teams(forensic pathology,anthropology,and odontology,federal police,and crime scene investigation)both on the scene of the attack at the Brussels National Airport(Zaventem)and in the laboratory work(autopsies,sample studies).

关键词： Forensic sciences forensic pathology terrorist attack blast injury body fragments identification

Molecular and Physiological Analysis of Growth-Limiting Drought Stress in Brachypodium distachyon Leaves

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular Plant 2013年第2期6卷 311-322页

作者： wim Verelst Edoardo Bertolini Stefanie De Bodt Klaas Vandepoele Marlies Demeulenaere Mario Enrico pè Dirk Inzé Department of Plant Systems Biology vie Technologiepark 927 9052 Gent Belgium Department of Plant Biotechnology and Bioinformatics Ghent University Technologiepark 927 9052 Gent Belgium Present address: Rijk Zwaan Zaadteelt en Zaadhandel B.V. Eerste Kruisweg 9 4793 RS Fijnaart The Netherlands Scuola Superiore Sant'Anna Piazza Martiri della Liberta 33 56127 Pisa Italy

The drought-tolerant grass Brachypodium distachyon is an emerging model species for temperate grasses and cereal crops. To explore the usefulness of this species for drought studies, a reproducible in vivo drought assay was developed. Spontaneous soil drying led to a 45% reduction in leaf size, and this was mostly due to a decrease in cell expansion, whereas cell division remained largely unaffected by drought. To investigate the molecular basis of the observed leaf growth reduction, the third Brachypodium leaf was dissected in three zones, namely proliferation, expan- sion, and mature zones, and subjected to transcriptome analysis, based on a whole-genome tiling array. This approach allowed us to highlight that transcriptome profiles of different developmental leaf zones respond differently to drought. Several genes and functional processes involved in drought tolerance were identified. The transcriptome data suggest an increased energy availability in the proliferation zones, along with an up-regulation of sterol synthesis that may influ-ence membrane fluidity. This information may be used to improve the tolerance of temperate cereals to drought, which is undoubtedly one of the major environmental challenges faced by agriculture today and in the near future.

关键词： Brachypodium drought stress plant growth leaf.

Addressing the Role of microRNAs in Reprogramming Leaf Growth during Drought Stress in Brachypodium distachyon

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular Plant 2013年第2期6卷 423-443页

作者： Edoardo Bertolini wim Verelst David Stephen Horner Luca Gianfranceschi Viviana Piccolo Dirk Iné Mario Enrico Pè Erica Mica Institute of Life Sciences Scuola Superiore Sant'Anna Piazza Martiri della Libertà 33 56127 Pisa Italy Department of Plant Biotechnology and Bioinformatics Ghent University Technologiepark 927 9052 Ghent Belgium Department of Plant Systems Biology VIB Technologiepark 927 9052 Gtlent. Belgium Department of BioSciences University of Milan via Celoria 26 20133 Milan Italy

Plant responses to drought are regulated by complex genetic and epigenetic networks leading to rapid reprogramming of plant growth, miRNAs have been widely indicated as key players in the regulation of growth and development. The role of miRNAs in drought response was investigated in young leaves of Brachypodium dis- tachyon, a drought-tolerant monocot model species. Adopting an in vivo drought assay, shown to cause a dramatic reduction in leaf size, mostly due to reduced cell expansion, small RNA libraries were produced from proliferating and expanding leaf cells. Next-generation sequencing data were analyzed using an in-house bioinformatics pipeline allowing the identification of 66 annotated miRNA genes and 122 new high confidence predictions greatly expand- ing the number of known Brachypodium miRNAs. In addition, we identified four TAS3 loci and a large number of siRNA-producing loci that show characteristics suggesting that they may represent young miRNA genes. Most miR- NAs showed a high expression level, consistent with their involvement in early leaf development and cell identity. Proliferating and expanding leaf cells respond differently to drought treatment and differential expression analyses suggest novel evidence for an miRNA regulatory network controlling cell division in both normal and stressed condi-tions and demonstrate that drought trigger a genetic reprogramming of leaf growth in which miRNAs are deeply involved.

关键词： miRNAs drought Brachypodium leaf development.

Working Capital Management Programs： Yesterday, Today, Tomorrow

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Modern Accounting and Auditing 2015年第4期11卷 210-217页

作者： wim Westerman University of Groningen Groningen the Netherlands

The paper develops a view on the history and future of working capital programs and focuses on the state of the art in four remarkable years： 1900, 1930, 1960, and 1990. In these years, an operations approach, an accounting approach, an economic approach, and a capital market approach, respectively, were prevalent. The paper shows that all of the approaches have their merits for today＇s working capital management （WCM） programs and discusses useful working capital program indicators, taking into account the cash conversion cycle （CCC） and its delineation into accounts receivables （A/R）, inventory, and accounts payables （A/P） periods. This enables the author to take step ahead to the magic year 2020. Finally, the paper discusses briefly an academic development agenda.

关键词： working capital programs working capital approaches program indicators academic agenda

Early detection of neuropathy in leprosy:a comparison of five tests for field settings

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Infectious Diseases of Poverty 2017年第1期6卷 1034-1042页

作者： Inge Wagenaar Erik Post wim Brandsma Dan Ziegler Moshiur Rahman Khorshed Alam Jan Hendrik Richardus Department of Public Health Erasmus MCRotterdamThe Netherlands KIT Health Royal Tropical InstituteAmsterdamThe Netherlands Independent leprosy consultant AmsterdamThe Netherlands Institute for Clinical Diabetology German Diabetes Center at Heinrich Heine UniversityLeibniz Center for Diabetes ResearchDusseldorfGermany Department of Endocrinology and Diabetology Medical FacultyHeinrich Heine UniversityDüsseldorfGermany Rural Health Program The Leprosy Mission International-BangladeshNilphamariBangladesh

Background:Early detection and treatment of neuropathy in leprosy is important to prevent disabilities.A recent study showed that the Nerve Conduction Studies(NCS)and Warm Detection Thresholds(WDT)tests can detect leprosy neuropathy the *** two tests are not practical under field conditions,however,because they require climate-controlled rooms and highly trained staff and are *** assessed the usefulness of alternative test methods and their sensitivity and specificity to detect neuropathy at an early ***:Through a literature search we identified five alternative devices that appeared user-friendly,more affordable,portable and/or battery-operated:the Neuropad^(■),Vibratip^(TM),NC-Stat^(■)DPNCheck^(TM),NeuroQuick and the Thermal Sensibility Tester(TST),assessing respectively sweat function,vibration sensation,nerve conduction,cold sensation and warm *** leprosy patients in Bangladesh,the posterior tibial and sural nerves that tested normal for the monofilament test and voluntary muscle test were assessed with the NCS and WDT as reference standard *** alternative devices were then tested on 94 nerves with abnormal WDT and/or NCS results and on 94 unaffected *** and specificity were the main ***:The NeuroQuick and the TST showed very good sensitivity and *** the sural nerve,the NeuroQuick had both a sensitivity and a specificity of 86%.The TST had a sensitivity of 83%and a specificity of 82%.Both the NC-Stat^(■)DPNCheck^(TM)and Vibratip^(TM)had a high specificity(88%and 100%),but a low sensitivity(16%and 0%).On the posterior tibial nerve,the NeuroQuick and the TST also showed good sensitivity,but the sensitivity was lower than for the sural *** Neuropad^(■)had a sensitivity of 56%and a specificity of 61%.Conclusions:The NeuroQuick and TST are good candidates for further field-testing for reliability and *** feasibility of production on a larger scale should be exami

关键词： Leprosy Neuropathy Detection Subclinical Field use

Alternative splicing enhances transcriptome complexity in desiccating seeds

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Plant Biology 2016年第12期58卷 947-958页

作者： Arunkumar Srinivasan Jose M. Jimenez-Gomez Fabio Fornara wim J. J. Soppe Vittoria Brambilla Department of Plant Breeding and Genetics Max Planck Institute for Plant Breeding Research Cologne Germany Open Analytics Antwerp Belgium Institut Jean-Pierre Bourgin Institut National de la Recherche Agronomique Versailles France University of Milan Department of Biosciences Milano 20133 Italy University of Milan Department of Agricultural and Environmental Sciences via Celoria 220133 Milano Italy

Before being dispersed in the environment, mature seeds need to be dehydrated. The survival of seeds after dispersal depends on their low hydration in combination with high desiccation tolerance. These characteristics are estab- lished during seed maturation. Some key seed maturation genes have been reported to be regulated by alternative splicing （AS）. However, so far AS was described only for single genes and a comprehensive analysis of AS during seed maturation has been lacking. We investigated gene expression and AS during Arabidopsis thaliana seed development at a global level, before and after desiccation. Bioinformatics tools were developed to identify differentially spliced regions within genes. Our data suggest the importance and shows the peculiar features of AS during seed desiccation. We identified AS in 347o of genes that are expressed at both timepoints before and after desiccation. Most of these AS transcript variants had not been found before in other tissues. Among the AS genes some seed master regulators could be found. Interestingly, 6% of all expressed transcripts were not transcriptionally regulated during desiccation, but only modified by AS. We propose that AS should be more routinely taken into account in the analysis of transcriptomic data to prevent overlooking potentially important regulators.

关键词： Alternative splicing Arabidopsis thaliana seed desiccation

Epidemiology of foot burns in a Dutch burn centre

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Burns & Trauma 2015年第1期3卷 29-34页

作者： Tülay Kilic Pieta Krijnen wim E Tuinebreijer Roelf S Breederveld Department of Surgery Leiden University Medical Center University Leiden2300 RC LeidenThe Netherlands Acute Burn Care&Trauma Surgery Department Surgery/Burn CentreRode Kruis ZiekenhuisVondellaan 131942 LE BeverwijkThe Netherlands

Background:Although the feet involve a small percentage of the total body surface area,they can have major effects in daily life,caused by prolonged bed rest,hospitalization and high risk of both early and late *** aim of this study was to define the aetiology,treatment and outcomes of foot burns,with special interest in paediatric patients,patients with diabetic disease and burns acquired at the ***:This is a retrospective cohort study of 82 patients who were admitted to one of the three burn centres in the Netherlands during the period 2004 to *** patients had a median age of 43.5 years(range 0.01–85.9),and included 14 children and 8 *** were collected from the hospital ***:Scalding was the most common cause of the *** all patients required surgical *** is notable that most of hospitalized patients(82%)were not admitted on the day of *** had a significantly shorter length of stay compared to adults(p=0.01).The eight patients with diabetes had a significantly longer length of hospital stay,more complications and more often residual defects compared to the non-diabetic *** 13 patients,the injury took place at *** of these burns were caused by scalding,and foot burns caused by chemicals at work were rare(two patients).Conclusions:Although the incidence of foot burns is low,there is a significant morbidity due to complications and long hospital *** following three points are *** referral to a burn centre is *** is important to educate diabetic patients on the risk of complications and adverse outcomes after burn *** measures at the workplace are worth considering.

关键词： burns admitted centre