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A dicistrovirus increases pupal mortality in Spodoptera frugiperda by suppressing protease activity and inhibiting larval diet consumption

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Journal of Integrative Agriculture 2024年第8期23卷 2723-2734页

作者： Meixue Sun Tong Li yingjie Liu Kenneth wilson Xingyu chen Robert I.Graham Xianming yang Guangwei Ren Pengjun Xu Key Laboratory of Tobacco Pest Monitoring&Integrated Management Tobacco Research InstituteChinese Academy of Agricultural SciencesQingdao 266101China Institute of Plant Protection Henan Academy of Agricultural SciencesZhengzhou 450000China Staff Development Institute of china National Tobacco corporation Zhengzhou 450000China Lancaster Environment centre Lancaster UniversityLancaster LA14YWUK Department of Rural Land Use Scotland’s Rural CollegeCraibstone CampusAberdeen AB01ABUK State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193China

Understanding interactions between viruses and their hosts is conducive to enabling better application of viruses as biocontrol *** viruses carried by parasitic wasps enhance the parasitic efficiency of wasp-larvae by protecting them against the immune system of their Lepidopteran ***,the relationship between prey pests and viruses found in predatory natural enemies remains ***,we report the interaction between Arma chinensis virus-1(AcV-1),originally isolated from a predatory natural enemy,Arma chinensis(Hemiptera:Pentatomidae),and one of its prey species,Spodoptera frugiperda(Lepidoptera:Noctuidae).The results showed that the AcV-1 virus appeared harmful to the novel host *** by inhibiting larval diet consumption and increasing pupal ***,sequencing data indicated that the virus altered the gene expression profiles of *** analysis showed that the proteasome and phagosome pathways related to protein degradation and immune response were significantly *** the expression levels of digestive enzyme genes did not change significantly,the total protease activity of AcV-1 virus-positive individuals was significantly decreased,suggesting that the virus inhibited diet consumption of *** via the down-regulation of digestive enzyme *** results indicate that a virus initially isolated in a predatory natural enemy can decrease the fitness of its prey *** virus was found to impact the host proteasome and phagosome pathways related to protein degradation and immunity,providing a potential mechanism to enhance controlling efficiency.

关键词： Arma chinensis virus-1 diet consumption fitness transcriptome protease activity

识别液态和固态水的四波段水指数及其在咸海流域的应用

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中国科学：地球科学 2024年第3期54卷 788-807页

作者：岳兵陈曦李赛博杜正平 John wilson 杨筠慧焦毅蒙黄双燕周成虎中国科学院新疆生态与地理研究所乌鲁木齐830011 中国科学院大学资源与环境学院北京100049 中国科学院地理科学与资源研究所北京100101 Spatial Sciences Institute University of Southern CaliforniaLos AngelesCA 90089-0374USA

虽然已有许多水指数被运用于咸海和咸海流域的水域面积分析,然而已有研究尚存在很大的不确定性.由于所使用水指数存在水体误识别的问题,导致不同研究得出的结论差异很大.此外,各种研究采用的咸海流域面积也差异很大,流域面积从约1百万km... 详细信息

虽然已有许多水指数被运用于咸海和咸海流域的水域面积分析,然而已有研究尚存在很大的不确定性.由于所使用水指数存在水体误识别的问题,导致不同研究得出的结论差异很大.此外,各种研究采用的咸海流域面积也差异很大,流域面积从约1百万km^(2)到2百万km^(2)不等.因此,我们首先界定咸海流域、锡尔河和阿姆河流域以及它们的上、中、下游的边界,然后提出可识别液态水和固态水的四波段指数(ILSW),以解决传统水指数的误别偏差问题.ILSW基于绿色、红色、近红外和热红外波段反射值,是归一化差异水指数(NDWI)和地表温度(LST)的合成.验证结果显示,ILSW水指数在咸海流域的准确性远远超过其他指数.研究结果表明,南咸海的水域面积平均每年缩小963km^(2),而北咸海几乎没有变化;由于气候变暖,咸海流域上游常年冰雪面积有大幅度退缩趋势,阿姆河上游和锡尔河上游常年冰雪的退缩速率分别为年均6233和384km^(2)/a.气候变化和人类活动引起了严重的水亏问题.自20世纪90年代以来,水亏呈增长趋势,平均每年增长3.778亿m^(3).2011~2020年期间,整个咸海流域平均总水亏量为76.967亿m^(3),而锡尔河流域上游(咸海流域的一个组成部分)水盈余量为25.461亿m^(3).研究结果对制定咸海流域可持续发展战略具有重要意义.

关键词：咸海流域锡尔河流域阿姆河流域水指数水面积覆盖水亏缺气候变化

Subnormal Serum Liver Enzyme Levels:A Review of Pathophysiology and clinical Significance

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Journal of clinical and Translational Hepatology 2024年第4期12卷 428-435页

作者： Elham M.youssef George y.Wu Biochemistry Department National Research CenterCairoEgypt Department of Medicine Division of Gastroenterology-HepatologyUniversity of Connecticut Health CenterFarmingtonCTUSA

Subnormal levels of liver enzymes,below the lower limit of normal on local laboratory reports,can be useful *** instance,subnormal levels of aminotransferases can be observed in vitamin B6 deficiency and chronic kidney *** alkaline phosphatase levels may indicate the presence of hypophosphatasia,wilson's disease,deficiencies of divalent ions,or *** levels of gamma glutamyl transferase may be seen in cases of acute intrahepatic cholestasis,the use of certain medications,and in bone ***,subnormal levels of 5'-nucleotidase have been reported in lead poisoning and nonspherocytic hemolytic *** aim of this review is to bring attention to the fact that subnormal levels of these enzymes should not be ignored as they may indicate pathological conditions and provide a means of early diagnosis.

关键词： Transaminases Vitamin B6 celiac disease Renal insufficiency Hepatolenticular Degeneration crohn disease Malnutrition clofibrate Bone diseases Lead poisoning Anemia Hemolytic

clinical-DNA correlates of Anxiety in Patients with Ehlers-Danlos Syndrome

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Open Journal of Psychiatry 2024年第4期14卷 319-333页

作者： Golder N. wilson Vijay S. Tonk Department of Pediatrics Texas Tech University Health Sciences Center Lubbock TX USA Kinder Genome Genetics Private Practice Dallas TX USA Medical Genetics and the cytogenomic Laboratory Department of Pediatrics Texas Tech University Health Sciences Center Lubbock TX USA

Introduction: Anxiety disorders have a lifetime prevalence of 34% with a similar level of heritability (31%) yet lack objective markers that could differentiate patients with underlying conditions. Up to 60%-70% of patients with Ehlers-Danlos syndrome have anxiety that meets criteria of generalized anxiety disorder, their clinical-DNA findings worth examining as biomarkers for patients with generalized anxiety. Method: Of the 1899 patients diagnosed with Ehlers-Danlos syndrome, 1261 were systematically evaluated for 80 history and 40 physical findings and separated into 826 who reported anxiety and 435 who did not. The most consistently reported or management-directing 60 of these clinical findings were, along with variations in genes relevant to these disorders, examined for association with anxiety. Results: Among the 30 anxiety- associated findings judged most predictive of Ehlers-Danlos syndrome in patients with anxiety were expected ones of adrenergic stimulation (difficulty concentrating-87% frequency and 1.26 anxiety/no anxiety ratio;chronic fatigue-84%, 1.17;sleep issues 69%, 1.52 that are criteria for generalized anxiety disorder) or of cholinergic suppression (e.g., frequent nausea 64%, 1.26). Less associated but more discriminating for underlying disease were those reflective of neuromuscular impact (e.g., chronic daily headaches 76%, 1.12);hypermobility (e.g., awareness of flexibility 72%, 1.03), or skin changes (e.g., elasticity around jaw 71%, 1.06). Anxiety-associated DNA variants included 54 of 88 in collagen type I/V/VII/IX genes, 14 of 16 in sodium channel ScN9A/10A/ 11A genes, 59 of 85 in POLG/MT-DNA genes, and 21 of 28 in profilaggrin- FLG genes that respectively impacted tissue laxity, sensory neural, autonomic-mitochondrial, and autonomic-inflammatory functions. conclusion: Analysis of pathogenetic mechanisms in Ehlers-Danlos syndrome selected some 50 clinical-DNA findings useful for its diagnosis in those with generalized anxiety disorders.

关键词： Anxiety Generalized Anxiety Disorder Ehlers-Danlos Syndrome Long cOVID19 Joint Hypermobility Dysautonomia DNA Testing Whole Exome Sequencing DNA Variant Qualification

Detection of a reassortant swine H1N2 influenza A virus from pigs in Hong Kong

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Virologica Sinica 2024年第2期39卷 343-346页

作者： Guoqian Gu congnuan Liu Song Hao Lee Lewis Sze chun choi Michael T.wilson Dirk U.Pfeiffer yun young Go Department of Infectious Diseases and Public Health Jockey Club College of Veterinary Medicine and Life SciencesCity University of Hong KongHong Kong SARChina center for Applied One Health Research and Policy Advice Jockey Club College of Veterinary Medicine and Life SciencesCity University of Hong KongHong Kong SARChina college of Veterinary Medicine Konkuk UniversitySeoul143-701Republic of Korea

Dear Editor,Influenza A viruses(IAVs)are responsible for significant respiratory illnesses in humans and a broad range of animal *** outbreaks and the rapid spread of genetically and antigenically distinct IAVs represent a considerable challenge for swine *** are susceptible to avian and human IAV infections and are considered“mixing vessels”where human,avian,and swine IAVs can recombine and generate novel reassortant influenza viruses with pandemic potential(Vincent et al.,2014).

关键词： swine influenza mixing

Rare case of Large Anterior Meningocele Associated with Uterine Didelphys

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Open Journal of Modern Neurosurgery 2024年第2期14卷 104-107页

作者： Joseph Maalouly Matt wilson Sanjay Adusumilli Vijidha Rajkumar Shanu Gambhir Department of Neurosurgery Norwest Private Hospital Bella Vista Australia Department of Obstetrics and Gynecology Norwest Private Hospital Bella Vista Australia Department of General Surgery Norwest Private Hospital Bella Vista Australia

We report a 27-year-old female who presented with abdominal distension, saddle anesthesia, and lower back pain. cT and MRI of the abdomen/spine were performed which showed a large anterior sacral meningocele occupying most of the pelvic and abdominal cavity and displacement of their respective contents. Anterior approach was chosen, uterine didelphys was identified and mobilized, meningocele identified and gentle drainage with subsequent resection of the cyst wall and watertight closure was achieved. Subsequent MRI demonstrated resolution of most the sacral meningocele. Patient symptoms improved and are doing well.

关键词： Sacral Agenesis curarino Triad Large Meningocele

Successful Vaginal Delivery after Implantable cardiac Defibrillator Placement for Management of Ventricular Tachycardia

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congenital Heart Disease 2021年第2期16卷 137-139页

作者： Sara Moufarrij Manisha Gandhi wilson lam Angeline Opina Department of Obstetrics and Gynecology Baylor College of MedicineHoustonUSA Department of Pediatric cardiology Baylor College of MedicineHoustonUSA

A 23-year-old female with Tetralogy of Fallot who is 30w6d pregnant presented with palpitations and syncope from an outside *** was found to have ventricular *** placement of a transvenous implantable cardiac defibril... 详细信息

关键词： Ventricular tachycardia pregnancy intracardiac defibrillatory

Leptomeningeal metastases in prostate cancer:A review of the current literature

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current Urology 2024年第3期18卷 159-166页

作者： Umar Durrani Kasem Rifai Maha Arshad Awais Paracha Ekamjit Deol Maria Paracha Fatima Waheed Zohair Siddiqui Ali Abid Esed Mustafic wilson Rodriguez Zachary Hamilton Saint Louis University School of Medicine Saint LouisMOUSA University of Missouri School of Medicine ColumbiaMOUSA University of Virginia CharlottesvilleVAUSA New york Institute of Technology college of Osteopathic Medicine Old WestburyNYUSA Saint Louis University Saint LouisMOUSA Department of Neurology Saint Louis University School of MedicineSaint LouisMOUSA Division of Urology Department of SurgerySaint Louis University School of MedicineSaint LouisMOUSA

Leptomeningeal metastasis/leptomeningeal carcinomatosis(LMc;terms used interchangeably)is an inflammatory complication of primary tumors that involves the spread of the disease to the meninges(specifically the arachnoid and pia maters)and spinal *** the United States,approximately 110,000 new cases are diagnosed each year,and the prognosis is usually *** of LMc include cognitive impairment,cranial nerve dysfunction,ischemic stroke,and *** survival times of untreated and treated LMc are approximately 4–6 weeks and 2–4 months,*** carcinomatoses are usually metastatic cancers that spread to the central nervous *** lung and breast cancers have a clearly defined relationship with LMc,it remains unclear whether prostate cancer(Pc)is also directly associated with *** determine whether such association exists,we conducted a PubMed review of the literature on patients with Pc with coexisting *** search yielded 23 case reports of patients with preexisting Pc who developed *** addition,2 retrospective cohort studies were *** findings were identified in the revised cases and *** first 3 findings were related to the progression of the disease:patients presenting with neurological disease symptoms were in remission from Pc for 7 years on average,LMcs tended to occur after other cancer diagnoses,and the disease had already rapidly progressed by the time the symptoms were *** diagnosis,the major finding was that most LMcs were detected by magnetic resonance imaging(which does not detect early dissemination),and it was suggested that single-photon emission computed tomography or positron emission tomography imaging could be used for earlier ***,in terms of treatment,the main finding was that treatment was palliative rather than curative and that prognosis remained poor despite *** the basis of these results,we recommend for individuals with risk facto

关键词： Leptomeningeal carcinomatosis Prostate cancer Prostate cancer metastasis

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***自动化非织造布加工设备助力工厂运行

生活用纸 2024年第3期24卷 63-64页

作者： Adrian wilson 不详

非织造布加工设备,2023年,意大利*** Nonwovens推出了一整套用于吸收性卫生用品(AHP)和医疗用品行业的非织造布制品加工设备,包括复卷机、分切机和包装设备,以及***公司全新的自动化存储和检索系统(ASRS),旨在提升工厂运营的灵活性和生... 详细信息

非织造布加工设备,2023年,意大利*** Nonwovens推出了一整套用于吸收性卫生用品(AHP)和医疗用品行业的非织造布制品加工设备,包括复卷机、分切机和包装设备,以及***公司全新的自动化存储和检索系统(ASRS),旨在提升工厂运营的灵活性和生产效率,并增加其商业价值。

关键词：非织造布复卷机分切机包装设备检索系统加工设备医疗用品商业价值