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Emerging contaminants:A One Health perspective

The Innovation 2024年第4期5卷 140-170,139页

作者： Fang Wang Leilei Xiang Kelvin Sze-Yin Leung Martin Elsner Ying Zhang Yuming Guo Bo Pan Hongwen Sun Taicheng An Guangguo Ying Bryan WBrooks Deyi Hou Damian EHelbling Jianqiang Sun Hao Qiu Timothy MVogel Wei Zhang Yanzheng Gao Myrna JSimpson Yi Luo Scott XChang Guanyong Su Bryan MWong Tzung-May Fu Dong Zhu Karl JJobst Chengjun Ge Frederic Coulon Jean Damascene Harindintwali Xiankui Zeng Haijun Wang Yuhao Fu Zhong Wei Rainer Lohmann Changer Chen Yang Song Concepcion Sanchez-Cid Yu Wang Ali El-Naggar Yiming Yao Yanran Huang Japhet Cheuk-Fung Law Chenggang Gu Huizhong Shen Yanpeng Gao Chao Qin Hao Li Tong Zhang Natàlia Corcoll Min Liu Daniel SAlessi Hui Li Kristian KBrandt Yolanda Pico Cheng Gu Jianhua Guo Jianqiang Su Philippe Corvini Mao Ye Teresa Rocha-Santos Huan He Yi Yang Meiping Tong Weina Zhang Fidèle Suanon Ferdi Brahushi Zhenyu Wang Syed AHashsham Marko Virta Qingbin Yuan Gaofei Jiang Louis A.Tremblay Qingwei Bu Jichun Wu willie peijnenburg Edward Topp Xinde Cao Xin Jiang Minghui Zheng Taolin Zhang Yongming Luo Lizhong Zhu Xiangdong Li DamiàBarceló Jianmin Chen Baoshan Xing Wulf Amelung Zongwei Cai Ravi Naidu Qirong Shen Janusz Pawliszyn Yong-guan Zhu Andreas Schaeffer Matthias C.Rillig Fengchang Wu Gang Yu James M.Tiedje State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China University of Chinese Academy of Sciences Beijing 100049China Department of Chemistry Hong Kong Baptist UniversityHong KongChina HKBU Institute of Research and Continuing Education Shenzhen Virtual University ParkShenzhenChina Technical University of Munich TUM School of Natural SciencesInstitute of Hydrochemistry85748 GarchingGermany School of Resources&Environment Northeast Agricultural UniversityHarbin 150030China Climate Air Quality Research UnitSchool of Public Health and Preventive MedicineMonash UniversityMelbourneVICAustralia Faculty of Environmental Science&Engineering Kunming University of Science&TechnologyKunming 650500China Ministry of Education Key Laboratory of Pollution Processes and Environmental Criteria College of Environmental Science and EngineeringNankai UniversityTianjin 300350China Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control School of Environmental Science and EngineeringInstitute of Environmental Health and Pollution ControlGuangdong University of TechnologyGuangzhou 510006China Ministry of Education Key Laboratory of Environmental Theoretical Chemistry South China Normal UniversityGuangzhouGuangdong 510006China Department of Environmental Science Baylor UniversityWacoTXUSA Center for Reservoir and Aquatic Systems Research(CRASR) Baylor UniversityWacoTXUSA School of Environment Tsinghua UniversityBeijing 100084China School of Civil and Environmental Engineering Cornell UniversityIthacaNY 14853USA Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province Zhejiang University of TechnologyHangzhou 310014China School of Environmental Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China Laboratoire d’Ecologie Microbienne Universite Claude Bernard Lyon 1UMR CNRS 5557UMR INRAE 1418VetAgro Sup69622 VilleurbanneFrance Department of Pla

Environmental pollution is escalating due to rapid global development that often prioritizes human needs over planetary *** global efforts to mitigate legacy pollutants,the continuous introduction of new substances remains a major threat to both people and the *** response,global initiatives are focusing on risk assessment and regulation of emerging contaminants,as demonstrated by the ongoing efforts to establish the UN’s Intergovernmental Science-Policy Panel on Chemicals,Waste,and Pollution *** review identifies the sources and impacts of emerging contaminants on planetary health,emphasizing the importance of adopting a One Health *** for monitoring and addressing these pollutants are discussed,underscoring the need for robust and socially equitable environmental policies at both regional and international *** actions are needed to transition toward sustainable pollution management practices to safeguard our planet for future generations.

关键词： pollution planet contaminants

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;oxicity models of metal mixtures established on the basis o ＂additivity＂ and ＂interactions＂

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Frontiers of Environmental Science & Engineering 2017年第2期11卷 11-23页

作者： Yang Liu Martina G. Vijver Bo Pan willie J. G. M. peijnenburg Faculty of Environmental Science and Engineering Kunming University of Science and Technology Kunming 650500 China Institute of Environmental Sciences (CML) Leiden University Leiden 2300 RA The Netherlands National Institute of Public Health and the Environment (RIVM) Center for Safety of Substances and Products Bilthoven 3720 BA The Netherlands

Observed effects of metal mixtures on animals and plants often differ from the estimates, which are commonly calculated by adding up the biological responses of individual metals. This difference from additivity is commonly referred to as being a consequence of specific interactions between metals. The science of how to quantify metal interactions and whether to include them in risk assessment models is in its infancy. This review summarizes the existing predictive tools for evaluating the combined toxicity of metals present in mixtures and indicates the advantages and disadvantages of each method. We intend to provide eco-toxicologists with background information on how to make good use of the tools and how to advance the methods for assessing toxicity of metal mixtures, It is concluded that statistically significant deviations from additivity are not necessarily biologically relevant. Incorporation of interactions between metals in a model does not on forehand mean that the model is more accurate than a model developed based on additivity only. It is recommended to first use a relatively simple method for effect prediction of uninvestigated metal mixtures. To improve the reliability of toxicity modeling for metal mixtures, further efforts should focus on balancing the relationship between the significance of statistics and the biological meaning, and unraveling the toxicity mechanisms of metals and their mixtures.

关键词： Metal Mixtures Toxicity Additivity Modeling Interactions

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A systematic review of the impacts of exposure to micro-and nano-plastics on human tissue accumulation and health

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Eco-Environment & Health 2023年第4期2卷 195-207页

作者： Yudong Feng Chen Tu Ruijie Li Di Wu Jie Yang Yankai Xia willie J.G.M.peijnenburg Yongming Luo CAS Key Laboratory of Soil Environment and Pollution Remediation Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Reproductive Medicine Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjing 211166China Key Laboratory of Modern Toxicology of Ministry of Education School of Public HealthNanjing Medical UniversityNanjing 211166China National Institute of Public Health and the Environment Center for Safety of Substances and ProductsBilthoventhe Netherlands Institute of Environmental Sciences(CML) Leiden UniversityLeidenthe Netherlands

Micro-and nano-plastics(MNPs)pollution has become a pressing global environmental issue,with growing concerns regarding its impact on human ***,evidence on the effects of MNPs on human health remains *** paper reviews the three routes of human exposure to MNPs,which include ingestion,inhalation,and dermal *** further discusses the potential routes of translocation of MNPs in human lungs,intestines,and skin,analyses the potential impact of MNPs on the homeostasis of human organ systems,and provides an outlook on future research priorities for MNPs in human *** is growing evidence that MNPs are present in human tissues or *** studies,including in vivo animal models and in vitro human-derived cell cultures,revealed that MNPs exposure could negatively affect human *** exposure could cause oxidative stress,cytotoxicity,disruption of internal barriers like the intestinal,the air–blood and the placental barrier,tissue damage,as well as immune homeostasis imbalance,endocrine disruption,and reproductive and developmental *** available epidemiological studies suggest that disorders like lung nodules,asthma,and blood thrombus might be caused or exacerbated by MNPs ***,direct evidence for the effects of MNPs on human health is still scarce,and future research in this area is needed to provide quantitative support for assessing the risk of MNPs to human health.

关键词： Microplastics Nanoplastics Environmental exposure Human system homeostasis Health effects Risk assessment

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聚苯乙烯纳米塑料和微塑料在水蚤体内的积累动力学及向糠虾的营养转移

聚苯乙烯纳米塑料和微塑料在水蚤体内的积累动力学及向糠虾的营养...

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中国毒理学会第十次全国毒理学大会

作者： Qi Yu Tom A.P.Nederstigt Zhuang Wang Juan Wu Aranka Kolmas Thijs Bosker Zuzanna Filipiak willie J.G.M.peijnenburg Martina G.Vijver 生态环境部华南环境科学研究所

微纳塑料颗粒是当前国际上重点关注的新污染物之一,其营养转移是领域关注的前沿问题。颗粒尺寸大小是可能影响颗粒态污染物生物蓄积和营养级迁移的潜在因素,目前微纳塑料颗粒以粒径为主导因素的食物链累积动力仍鲜有研究。本文研究了不... 详细信息

微纳塑料颗粒是当前国际上重点关注的新污染物之一,其营养转移是领域关注的前沿问题。颗粒尺寸大小是可能影响颗粒态污染物生物蓄积和营养级迁移的潜在因素,目前微纳塑料颗粒以粒径为主导因素的食物链累积动力仍鲜有研究。本文研究了不同尺寸聚苯乙烯颗粒(PSPs)在水蚤Daphnia magna体内的生物富集,及其随后迁移到捕食者糠虾Limnomysis benedeni体内的情况,阐明了PSPs在水生系统中的归趋与其颗粒尺寸(26、500和4800 nm)的相关关系。用暴露于8 mg/L PSPs(8.3×10个颗粒/mL26 nm PSPs、1.2×10个颗粒/mL 500 nm PSPs和1.3×10个颗粒/mL 4800 nm PSPs)的D. magna投喂L. benedeni 16小时,随后糠虾经历48小时净化(即无投喂)。根据微纳颗粒在生物体内质量浓度结果发现,4800 nm PSPs在D. magna体内的质量浓度是26 nm和500 nm PSPs的4～10倍。D. magna对26nm PSPs(1.7±0.4 L/g·h)和4800 nm PSPs(1.7±0.4 L/g·h)的吸收速率常数显著高于对500 nm PSPs(0.7±0.1 L/g·h)的吸收速率常数(P <0.05)。据估算,仅有1～5%被***摄入的PSPs被转移到L. benedeni体内。值得一提的是,研究发现颗粒尺寸越大,PSPs在食物链中的转移程度越高。对于26 nm、500 nm和4800 nm的PSPs,在L. benedeni体内的消除速率常数分别为0.03±0.03、0.1±0.2和0.2±0.8 L/g·h,并且彼此之间没有显著差异。荧光显微镜观察显示,PSPs主要分布在L. benedeni的胃和肠道中,未发现进入其他组织脏器。此外,所有PSPs暴露组基于生物中积累的颗粒质量浓度计算的营养级迁移因子(TTF)均小于1,这证明在捕食者中未观察到生物放大想象。综上表明,微纳塑料颗粒可以沿着水蚤-糠虾的食物链迁移,但不会发生生物放大;颗粒尺寸大小会影响其生物积累和营养级迁移程度,故在评估微纳塑料在水生环境中的生物蓄积和归趋时不能忽视颗粒尺寸这一重要因素。

关键词：聚苯乙烯颗粒水生食物链生物分布吸收速率常数消除速率常数

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