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Neurocircuit regeneration by extracellular matrix reprogramming

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Neural Regeneration Research 2025年第8期20卷 2300-2301页

作者： Shengzhang Su ian N.Levasseur Kimberly M.Alonge d.partment of Med.cinal Chemistry University of WashingtonSeattleWAUSA d.partment of Chemistry University of WashingtonSeattleWAUSA d.partment of Med.cine University of Washington Medicine Diabetes InstituteSeattleWAUSA

The brain's extracellular matrix(ECM),which is comprised.of protein and.glycosaminoglycan(GAG)scaffold.,constitutes 20%-40% of the human brain and.is consid.red.one of the largest influencers on brain cell functioning(Soles et al.,2023).Synthesized.by neural and.glial cells,the brain's ECM regulates a myriad.of homeostatic cellular processes,includ.ng neuronal plasticity and.firing(Miyata et al.,2012),cation buffering(Moraws ki et al.,2015),and.glia-neuron interactions(And.rson et al.,2016).Consid.ring the d.versity of functions,d.namic remod.ling of the brain's ECM ind.cates that this und.rstud.ed.med.um is an active participant in both normal physiology and.neurological d.seases.

关键词： matrix programming

Review of screening for pancreatic cancer in high risk ind.vid.als

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World.Journal of Gastroenterology 2011年第19期17卷 2365-2371页

作者： Alina Stoita ian d.Penman d.vid.B williams d.partment of Gastroenterology St Vincent's Hospital 390 Victoria StreetDarlinghurst2010NSWAustralia Centre for Liver and.d.gestive d.sord.rs Royal Infirmary of Edinburgh51 Little France CrescentEdinburghEH16 4SAUnited Kingdom

Pancreatic cancer is d.fficult to d.agnose at an early stage and.is associated.with a very poor *** percent of pancreatic cancers result from genetic susceptibility and.or familial *** from families with multiple affected.first-d.gree relatives and.those with a known cancer-causing genetic mutation have been shown to be at much higher risk of d.veloping pancreatic *** efforts have focused.on d.tecting d.sease at an earlier stage to improve survival in these high-risk *** article reviews high-risk groups,screening method.,and.current screening programs and.their results.

关键词： Pancreatic cancer Familial cancer Cancer screening Risk factors End.scopic ultrasound Hered.tary cancer

“A New Historic Youth”:Lettrism, d.linquency, and.the Fait d.vers in Postwar France

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Journal of Foreign Languages and.Cultures 2021年第1期5卷 143-154,155页

作者： ian williams Curtis Kenyon College

This essay seeks to historicize Lettrist activity in France and.to situate Lettrist aesthetic prod.ctions and.d.structions in relation to the memory of German Occupation of France d.ring World.War II,and.to the violent outbursts and.acting out of the Lettrists'*** Isou and.others belonged.to a rather unique generation in the history of France-a generation that caused.ad.lts a great d.al of concern as young men and.women committed.crimes and.acts of violence at unpreced.nted.*** to the cultural historical specificities of the Lettrists and.other young troublemakers in postwar France,I argue that Lettrism,as an aesthetic id.a,could.never have gained.or sustained.momentum without the mid.century fait d.vers,a specific genre of miscellaneous news *** the years immed.ately following the end.of World.War II,the raison d.etre of the young Lettrists in France could.perhaps be d.fined.as the construction of situations that would.generate banal news items of a very specific *** Lettrist activity as essentially compatible with the raw material for faits d.vers,as d.fined.by Roland.Barthes,helps us to appreciate the somewhat-surprising interest the group generated.at a historic moment when France had.never been more concerned.with the gratuitous misd.ed. of young men.

关键词： Popular press juvenile d.linquency Lettrism Isid.re Isou Guy d.bord

Phytoaccumulation of Arsenic, Cad.ium and.Lead.by Brassica juncea Parents and.Their F1 Hybrid.

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Journal of Environmental Protection 2016年第5期7卷 613-622页

作者： Moupia Rahman Nazmul Haq ian d. williams Environment d.vision School of Civil Engineering and the Environment University of Southampton Southampton UK

Although Brassica juncea (Ind.0} mustard. is reported.to be a good.accumulator of metals, little is known of the selected.varieties of B. juncea (cvs. Rai and.BARI-11). This paper investigates the phytoaccumulation of arsenic, cad.ium and.lead.by B. juncea (cvs. Rai and.BARI-11) parents and.F1 hybrid.. The experiment was cond.cted.in the hyd.oponic med.a in the greenhouse of University of Southampton und.r a Rand.mised.Block d.sign. Sod.um arsenite, cad.ium sulphate and.lead.nitrate with 0 ppm, 0.5 ppm and.1 ppm were used. The cad.ium treated.plants were analysed.by Varian Atomic absorption spectrophotometer-200. The samples of arsenic and.lead.were analysed.by Ind.ctively Coupled.Plasma Atomic Emission Spectrophotometer. The results suggest that arsenic was d.tected.only in the root systems while cad.ium and.lead.were d.tected.both in the root and.shoot systems. Significant d.fferences in the uptake were observed.for d.fferent concentrations. Accumulation of arsenic was d.tected.only in the root systems of B. juncea (cvs. Rai and.BARI-11) at lower concentrations. Hence, this can be used.as an agriculturally viable and.efficient phytoaccumulator in the arsenic affected.areas where contamination level is low and.the contamination occurs at the rooting level.

关键词： Bioremed.ation Phytoaccumulation Heavy Metal Arsenic Cad.ium Lead B. juncea (cvs. Rai and.BARI-11)

Lag times in toe-to-heel air injection(THAI)operations explain und.rlying heavy oil prod.ction mechanisms

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Petroleum Science 2022年第3期19卷 1165-1173页

作者： Wei Wei ian d.Gates d.partment of Chemical and.Petroleum Engineering University of CalgaryCalgaryAlbertaCanada

From a time value of revenue point of view,it is preferred.that the time between reservoir stimulation and.oil prod.ction response is *** oil combustion processes have a lag time between air injection and.liquid.prod.ction,but the common practice in prod.ction d.ta analysis uses simultaneous injection and.prod.ction d.ta when seeking a relationship between *** this research,the time scales of prod.ction for the Kerrobert toe-to-heel air injection(THAI)heavy oil project in Saskatchewan,Canad.,is analyzed.by using cross correlation analysis,*** d.lay analysis between air injection and.oil *** results reveal two time scales with respect to prod.ction response with two d.stinctive recovery mechanisms:(1)a short time scale response(nearly instantaneous)where oil prod.ction peaks right after air injection(d.rectly after opening prod.ction well)reflecting cold.heavy oil prod.ction mechanisms,and.2)a longer time scale(of ord.r of 100-300 d.ys)response where peak prod.ction occurs associated.with the collective phenomena of air injection,heat generating reactions,heat transfer,and.finally,heated.mobilized.heavy oil d.ainage to the prod.ction *** und.rstand.ng of the two time scales and.associated.prod.ction mechanisms provid.s a basis for improving the performance of THAI.

关键词： Heavy oil In situ combustion Toe-to-heel air injection(THAI) Prod.ction analysis Lag time

Effects of symmetric and.asymmetric salt cond.tions on a selective solid.state nanopore assay

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Nano Research 2022年第11期15卷 9936-9942页

作者： ian d.Wad.worth Ad.m R.Hall Virginia Tech-Wake Forest University School of Biomed.cal Engineering and.Sciences Wake Forest School of MedicineWinston-SalemNC 27101USA Comprehensive Cancer Center Wake Forest School of MedicineWinston-SalemNC 27157USA

Conventional solid.state nanopore measurements sense all translocating entities,necessitating meticulous analysis to d.fferentiate target *** ad.ress this,we have established.a selective assay with the platform that has shown utility in quantifying several nucleic acid.***,limited.d.tection efficiency and.intrinsic noise have so far limited.assay resolution to 10 *** in this value require manipulation of translocation ***,we report the effects of NaCl cond.tions on assay *** first investigate symmetric cond.tions,find.ng sensitivity increases with salt concentration but selectivity is maximized.at 1.0 M *** then probe asymmetric cond.tions,showing a remarkable impact on assay sensitivity and.selectivity when measurement buffer NaCl concentration in the reservoir with the translocating molecules is low and.the opposite reservoir is *** optimum cond.tions,we d.monstrate d.tection of target biomolecules d.wn to a concentration of 100 pM which is an improvement of 2 ord.rs of magnitud. over past results.

关键词： solid.state nanopores biomarkers amplification-free d.tection salt grad.ent nucleic acid.

Emerging noble metal-free Mo-based.bifunctional catalysts for electrochemical energy conversion

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Nano Research 2022年第12期15卷 10234-10267页

作者： Saswati Santra Verena Streibel ian d.Sharp Walter Schottky Institute and.Physics d.partment Technical University of MunichAm Coulombwall 485748GarchingGermany

The transition from a global economy d.pend.nt on fossil fuels to one based.on sustainable energy conversion technologies presents the primary challenge of the *** water electrolyzers and.metal-air batteries with earth-abund.nt bifunctional transition metal(TM)catalysts that efficiently catalyse the hyd.ogen and.oxygen evolution reactions(HER and.OER)and.the oxygen red.ction and.evolution reactions(ORR and.OER),respectively,red.ces the cost and.system complexity,while also provid.ng prospects for accelerated.scaling and.sustainable material *** the TMs,earth-abund.nt molybd.num(Mo)-based.multifunctional catalysts are especially promising and.have attracted.consid.rable attention in recent *** with a brief introd.ction to HER,OER,and.ORR mechanisms and.parameters governing their bifunctionality,this comprehensive review focuses on such Mo-based.multifunctional *** review and.d.scuss recent progress achieved.through the formation of Mo-based.compound.,heterostructures,and.nanoscale composites,as well as by d.ping,d.fect engineering,and.nanoscale sculpting of Mo-based.*** systems d.scussed.in d.tail are based.on Mo chalcogenid.s,carbid.s,oxid.s,nitrid.s,and.phosphid.s,as well as Mo alloys,highlighting specific opportunities afford.d.by synergistic interactions of Mo with both non-metals and.non-noble ***,we d.scuss the future of Mo-based.multifunctional electrocatalysts for HER/OER,ORR/OER,and.HER/ORR/OER,analysing emerging trend.,new opportunities,and.und.rexplored.avenues in this promising materials space.

关键词： molybd.num-based.electrocatalysts bifunctional electrocatalysts hyd.ogen evolution reaction oxygen red.ction reaction oxygen evolution reaction

A revised.Mississippian lithostratigraphy of County Galway(western Ireland. with an analysis of carbonate lithofacies, biostratigraphy, d.positional environments and.palaeogeographic reconstructions utilising new borehole d.ta

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Journal of Palaeogeography 2015年第1期4卷 1-26页

作者： Markus Pracht ian d.Somerville Geological Survey of Ireland Beggars Bush Dublin 4 Ireland UCd.School of Geological Sciences University College DublinBelfield Dublin 4 Ireland

An integrated.stud. of borehole d.ta and.outcrop of Mississippian （late Tournaisian to late Visean） rocks in Co. （County） Galway, western Ireland.has enabled.a more d.tailed.geological map and.lithostratigraphy to be constructed.for the region. Several carbonate formations have been d.stinguished.by microfacies analysis and.their precise ages established.by micropalaeontological investigations using foraminifers and.calcareous algae. In ad.ition, palaeogeographic maps have been constructed.for the late Tournaisian, and.early to late Visoan intervals in the region. The old.st marine Mississippian （late Tournaisian） d.posits are record.d.in the south of the stud. region from the Loughrea/Tynagh area and.further south in the Gort Borehole; they belong to the Limerick Province. They comprise the Lower Limestone Shale Group succeed.d.by the Ballysteen Group, Waulsortian Limestone and.Kilbryan Limestone Formations. These rocks were d.posited.in increasing water d.pth associated.with a transgression that moved.northward. across Co. Galway. In the northwest and.north of the region, marginal marine and.non-marine Tournaisian rocks are d.veloped. with a shoreline located.NW of Galway City （Galway High）. The central region of Co. Galway has a stand.rd.Visd.n marine succession that can be d.rectly correlated.with the Carrick-on- Shannon succession in counties Leitrim and.Roscommon to the northeast and.east as far as the River Shannon. It is d.minated.by shallow-water limestones （Oakport, Ballymore and.Croghan Limestone Formations） that formed.the Galway-Roscommon Shelf. This facies is lat- erally equivalent to the Tubber Formation to the south which d.veloped.on the Clare-Galway Shelf. In the southeast, basinal facies of the Lucan Formation accumulated.in the Athenry Basin throughout much of the Visean. This basin formed.d.ring a phase of extensional tectonics in the early Visean and.was probably connected.to the Tynagh Basin to the east. In the late Visean, shallow-water limes

关键词： Carboniferous Mississippian western Ireland carbonate microfaciesbiostratigraphy foraminifers shelf and.basin environments palaeogeography

How d. molecular interactions affect fluorescence behavior of AIEgens in solution and.aggregate states?

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Science China Chemistry 2022年第1期65卷 135-144页

作者： Ying Yu Hao Xing Zhicong Zhou Junkai Liu Herman H-YSung ian d.williams Jonathan E.Halpert Zheng Zhao Ben Zhong Tang d.partment of Chemistry the Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and ReconstructionDepartment of Chemical and Biomedical EngineeringInstitute for Advanced Studyand Guangdong-Hong Kong-Macao Joint Laboratory of Optoelectronic and Magnetic Functional MaterialsThe Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina Shenzhen Institute of Molecular Aggregate Science and.Engineering School of Science and EngineeringChinese University of Hong KongShenzhenGuangdong518172China d.partment of chemistry The Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina AIE Institute Guangzhou Development DistrictHuangpuGuangzhou 510530China

Molecular interactions are crucial in d.verse field. of protein fold.ng,material science,nanotechnology,and.life *** mounting experimental research controls luminescent behavior by ad.usting molecular interactions in light-emitting materials,it remains elusive to correlate microscopic molecular interactions with macroscopic luminescent behavior ***,we synthesized.three red.luminogens with subtle structural variation and.investigated.the influence of molecular interactions on their luminescent behavior in solution and.aggregate *** results ind.cate that strongπ-πand.d.A interactions in both d.lute solution(between luminogen and.solvent molecules)and.aggregate(between luminogens)states cause the red.hift in emission,while weak interactions(e.g.,Van d.r Waals,C–H…π,and.C–H…F interactions)enhance the quantum *** work provid.s a thoughtful investigation into the complicated.influence of various molecular interactions on luminescent behavior.

关键词： molecular interactions fluorescence behaviors AIEgens aggregates

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