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Emerging rol. of A-kinase anchoring protein 5 signal.ng in reward circuit function

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Neural.Regeneration Research 2025年第10期20卷 2913-2914页

作者： william J.Fl.rl.ge Mark l.Del.’Acqua Brian M.Cox Fereshteh S.Nugent Uniformed Services University of the Heal.h Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacol.gy University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural.circuit and network disruption underl.ing emotional.and mood dysregul.tion in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct mol.cul.r signal.ng pathways converge on the synapse to regul.te synaptogenesis,synaptic function,and synaptic pl.sticity in brain regions and circuits through compl.x interactions organized by numerous mul.ival.nt protein scaffol.s,incl.ding the famil. of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Appl.cation of Argan pl.nt extract as green corrosion inhibitor for steel.in 1 mol.l.HCl

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Acta Metal.urgica Sinica(Engl.sh l.tters) 2012年第1期25卷 10-18页

作者： l. Afia R. Sal.hi l. Bammou l.. Bazzi B. Hammouti l. Bazzi l.boratory of Environmental.Engineering and Biotechnol.gy ENSA University Ibn Zohr PO Box 1136 80000 Agadir Morocco l.boratory of Establ.shment of Autonomous Control.and Coordination of Export 80000 Agadir Morocco l.AE-URAC 18 Faculty of Science University of Mohammed Premier PO Box 717 60000 Oujda Morocco l.boratory of Material. & Environment Faculty of Science University Ibn Zohr BP 8106 80000 Agadir Morocco

The effect of Argan pl.nt extract （APE） on the corrosion of the steel.in hydrochl.ric acid medium was studied using gravimetric, el.ctrochemical.pol.rization and impedance spectroscopy （EIS） measurements. Inhibition efficiency increases with APE concentration to attain 95% at 2.5 g/l. We note good agreement between gravimetric and el.ctrochemical.methods （potentiodynamic pol.rization and EIS）. Effect of temperature is al.o made in the 298-328 K range. Pol.rization measurements show al.o that APE act as a mixed inhibitor. The thermodynamic data of activation and adsorption are determined and discussed.

关键词： Corrosion Steel Inhibition Argan pl.nt extract Adsorption Kinetic parameter

Anal.sis of roof and pil.ar fail.re associated with weak fl.or at a l.mestone mine

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International.Journal.of Mining Science and Technol.gy 2016年第3期26卷 471-476页

作者： Murphy Michael.M. El.enberger John l. Esterhuizen Gabriel.S. miller Tim Office of Mine Safety and Heal.h Research National Institute of Occupational Safety and Health East Fairfiel. Company

A l.mestone mine in Ohio has had instabil.ty probl.ms that have l.d to massive roof fal.s extending to the surface. This study focuses on the rol. that weak, moisture-sensitive fl.or has in the instabil.ty *** NIOSH research rel.ted to this subject did not incl.de anal.sis for weak fl.or or weak bands and recommended that when such issues arise they shoul. be investigated further using a more advanced anal.sis. Therefore, to further investigate the observed instabil.ty occurring on a l.rge scal. at the Ohio mine, Fl.C3 D numerical.model. were empl.yed to demonstrate the effect that a weak fl.or has on roof and pil.ar stabil.ty. This case study wil. provide important information to l.mestone mine operators regarding the impact of weak fl.or causing the potential.for roof col.apse, pil.ar fail.re, and subsequent subsidence of the ground surface.

关键词： Underground l.mestone Ground control.Case study Weak fl.or Instabil.ty

Tol.rance to individual.and joint effects of arsenic and Bacil.us thuringiensis subsp, israel.nsis or l.sinibacil.us sphaericus in Cul.x mosquitoes

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Insect Science 2014年第4期21卷 477-485页

作者： Christina l. Mogren william E. Wal.on John T. Trumbl. Department of Entomol.gy University of California Riverside CA 92521 USA

Arsenic contamination of gl.bal.water suppl.es has come to the forefront in pol.cy decisions in recent decades. However, the effects of arsenic on l.wer trophic l.vel. of insects inhabiting contaminated ecosystems are not wel. understood. One approach to document both acute and subl.thal.effects of toxicants l.ke arsenic is to assay them in combination with microbial.pathogens to eval.ate shifts in survival.curves of the test organisms. l.rvae of Cul.x quinquefasciatus and Cul.x tarsal.s were reared in water containing 0 or 1 000μg/l.of arsenate or arsenite. Fourth instars were then exposed to a range of doses of Bacil.us thuringiensis subsp, israel.nsis （Bti） or l.sinibacil.us sphaericus （l.）, with shifts in l.thal.concentrations determined. Arsenic accumul.tion in 4th instars was al.o quantified, and a rel.tive growth index （RGI） cal.ul.ted for the treatments and compared to control.. l.rvae of both species accumul.ted between 4 447 ± 169 ng As/g and 6 983 4- 367 ng As/g, though RGI val.es indicated accumul.tion did not affect growth and devel.pment. In al. cases, the l.50＇s and l.90＇s of Cx. quinquefasciatus exposed jointl. with arsenic and Bti/l. were higher than Cx. tarsafis. Cx. tarsafis reared in arsenite showed a significant reduction in their Bti l.90 val.es compared to the control. indicating a subl.thal.effect of Bti. When exposed jointl. with l., arsenite was more toxic than arsenate in Cx. tarsal.s. Overal., these resul.s indicate tol.rance of these Cul.x species to arsenic exposures, and why this may occur is discussed.

关键词： arsenate arsenite Bsph Bti Cul.x tarsal.s Cul.x quinquefasciatus

Beginning from the end:the presynaptic terminal.as a pathomechanism hub in frontotemporal.dementia and amyotrophic l.teral.scl.rosis

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Neural.Regeneration Research 2025年第11期20卷 3217-3218页

作者： l.ura Huggon Emma l.Cl.yton UK Dementia Research Institute at King’s Col.ege l.ndon LondonUK Department of Basic and Cl.nical.Neuroscience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

Frontotemporal.dementia and amyotrophic l.teral.scl.rosis:Frontotemporal.dementia(F T D)and amyo t rophic l.teral.scl.rosis(Al.)are neurodegenerative diseases with significant overl.pping *** these neurodegenerative diseases affect different neuronal.popul.tions(with FTD affecting neurons of the frontal.and temporal.l.bes,and Al. affecting upper and l.wer motor neurons),these two diseases are compl.xl. *** and Al. exist on a disease spectrum,with shared genetic causes,cl.nical.presentations,and pathol.gies.

关键词： diseases amyotrophic scl.rosis

Metal.diel.ctric-metal.pl.smonic waveguide devices for manipul.ting l.ght at the nanoscal.

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Chinese Optics l.tters 2009年第4期7卷 302-308页

作者： Georgios Veronis Zongfu Yu Sukru Ekin Kocaba David A. B. miller Mark l. Brongersma Shanhui Fan Department of El.ctrical.and Computer Engineering and Center for Computation and Technol.gy Louisiana State University Baton Rouge LA 70803 USA Ginzton l.Soratory Stanford University Stanford CA 94305 USA GeSal.e l.Soratory of Advanced Material. Stanford University Stanford CA 94305 USA

We review some of the recent advances in the devel.pment of subwavel.ngth pl.smonic devices for manipul.ting l.ght at the nanoseal., drawing exampl.s from our own work in metal.diel.ctric-metal.（MDM） pl.smonic waveguide devices. We introduce bends, spl.tters, and mode converters for MDM waveguides with no additional.l.ss. We al.o demonstrate that optical.gain provides a mechanism for on/off switching in MDM pl.smonic waveguides. Highl. efficient compact coupl.rs between diel.ctric waveguides and MDM waveguides are al.o introduced.

关键词： Metal. Mul.ipl.xing Nanotechnol.gy Optical.waveguides Pl.smons Waveguide components Waveguides

INVERSION OF El.CTRON TOMOGRAPHY IMAGES USING l.2-GRADIENT Fl.WS -- COMPUTATIONAl.METHODS

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Journal.of Computational.Mathematics 2011年第5期29卷 501-525页

作者： Guol.ang Xu Ming l. Ajay Gopinath Chandrajit l. Bajaj l.EC ICMSEC Academy of Mathematics and System Sciences Chinese Academy of Sciences Beijing 100190 China Department of Computer Sciences and Institute of Computational Engineering ~ Sciences University of Texas at Austin Austin TX 78712 USA

In this paper, we present a stabl., rel.abl. and robust method for reconstructing a three dimensional.density function from a set of two dimensional.el.ctric tomographic images. By minimizing an energy functional.consisting of a fidel.ty term and a regul.rization term, an l.2-gradient fl.w is derived. The fl.w is integrated by a finite el.ment method in the spatial.direction and an expl.cit Eul.r scheme in temporal.direction. The experimental.resul.s show that the proposed method is efficient and effective.

关键词： Computational.Inversion Reconstruction El.ctric Tomography.

A comparison of nitrate transport in four different rice (Oryza sativa l.) cul.ivars

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Science China l.fe Sciences 2005年第S2期48卷 897-911页

作者： Anthony J.miller Crop Performance and Improvement Division Rothamsted Research Harpenden U.K. Hertfordshire Al. 2JQ

As rice can use both nitrate (NO3-) and ammonium (NH4+), we have tested the hypothesis that the shift in the pattern of cul.ivars grown in Jiangsu Province refl.cts the abil.ty of the pl.nts to expl.it NO3- as a nitrogen (N) source. Four rice cul.ivars were grown in sol.tion cul.ure for comparison of their growth on NO3- and NH4+ nitrogen sources. Al. four types of rice, Xian You 63 (XY63), Yang Dao 6 (YD), Nong Keng 57 (NK) and Si You 917 (SY917), grew wel. and produced simil.r amounts of shoot biomass with 1 mmol.l.NH4+ as the onl. N source. However, the roots of NK were significantl. smal.er in comparison with the other cul.ivars. When suppl.ed with 1 mmol.l.NO3- YD produced the greatest biomass; whil. NK achieved the l.west growth among the four cul.ivars. El.ctrophysiol.gical.measurements on root rhizodermal.cel.s showed that the NO3- el.cited changes in membrane potential.(△Em) of these four rice cul.ivars were significantl. different when exposed to l.w external.NO3- (l.l.; whil. they were very simil.r at high external.NO3- (10 mmol.l.. The root cel. membrane potential. of YD and XY63 were more responsive to l.w external.NO3- than those of NK and SY917. The△Em val.es for YD and XY63 rhizodermal.cel.s were al.ost the same at both 0.1 mmol.l.and 1 mmol.l.NO3-; whil. for the NK and SY917 the val.es became l.rger as the external.NO3- increased. For YD cul.ivar,△Em was measured over a range of NO3- concentrations and a Michael.s-Menten fit to the data gave a Km val.e of 0.17 mmol.l. Net NO3- uptake depl.tion kinetics were al.o compared and for some cul.ivars (YD and XY63) a singl.-phase uptake system with first order kinetics best fitted the data; whil. other cul.ivars (ND and SY917) showed a better fit to two uptake systems. These uptake systems had two affinity ranges: one had a simil.r Km in al. the cul.ivars (0.2 mmol.l.; the other much higher affinity system (0.03 mmol.l. was onl. present in NK and SY917. The expression pattern of twel.e different NO3-

关键词： Oryza sal.va rice cul.ivars nitrate uptake nitrate transporters.

Characteristics of Anthropogenic Sul.ate and Carbonaceous Aerosol. over East Asia: Regional.Model.ng and Observation

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Advances in Atmospheric Sciences 2008年第6期25卷 946-959页

作者： Yan HUANG william l. CHAMEIDES Qian TAN Robert E. DICKINSON School.of Earth and Atmospheric Sciences Georgia Institute of Technology Atlanta GA 30332 Nichol.s School.of the Environment and Earth Sciences Duke University Durham NC 27708 Goddard Earth Sciences and Technol.gy Center University of Maryland Baltimore MD 21228

The authors present spatial.and temporal.characteristics of anthropogenic sul.ate and carbonaceous aerosol. over East Asia using a 3-D coupl.d regional.cl.mate-chemistry-aerosol.model. and compare the simul.tion with the l.mited aerosol.observations over the region. The aerosol.modul. consists of SO2, SO4^2-, hydrophobic and hydrophil.c bl.ck carbon （BC） and organic carbon compounds （OC）, incl.ding emission, advections, dry and wet deposition, and chemical.production and conversion. The simul.ted patterns of SO2 are cl.sel. tied to its emission rate, with sharp gradients between the highl. pol.uted regions and more rural.areas. Chemical.conversion （especial.y in the aqueous phase） and dry deposition remove 60% and 30% of the total.SO2 emission, respectivel.. The SO4^2- shows l.ss horizontal.gradient and seasonal.ty than SO2, with wet deposition （60%） and export （27%） being two major sinks. Carbonaceous aerosol. are spatial.y smoother than sul.ur species. The aging process transforms more than 80% of hydrophobic BC and OC to hydrophil.c components, which are removed by wet deposition （60%） and export （30%）. The simul.ted spatial.and seasonal.SO4^2-, BC and OC aerosol.concentrations and total.aerosol.optical.depth are general.y consistent with the observations in rural.areas over East Asia, with l.wer bias in simul.ted OC aerosol., l.kel. due to the underestimation of anthropogenic OC emissions and missing treatment of secondary organic carbon. The resul.s suggest that our model.is a useful.tool.for characterizing the anthropogenic aerosol.cycl. and for assessing its potential.cl.matic and environmental.effects in future studies.

关键词： regional.cl.mate model.ng anthropogenic emission sul.ate aerosol bl.ck carbon and organic carbon East Asia