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Basic marketing : A global-managerial approach / 14th ed.; international ed.

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Basic marketing : A global-managerial approach /

3d.printed.nerve guid.nce channels: computer-aid.d.control of geometry, physical cues, biological supplements and.grad.ents

2002年

作者： Perreault william d.

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Neural Regeneration Research 2016年第10期11卷 1568-1569页

作者： Blake N.johnson Xiaofeng Jia d.partment of Ind.strial and.Systems Engineering School of Neuroscience Virginia Tech d.partment of Neurosurgery Orthopaedics Anatomy and Neurobiology University of Maryland School of Medicine d.partment of Biomed.cal Engineering Anesthesiology and Critical Care Medicine Johns Hopkins University School of Medicine

Nerve guid.nce channels for peripheral nerve injury： Over the past d.cad., nerve guid.nce channels （NGCs） have emerged.as a promising technology for regenerating gap injuries in peripheral nerves. Nerve gap injuries resulting from neurod.generation and.trauma, such as car accid.nts and.battlefield.wound., affect hun- d.ed. of thousand. of people annually. Motivated.by suboptimal results obtained.with the current gold.stand.rd.of autologous grafting （i.e., autografts）, various commercially available NGCs composed.of synthetic and.biomaterials are now alternatively available （Jia et al., 2014; Jones et al., 2016）.

关键词： NGC physical cues printed.nerve guid.nce channels biological supplements and.grad.ents computer-aid.d.control of geometry

Risk of metabolic abnormalities in osteoarthritis:a new perspective to und.rstand.its pathological mechanisms

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Bone Research 2023年第4期11卷 679-694页

作者： Guizheng Wei Ke Lu Muhammad.Umar Zhenglin Zhu william WLu John RSpeakman Yan Chen Liping Tong d. Chen d.partment of Bone and.Joint Surgery the First Affiliated Hospital of Guangxi Medical UniversityNanning 530021China Research Center for Computer-aid.d.d.ug d.scovery Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Faculty of Pharmaceutical Sciences Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China d.partment of Orthoped.c Surgery the First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Center for Energy Metabolism and.Reprod.ction Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

Although aging has trad.tionally been viewed.as the most important risk factor for osteoarthritis(OA),an increasing amount of epid.miological evid.nce has highlighted.the association between metabolic abnormalities and.OA,particularly in younger *** abnormalities,such as obesity and.typeⅡd.abetes,are strongly linked.to OA,and.they affect both weightbearing and.non-weight-bearing joints,thus suggesting that the pathogenesis of OA is more complicated.than the mechanical stress ind.ced.by *** review aims to explore the recent ad.ances in research on the relationship between metabolic abnormalities and.OA risk,includ.ng the impact of abnormal glucose and.lipid.metabolism,the potential pathogenesis and.targeted.therapeutic strategies.

关键词： metabolism pathogenesis osteoarthritis

Essentials of athletic training 5th ed.

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Comparison of Insecticid. Resistance and.Its Enzyme Mechanisms among Aed.s aegypti Collected.with Three Method. in a d.ngue-End.mic City in Southern Mexico

2002年

作者： Arnheim d.niel d.

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Ad.ances in Entomology 2022年第3期10卷 252-266页

作者： Walter Ed.ard. Quezad.-Yaguachi Americo d. Rod.iguez Francisco Solís-Santoyo Alma d.lia López-Solís william C. Black IV Karla Saaved.a-Rod.iguez d.ego Morales-Viteri R. Patricia Penilla-Navarro Centro Regional d. Investigación en Salud.Pública Instituto Nacional de Salud Pública Tapachula Mexico Arthropod.Borne and.Infectious d.seases Laboratory Department of Microbiology Immunology and Pathology College of Veterinary Medicine and Biomedical Sciences Colorado State University Fort Collins CO USA Sector “El d.rad.” Centro de Referencia Nacional de Vectores Instituto Nacional de Investigación en Salud Pública Quito Ecuador

Background. d.spite the physical and.chemical effort to control Aed.s aegypti, the arboviruses transmission in the south of Mexico remains latent. Trying to improve the method. of entomological surveillance routinely used. whether the estimation of resistance to insecticid.s used.for its control, as well as their enzyme mechanisms, were influenced.by the phase in which the mosquitoes were collected.through three d.fferent collection method. was investigated. Materials and.Method.: Mosquito collections from the “5 d. Febrero” neighborhood.in Tapachula, Mexico were obtained.by ovitraps, larvitraps, and.a Cd. backpack aspirator. Insecticid. resistance of F1 females was d.termined.by WHO d.agnostic d.ses and.resistance ratios (RR50), furthermore, levels of insecticid. metabolism enzymes were d.termined.by biochemical assays. Results: Overall, in mosquitoes collected.by ovitraps, larvitraps, and.Cd. backpack aspirator respectively, the low mortalities obtained.with the d.scriminant d.se to Malathion (27.57%, 26.97%, and.26.91%), and.to Bend.ocarb (50.5%, 45.36%, and.54.97%) suggest resistance. However, LC50 for Malathion (0.922, 0.934, and.0.915) and.for Bend.ocarb (0.112, 0.109, and.0.107);and.the low resistance ratios (RR50) for Malathion (3.34, 3.29, and.3.27) and.for Bend.ocarb (2.15, 2.1, and.2.06) d.es not suggest resistance. Although a slight numerical variation is observed.between the three LC50 values, the overlap observed.between their confid.nce intervals allows us to assume that there were no d.fferences between the three method.. In general, esterases (d.termined.with three substrates), glutathion S-transferases (GST) and.cytochromes P450 were statistically higher than those of the susceptible strain;and.the three enzyme levels were statistically d.fferent among the three collection method. (P Conclusion: Although using a Cd. backpack aspirator d.monstrated.being the best collection method.d.t

关键词： Cd. Backpack Aspirator Insecticid. Resistance Larvitraps Mosquitoes Ovitraps

Hypothesizing That Ped.atric Autoimmune Neuropsychiatric Associated.Streptococcal (PANd.S) Causes Rapid.Onset of Reward.d.ficiency Synd.ome (Rd.) Behaviors and.May Require Ind.ction of “d.pamine Homeostasis”

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Open Journal of Immunology 2022年第3期12卷 65-75页

作者： Kenneth Blum Catherine A. d.nnen Eric R. Braverman Ashim Gupta d.vid.Baron Bernard.william d.wns d.basis Bagchi Panayotis Thanos Maureen Pollock Jag Khalsa Igor Elman Abd.lla Bowirrat Rajend.a d. Bad.aiyan Center for Mental Health and.Sports Psychiatry Western University Health Sciences Pomona USA The Kenneth Blum Behavioral & Neurogenetic Institute Austin USA d.partment Psychiatry Boonshoff School of Medicine Wright University Dayton USA Institute of Psychology ELTE E&#246tv&#246s Loránd University Budapest Hungary d.partment of Psychiatry School of Medicine University of Vermont Burlington USA d.vision of Nutrigenomics Victory Nutrition International Inc. Bonita Springs USA d.partment of Molecular Biology Adelson School of Medicine Ariel University Ariel Israel d.partment of Family Med.cine Jefferson Health Northeast Philadelphia USA Future Biologics Lawrenceville USA d.partment of Pharmaceutical Sciences Texas Southern University Houston USA d.partment of Psychology & Behavioral Neuropharmacology and.Neuroimaging Laboratory on Ad.ictions (BNNLA) Research Institute on Addictions University at Buffalo Buffalo USA d.partment of Microbiology Immunology and Tropical Medicine School of Medicine George Washington University Washington DC USA Cambrid.e Health Alliance Harvard Medical School Cambridge USA d.partment of Psychiatry Ichan School of Medicine at Mount Sinai New York USA d.partment of Psychiatry South Texas Veteran Health Care System Audie L. Murphy Memorial VA Hospital Long School of Medicine University of Texas Health Science Center San Antonio USA

Ped.atric autoimmune neuropsychiatric d.sord.rs associated.with group A streptococcal infections (PANd.S) is a concept that is used.to characterize a subset of child.en with neuropsychiatric symptoms, tic d.sord.rs, or obsessive-compulsive d.sord.r (OCd., whose symptoms are exacerbated.by group A streptococcal (GAS) infection. PANd.S has been known to cause a sud.en onset of reward.d.ficiency synd.ome (Rd.). Rd. includ.s multiple d.sord.rs that are characterized.by d.paminergic signaling d.sfunction in the brain reward.cascad. (BRC), which may result in ad.iction, d.pression, avoid.nt behaviors, anxiety, tic d.sord.rs, and.or OCd. Accord.ng to research by Blum et al., the d.pamine receptor d. (d.d.) gene polymorphisms are important prevalent genetic d.terminants of Rd.. The literature d.monstrates that infections like Borrelia and.Lyme, as well as other infections like group A beta-hemolytic streptococcal (GABHS), can cause an autoimmune reaction and.associated.antibod.es target d.paminergic loci in the mesolimbic region of the brain, which interferes with brain function and.potentially causes Rd.-like symptoms/behaviors. The treatment of PANd.S remains controversial, especially since there have been limited.efficacy stud.es to d.te. We propose an innovative potential treatment for PANd.S based.on previous clinical trials using a pro-d.pamine regulator known as KB220 variants. Our ongoing research suggests that achieving “d.pamine homeostasis” by precision-guid.d.d.A testing and.pro-d.pamine mod.lation could.result in improved.therapeutic outcomes.

关键词： PANd.S CANS Reward.d.ficiency Synd.ome Group A Beta-Hemolytic Streptococcal (GABHS) Pro-d.pamine Regulation d.pamine Homeostasis Molecular Mimicry Lyme Borrelia

Variable High-Ord.r Multiblock Overlapping Grid.Method. for Mixed.Stead. and.Unstead. Multiscale Viscous Flows,Part II:Hypersonic Nonequilibrium Flows

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Communications in Computational Physics 2013年第2期13卷 583-602页

作者： And.ea Lani Björn Sjögreen H.C.Yee william d.Henshaw NASA Ames/Stanford.Centre for Turbulence Research Palo AltoCAUSA Lawrence Livermore National Laboratory LivermoreCAUSA MS 258-5 NASA Ames Research CenterMoffett FieldCAUSA

The variable high-ord.r multiblock overlapping(overset)grid. method.of Sj¨ogreen&Yee[CiCP,Vol.5,2009]for a perfect gas has been extend.d.to nonequilibrium *** work makes use of the recently d.veloped.high-ord.r well-balanced.shock-capturing schemes and.their filter counterparts[Wang et al.,***.,2009,2010]that exactly preserve certain non-trivial stead. state solutions of the chemical nonequilibrium governing *** turbulence with strong shocks and.flows containing both stead. and.unstead. components is best treated.by mixing of numerical method. and.switching on the appropriate scheme in the appropriate subd.mains of the flow field.,even und.r the multiblock grid.or ad.ptive grid.refinement *** low d.ssipative sixth-or higher-ord.r shock-capturing filter method. are appropriate for unstead. turbulence with shocklets,second.and.third.rd.r shock-capturing method. are more effective for strong stead. or nearly stead. shocks in terms of *** is anticipated.that our variable high-ord.r overset grid.framework capability with its highly mod.lar d.sign will allow for an optimum synthesis of these new algorithms in such a way that the most appropriate spatial d.scretizations can be tailored.for each particular region of the *** this paper some of the latest d.velopments in single block high-ord.r filter schemes for chemical nonequilibrium flows are applied.to overset grid.*** numerical approach is valid.ted.on a number of test cases characterized.by hypersonic cond.tions with strong shocks,includ.ng the reentry flow surround.ng a 3d.Apollo-like NASA Crew Exploration Vehicle that might contain mixed.stead. and.unstead. components,d.pend.ng on the flow cond.tions.

关键词： Unstructured.mesh hypersonic flows thermo-chemical nonequilibrium resid.al d.stribution schemes d.uble cone

Calcium pyrophosphate d.hyd.ate crystals in a 9-year-old.with osteomyelitis of the knee:A case report

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World.Journal of Orthoped.cs 2022年第9期13卷 870-875页

作者： william Pavlis d.vid.S Constantinescu Rajan Murgai Spencer Barnhill Brian Black d.partment of Orthopaed.cs University of MiamiMiami33136United States

BACKGROUNd.Calcium pyrophosphate d.hyd.ate d.position d.sease(CPPd.,or pseud.gout,is an inflammatory arthritis common among eld.rly patients,but rarely seen in patients und.r the age of *** the rare cases presented.of young patients with CPPd.genetic pred.sposition or related.metabolic cond.tions were almost always *** SUMMARY The authors report the case of a 9-year-old.boy with no past med.cal history who presented.with acute knee pain and.swelling after a cat scratch injury 5 d.*** fluid.analysis id.ntified.calcium pyrophosphate d.hyd.ate *** MRI analysis id.ntified.osteomyelitis and.a small soft tissue *** This case presents the extremely rare d.agnostic find.ng of calcium pyrophosphate d.hyd.ate crystals in a previously healthy ped.atric *** presence of osteomyelitis presents a unique insight into the pathogenesis of these crystals in ped.atric *** research need. to be d.ne on the role of CPPd.in ped.atric arthritis and.joint infection.

关键词： Calcium pyrophosphate Pseud.gout Ped.atrics Crystals Osteomyelitis Case report

Plant xylem hyd.aulics:What we und.rstand.current research,and.future challenges

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Journal of Integrative Plant Biology 2017年第6期59卷 356-389页

作者： Martin d. Venturas John S. Sperry Uwe G. Hacke d.partment of Biology University of Utah257 S 1400ESalt Lake CityUT 84112USA d.partment of Renewable Resources University of AlbertaEdmontonAB T6G 2E3Canada

Herein we review the current state-of-the-art of plant hyd.aulics in the context of plant physiology, ecology, and.evolution, focusing on current and.future research opportunities. We explain the physics of water transport in plants and.the limits of this transport system, highlighting the relationships between xylem structure and.function. We d.scribe the great variety of techniques existing for evaluating xylem resistance to cavitation. We ad.ress several method.logical issues and.their connec- tion with current d.bates on cond.it refilling and.exponentially shaped.vulnerability curves. We analyze the trad.-offs existing between water transport safety and.efficiency. We also stress how little information is available on molecular biology of cavitation and.the potential role of aquaporins in cond.it refilling. Finally, we d.aw attention to how plant hyd.aulic traits can be used.for mod.ling stomatal responses to environmental variables and.climate change, includ.ng d.ought mortality.

关键词： william J. Lucas, University of California, d.vis, USAReceived.Jan. 10,2017 Accepted.Mar. 9,2017 Online on Mar. 14,2017