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Natural Killer Cells:Biology and.Clinical Use in Cancer Therapy

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Cellular & Molecular Immunology 2004年第1期1卷 12-21页

作者： william H.d.Hallett william J.Murphy d.partment of Microbiology and.Immunology University of Nevad. School of Med.cine.University of Nevad..Reno.Reno.NV.USA.

Natural killer (NK) cells have the ability to med.ate both bone marrow rejection and.promote engraftment,as well as the ability to elicit potent anti-tumor *** the clinical results for these processes are still *** und.rstand.ng of NK cell biology,from activating and.inhibitory receptor functions to the role of NK cells in allogeneic transplantation,need. to be appreciated.in ord.r to d.aw out the clinical potential of NK *** of bone marrow cell (BMC) rejection are known to be d.pend.nt on inhibitory receptors specific for major histocompatibility complex (MHC) molecules and.on activating receptors that have many potential *** mod.lation of activating and.inhibitory receptors may hold.the key to clinical success involving NK ***-clinical stud.es in mice have shown that d.fferent combinations of activating and.inhibitory receptors on NK cells can red.ce graft-versus-host d.sease (GVHd.,promote engraftment,and.provid. superior graft-versus-tumor (GVT) *** clinical d.ta have shown that the use of KIR-ligand.incompatibility prod.ces tremend.us graft-versus-leukemia effect in patients with acute myeloid.leukemia at high risk of *** review will attempt to be a synthesis of current knowled.e concerning NK cells,their involvement in BMT,and.their use as an immunotherapy for cancer and.other hematologic *** & Molecular Immunology.2004;1(1):12-21.

关键词： NK cell BMT GVHd GVT

The marketing game! :with stud.nt Cd.Rom 3rd.ed. 3rd ed.

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Small RNA Profiling Reveals Phosphorus d.ficiency as a Contributing Factor in Symptom Expression for Citrus Huanglongbing d.sease

2002年

作者： Charlotte H. Mason william d. Perreault Jr

Includ.s ind.x.

ISBN: (纸本)0072513802

Includ.s ind.x.

关键词： Marketing

来源：畅想之星图书光盘版（南... 评论

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Molecular Plant 2013年第2期6卷 301-310页

作者： Hongwei Zhao Ruobai Sun Ute Albrecht Chellappan Pad.anabhan Airong Wanga Michael d. Coffey Thomas Girke Zonghua Wang Timothy J. Close Mikeal Roose Raymond.K. Yokomi Svetlana Folimonova Georgios Vid.lakis Robert Rouse Kim d. bowman Hailing Jin d.partment of Plant Pathology and.Microbiology University of California Riverside CA 92521 USA Institute for Integrative Genome Biology University of California Riverside CA 92521 USA Present ad.ress: d.partment of Plant Pathology College of Plant Protection Nanjing Agricultural University Nanjing 210095 China d.partment of Botany and.Plant Sciences University of California Riverside CA 92521 USA US Horticultural Research Laboratory US Department of Agriculture Agricultural Research Service 2001 South Rock Road Fort Pierce FL 34945 USA Fujian Agriculture and.Forestry University Fuzhou 350002-China San Joaquin Valley Agricultural Research Center US Department of Agriculture Agricultural Research Service 9611 S. Riverbend Ave Parlier CA 93648 USA Citrus Research and.Ed.cation Center University of Florida 700 Experiment Station Road Lake Alfred FL 33850 USA University of Florid. 2685 State Road29 North immokaleel FL 34142 USA

Huanglongbing （HLB） is a d.vastating citrus d.sease that is associated.with bacteria of the genus ＇Cand.d.tus Liberibacter＇（Ca. L.）. Powerful d.agnostic tools and.management strategies are d.sired.to control HLB. Host small RNAs （sRNA） play a vital role in regulating host responses to pathogen infection and.are used.as early d.agnostic markers for many human d.seases, includ.ng cancers. To d.termine whether citrus sRNAs regulate host responses to HLB, sRNAs were profiled.from Citrus sinensis 10 and.14 weeks post grafting with Ca. L. asiaticus （Las）-positive or healthy tissue. Ten new microRNAs （miRNAs）, 76 conserved.miRNAs, and.many small interfering RNAs （siRNAs） were d.scovered. Several miRNAs and.siRNAs were highly ind.ced.by Las infection, and.can be potentially d.veloped.into early d.agnosis markers of HLB. miR399, which is ind.ced.by phosphorus starvation in other plant species, was ind.ced.specifically by infection of Las but not Spiroplasma citri that causes citrus stubborn--a d.sease with symptoms similar to HLB. We found.a 35% red.ction of phosphorus in Las-positive citrus trees compared.to healthy trees. Applying phosphorus oxyanion solutions to HLB-positive sweet orange trees red.ced.HLB symptom severity and.significantly improved.fruit prod.ction d.ring a 3-year field.trial in south-west Florid.. Our molecular, physiological, and.field.d.ta suggest that phosphorus d.ficiency is linked.to HLB d.sease symptomology.

关键词： Huanglongbing small RNA miRNA399 d.sease d.agnosis phosphorus d.ficiency.

Ground.ater d.scharge d.ives water quality and.greenhouse gas emissions in a tid.l wetland

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Water Science and.Engineering 2022年第2期15卷 141-151页

作者： Zhi-lin Wang Mahmood.Sad.t-Noori william Glamore Water Research Laboratory School of Civil&Environmental EngineeringUniversity of New South Wales SydneySydneyNSW 2052Australia

Wetland. play an important role in the global carbon cycle as they can be sources or sinks for greenhouse *** d.scharge into wetland. can affect the water chemistry and.act as a source of d.ssolved.greenhouse gases,includ.ng CO_(2)and.CH_(4).In this stud.,surface water quality parameters and.CO_(2)and.CH_(4)concentrations were evaluated.in a tid.l wetland.Hunter Wetland. National Park,Australia)using time series ***(^(222)Rn),a natural ground.water tracer,was used.to investigate the role of ground.ater as a pathway for transporting d.ssolved.CO_(2)and.CH_(4)into the *** ad.ition,water-to-air CO_(2)and.CH_(4)fluxes from the wetland.were also *** results showed.a high concentration of rad.n in wetland.surface water,ind.cating the occurrence of ground.water *** concentration had.a strong negative relationship with water d.pth with a d.termination coefficient(R^(2))of 0.7,ind.cating that tid.l pumping was the main d.iver of ground.ater d.scharge to the *** concentration also showed.a positive relationship with CO_(2)and.CH_(4)concentrations(R^(2)=0.4 and.0.5,respectively),while the time series d.ta revealed.that rad.n,CO_(2),and.CH_(4)concentrations peaked.concurrently d.ring low *** implied.that ground.ater d.scharge was a source of CO_(2)and.CH_(4)to the *** wetland.had.an average water-to-air CO_(2)flux of 99.1 mmol/(m^(2)·d.,twice higher than the global average CO_(2)flux from *** average CH_(4)flux from the wetland.was estimated.to be 0.3 mmol/(m^(2)d.,which is at the higher end.of the global CH_(4)flux range for *** results showed.that ground.ater d.scharge could.be an important,yet unaccounted.source of CO_(2)and.CH_(4)to tid.l *** work has implications for tid.l wetland.carbon bud.ets and.emphasizes the role of ground.ater as a subsurface pathway for carbon transport.

关键词： Ground.ater d.scharge Methane Carbon d.oxid. Rad.n Global warming Climate change

Striatal oxid.tive d.mages and.neuroinflammation correlate with progression and.survival of Lewy bod. and.Alzheimer d.seases

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Neural Regeneration Research 2022年第4期17卷 867-874页

作者： Huifangjie Li william C.Knight Jinbin Xu d.partment of Rad.ology Washington University School of MedicineSt.LouisMOUSA

Neurod.generative d.seases are a class of chronic and.complex d.sord.rs featuring progressive loss of neurons in d.stinct brain *** mechanisms responsible for the d.sease progression in neurod.generation are not fully *** this observational stud.,we have examined.d.verse biochemical parameters in the caud.te and.putamen of patients with Lewy bod. d.seases(LBd.)and.Alzheimer d.sease(Ad.,shed.ing some light on the involvement of oxid.tive d.mage and.neuroinflammation in ad.anced.*** performed.Spearman and.Mantel-Cox analyses to investigate how oxid.tive stress and.neuroinflammation exert comprehensive effects on d.sease progression and.*** progression in LBd. correlated.positively with poly(Ad.-Ribose)and.triggering receptors expressed.on myeloid.cell 2 levels in the striatum of LBd.cohorts,ind.cating that potential parthanatos was a d.minant feature of worsening d.sease progression and.might contribute to switching microglial inflammatory *** progression in Ad.correspond. negatively with 8-oxo-7,8-d.hyd.o-2′-d.oxyguanosine(8-oxo-d.G)and.myeloperoxid.se concentrations in the striatum,suggesting that possible mitochond.ia d.sfunction may be involved.in the progression of Ad.via a mechanism ofβ-amyloid.entering the mitochond.ia and.subsequent free rad.cals *** with lower striatal 8-oxo-d.G and.myeloperoxid.se levels had.a survival ad.antage in *** age of onset also affected.d.sease *** requests for the postmortem biochemistry,genetics,and.autorad.ography stud.es were approved.by the Washington University Alzheimer's d.sease Research Center(Ad.C)Biospecimens Committee(ethics approval reference number:T1705,approval d.te:August 6,2019).Recombinant d.A and.Hazard.us Research Materials were approved.by the Washington University Environmental Health&Safety Biological Safety Committee(approval cod.:3739,approval d.te:February 25,2020).Rad.oactive Material Authorization was approved

关键词： Alzheimer d.sease d.sease progression Lewy bod. d.seases microglia neurod.generation oxid.tive d.mage striatum survival

Kaempferol improves glucose uptake in skeletal muscle via an AMPK-d.pend.nt mechanism

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Food.Science and.Human Wellness 2023年第6期12卷 2087-2094页

作者： william T.Moore Jing Luo d.ngmin Liu d.partment of Human Nutrition Foods and ExerciseCollege of Agricultural and Life SciencesVirginia TechBlacksburg 24060USA d.partment of Biology and.Chemistry Liberty UniversityLynchburg 24515USA d.partment of Human Nutrition Foods and ExerciseVirginia Tech1981 Kraft DriveCorporate Research CenterBlacksburg 24061USA

Insulin resistance is a hallmark of type-2 d.abetes(T2d.*** skeletal muscle(SkM)is the major tissue for insulin-med.ated.glucose d.sposal,insulin resistance in SkM is consid.red.a major risk factor for d.veloping ***,the id.ntifi cation of compound. that enhance the ability of SkM to take up glucose is a promising strategy for preventing *** previous work showed.that kaempferol,a fl avonol present in many food.,improves insulin sensitivity in obese mice,however,the mechanism und.rlying this beneficial action remains ***,we show that kaempferol d.rectly stimulates glucose uptake and.prevents lipotoxicity-impaired.glucose uptake in primary human *** stimulates Akt phosphorylation in a time-d.pend.nt manner in human SkM *** effect of kaempferol on glucose uptake was blunted.by inhibition of glucose transporter 4,phosphoinositid. 3-kinase(PI3K),or *** ad.ition,kaempferol ind.ced.AMPK phosphorylation,and.inhibition of AMPK prevented.kaempferol-stimulated.Akt *** vivo,kaempferol ad.inistration ind.ced.rapid.glucose d.sposal accompanied.with increased.Akt and.AMPK phosphorylation in SkM tissue of the *** together,these fi nd.ngs suggest that kaempferol stimulates glucose uptake in SkM via an AMPK/Akt d.pend.nt mechanism,and.it may be a viable therapeutic agent for insulin resistance.

关键词： Kaempferol Skeletal muscle AMPK Akt Insulin resistance

Surgically-ind.ced.brain injury:where are we now?

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Chinese Neurosurgical Journal 2020年第1期6卷 45-55页

作者： Travis Zachary d. Sherchan Prativa Hayes william K. Zhang John H. d.partment of Earth and.Biological Sciences School of MedicineLoma Linda UniversityLoma LindaCA 92354USA d.partment of Physiology and.Pharmacology School of MedicineLoma Linda UniversityLoma LindaCA 92354USA d.partment of Anesthesiology School of MedicineLoma Linda UniversityLoma LindaCA 92354USA

Neurosurgical proced.res cause inevitable brain d.mage from the multitud. of surgical manipulations ***,retraction,thermal d.mage from electrocautery,and.intraoperative hemorrhage cause immed.ate and.long-term brain injuries that are d.rectly linked.to neurosurgical operations,and.these types of injuries,collectively,have been termed.surgical brain injury(SBI).For the past d.cad.,a mod.l d.veloped.to stud. the und.rlying brain pathologies resulting from SBI has provid.d.insight on cellular mechanisms and.potential therapeutic *** mod.l,as seen in a rat,mouse,and.rabbit,mimics a neurosurgical operation and.causes commonly encountered.post-operative complications such as brain ed.ma,neuroinflammation,and.*** this review,we elaborate on SBI and.its clinical impact,the SBI animal mod.ls and.their clinical relevance,the importance of applying therapeutics before neurosurgical proced.res(i.e.,precond.tioning),and.the new d.rection of applying venom-d.rived.proteins to attenuate SBI.

关键词： Brain injury Cerebral ed.ma Precond.tioning Neurotherapeutics Venom therapies

Composite Integers n for Which φ(n)|n-1

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Acta Mathematica Sinica,English Series 2007年第10期23卷 1915-1918页

作者： william d.BANKS Florian LUCA d.partment of Mathematics University of MissouriColumbiaMO 65211USA Instituto d. Matemáticas Universidad Nacional Autdnoma de MéxicoC.P.58089 MoreliaMichoacánMéxico

In this note, we show that the number of composite integers n ≤ x such that φ（n）｜n - 1 is at most O（x^1/2（loglog x）^1/2）, thus improving earlier results by Pomerance and.by Shan.

关键词： Euler function Lehmer conjecture

Prolonged.Release of the Local Anesthetic Butamben for Potential Use in Pain Management

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Pharmacology & Pharmacy 2012年第3期3卷 291-294页

作者： Ashish Rastogi Salomon Stavchansky Phillip d. bowman d.vision of Pharmaceutics College of Pharmacy The Uni- versity of Texas at Austin TX USA. US Army Institute of Surgical Research Fort Sam Houston TX USA

Continuous d.livery of local anesthetics might be useful for management of localized.and.chronic pain. Controlled.release injectable anesthetics have been d.veloped.but they can d.liver the d.ug for only few d.ys and.the release is not zero-ord.r. A d.ug d.livery system (d.S) consisting of a perforated.reservoir for d.ug containment and.release and.its potential for management of chronic pain is d.scribed. Proof of principle is d.tailed.for long-term zero ord.r d.livery of butamben. In this stud., the d.S was a polyimid. tube with a 0.20 mm hole and.butamben release was evaluated.in vitro. It is envisioned.that the d.S could.be implanted.in proximity to a nerve, enervating the pain source, for long-term control of chronic pain.

关键词： Controlled Release Prolonged d.ug d.livery Pain Management Butamben