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Abnormal mitochondrial function impairs calcium influx in diabetic mouse pancreatic beta cells

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Chinese Medical Journal 2012年第3期000卷 502-510页

作者： Li Fei porterfield, D. Marshall Zheng Xi-yan wang wen-jun Xu Yue Zhang Zong-ming Tsinghua Univ Dept Gen Surg Digest Med Ctr Med SchAffiliated Hosp 1 Beijing 100016 Peoples R China Purdue Univ Birck Bindley Biosci Ctr Dept Agr & Biol Engn Dept Hort & Landscape ArchitectureWeldon Sch Bio W Lafayette IN 47906 USA Beijing Sci & Technol Co Ltd Beijing 100080 Peoples R China

Background Abnormal insulin secretion of pancreatic beta cells is now regarded as the more primary defect than the insulin function in the etiology of type 2 *** studies found impaired mitochondrial function and impaired Ca2＋ influx in beta cells in diabetic patients and animal models,suggesting a role for these processes in proper insulin *** aim of this study was to investigate the detailed relationship of mitochondrial function,Ca2＋ influx,and defective insulin *** we investigated mitochondrial function and morphology in pancreatic beta cell of diabetic KK-Ay mice and C57BL/6J *** types of Ca2＋ channel activities,L-type and store-operated Ca2＋（SOC）,were evaluated using whole-cell patch-clamp *** glucose induced Ca2＋ influx was measured by a non-invasive micro-test technique （NMT）.Results Mitochondria in KK-Ay mice pancreatic beta cells were swollen with disordered cristae,and mitochondrial function decreased compared with C57BL/6J ***2＋ channel activity was increased and glucose induced Ca2＋ influx was impaired,but could be recovered by *** Defective mitochondrial function in diabetic mice pancreatic beta cells is a key cause of abnormal insulin secretion by altering Ca2＋ influx,but not via Ca2＋ channel activity.

关键词： type 2 diabetes pancreatic beta cell insulin secretion Ca2+ influx mitochondrial function

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病毒性疾病和单克隆抗体

国际流行病学传染病学杂志 1985年第3期 107-109页

作者： porterfield J S 王懋梁

单克隆抗体可作为非常敏感和特异的探针识别病毒表面上存在的独特的抗原决定簇或表位(epitope)。由于此种特性,单克隆抗体不是同整个病毒反应,而只同有特异性的病毒表面的某一部分发生反应。然而,在很多情况下,识别一种特异性的病毒表位... 详细信息

单克隆抗体可作为非常敏感和特异的探针识别病毒表面上存在的独特的抗原决定簇或表位(epitope)。由于此种特性,单克隆抗体不是同整个病毒反应,而只同有特异性的病毒表面的某一部分发生反应。然而,在很多情况下,识别一种特异性的病毒表位,可被用作识别某种病毒存在的方法。如果一种单克隆抗体特异性针对一种高度保守的抗原或表

关键词：单克隆抗体流感病毒抗原决定簇血凝素检出交叉反应性表位

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抗体促进病毒在巨噬细胞内的生长

国外医学(微生物学分册) 1986年第5期 207-209页

作者： porterfield JS 钟光明

巨噬细胞(M(φ)是一种职业性吞噬细胞,它在保护机体免受病毒在内的异物侵袭时起着重要作用。机体抗御病毒的第二个武器是抗体。人们也许认为这两种防御机能会相互加强,在大多数病毒感染情况下确实如此,但在某些情况下,抗病毒抗体能促进... 详细信息

巨噬细胞(M(φ)是一种职业性吞噬细胞,它在保护机体免受病毒在内的异物侵袭时起着重要作用。机体抗御病毒的第二个武器是抗体。人们也许认为这两种防御机能会相互加强,在大多数病毒感染情况下确实如此,但在某些情况下,抗病毒抗体能促进病毒在Mφ内的增殖,结果可能有害于机体。本文对在Mφ内抗体依赖促进(ADE)病毒增殖加以综述。

关键词：抗体 ADE 巨噬细胞吞噬细胞

The Value of the Scientific Study of Botany to Chinese Medical Students

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中华医学杂志 1917年第4期3卷

作者： porterfield w. M. St. John's University Shanghai

Rice with high K utilization efficiency

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Chinese Rice Research Newsletter 2002年第3期10卷 26-26页

作者： Liu Guodong and Liu Gengling, Inst of Natural Resources and Regional Planning, Chinese Acad of Agri Sci, Beijing 200081, China Marshall porterfield, Dept of Biological Sci, Univ of Missouri-Rolla, MO 65409, USA

China is short of potassium resources, it only produces about 30 t of potash fertilizers per year. while China used about 650 t of potash fertilizer in 2000 by importing more than 95% of its potash fertilizers from Ca... 详细信息

关键词： high Rice with high K utilization efficiency very

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Rice with high K utilization efficiency

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Rice Science 2002年第Z1期 26-26页

作者： LIR Guodong LIU Gengling,Inst of Natural Resources and Regional Planning,Chinese Acnd of Agri Sci,Beijing 100081,China Marshall porterfield,Dept of Biological Sci,Univ of Missouri-Rolla,MO 65409,USA

China is short of potassium re-sources,it only produces about 30 tof potash fertilizers per *** used about 650 t of potashfertilizer in 2000 by importing morethan 95% of its potash fertilizers fromCanada or ***,using ... 详细信息

关键词： high rate Rice with high K utilization efficiency