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The CoVID-19 pandemic and physical activity

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Sports Medicine and Health Science 2020年第2期2卷 55-64页

作者： Jeffrey A.Woods Noah T.Hutchinson Scott K.Powers william o.roberts Mari Carmen Gomez-Cabrera Zsolt Radak Istvan Berkes Anita Boros Istvan Boldogh Christiaan Leeuwenburgh Helio Jose Coelho-Júnior Emanuele Marzetti Ying Cheng Jiankang Liu J.Larry Durstine Junzhi Sun Li Li Ji Department of Kinesiology and Community Health University of Illinois at Urbana-ChampaignUSA Division of Nutritional Sciences University of Illinois at Urbana-ChampaignUSA Department of Applied Physiology and Kinesiology University of FloridaGainesvilleUSA Department of Family Medicine and Community Health University of Minnesota Medical SchoolMinneapolisUSA Freshage Research Group Department of Physiology Faculty of MedicineUniversity of Valencia and CIBERFES.Fundacion Investigacion Hospital Clínico Universitario/INCLIVAValenciaSpain Research Institute of Sport Science University of Physical EducationBudapestHungary National University of Public Service BudapestHungary Department of Microbiology and Immunology University of Texas Medical Branch at GalvestonUSA Institute on Aging College of MedicineUniversity of FloridaGainesvilleUSA Universita Cattolica Del Sacro Cuore RomeItaly Fondazione Policlinico Universitario“Agostino Gemelli”IRCCS Universita Cattolica Del Sacro CuoreRomeItaly Center for Mitochondrial Biology and Medicine The Key Laboratory of Biomedical Information Engineering of Ministry of EducationSchool of Life Science and TechnologyXi'an Jiaotong UniversityXi'anChina Department of Exercise Science Norman J.Arnold School of Public HealthUniversity of South CarolinaColumbiaUSA Institute of Sports Medicine and Health Chengdu Sport UniversityChengduChina The Laboratory of Physiological Hygiene and Exercise Science School of KinesiologyUniversity of Minnesota Twin CitiesMinneapolisUSA

The SARS-CoV-2-caused CoVID-19 pandemic has resulted in a devastating threat to human society in terms of health,economy,and *** the virus usually first invades and infects the lung and respiratory track tissue,in extreme cases,almost all major organs in the body are now known to be negatively impacted often leading to severe systemic failure in some ***,there is currently no effective treatment for this ***-existing pathological conditions or comorbidities such as age are a major reason for premature death and increased morbidity and *** immobilization due to hospitalization and bed rest and the physical inactivity due to sustained quarantine and social distancing can downregulate the ability of organs systems to resist to viral infection and increase the risk of damage to the immune,respiratory,cardiovascular,musculoskeletal systems and the *** cellular mechanisms and danger of this“second wave”effect of CoVID-19 to the human body,along with the effects of aging,proper nutrition,and regular physical activity,are reviewed in this article.

关键词： Aging Brain Cardiovascular CoVID-19 Immune Muscle Nutrition Physical inactivity Respiratory

Blood biomarkers of Alzheimer’s disease:important considerations for use in clinical practice

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Neural Regeneration Research 2025年第1期20卷 205-206页

作者： Sarah Fullam Sean o’Dowd Antoinette o’Connor Department of Neurology Tallaght University HospitalDublinIreland Academic Unit of Neurology Trinity College DublinIreland

Introduction:Fluid and positron emission tomography(PET)biomarkers that enable the detection of the hallmark proteins of Alzheimer’s disease(AD)(amyloid and tau)have revolutionized our approach to the diagnosis of *** evolution of AD diagnostic criteria to include biological characterization(Alzheimer’s Association Working Group,2023)provides an appropriate framework to reduce levels of clinico-pathologic mismatch and improve in-vivo diagnostic *** the therapeutic landscape for neurodegenerative disease evolves,it is increasingly incumbent on clinicians to provide timely,and pathologically precise diagnoses for ***,the expensive and invasive nature of these tests limits their scalability.

关键词： Blood Alzheimer diagnosis

Dynamic stress concentration in an infinitely long cylindrical cavity due to a point spherical source embedded within a fluid-saturated poroelastic formation of infinite extent

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 139-156页

作者： H.HoSSEINI o.BALILASHAKI Department of Mechanical Engineering Faculty of EngineeringGolestan University

The effects of a harmonically exciting monopole source on an infinitely long cylindrical cavity embedded entirely within a fluid-saturated poroelastic formation of infinite extent are examined theoretically. It is assumed that the source is located outside the cavity at a specified distance from the borehole axis. The magnitudes of the hoop and radial stresses beside the pore pressures exerted on the interface and inside the porous medium surrounding the borehole are calculated and discussed. Biot's poroelastic modeling along with three types of boundary conditions for the cylindrical interface including the ideal fluid, empty borehole, and rigid inclusion with a hard boundary is employed for the analysis. Utilizing a proper translational addition theorem for expressing the incident spherical wave in terms of cylindrical wave expansions, the proposed boundary conditions at the interface are satisfied. Stresses are formulated by means of wave potential functions in a three-dimensional(3D) manner. The effects of the frequency and the radial distance between the source and borehole on the induced stresses are examined for the first cylindrical modes over frequency spectra. Two permeability conditions for the interface and three types of soils for the porous formation are considered throughout the analysis. To give an overall outline of the study, a numerical example is presented. The results clearly indicate that the distance is a key parameter and has considerable effects on the induced stress values. In addition, the interface permeability condition and soil characteristics play an important role in determining the dynamic response of the borehole. Finally,the obtained results are compared with the relevant analyses existing in the literature for some limit cases, and good agreement is achieved.

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Neuroprotection by resveratrol-glucuronide and quercetin-glucuronide via binding to polyphenol-and glycosaminoglycan-binding sites in the laminin receptor

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Neural Regeneration Research 2025年第3期20卷 819-820页

作者： Rayudu Gopalakrishna Jennifer Aguilar Emily Lee william J.Mack Department of Integrative Anatomical Sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Department of Neurological Surgery Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA

The dietary polyphenolic compounds resveratrol and quercetin prevent neurodegenerative diseases in experimental models;however, they reach the brain only in nanomolar concentrations in the glucuronidated and sulfated ... 详细信息

关键词： resveratrol molar dated

Neuroinflammation revisited through the microglial lens

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Neural Regeneration Research 2025年第7期20卷 1989-1990页

作者： Renato Socodato João B.Relvas Institute of Research and Innovation in Health(i3S)and Institute for Molecular and Cell Biology(IBMC) University of PortoPortoPortugal Department of Biomedicine Faculty of Medicine of the University of Porto(FMUP)PortoPortugal

Neuroimmunology is emerging as a pivotal field,shedding light on the intricate dialogues between the central nervous system(CNS)and the immune *** exploration is particularly significant in understanding microglia,the CNS’s innate immune cells,beyond the conventional conflation of“neuroinflammation”and“microglial activation.”This conflation has clouded the true complexity of these processes,potentially stalling scientific progress and the development of new *** challenge the long-standing perspectives that have oversimplified these interactions,advocating for a deeper exploration of the dynamic relationship between neuroinflammation and microglial *** dissecting specific molecular pathways,we aim to illuminate their elaborate roles in neuroinflammatory responses,especially in the context of Alzheimer’s disease(AD).Here,neuroinflammation is not merely a passive observer or a direct antagonist but a complex agent in the disease’s *** article calls for a significant paradigm shift towards an integrative,multi-omics approach to *** such a comprehensive framework is crucial for advancing our understanding of neuroinflammatory conditions and paving the way for targeted therapeutic strategies for brain diseases.

关键词： inflammation simplified activation

Contribution of mechanical forces to structural synaptic plasticity:insights from 3D cellular motility mechanisms

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Neural Regeneration Research 2025年第7期20卷 1995-1996页

作者： Rita o.Teodoro Mafalda Ribeiro Ramos Lara Carvalho iNoVA4Health NOVA Medical School|Faculdade de Ciências MédicasNMS|FCMUniversidade Nova de LisboaLisboaPortugal

Cells,tissues,and organs are constantly subjected to the action of mechanical forces from the extracellular environment-and the nervous system is no ***-intrinsic properties such as membrane lipid composition,abundance of mechanosensors,and cytoskeletal dynamics make cells more or less likely to sense these *** and extrinsic cues are integrated by cells and this combined information determines the rate and dynamics of membrane protrusion growth or retraction(Yamada and Sixt,2019).Cell protrusions are extensions of the plasma membrane that play crucial roles in diverse contexts such as cell migration and neuronal synapse *** the nervous system,neurons are highly dynamic cells that can change the size and number of their pre-and postsynaptic elements(called synaptic boutons and dendritic spines,respectively),in response to changes in the levels of synaptic activity through a process called *** plasticity is a hallmark of the nervous system and is present throughout our lives,being required for functions like memory formation or the learning of new motor skills(Minegishi et al.,2023;Pillai and Franze,2024).

关键词： plasticity structural mechanisms

Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher J.o’Connell Matthew J.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA James L.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

Comment on profitability analysis of a femtosecond laser system for cataract surgery using a fuzzy logic approach

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International Journal of ophthalmology(English edition) 2017年第3期10卷 497-498页

作者： Harrv william roberts Melody Zhifang Ni David Phillip S. o'Brart Department of ophthalmology Guy's and St. Thomas' NHS Foundation Trust London SE1 7ET UK King's College London London WC2R 2LS UK 3Division of Surgery Department of Surgery and Cancer Imperial College London St Mary's Hospital London W2 1NY UK Division of Surgery Department of Surgery and CancerImperial College London St Mary's Hospital London W21NY UK

Dear Editor,We read with interest the recently published study by Trigueros et al（[1]）,highlighting the financial and management conditions of femtosecond laser-assisted cataract surgery（FLACS）.The authors derived... 详细信息

关键词： cataract operations carefully nothing something enough sparse currently details comment

Profile of Implanon~ acceptors and pattern of side effects

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Journal of Reproduction and Contraception 2015年第1期26卷 46-52页

作者： Adebola o.roberts Imran o.Morhason-Bello Michael A.okunlola Adeyemi o.Adekunle Department of obstetrics and Gynaecology Faculty of Clinical Sciences College of Medicine/University College Hospital University of Ibadan

objective To determine the social and biological characteristics of Implanon acceptors at Ibadan Nigeria, and also to describe reasons why they opt for this choice and their concerns. Methods This was a descriptive study that retrospectively reviewed all records of the Implanon acceptors from January 2006 to December 2009 at University College Hospital Ibadan, Nigeria. Results one hundred and twenty-eight women accepted Implanon as a modern contraception accounting 4.3% of the total number of clients seen （2 972） during the period. The age range of the client that accepted Implanon was 26-43 years with a mean of 33.6 ±2.4 years. of the 128 Implanon acceptors, 101 （78.9%） had used other contraceptive methods before. The commonest reason for switching to Implanon by clients was failure of the contraceptive method that was previously used （32.7%）. Within the first year follow-up of insertion, none of the Implanon acceptors had expressed desire for removal due to any of the side effects, and none contraceptive failure was observed during their follow-up evaluation. Conclusion The findings suggest that Implanon could safely be used by all women of reproductive age group including those who desire future fertility.

关键词： implanon contraceptive methods hormonal contraception women acceptors Nigeria