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Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： william J.Flerlage mark L.Dell’Acqua Brian m.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

The origin of different morphology of internal oxide precipitates in ferritic and austenitic steels

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Journal of materials Science & Technology 2023年第30期161卷 88-100页

作者： Zhao Shen Xiaoqin Zeng Shengchuan Wu Hongbing Yu Benjamin m.jenkins Phani Karamched michael P.moody Jianqiang Zhang You Wang Sergio Lozano-Perez National Engineering Research Center of Light Alloy Net Forming and State Key Laboratory of metal matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Traction Power Southwest Jiaotong UniversityChengdu 610031China Department of Engineering Science University of OxfordParks RoadOX13PJ OxfordUK Department of materials University of OxfordParks RoadOX13PH OxfordUK School of materials Science and Engineering University of New South WalesSydneyNSW 2052Australia School of materials Science and Engineering University of Science and Technology BeijingBeijing 100083China

The internal oxide precipitates were supposed to be spherical in Wagner’s original theory,while the fol-lowing research demonstrated that this assumption is an exception rather than the truth,which caused deviations in the application of this *** this study,the internal oxide precipitates have a needle-like and a near-spherical morphology in a Fe-9Cr ferritic and a Fe-17Cr-9Ni austenitic steels after expo-sure to 600℃ deaerated steam for 600 h,*** nano-to-atomic scale characterization shows that the morphology of the internal oxide precipitates is controlled by the structure of the interfaces be-tween the metal matrix and the internal oxide,while the interface structure is mainly affected by the crystallographic structure of the two phases and their orientation *** addition,the internal oxide precipitation-induced volume expansion and the outward Fe diffusion-induced volume shrink oc-cur simultaneously during the oxidation *** stress status in the internal oxidation zone(IOZ)is the competing result of the two factors,which could dynamically affect the high-temperature *** results obtained in this study suggest that there is potential to control the distribution,morphology,and interface structure of the internal oxide precipitates by selecting appropriate base metal and internal oxide-forming element,in order to obtain better high-temperature oxidation-resistant materials.

关键词： Austenitic steel Ferritic steel Oxide precipitates Phase boundary Orientation relationship

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解析西格蒙德·弗洛伊德《梦的解析》

Adjusting Temperature and Salinity Effects on Single Capacitance Sensors

作者： william J. jenkins

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Pedosphere 2009年第5期19卷 588-596页

作者： A.FARES m.SAFEEQ D.m.jenkins Department of Natural Resources and Environmental management University of Hawaii at Manoa Department of molecular Biosciences and Bioengineering University of Hawaii at Manoa

Several newly developed capacitance sensors have simplified real-time determination of soil water *** work has shown that salinity and temperature can affect these sensors,but relatively little has been done to correct these *** objectives of this study were to evaluate the effect of media temperature and salinity on the apparent water content measured with a single capacitance sensor(SCS),and to mitigate this effect using a temperature dependent scaled voltage technique under laboratory conditions.A column study was conducted containing two media:pure deionized water and quartz sand under varying water contents(0.05 to 0.30 cm3 cm-3) and salinity(0 to 80 mmol L-1).media temperature was varied between 5 and 45℃ using an *** SCS probes and thermocouples were placed in the middle of the columns and were logged at an interval of 1 *** was strong negative correlation between sensor reading and temperature of deionized water with a rate of-0.779 mV ℃-*** of SCS apparent output were 0.454 and 0.535 mV ℃-1 for air in heating and cooling cycles,respectively.A similar positive correlation with temperature was observed in sand at different water *** SCS probe was less sensitive to temperature as salinity and water content *** a temperature-corrected voltage calibration model,the effect of temperature was reduced by 98%.An analytical model for salinity correction was able to minimize the error as low as ± 2% over the salinity level tested.

关键词： calibration ECH2O probes quartz sand water content

Durability Properties of materials and mixture Composition of Bitumen Stabilized materials

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武汉理工大学学报 2010年第17期32卷 215-226页

作者： TWAGIRA m E jenkins J K Dept of Civil Engineering Stellenbosch University

Bitumen Stabilized materials (BSms) are widely recognized as environmentally friendly through significantly reduced energy consumption,reduced emissions and reuse of high percentage of RAP and recycled pavement materials. In order for these materials to be cost effective,their life-cycle performance needs to be proven. Durability of BSms is a long-term phenomena that requires consideration during mix design. Time is very important variable for performance consideration under field conditions. The factors that influence durability and long-term performance of BSms include the mineral aggregates,binder and mixture compositions. In this study,the important,but less understood aspects of durability properties of BSms were investigated. These include wear and tear of mineral aggregates,age-hardening of binder (foamed bitumen and bitumen emulsion) and moisture susceptibility of typical mix composition. The wear and tear was investigated using Durability mill Index (DmI) test,binder ageing was investigated for short and long-term effect,and moisture susceptibility was investigated by pulsing water pressures using new device i.e. moisture induction simulation test (mIST). The accelerated moisture conditioning simulates field conditions whereafter retained shear properties are evaluated. The results found that durability of mineral aggregates is significantly influences by the type and nature of mineral composition. The ageing of binder occurred in both short and long-term conditions,with short-term effects being dominating the foamed bitumen properties during laboratory production. moisture susceptibility is significantly influenced by the mix compositions of aggregates blends with and without RAP,with different bitumen binder types (foamed bitumen or bitumen emulsion) and active filler type (cement or lime) and contents. The evaluation and ranking of mixes which are resistant and susceptible to moisture damage was done using retained cohesion (RC) after dry and wet monoton

关键词： durability properties bitumen stabilized materials moisture susceptibility ageing

Using a 3-D multicellular simulation of spinal cord injury with live cell imaging to study the neural immune barrier to nanoparticle uptake

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Nano Research 2016年第8期9卷 2384-2397页

作者： Alan P. Weightman Stuart I. jenkins Divya m. Chari Cellular and Neural Engineering Group Institute for Science and Technology in Medicine Huxley Building Keele University Keele ST55BG UK

Development of nanoparticle （NP） based therapies to promote regeneration in sites of central nervous system （CNS; i.e, brain and spinal cord） pathology relies critically on the availability of experimental models that offer biologically valid predictions of NP fate in vivo. However, there is a major lack of biological models that mimic the pathological complexity of target neural sites in vivo, particularly the responses of resident neural immune cells to NPs. Here, we have utilised a previously developed in vitro model of traumatic spinal cord injury （based on 3-D organotypic slice arrays） with dynamic time lapse imaging to reveal in real-time the acute cellular fate of NPs within injury foci. We demonstrate the utility of our model in revealing the well documented phenomenon of avid NP sequestration by the intrinsic immune cells of the CNS （the microglia）. Such immune sequestration is a known translational barrier to the use of NP-based therapeutics for neurological injury. Accordingly, we suggest that the utility of our model in mimicking microglial sequestration behaviours offers a valuable investigative tool to evaluate strategies to overcome this cellular response within a simple and biologically relevant experimental system, whilst reducing the use of live animal neurological injury models for such studies.

关键词： organotypic slice culture microglia immune barrier corticosteroid dexamethasone time lapse microscopy

Therapeutic use of melatonin in schizophrenia:A systematic review

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World Journal of Psychiatry 2021年第8期11卷 463-476页

作者： Cathy Duan Zoe m.jenkins David Castle Department of Psychiatry University of MelbourneParkville 3010VICAustralia mental Health Service St.Vincent's HospitalMelbourne 3065VICAustralia Centre for Complex Interventions Centre for Addictions and Mental HealthToronto ON M6J 1H4Canada Department of Psychiatry University of TorontoToronto ON M5SCanada

BACKGROUND Sleep dysfunction is a common problem in people with schizophrenia,and side effects of treatment often exacerbate metabolic and cardiovascular risk and may induce extrapyramidal side ***(N-acetyl-5-methoxytryptamine)is an endogenously produced hormone which has demonstrated direct and indirect antioxidant and neuroprotective *** studies have explored the use of exogenous melatonin in improving sleep outcomes in the general population,yet indications for use in schizophrenia are *** To synthesize the evidence from clinical trials investigating prescribed melatonin as an adjunctive therapy in patients with *** A systematic literature review of mEDLINE(Ovid),Embase,PsychINFO,and Pubmed on the 27/08/20;and CINAHL and Cochrane Library databases,was *** criteria were:a peer-reviewed clinical trial published in English;included a group of patients with schizophrenia;used melatonin as an adjunctive therapy;and reported any outcome of any *** criteria were:neurodegenerative diseases,primary sleep disorders,co-morbid substance use or animal *** Fifteen studies were included in the current review with the following primary outcomes:sleep(n=6),metabolic profile(n=3),tardive dyskinesia(n=3),cognitive function(n=2)and benzodiazepine discontinuation(n=1).CONCLUSION Adjunctive melatonin therapy has some positive outcomes for sleep,metabolic profile and tardive dyskinesia in patients with *** beneficial effect of melatonin was observed on outcomes of cognition or benzodiazepine *** studies utilizing larger samples and investigations specifically comparing the effect of melatonin as adjunctive therapy with different antipsychotics in patients with schizophrenia are required.

关键词： Schizophrenia melatonin Clinical trials Sleep metabolic syndrome Tardive dyskinesia

Electrophysiological assessment of primary cortical neurons genetically engineered using iron oxide nanoparticles

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Nano Research 2017年第8期10卷 2881-2890页

作者： michael G. Evans Arwa Al-Shakli Stuart I. jenkins Divya m. Chari School of Life Sciences Keele University Keele Staffordshire ST5 5BG UK Institute for Science and Technology in medicine Keele University Keele Staffordshire ST5 5BG UK

The development of safe technologies to genetically modify neurons is of great interest in regenerative neurology, for both translational and basic science applications. Such approaches have conventionally been heavily reliant on viral transduction methods, which have safety and production limitations. magnetofection （magnet-assisted gene transfer using iron oxide nanoparticles as vectors） has emerged as a highly promising non-viral alternative for safe and reproducible genetic modification of neurons. Despite the high potential of this technology, there is an important gap in our knowledge of the safety of this approach, namely, whether it alters neuronal function in adverse ways, such as by altering neuronal excitability and signaling. We have investigated the effects of magnetofection in primary cortical neurons by examining neuronal excitability using the whole cell patch clamp technique. We found no evidence that magnetofection alters the voltage-dependent sodium and potassium ionic currents that underpin excitability. Our study provides important new data supporting magnetofection as a safe technology for bioengineering of neuronal cell populations.

关键词： transfection magnetic nanoparticle green fluorescent protein (GFP) whole-cell patch clamp fluorescence microscopy

The Aerosol-monsoon Climate System of Asia:A New Paradigm

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Journal of meteorological Research 2016年第1期30卷 1-11页

作者： william K.m.Lau Earth Science Interdisciplinary Center University of MarylandCollege Park

This commentary is based on a series of recent lectures on aerosol-monsoon interactions I gave at the Beijing Normal University in August 2015. A main theme of the lectures is on a new paradigm of ＂An Aerosol-monsoon-Climate-System＂, which posits that aerosol, like rainfall, cloud, and wind, is an integral component of the monsoon climate system, influencing monsoon weather and climate on m1 timescales. Here, salient issues discussed in my lectures and my personal perspective regarding interactions between atmospheric dynamics and aerosols from both natural and anthropogenic sources are summarized. my hope is that under this new paradigm, we can break down traditional disciplinary barriers, advance a deeper understanding of weather and climate in monsoon regions, as well as entrain a new generation of geoscientists to strive for a sustainable future for one of the most complex and challenging human-natural climate sub-system of the earth.

关键词： aerosol monsoon climate system interaction new paradigm